Plant Comparison

Greater Plantain vs White clover

A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.

First plant

Second plant

Plant AGreater PlantainPlantago majorPlantaginaceaeFull monograph →

Plant BWhite cloverTrifolium repensFabaceaeFull monograph →

At a glance

Greater Plantain and White clover: they share 8 indicated uses (arthritis / joint pain, bruising, infection (general), …); 6 pharmacological actions in common.

Greater PlantainWhite clover

Constituents53

Pharmacological actions1311

Indicated uses1515

Safety notes52

Cited sources5433

Indicated uses

Only Greater Plantain

BronchitisConstipationCoughDiarrhoeaRespiratory supportSore throatCardiovascular / heart health

Shared (8)

Arthritis / joint painBruisingInfection (general)Inflammation (general)Skin irritationWoundsImmune supportCancer (anticancer research)

Only White clover

Cold & fluMenstrual crampsMuscle spasmKidney supportLiver supportBlood sugar / diabetes supportCognitive function

Pharmacological actions

Only Greater Plantain

AstringentDemulcent (soothing mucilage)ExpectorantLaxativeAntiviralAnalgesic (pain relief)Antifungal

Shared (6)

Anti-inflammatoryAntimicrobialAntioxidantVulnerary (wound healing)Immunomodulator / immune supportAnticancer (preclinical)

Only White clover

AntispasmodicNephroprotective (kidney support)Hepatoprotective (liver support)Antidiabetic (blood-sugar lowering)Neuroprotective / cognition support

Evidence face-off — shared uses

Condition	Greater Plantain	White clover	Verdict
Arthritis / joint pain	1/10	1/10	Comparable evidence
Bruising	1/10	1/10	Comparable evidence
Infection (general)	1/10	2/10	Comparable evidence
Inflammation (general)	1/10	2/10	Comparable evidence
Skin irritation	1/10	1/10	Comparable evidence
Wounds	2/10	7/10	Stronger for White clover
Immune support	2/10	1/10	Comparable evidence
Cancer (anticancer research)	2/10	2/10	Comparable evidence

Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.

Key Constituents

Iridoid glycosides (aucubin, catalpol)^{[1, 36]}

Characteristic iridoids of Plantago major.

Iridoid glycosidesGlycosides

Caffeic acid esters (plantamajoside, acteoside/verbascoside)^{[1, 36]}

Polyphenolic esters contributing to antioxidant and anti-inflammatory activity.

Caffeic acidVerbascoside (acteoside)

Flavonoids (baicalein, luteolin, hispidulin)^[1]

Flavonoid constituents of the leaf.

FlavonoidsLuteolin

Allantoin^[36]

Cell-proliferative compound supporting wound healing.

Allantoin

Mucilage and triterpenes (ursolic and oleanolic acid)^{[1, 36]}

Demulcent mucilage plus anti-inflammatory triterpenes.

Terpenes / terpenoidsMucilage

Isoflavones^[32]

Phytoestrogenic isoflavones, present at lower levels than in red clover.

Flavonoids

Cyanogenic glycosides (trace)^[30]

Present in small amounts; not significant in normal food or tea use.

Glycosides

Phenolic acids and flavonoids^[32]

Contribute to antioxidant activity.

Phenolic acidsFlavonoids

Pharmacological Actions

Anti-inflammatory^{[7, 8, 29, 30, 31, 39, 40, 41]}

Antimicrobial^{[1, 9, 32, 35]}

Antioxidant^{[1, 11, 12, 23, 24, 34, 39, 40, 41]}

Astringent^{[37, 38]}

Astringent (diarrhoea)

Demulcent (soothing mucilage)^{[6, 13, 37, 38]}

Demulcent / expectorant (coughs, catarrh, irritated airways)

Expectorant^{[2, 10, 37, 38, 39, 40, 41]}

Demulcent / expectorant (coughs, catarrh, irritated airways)

Laxative^{[2, 13, 38]}

Bulk laxative (mucilaginous seeds)

