Plant Comparison

Selfheal vs Fenugreek

A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.

First plant
Second plant
Show:
Plant ASelfhealPrunella vulgarisLamiaceaeFull monograph →
Plant BFenugreekTrigonella foenum-graecumFabaceaeFull monograph →

At a glance

Selfheal and Fenugreek: they share 6 indicated uses (arthritis / joint pain, inflammation (general), skin irritation, …); 3 pharmacological actions in common.

SelfhealFenugreek
Constituents24
Pharmacological actions104
Indicated uses128
Safety notes23
Cited sources3717
Indicated uses
Only Selfheal
BruisingCold & fluImmune supportInfection (general)WoundsCognitive function
Shared (6)
Arthritis / joint painInflammation (general)Skin irritationCancer (anticancer research)Blood sugar / diabetes supportCardiovascular / heart health
Only Fenugreek
FertilityMetabolic support
Pharmacological actions
Only Selfheal
AntimicrobialAntioxidantAntiviralImmunomodulator / immune supportVulnerary (wound healing)Neuroprotective / cognition supportHepatoprotective (liver support)
Shared (3)
Anti-inflammatoryAnticancer (preclinical)Antidiabetic (blood-sugar lowering)
Only Fenugreek
Aphrodisiac

Evidence face-off — shared uses

ConditionSelfhealFenugreekVerdict
Arthritis / joint pain2/108/10Stronger for Fenugreek
Inflammation (general)2/107/10Stronger for Fenugreek
Skin irritation2/107/10Stronger for Fenugreek
Cancer (anticancer research)7/107/10Comparable evidence
Blood sugar / diabetes support2/107/10Stronger for Fenugreek
Cardiovascular / heart health2/107/10Stronger for Fenugreek

Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.

Key Constituents

Triterpenoids and phenolic acids[1, 3]

Pentacyclic triterpenoids (ursolic, oleanolic and betulinic acids), the phenolic acid rosmarinic acid, coumarins (umbelliferone, scopoletin, esculetin) and the flavonoid luteolin are the main bioactives behind self-heal's antioxidant, anti-inflammatory and antimicrobial activity.

Rosmarinic acidPhenolic acidsCoumarinsFlavonoidsLuteolin
Sulphated and polyphenol-conjugated polysaccharides[4, 29, 30, 31]

Water-extracted polysaccharides — including a partially sulphated arabinogalactomannan (PSP-2B) and polyphenolic-protein-polysaccharide conjugates (PVG/PVE30) — are the principal antiviral and immunomodulatory constituents, blocking herpes simplex virus attachment and modulating innate immune signalling.

PolysaccharidesPhenolic compounds
Steroidal saponins (diosgenin)[12]

Thought to contribute to the antidiabetic and cholesterol-lowering effects.

Saponins
Galactomannan (soluble fiber)[5]

Mucilaginous soluble fiber that slows carbohydrate absorption, a key mechanism behind the blood-sugar-lowering effect.

Polysaccharides
4-hydroxyisoleucine (amino acid)[12]

An unusual amino acid studied for insulin-potentiating activity.

Sotolon (flavor compound)[11]

Aromatic lactone responsible for fenugreek's characteristic maple-syrup smell, including the body-odor effect reported with supplementation.

Pharmacological Actions

Anti-inflammatory[1, 2, 3, 4, 12, 15, 18, 20, 26, 27, 29, 32, 33, 34, 35]
Antimicrobial[1, 3, 32, 33, 34]
Antioxidant[1, 2, 5, 9, 12, 17, 32, 33, 34]
Antiviral[2, 29, 30, 31, 32, 33, 34, 36]
Immunomodulator / immune support[4, 5, 9, 10, 15, 23, 26, 29, 32, 33, 34, 35, 36]
Vulnerary (wound healing)[1, 27, 32, 33, 34]
Anticancer (preclinical)[6, 7, 10, 13, 14, 16, 21, 22, 28]
Neuroprotective / cognition support[11, 25]
Hepatoprotective (liver support)[12, 16, 17]
Antidiabetic (blood-sugar lowering)[19, 20, 24]
Anti-inflammatory[1, 5, 6, 9, 10, 11, 12]
Anticancer (preclinical)[8]
Antidiabetic (blood-sugar lowering)[4, 5, 6, 11, 12]
Aphrodisiac[3, 5, 11, 12]