Vulnerary (wound healing)^{[3, 4, 5, 25, 26, 27, 28, 36, 38, 39, 40, 41, 42]}

Vulnerary (wound healing) - fresh leaf poultice

Immunomodulator / immune support^{[16, 17, 18, 19, 20]}

Antiviral^{[16, 33]}

Anticancer (preclinical)^{[16, 21, 22]}

Analgesic (pain relief)^[30]

Antifungal^[35]

Anti-inflammatory^{[1, 2, 5, 6, 22, 28, 30, 31, 32]}

Antioxidant^{[1, 2, 4, 5, 7, 8, 9, 10, 14, 16, 17, 20, 21, 23, 24, 25, 28, 30, 31, 32]}

Antispasmodic^{[30, 31, 32]}

Antispasmodic (cramp easing)

Immunomodulator / immune support^{[2, 30, 31, 32]}

Vulnerary (wound healing)^{[1, 7, 13, 30, 31, 32]}

Nephroprotective (kidney support)^[4]

Anticancer (preclinical)^{[3, 10]}

Hepatoprotective (liver support)^[9]

Antimicrobial^{[12, 18, 22, 26, 28]}

Antidiabetic (blood-sugar lowering)^{[10, 20]}

Neuroprotective / cognition support^{[22, 23]}

Traditional & Indicated Uses

Arthritis / joint pain^{[39, 40, 41]}Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1

Label: Arthritis / joint pain

Bronchitis^{[37, 38, 39, 40, 41]}Traditional · 1/10

inferred from expectorant action

Evidence: 1

Label: Bronchitis

Bruising^{[36, 38, 39, 40, 41, 42]}Traditional · 1/10

inferred from vulnerary action

Evidence: 1

Label: Bruising

Constipation^[38]Traditional · 1/10

inferred from laxative action

Evidence: 1

Label: Constipation

Cough^{[37, 38]}Traditional · 1/10

Demulcent / expectorant (coughs, catarrh, irritated airways)

Evidence: 1

Label: Cough

Diarrhoea^{[37, 38]}Traditional · 1/10

Astringent (diarrhoea)

Evidence: 1

Label: Diarrhoea

Infection (general)^[1]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1

Label: Infection (general)

Inflammation (general)^{[39, 40, 41]}Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1

Label: Inflammation (general)

Respiratory support^{[37, 38, 39, 40, 41]}Traditional · 1/10

inferred from expectorant action

Evidence: 1

Label: Respiratory support

Skin irritation^{[39, 40, 41]}Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1

Label: Skin irritation

Sore throat^{[37, 38]}Traditional · 1/10

inferred from demulcent action

Evidence: 1

Label: Sore throat

Wounds^{[25, 36, 38, 39, 40, 41, 42]}Traditional · 2/10

inferred from vulnerary action

Evidence: 2

Label: Wounds

Immune support^[16]Traditional · 2/10

P. major extract showed immunomodulatory, antiviral and cytotoxic effects in vitro.

Evidence: 2

Label: Immune support

Cancer (anticancer research)^[21]Traditional · 2/10

P. major extracts/compounds inhibited proliferation of cancer cell lines (preclinical).

Evidence: 2

Label: Cancer (anticancer research)

Cardiovascular / heart health^{[23, 24]}Traditional · 2/10

Plantamajoside attenuated cardiac fibrosis via AGEs/RAGE inhibition (preclinical).