Traditional & Indicated Uses

Arthritis / joint pain[1, 29, 32, 33, 34, 35]Traditional · 2/10

inferred from anti-inflammatory action

Evidence: 2
Label: Arthritis / joint pain
Bruising[1, 32, 33, 34]Traditional · 2/10

inferred from vulnerary action

Evidence: 2
Label: Bruising
Cold & flu[29, 30, 31, 32, 33, 34, 36]Traditional · 2/10

inferred from antiviral action

Evidence: 2
Label: Cold & flu
Immune support[10, 15, 29, 32, 33, 34, 35, 36]Traditional · 2/10
Evidence: 2
Label: Immune support
Infection (general)[1, 32, 33, 34]Traditional · 2/10

inferred from antimicrobial action

Evidence: 2
Label: Infection (general)
Inflammation (general)[1, 12, 15, 29, 32, 33, 34, 35]Traditional · 2/10

inferred from anti-inflammatory action

Evidence: 2
Label: Inflammation (general)
Skin irritation[1, 29, 32, 33, 34, 35]Traditional · 2/10

inferred from anti-inflammatory action

Evidence: 2
Label: Skin irritation
Wounds[1, 27, 32, 33, 34]Traditional · 2/10

inferred from antimicrobial action

Evidence: 2
Label: Wounds
Cancer (anticancer research)[6, 7, 10, 13, 14, 16, 21, 22, 28]Good · 7/10

inferred from anticancer action

Evidence: 7
Label: Cancer (anticancer research)
Blood sugar / diabetes support[19, 20, 24]Traditional · 2/10
Evidence: 2
Label: Blood sugar / diabetes support
Cardiovascular / heart health[18, 19]Traditional · 2/10
Evidence: 2
Label: Cardiovascular / heart health
Cognitive function[25]Traditional · 2/10
Evidence: 2
Label: Cognitive function
Arthritis / joint pain[1, 5, 11, 12]Good · 8/10

inferred from anti-inflammatory action

Evidence: 8
Label: Arthritis / joint pain
Blood sugar / diabetes support[4, 5, 11, 12]Good · 7/10

inferred from antidiabetic action

Evidence: 7
Label: Blood sugar / diabetes support
Cancer (anticancer research)[8]Good · 7/10

inferred from anticancer action

Evidence: 7
Label: Cancer (anticancer research)
Cardiovascular / heart health[5, 11, 12]Good · 7/10
Evidence: 7
Label: Cardiovascular / heart health
Fertility[3, 5, 11, 12]Good · 8/10
Evidence: 8
Label: Fertility
Inflammation (general)[5, 9, 10, 11, 12]Good · 7/10

inferred from anti-inflammatory action

Evidence: 7
Label: Inflammation (general)
Metabolic support[5, 11, 12]Good · 7/10
Evidence: 7
Label: Metabolic support
Skin irritation[5, 11, 12]Good · 7/10

inferred from anti-inflammatory action

Evidence: 7
Label: Skin irritation

Safety, Cautions & Contraindications

Safety note[32, 33, 34]Caution

Generally very safe and well tolerated. No significant known toxicity or drug interactions. Safe for topical and internal use in normal medicinal doses. Suitable for most adults including children in appropriate doses.

Safety note[32, 33, 34, 37]Info

Duke (2002) rates self-heal as +++ and notes antioxidant (score 2), anti-inflammatory, antiviral, and COX-2 inhibitory activities. The plant contains luteolin, rosmarinic acid, and hyperoside — all with well-documented bioactivities. Hepatoprotective activity has been experimentally demonstrated. Duke notes that self-heal has a broad antimicrobial spectrum and an impressive antioxidant profile, supporting its traditional reputation as a versatile wound-healing herb. No significant safety concerns at normal herbal doses (Duke, 2002).

Safety note[5, 11, 12]Info

Fenugreek appears https://www.nccih.nih.gov/health/fenugreek for most people.

Safety note[5, 11, 12]Caution

Less serious side effects like diarrhea and indigestion have been reported anecdotally. You may also experience https://pubmed.ncbi.nlm.nih.gov/26251835/, which could be harmful if you have an eating disorder or are trying to https://www.healthline.com/nutrition/how-to-gain-weight. Moreover, some people report a strange and slightly sweet body odor when supplementing, but this is unconfirmed. Given its effect on blood sugar, fenugreek should be used with caution if you’re taking diabetes medication or other supplements that lower blood sugar levels.

Safety note[5, 11, 12, 13]Caution

Duke (2002) provides strong clinical evidence (score 2) for fenugreek's hypoglycemic and hypocholesterolemic activities — among the best-evidenced herbal treatments for blood sugar and lipid management. Anti-inflammatory and demulcent activities also have clinical support. The seed is Commission E approved as an appetite stimulant. Dose: 6–50 g of ground seeds daily for blood sugar management; 1–4 g seeds in tea for digestive use. The plant has lactagogue effects and can cause maple syrup-like body odor due to sotolon content. Contraindicated in pregnancy at medicinal doses due to uterotonic effects (Duke, 2002).

External Ids

Gbif: 5341297
Wikidata: Q158469
Gbif: 5360475
Wikidata: Q133205

Botanical Description

Low, creeping to semi-erect perennial herb (Lamiaceae), 5-30 cm tall, with square, often purplish stems. Leaves are opposite, ovate with slightly toothed margins. Small, two-lipped, violet-purple flowers are densely packed into a compact, club-shaped terminal spike subtended by purplish bracts.[1]

Height: 5-30 cm
Habit: Low, creeping to semi-erect perennial herb
Leaves: Opposite, ovate, slightly toothed
Flowers: Small, two-lipped, violet-purple, in a compact club-shaped terminal spike
Stem: Square, often purplish
Root: Fibrous, spreading perennial rootstock
Fruit: Four small nutlets (typical Lamiaceae schizocarp)
Flowering Period: June-September

Erect annual herb with trifoliate leaves, each leaflet oblong and finely toothed toward the tip. Small, pale yellow to white, pea-like flowers are borne singly or in pairs in the leaf axils, followed by long, slender, curved seed pods.[11]

Height: 30-80 cm
Habit: Erect annual herb
Leaves: Trifoliate, each leaflet oblong, finely toothed toward the tip
Flowers: Small, pale yellow to white, pea-like, borne singly or in pairs in leaf axils
Stem: Erect, branching, slightly hairy
Root: Taproot with nitrogen-fixing nodules
Fruit: Long, slender, curved seed pod (10-15 cm) containing 10-20 hard, angular, yellow-brown seeds
Flowering Period: May-June

Habitat

Native throughout Europe, Asia and North America (circumboreal), extremely common in lawns, meadows, woodland clearings, roadsides and waste ground, tolerating mowing and a wide range of soils.[1]

Cultivated widely as a food and forage crop; native to the eastern Mediterranean and western Asia, now grown throughout South Asia, the Middle East and North Africa.[11]

Harvesting

Whole flowering aerial parts (flower, leaf and stem) are cut during flowering (summer) and dried.[1]

Parts: Flower, Leaf, Stem
Season: Summer, during flowering

Leaves and young sprouts are harvested throughout the growing season; seed pods are collected when fully mature and dried, then the hard seeds are threshed out.[11]

Parts: Leaf, Seed, Young sprouts
Season: Leaf/sprouts through growing season; seed at maturity

Traditional Uses

Selfheal has an extremely broad folk-medicine reputation across European, North American and Traditional Chinese Medicine traditions - as its name suggests, used as an all-purpose wound herb, gargle for sore throat, and internal remedy for fevers and inflammation. Modern research on its triterpenoid, phenolic and polysaccharide constituents supports wide-ranging antioxidant, anti-inflammatory, antimicrobial and antiviral activity.[1]

Fenugreek seed has an ancient tradition across the Mediterranean, Middle East and South Asia as a digestive and appetite-stimulant remedy and lactation aid, and modern clinical research strongly supports its traditional use for blood sugar and cholesterol management, formalised in Commission E approval as an appetite stimulant.[5, 11, 12]

Preparations

Infusion (tea)[1]

Dried aerial parts steeped in hot water, taken internally or used as a gargle or wash.

Ground seed / seed tea[5]

Ground seeds taken with food, or whole seeds soaked/simmered as a tea, the traditional preparation for digestive and blood sugar support.

Standardized extract (capsule)[5]

Standardized seed extract in capsule form, the form most used in clinical trials on blood sugar and cholesterol.

Dosage

Infusion (tea)[1]

Traditional guidance suggests roughly 2-4 g dried herb per cup as an infusion, up to three times daily, or an equivalent tincture; used topically as a wash or gargle at similar strength. Educational reference only, not a prescription.

Seed[5, 12]

Clinical research and traditional sources suggest around 6-50 g of ground seed daily (higher end for blood sugar management), or 1-4 g in tea for digestive use. Educational reference only, not a prescription.

References

REF-0659, REF-2422, REF-2423, REF-2424, REF-2425, REF-2878, REF-2879, REF-2880, REF-2881, REF-2882, REF-2883, REF-2884, REF-2885, REF-2886, REF-2887, REF-2888, REF-2911, REF-2912, REF-2913, REF-2914, REF-2915, REF-2916, REF-2917, REF-2918, REF-2919, REF-2920, REF-2921, REF-2922
REF-1114, REF-1115, REF-1116, REF-1117, REF-0182, REF-1118, REF-1119, REF-1120, REF-1121, REF-1122

Lookalikes Review

Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07
Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