Evidence: 2

Label: Cardiovascular / heart health

Arthritis / joint pain^{[30, 31, 32]}Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1

Label: Arthritis / joint pain

Bruising^{[30, 31, 32]}Traditional · 1/10

inferred from vulnerary action

Evidence: 1

Label: Bruising

Cancer (anticancer research)^{[3, 10]}Traditional · 2/10

inferred from anticancer action

Evidence: 2

Label: Cancer (anticancer research)

Cold & flu^{[30, 31, 32]}Traditional · 1/10

inferred from immunomodulator action

Evidence: 1

Label: Cold & flu

Immune support^{[30, 31, 32]}Traditional · 1/10

Evidence: 1

Label: Immune support

Inflammation (general)^{[6, 30, 31, 32]}Traditional · 2/10

inferred from anti-inflammatory action

Evidence: 2

Label: Inflammation (general)

Menstrual cramps^{[30, 31, 32]}Traditional · 1/10

inferred from antispasmodic action

Evidence: 1

Label: Menstrual cramps

Muscle spasm^{[30, 31, 32]}Traditional · 1/10

inferred from antispasmodic action

Evidence: 1

Label: Muscle spasm

Skin irritation^{[30, 31, 32]}Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1

Label: Skin irritation

Wounds^{[1, 7, 13, 30, 31, 32]}Good · 7/10

inferred from vulnerary action

Evidence: 7

Label: Wounds

Kidney support^[4]Traditional · 2/10

Evidence: 2

Label: Kidney support

Liver support^[9]Traditional · 2/10

Evidence: 2

Label: Liver support

Blood sugar / diabetes support^{[10, 20]}Traditional · 2/10

Evidence: 2

Label: Blood sugar / diabetes support

Infection (general)^{[12, 18, 22, 26]}Traditional · 2/10

inferred from antimicrobial action

Evidence: 2

Label: Infection (general)

Cognitive function^{[22, 23]}Traditional · 2/10

Evidence: 2

Label: Cognitive function

Safety, Cautions & Contraindications

Safety note^{[39, 40, 41]}Caution

Extremely safe; one of the most widely used edible and medicinal plants in the world. Psyllium seeds (closely related) are well-studied as a bulk laxative but should always be taken with adequate water. Allergic reactions are rare but possible. No significant drug interactions documented at normal doses.

Safety note^{[39, 40, 41, 43]}Info

Duke (2002) rates plantain as ++ and notes anti-inflammatory, antitussive, antiatherosclerotic, and COX-2-inhibitory activities at the experimental level (score 1). The seeds (psyllium) of related species have clinical evidence for cholesterol reduction and as bulk laxatives, though entries here apply to the leaf. Dose: leaf as tea or poultice for wounds, sore throat, and bronchial conditions. Duke notes the plant is generally safe with anti-inflammatory topical use well-supported in traditional practice. Commission E approved plantain (ribwort species) for catarrh and wound healing (Duke, 2002).

Safety note^{[36, 38]}Info

Generally regarded as safe as food and in customary medicinal use; allergic reactions are uncommon, though the abundant wind-borne pollen can aggravate hay fever in sensitive people.

Safety note^{[36, 44]}Info

Correct identification is essential and material should be gathered away from roadsides, sprayed lawns and other contaminated ground; deep or infected wounds warrant proper medical care.

Safety note^{[45, 46, 47, 48, 49, 50, 51, 52, 53, 54]}Info

Additional omniasana.bio sources cited for Plantago major (identification, distribution, foraging, traditional use and supporting evidence; see bibliography).

Safety note^{[30, 31, 32]}Caution

Generally very safe as a food and in moderate herbal use. Cyanogenic glucosides present in very small amounts — not significant in normal food or tea use. Isoflavones are phytoestrogens (as in red clover) — same precautions apply in hormone-sensitive conditions. Well tolerated by most people.

Safety note^{[30, 31, 32, 33]}Info

Duke (2002) does not include a dedicated entry for white clover (Trifolium repens) in the Handbook of Medicinal Herbs, Second Edition.