Drug Class Interactions

Not documented

Safety note[14, 15]Caution
Drug Class: antidiabetics
Mechanism: Fenugreek seed lowers fasting and post-meal blood sugar (confirmed by a meta-analysis of randomised trials in type 2 diabetes and prediabetes), so taken with diabetes medicines it may add to their effect and increase the risk of hypoglycaemia; monitor blood glucose.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

Pairings

Not documented

Fenugreek and bitter melon can each lower blood sugar, so taking them together — especially alongside diabetes medicines — may add up and increase the risk of hypoglycaemia. Monitor your blood glucose.[15, 16]

Partner Id: momordica-charantia
Type: caution
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

Fenugreek and black seed (Nigella sativa) can each lower blood sugar, so taking them together — especially alongside diabetes medicines — may add up and increase the risk of hypoglycaemia. Monitor your blood glucose.[15, 17]

Partner Id: nigella-sativa
Type: caution
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

References & Sources

  1. Mir, R.H., Bhat, M.F., Sawhney, G., Kumar, P., Andrabi, N.I., Shaikh, M., Mohi-Ud-Din, R. and Masoodi, M.H (2022) 'Prunella vulgaris L.: Critical Pharmacological, Expository Traditional Uses and Extensive Phytochemistry: A Review', Current Drug Discovery Technologies, 19(1). doi:10.2174/1570163818666210203181542 Traditional / reference
    https://doi.org/10.2174/1570163818666210203181542
  2. Pan, J. and Wang, H. and Chen, Y (2022) 'Prunella vulgaris L. - A Review of its Ethnopharmacology, Phytochemistry, Quality Control and Pharmacological Effects', Frontiers in Pharmacology, 13, pp. 903171. doi:10.3389/fphar.2022.903171 Meta-analysis / review
    https://doi.org/10.3389/fphar.2022.903171
  3. Wang, S.J. and Wang, X.H. and Dai, Y.Y. and Ma, M.H. and Rahman, K. and Nian, H. and Zhang, H (2019) 'Prunella vulgaris: A Comprehensive Review of Chemical Constituents, Pharmacological Effects and Clinical Applications', Current Pharmaceutical Design, 25(3), pp. 359-369. doi:10.2174/1381612825666190313121608 Meta-analysis / review
    https://doi.org/10.2174/1381612825666190313121608
  4. Zhu, M.J. and Song, Y.J. and Rao, P.L. and Gu, W.Y. and Xu, Y. and Xu, H.X (2025) 'Therapeutic role of Prunella vulgaris L. polysaccharides in non-alcoholic steatohepatitis and gut dysbiosis', Journal of Integrative Medicine, 23(3), pp. 297-308. doi:10.1016/j.joim.2025.03.002 Preclinical
    https://doi.org/10.1016/j.joim.2025.03.002
  5. Zhang, Y. and Qu, X. and Xu, N. and He, H. and Li, Q. and Wei, X. and Chen, Y. and Xu, Y. and Li, X. and Zhang, R. and Zhong, R. and Liu, C. and Xiang, P. and Zhu, F (2024) 'Mechanism of Prunella vulgaris L. and luteolin in restoring Tfh/Tfr balance and alleviating oxidative stress in Graves' disease', Phytomedicine, 132, pp. 155818. doi:10.1016/j.phymed.2024.155818 Preclinical
    https://doi.org/10.1016/j.phymed.2024.155818
  6. Zhang, S. and Wang, Y. and Wang, M. and Jiang, L. and Ma, X. and Huang, Y. and Liu, T. and Zheng, L. and Li, Y (2024) 'Construction and anti-pancreatic cancer activity of selenium nanoparticles stabilized by Prunella vulgaris polysaccharide', Int J Biol Macromol, 278(Pt 3), pp. 134924. doi:10.1016/j.ijbiomac.2024.134924 Preclinical
    https://doi.org/10.1016/j.ijbiomac.2024.134924
  7. Ning, N. and Nan, Y. and Chen, G. and Huang, S. and Lu, D. and Yang, Y. and Meng, F. and Yuan, L (2024) 'Anti-Tumor Effects and Toxicity Reduction Mechanisms of Prunella vulgaris: A Comprehensive Review', Molecules, 29(8). doi:10.3390/molecules29081843 Meta-analysis / review
    https://doi.org/10.3390/molecules29081843