External Ids

Gbif: 3189767

Wikidata: Q157154

Gbif: 5358748

Wikidata: Q148675

Botanical Description

Low, rosette-forming perennial herb (Plantaginaceae) with broad, oval to rounded leaves marked by 5-9 prominent parallel ribs, borne on long, channelled petioles. Slender, leafless flowering spikes rise from the rosette bearing tiny, densely packed greenish flowers, followed by small seed capsules.^[36]

Height: Low rosette; flowering spikes 10-40 cm

Habit: Low rosette-forming perennial herb

Leaves: Broad, oval to rounded, 5-9-ribbed, long-petioled

Flowers: Tiny, densely packed, greenish, in slender spikes

Stem: Slender, leafless flowering spike

Root: Fibrous perennial rootstock

Fruit: Small seed capsule

Flowering Period: June-September

Low, creeping perennial herb rooting at the nodes, with trifoliate leaves, each leaflet oval and often marked with a pale chevron. Rounded white (sometimes pink-tinged) flower heads are borne on long stalks above the foliage.^[30]

Height: 5-15 cm (creeping, flower stalks slightly taller)

Habit: Low, creeping, mat-forming perennial herb

Leaves: Trifoliate, each leaflet oval, often marked with a pale chevron

Flowers: Rounded white (sometimes pink-tinged) heads of small pea-like flowers on long stalks

Stem: Creeping, rooting at the nodes

Root: Fibrous roots with nitrogen-fixing nodules

Fruit: Small pod containing 3-4 seeds

Flowering Period: May-October

Habitat

Native to Europe and temperate Asia and now one of the most widespread naturalised weeds worldwide (the name 'waybread', or historically 'white man's foot', reflects its spread along paths and trails); thrives on compacted, disturbed ground such as paths, lawns and roadsides.^[36]

Grows in lawns, pastures, meadows and grassy waste ground; native to Europe and western Asia and now naturalised worldwide, including as a common lawn and forage plant.^[30]

Harvesting

Leaves are gathered fresh throughout the growing season, especially for poultice use; seed is collected in autumn once ripe.^[36]

Parts: Leaf, Seed

Season: Leaf throughout the growing season; seed in autumn

Flowering heads and leaves are picked through the flowering season and dried in a warm, shaded, airy place.^[30]

Parts: Flower, Leaf

Season: May-October

Traditional Uses

Greater plantain is one of the most widely used wound herbs across world folk-medicine traditions, applied fresh as a poultice to cuts, stings and insect bites, and taken as a tea for cough, digestive upset and mild diarrhoea. Modern reviews confirm broad anti-inflammatory, antimicrobial, antioxidant and wound-healing activity supporting these traditional uses.^{[1, 36]}

White clover has a folk tradition, similar to but lighter than its relative red clover, as an anti-inflammatory and wound-healing remedy and mild expectorant, and modern research on its isoflavones and phenolics has additionally investigated antioxidant, kidney-protective and liver-protective activity.^{[30, 31, 32]}

Preparations

Fresh leaf poultice^[36]

Crushed or chewed fresh leaf applied directly to wounds, stings and insect bites - the classic traditional first-aid use.

Infusion (tea)^{[37, 38]}

Dried leaf steeped in hot water for cough, digestive complaints and mild diarrhoea.

Seed (bulk fibre)^[38]

The mucilaginous seed, related to psyllium, used traditionally as a mild bulk laxative.

Infusion (flower/leaf)^[30]

Dried flower and leaf infused in hot water as a traditional mild tonic and expectorant tea.

Dosage

Leaf tea / poultice^{[39, 40, 41]}

Duke (2002): leaf taken as a tea, or used fresh as a poultice, for wounds, sore throat and bronchial conditions. Educational reference only, not a prescription.

Not documented

References

REF-0354, REF-1758, REF-1759, REF-1760, REF-1761, REF-1762, REF-1763, REF-1764, REF-1765, REF-1766, REF-1767, REF-1768, REF-1769, REF-2993, REF-2994, REF-2995, REF-2996, REF-2997, REF-2998, REF-2999, REF-3000, REF-3001, REF-3002, REF-3003, REF-3004, REF-3005, REF-3006, REF-3007, REF-3008, REF-3009, REF-3010, REF-3011, REF-3012, REF-3013, REF-3014