  8. Han, Q. and Xu, N. and Chen, B. and Wu, W. and Sheng, L (2021) 'Safety and efficacy of Prunella vulgaris preparation in adjuvant treatment of thyroid nodules: A meta-analysis', Medicine (Baltimore), 100(41), pp. e27490. doi:10.1097/MD.0000000000027490 Meta-analysis / review
    https://doi.org/10.1097/MD.0000000000027490
  9. Li, P. and Lv, X. and Wang, J. and Zhang, C. and Zhao, J. and Yang, Y (2023) 'Research on the anti-ageing mechanism of Prunella vulgaris L', Sci Rep, 13(1), pp. 12398. doi:10.1038/s41598-023-39609-1 Preclinical
    https://doi.org/10.1038/s41598-023-39609-1
  10. Zhang, Q. and Chen, X. and Palen, K. and Johnson, B. and Bui, D. and Xiong, D. and Pan, J. and Hu, M. and Wang, Y. and You, M (2023) 'Cancer chemoprevention with PV-1, a novel Prunella vulgaris-containing herbal mixture that remodels the tumor immune microenvironment in mice', Front Immunol, 14, pp. 1196434. doi:10.3389/fimmu.2023.1196434 Preclinical
    https://doi.org/10.3389/fimmu.2023.1196434
  11. Ma, F. and Deng, Q. and Lou, H. and Li, J. and Xu, S. and Wu, W. and Wen, Q. and Tang, L. and Wang, X. and Pan, W (2022) 'Vulgarisin-type diterpenoids from self-heal (Prunella vulgaris) and their neuroprotective effects against ischemia/reperfusion (I/R) via a mitochondria-related pathway', Food Funct, 13(13), pp. 7062-7074. doi:10.1039/d2fo00150k Preclinical
    https://doi.org/10.1039/d2fo00150k
  12. Xie, J. and Xiong, S. and Yu, J. and Ma, X. and Xiang, F. and Chen, Y. and Xia, B. and Li, Y. and Zhang, Z. and Liao, D. and Lin, L (2025) 'Prunella vulgaris polyphenols alleviate liver injury-uveitis comorbidity by regulating acylcarnitine via the S100A9-PP2A-AMPK pathway', Phytomedicine, 141, pp. 156675. doi:10.1016/j.phymed.2025.156675 Preclinical
    https://doi.org/10.1016/j.phymed.2025.156675
  13. Li, Y. and Luo, H. and Lin, X. and Hua, L. and Wang, J. and Xie, J. and Zhang, Z. and Shi, Z. and Li, M. and Peng, Q. and Lin, L. and Liao, D. and Xia, B (2025) 'Triterpenes of Prunella vulgaris Inhibit Triple-Negative Breast Cancer by Regulating PTP1B/PI3K/AKT/mTOR and IL-24/CXCL12/CXCR4 Pathways', Int J Mol Sci, 26(5). doi:10.3390/ijms26051959 Preclinical
    https://doi.org/10.3390/ijms26051959
  14. Zeng, S. and Liu, B. and Ge, R. and Yuan, Z. and Yang, Y. and Zhu, W. and Wang, Z (2025) 'An integrative analysis reveals mechanisms of Prunella vulgaris in thyroid cancer metastasis', Phytomedicine, 145, pp. 157051. doi:10.1016/j.phymed.2025.157051 Preclinical
    https://doi.org/10.1016/j.phymed.2025.157051
  15. Zhu, Q. and Muyayalo, K.P. and Xu, Q.H. and Wang, J. and Wang, H. and Liao, A.H (2021) 'Prunella vulgaris can improve the pregnancy outcomes of experimental autoimmune thyroiditis rats by inhibiting Th1/Th17 immune responses', J Reprod Immunol, 149, pp. 103469. doi:10.1016/j.jri.2021.103469 Preclinical
    https://doi.org/10.1016/j.jri.2021.103469
  16. Lin, J. and Zhou, J. and Ye, K. and Xie, F (2025) 'Prunella vulgaris: A potential molecule for the treatment of hepatocellular carcinoma', Medicine (Baltimore), 104(17), pp. e42267. doi:10.1097/MD.0000000000042267 Preclinical
    https://doi.org/10.1097/MD.0000000000042267
  17. Li, L. and Lin, L. and Deng, J. and Lin, X. and Li, Y. and Xia, B (2021) 'The therapeutic effects of Prunella vulgaris against fluoride‐induced oxidative damage by using the metabolomics method', Environmental Toxicology, 36(9), pp. 1802-1816. doi:10.1002/tox.23301 Preclinical
    https://doi.org/10.1002/tox.23301
  18. Wei, J. and Leng, L. and Sui, Y. and Song, S. and Owusu, F.B. and Li, X. and Cao, Y. and Li, P. and Wang, H. and Li, R. and Yang, W. and Gao, X. and Wang, Q (2023) 'Phenolic acids from Prunella vulgaris alleviate cardiac remodeling following myocardial infarction partially by suppressing NLRP3 activation', Phytotherapy Research, 38(1), pp. 384-399. doi:10.1002/ptr.8024 Preclinical
    https://doi.org/10.1002/ptr.8024