REF-1323, REF-1324, REF-1325, REF-1326, REF-1327, REF-2366, REF-2367, REF-2368, REF-2369, REF-2901, REF-2902, REF-2903, REF-2904, REF-2905, REF-2906, REF-2907, REF-2908, REF-2909, REF-2910, REF-2935, REF-2936, REF-2937, REF-2938, REF-2939, REF-2940, REF-2941, REF-2942, REF-2943, REF-2944

Lookalikes Review

Outcome: none-known

Reviewed By: Omnia Sana (owner-authorized)

Reviewed Date: 2026-07-07

Outcome: none-known

Reviewed By: Omnia Sana (owner-authorized)

Reviewed Date: 2026-07-07

References & Sources

Adom, M.B., Taher, M., Mutalabisin, M.F., Amri, M.S., Abdul Kudos, M.B., Wan Sulaiman, M.W.A., Sengupta, P. and Susanti, D (2017) 'Chemical constituents and medical benefits of Plantago major', pp. 348--360. doi:10.1016/j.biopha.2017.09.152 Traditional / reference
https://doi.org/10.1016/j.biopha.2017.09.152
Najafian, Y., Hamedi, S.S., Farshchi, M.K. and Feyzabadi, Z (2018) 'Plantago major in Traditional Persian Medicine and modern phytotherapy: a narrative review', Electronic Physician, 10(2), pp. 6390-6399. doi:10.19082/6390 Meta-analysis / review
https://doi.org/10.19082/6390
Cardoso, F.C.I., Breder, J.C., Apolinario, P.P., Oliveira, H.C., Saidel, M.G.B., Dini, A.P., Oliveira-Kumakura, A.R. and Lima, M.H.M (2021) 'The Effect of Plantago major on Wound Healing in Preclinical Studies: A Systematic Review', Wound Management & Prevention, 67(1), pp. 27-34. doi:10.25270/wmp.2021.1.2734 Meta-analysis / review
https://doi.org/10.25270/wmp.2021.1.2734
Ghanadian, M., Soltani, R., Homayouni, A., Khorvash, F., Jouabadi, S.M. and Abdollahzadeh, M (2022) 'The Effect of Plantago major Hydroalcoholic Extract on the Healing of Diabetic Foot and Pressure Ulcers: A Randomized Open-Label Controlled Clinical Trial', The International Journal of Lower Extremity Wounds, 23(3), pp. 475-481. doi:10.1177/15347346211070723 Randomized trial
https://doi.org/10.1177/15347346211070723
Ghiasian, M., Niroomandi, Z., Dastan, D., Poorolajal, J., Zare, F. and Ataei, S (2021) 'Clinical and phytochemical studies of Plantago major in pressure ulcer treatment: A randomized controlled trial', Complementary Therapies in Clinical Practice, 43, pp. 101325. doi:10.1016/j.ctcp.2021.101325 Randomized trial
https://doi.org/10.1016/j.ctcp.2021.101325
Cabrera-Jaime, S., Martinez, C., Ferro-Garcia, T., Giner-Boya, P., Icart-Isern, T., Estrada-Masllorens, J.M. and Fernandez-Ortega, P (2017) 'Efficacy of Plantago major, chlorhexidine 0.12% and sodium bicarbonate 5% solution in the treatment of oral mucositis in cancer patients with solid tumour: A feasibility randomised triple-blind phase III clinical trial', European Journal of Oncology Nursing, 32, pp. 40-47. doi:10.1016/j.ejon.2017.11.006 Randomized trial
https://doi.org/10.1016/j.ejon.2017.11.006
Zubair, M., Widen, C., Renvert, S. and Rumpunen, K (2018) 'Water and ethanol extracts of Plantago major leaves show anti-inflammatory activity on oral epithelial cells', Journal of Traditional and Complementary Medicine, 9(3), pp. 169-171. doi:10.1016/j.jtcme.2017.09.002 Preclinical
https://doi.org/10.1016/j.jtcme.2017.09.002