  19. Jiao, X. and Liu, H. and Lu, Q. and Wang, Y. and Zhao, Y. and Liu, X. and Liu, F. and Zuo, Y. and Wang, W. and Li, Y (2021) 'Study on the Mechanism of Prunella Vulgaris L on Diabetes Mellitus Complicated with Hypertension Based on Network Pharmacology and Molecular Docking Analyses', Journal of Diabetes Research, 2021, pp. 1-14. doi:10.1155/2021/9949302 Preclinical
    https://doi.org/10.1155/2021/9949302
  20. Namgung, S. and Yoon, J.J. and Yoon, C. and Han, B.H. and Choi, E.S. and Oh, H. and Kim, Y. and Lee, Y.J. and Kang, D.G. and Lee, H.S (2017) 'Prunella vulgarisAttenuates Diabetic Renal Injury by Suppressing Glomerular Fibrosis and Inflammation', The American Journal of Chinese Medicine, 45(03), pp. 475-495. doi:10.1142/s0192415x1750029x Preclinical
    https://doi.org/10.1142/s0192415x1750029x
  21. Lim, G. and Sung, J.Y. and Yu, S. and Kim, Y. and Kim, Y. and Shim, J. and Kim, H.J. and Cho, M.L. and Lee, J. and Kim, Y. and Kim, Y (2020) 'Pygenic Acid A (PA) Sensitizes Metastatic Breast Cancer Cells to Anoikis and Inhibits Metastasis In Vivo', International Journal of Molecular Sciences, 21(22), pp. 8444-8444. doi:10.3390/ijms21228444 Preclinical
    https://doi.org/10.3390/ijms21228444
  22. Lin, Y. and Yang, C. and Tang, J. and Li, Q. and Zhang, Z. and Xia, B. and Li, Y. and He, Q. and Lin, L. and Liao, D (2020) 'Characterization and anti-uterine tumor effect of extract from Prunella vulgaris L', BMC Complementary Medicine and Therapies, 20(1), pp. 189-189. doi:10.1186/s12906-020-02986-5 Preclinical
    https://doi.org/10.1186/s12906-020-02986-5
  23. Chen, Y. and Jiang, B. and Qu, C. and Jiang, C. and Zhang, C. and Wang, Y. and Chen, F. and Sun, X. and Su, L. and Luo, Y (2024) 'Bioactive components in prunella vulgaris for treating Hashimoto's disease via regulation of innate immune response in human thyrocytes', Heliyon, 10(16), pp. e36103-e36103. doi:10.1016/j.heliyon.2024.e36103 Preclinical
    https://doi.org/10.1016/j.heliyon.2024.e36103
  24. Raafat, K. and Wurglics, M. and Schubert‐Zsilavecz, M (2016) 'Prunella vulgaris L. active components and their hypoglycemic and antinociceptive effects in alloxan-induced diabetic mice', Biomedicine & Pharmacotherapy, 84, pp. 1008-1018. doi:10.1016/j.biopha.2016.09.095 Preclinical
    https://doi.org/10.1016/j.biopha.2016.09.095
  25. Qu, Z. and Zhang, J. and Yang, H. and Gao, J. and Chen, H. and Liu, C. and Gao, W (2016) 'Prunella vulgaris L., an Edible and Medicinal Plant, Attenuates Scopolamine-Induced Memory Impairment in Rats', Journal of Agricultural and Food Chemistry, 65(2), pp. 291-300. doi:10.1021/acs.jafc.6b04597 Preclinical
    https://doi.org/10.1021/acs.jafc.6b04597
  26. Guo, Q. and Qu, H. and Zhang, H. and Zhong, X (2021) 'Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling', Drug Design Development and Therapy, Volume 15, pp. 4559-4574. doi:10.2147/dddt.s325814 Preclinical
    https://doi.org/10.2147/dddt.s325814
  27. Akkol, E.K. and Renda, G. and İlhan, M. and Bektaş, N.Y (2022) 'Wound healing acceleration and anti-inflammatory potential of Prunella vulgaris L.: From conventional use to preclinical scientific verification', Journal of Ethnopharmacology, 295, pp. 115411-115411. doi:10.1016/j.jep.2022.115411 Preclinical
    https://doi.org/10.1016/j.jep.2022.115411
  28. Yu, F. and Zhang, L. and Ma, R. and Liu, C. and Wang, Q. and Yin, D (2021) 'The Antitumour Effect of Prunella vulgaris Extract on Thyroid Cancer Cells In Vitro and In Vivo', Evidence-based Complementary and Alternative Medicine, 2021, pp. 1-12. doi:10.1155/2021/8869323 Preclinical
    https://doi.org/10.1155/2021/8869323
  29. Zhong, X., Zhang, Y., Yuan, M., Xu, L., Luo, X., Wu, R., Xi, Z., Li, Y. and Xu, H (2024) 'Prunella vulgaris polysaccharide inhibits herpes simplex virus infection by blocking TLR-mediated NF-kB activation', Chinese Medicine, 19(1). doi:10.1186/s13020-023-00865-y Preclinical