Turel, I., Ozbek, H., Erten, R., Oner, A.C., Cengiz, N. and Yilmaz, O (2009) 'Hepatoprotective and anti-inflammatory activities of Plantago major L', Indian Journal of Pharmacology, 41(3), pp. 120-124. doi:10.4103/0253-7613.55211 Preclinical
https://doi.org/10.4103/0253-7613.55211
Turki Monawer, A. and Mohammed Abdulkahar Mammani, I (2023) 'Antibacterial activity of ethanolic extracts of Plantago major leaves against Pseudomonas aeruginosa from burn infections', Journal of Infection in Developing Countries, 17(2), pp. 276-280. doi:10.3855/jidc.17576 Preclinical
https://doi.org/10.3855/jidc.17576
Boskabadi, J., Saadat, S. and Boskabady, M.H (2020) 'The Relaxant Effect of Plantago Major on Rat Tracheal Smooth Muscles and Its Possible Mechanisms', Iranian Journal of Allergy, Asthma and Immunology, 19(4), pp. 386-396. doi:10.18502/ijaai.v19i4.4113 Preclinical
https://doi.org/10.18502/ijaai.v19i4.4113
Parhizgar, S., Hosseinian, S., Soukhtanloo, M., Bideskan, A.E., Hadjzadeh, M., Shahraki, S., Noshahr, Z.S., Heravi, N.E., Haghshenas, M. and Rad, A.K (2018) 'Plantago major protects against cisplatin-induced renal dysfunction and tissue damage in rats', Saudi Journal of Kidney Diseases and Transplantation, 29(5), pp. 1057-1064. doi:10.4103/1319-2442.243960 Preclinical
https://doi.org/10.4103/1319-2442.243960
Naji Ebrahimi Yazd, Z., Shahraki, S., Hosseinian, S., Shafei, M.N., Bideskan, A.E., Mohebbati, R., Heravi, N.E., Mahzari, S. and Rad, A.K (2019) 'Renoprotective Effect of Plantago major Against Proteinuria and Apoptosis Induced by Adriamycin in Rat', Journal of Pharmacopuncture, 22(1), pp. 35-40. doi:10.3831/KPI.2019.22.004 Preclinical
https://doi.org/10.3831/KPI.2019.22.004
Alizadeh Behbahani, B., Tabatabaei Yazdi, F., Shahidi, F., Hesarinejad, M.A., Mortazavi, S.A. and Mohebbi, M (2016) 'Plantago major seed mucilage: Optimization of extraction and some physicochemical and rheological aspects', Carbohydrate Polymers, 155, pp. 68-77. doi:10.1016/j.carbpol.2016.08.051 Preclinical
https://doi.org/10.1016/j.carbpol.2016.08.051
Majeed, A. and Zulfiqar, Z. and Fatima, Z. and Fatima, S. and Muhammad, G. and Wajid, M. and Khan, R.R.M. and Mushtaq, M. and Ashraf, A (2026) 'Phytochemical profile and biological activities of Plantago major L.: A comprehensive review', Asian Pacific Journal of Tropical Biomedicine. doi:10.4103/apjtb.apjtb_644_25 Meta-analysis / review
https://doi.org/10.4103/apjtb.apjtb_644_25
Akram, M. and Hamid, A. and Khalil, A. and Ghaffar, A. and Tayyaba, N. and Saeed, A. and Ali, M. and Naveed, A (2014) 'Review on Medicinal Uses, Pharmacological, Phytochemistry and Immunomodulatory Activity of Plants', International Journal of Immunopathology and Pharmacology. doi:10.1177/039463201402700301 Meta-analysis / review
https://doi.org/10.1177/039463201402700301
Chiang, L. and Chiang, W.C. and Chang, M. and Lin, C (2003) 'In Vitro Cytotoxic, Antiviral and Immunomodulatory Effects of Plantago major and Plantago asiatica', The American Journal of Chinese Medicine. doi:10.1142/s0192415x03000874 Preclinical
https://doi.org/10.1142/s0192415x03000874