    https://doi.org/10.1186/s13020-023-00865-y
  30. Zhang, Q., Li, Y., Zhong, X., Fu, W., Luo, X., Feng, J., Yuan, M., Xiao, L. and Xu, H (2021) 'Polyphenolic-protein-polysaccharide conjugates from Spica of Prunella vulgaris: Chemical profile and anti-herpes simplex virus activities', International Journal of Biological Macromolecules. doi:10.1016/j.ijbiomac.2021.11.200 Preclinical
    https://doi.org/10.1016/j.ijbiomac.2021.11.200
  31. Ma, F.W., Kong, S.Y., Tan, H.S., Wu, R., Xia, B., Zhou, Y. and Xu, H.X (2016) 'Structural characterization and antiviral effect of a novel polysaccharide PSP-2B from Prunellae Spica', Carbohydrate Polymers, pp. 699--709. doi:10.1016/j.carbpol.2016.07.062 Preclinical
    https://doi.org/10.1016/j.carbpol.2016.07.062
  32. Grieve, M (1931) 'A Modern Herbal'. Traditional / reference
    https://scholar.google.com/scholar?q=A%20Modern%20Herbal
  33. Psotova, J. et al (2003) 'Biological activities of Prunella vulgaris extract', 17(9), pp. 1082--1087. doi:10.1002/ptr.1324 Preclinical
    https://doi.org/10.1002/ptr.1324
  34. Yang, Y.Q. et al (2007) 'Antiviral activity of aqueous extract of Prunella vulgaris L', 73(3), pp. 157--162. Traditional / reference
    https://scholar.google.com/scholar?q=Antiviral%20activity%20of%20aqueous%20extract%20of%20Prunella%20vulgaris%20L
  35. Haarberg, K.M.K., Wymore Brand, M.J., Overstreet, A.M.C., Hauck, C.C., Murphy, P.A., Hostetter, J.M., Ramer-Tait, A.E. and Wannemuehler, M.J (2015) 'Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a(-/-) mice', World Journal of Gastrointestinal Pharmacology and Therapeutics, 6(4), pp. 223--237. doi:10.4292/wjgpt.v6.i4.223 Preclinical
    https://doi.org/10.4292/wjgpt.v6.i4.223
  36. Zhang, Y.B., Xu, L., Yuan, M., Liu, M.F., Li, Y., Zhong, X.L., Lin, Z.X., Xian, Y.F., Lu, P., Xi, Z.C. and Xu, H.X (2025) 'Protective effects of Prunella vulgaris polysaccharides against herpes simplex virus type 1 infection through the STING-TBK1-IRF3 pathway', Journal of Integrative Medicine, 24(3), pp. 454--465. doi:10.1016/j.joim.2025.12.008 Preclinical
    https://doi.org/10.1016/j.joim.2025.12.008
  37. Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
    https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
  1. Faghfoori, Z., Javadivala, Z., Khalili, Y. and Malek Mahdavi, A (2023) 'Effects of Trigonella foenum-graecum (fenugreek) on rheumatoid arthritis: a systematic review', Immunopharmacology and Immunotoxicology, 45(5), pp. 626-634. doi:10.1080/08923973.2023.2202298 Meta-analysis / review
    https://doi.org/10.1080/08923973.2023.2202298
  2. Ouzir, M., El Bairi, K. and Amzazi, S (2016) 'Toxicological properties of fenugreek (Trigonella foenum graecum)', Food and Chemical Toxicology, 96, pp. 145-154. doi:10.1016/j.fct.2016.08.003 Meta-analysis / review
    https://doi.org/10.1016/j.fct.2016.08.003
  3. Rao, A., Steels, E., Inder, W.J., Abraham, S. and others (2016) 'Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a double-blind randomised clinical study', The Aging Male, 19(2), pp. 134-142. doi:10.3109/13685538.2015.1135323 Randomized trial
    https://doi.org/10.3109/13685538.2015.1135323
  4. Avalos-Soriano, A., De la Cruz-Cordero, R., Rosado, J.L. and Garcia-Gasca, T (2016) '4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity', Molecules, 21(11), pp. 1596. doi:10.3390/molecules21111596 Preclinical
    https://doi.org/10.3390/molecules21111596
  5. Neelakantan, N., Narayanan, M., de Souza, R.J. and van Dam, R.M (2014) 'Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials', pp. 7. Meta-analysis / review
    https://scholar.google.com/scholar?q=Effect%20of%20fenugreek%20%28Trigonella%20foenum-graecum%20L.%29%20intake%20on%20glycemia%3A%20a%20meta-analysis%20of%20clinical%20trials
  6. Nagulapalli Venkata, K.C., Swaroop, A., Bagchi, D. and Bishayee, A (2017) 'A small plant with big benefits: Fenugreek (Trigonella foenum-graecum Linn.) for disease prevention and health promotion', Molecular Nutrition & Food Research, 61(6), pp. 1600950. doi:10.1002/mnfr.201600950 Meta-analysis / review
    https://doi.org/10.1002/mnfr.201600950
  7. Ulbricht, C., Basch, E., Burke, D., Cheung, L. and others (2007) 'Fenugreek (Trigonella foenum-graecum L. Leguminosae): an evidence-based systematic review by the natural standard research collaboration', Journal of Herbal Pharmacotherapy, 7(3-4), pp. 143-177. doi:10.1080/15228940802142852 Meta-analysis / review
    https://doi.org/10.1080/15228940802142852
  8. El Bairi, K., Ouzir, M., Agnieszka, N. and Khalki, L (2017) 'Anticancer potential of Trigonella foenum graecum: Cellular and molecular targets', Biomedicine & Pharmacotherapy, 90, pp. 479-491. doi:10.1016/j.biopha.2017.03.071 Meta-analysis / review
    https://doi.org/10.1016/j.biopha.2017.03.071
  9. Piao, C.H., Bui, T.T., Song, C.H., Shin, H.S. and others (2017) 'Trigonella foenum-graecum alleviates airway inflammation of allergic asthma in ovalbumin-induced mouse model', Biochemical and Biophysical Research Communications, 482(4), pp. 1284-1288. doi:10.1016/j.bbrc.2016.12.029 Preclinical
    https://doi.org/10.1016/j.bbrc.2016.12.029
  10. Asif, M., Yousaf, H.M., Saleem, M., Saadullah, M. and others (2021) 'Trigonella foenum-graecum Seeds Oil Attenuated Inflammation and Angiogenesis in vivo through Down-Regulation of TNF-alpha', Anti-Cancer Agents in Medicinal Chemistry, 21(11), pp. 1460-1471. doi:10.2174/1871520620666201005100132 Preclinical
    https://doi.org/10.2174/1871520620666201005100132
  11. World Health Organization (1999) 'WHO Monographs on Selected Medicinal Plants'. Traditional / reference
    https://scholar.google.com/scholar?q=WHO%20Monographs%20on%20Selected%20Medicinal%20Plants
  12. Kumar, P. and Bhandari, U (2013) 'Protective effect of fenugreek (Trigonella foenum-graecum L.) seeds in experimentally-induced myocardial infarction', 23(2), pp. 255--261. Traditional / reference
    https://scholar.google.com/scholar?q=Protective%20effect%20of%20fenugreek%20%28Trigonella%20foenum-graecum%20L.%29%20seeds%20in%20experimentally-induced%20myocardial%20infarction
  13. Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
    https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
  14. Neelakantan, N., Narayanan, M., de Souza, R.J. and van Dam, R.M (2014) 'Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials', Nutrition Journal, 13, pp. 7. doi:10.1186/1475-2891-13-7 Meta-analysis / review
    https://doi.org/10.1186/1475-2891-13-7
  15. Kim, J., Noh, W., Kim, A., Choi, Y. and Kim, Y.S (2023) 'The effect of fenugreek in type 2 diabetes and prediabetes: a systematic review and meta-analysis of randomized controlled trials', International Journal of Molecular Sciences, 24(18), pp. 13999. doi:10.3390/ijms241813999 Meta-analysis / review
    https://doi.org/10.3390/ijms241813999
  16. Zhang, X., Zhao, Y., Song, Y. and Miao, M (2024) 'Effects of Momordica charantia L. supplementation on glycemic control and lipid profile in type 2 diabetes mellitus patients: a systematic review and meta-analysis of randomized controlled trials', Heliyon, 10(10), pp. e31126. doi:10.1016/j.heliyon.2024.e31126 Meta-analysis / review
    https://doi.org/10.1016/j.heliyon.2024.e31126
  17. Daryabeygi-Khotbehsara, R., Golzarand, M., Ghaffari, M.P. and Djafarian, K (2017) 'Nigella sativa improves glucose homeostasis and serum lipids in type 2 diabetes: a systematic review and meta-analysis', Complementary Therapies in Medicine, 35, pp. 6-13. doi:10.1016/j.ctim.2017.08.016 Meta-analysis / review
    https://doi.org/10.1016/j.ctim.2017.08.016

Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.