Gomez‐Flores, R. and Calderón, C.L. and Scheibel, L.W. and Tamez‐Guerra, P. and Rodrı́guez-Padilla, C. and Támez-Guerra, R. and Wéber, R (2000) 'Immunoenhancing properties ofPlantago major leaf extract', Phytotherapy Research. doi:10.1002/1099-1573(200012)14:8<617::aid-ptr674>3.0.co;2-n Preclinical
https://doi.org/10.1002/1099-1573(200012)14:8<617::aid-ptr674>3.0.co;2-n
Samuelsen, A.B. and Paulsen, B.S. and Wold, J.K. and Otsuka, H. and Yamada, H. and Espevik, T (1995) 'Isolation and partial characterization of biologically active polysaccharides from Plantago major L', Phytotherapy Research. doi:10.1002/ptr.2650090312 Preclinical
https://doi.org/10.1002/ptr.2650090312
Reina, E. and Al‐Shibani, N. and Allam, E. and Gregson, K.S. and Kowolik, M.J. and Windsor, L.J (2013) 'The Effects of Plantago major on the Activation of the Neutrophil Respiratory Burst', Journal of Traditional and Complementary Medicine. doi:10.4103/2225-4110.119706 Preclinical
https://doi.org/10.4103/2225-4110.119706
Lukova, P. and Karcheva‐Bahchevanska, D. and Bivolarski, V. and Mladenov, R. and Iliev, I. and Nikolova, M (2017) 'Enzymatic Hydrolysis of Water Extractable Polysaccharides from Leaves of Plantago major L', Folia Medica. doi:10.1515/folmed-2017-0023 Preclinical
https://doi.org/10.1515/folmed-2017-0023
Kartini, K. and Piyaviriyakul, S. and Thongpraditchote, S. and Siripong, P. and Vallisuta, O (2017) 'Effects of Plantago major extracts and its chemical compounds on proliferation of cancer cells and cytokines production of lipopolysaccharide-activated THP-1 macrophages', Pharmacognosy Magazine. doi:10.4103/pm.pm_406_16 Preclinical
https://doi.org/10.4103/pm.pm_406_16
Zuo, X. and Li, L. and Sun, L (2020) 'Plantamajoside inhibits hypoxia-induced migration and invasion of human cervical cancer cells through the NF-κB and PI3K/akt pathways', Journal of Receptors and Signal Transduction. doi:10.1080/10799893.2020.1808679 Preclinical
https://doi.org/10.1080/10799893.2020.1808679
Zhang, L. and Guo, Y. and Liu, J. and Wang, L. and Wang, L. and Wu, H. and Wang, T. and Deng, B. and Wang, J. and Lu, L. and Chen, Z. and He, J. and Liang, B. and Li, H. and Huang, Y (2022) 'Plantamajoside attenuates cardiac fibrosis via inhibiting AGEs activated‐RAGE/autophagy/EndMT pathway', Phytotherapy Research. doi:10.1002/ptr.7663 Preclinical
https://doi.org/10.1002/ptr.7663
Zeng, G. and An, H. and Fang, D. and Wang, W. and Han, Y. and Lian, C (2020) 'Plantamajoside protects H9c2 cells against hypoxia/reoxygenation-induced injury through regulating the akt/Nrf2/HO-1 and NF-κB signaling pathways', Journal of Receptors and Signal Transduction. doi:10.1080/10799893.2020.1859534 Preclinical
https://doi.org/10.1080/10799893.2020.1859534
Amini, M. and Kherad, M. and Mehrabani, D. and Azarpira, N. and Panjehshahin, M.R. and Tanideh, N (2010) 'Effect ofPlantago majoron Burn Wound Healing in Rat', Journal of Applied Animal Research. doi:10.1080/09712119.2010.9707093 Preclinical
https://doi.org/10.1080/09712119.2010.9707093
Zubaır, M. and Nybom, H. and Lindholm, C. and Brandner, J.M. and Rumpunen, K (2015) 'Promotion of wound healing byPlantago majorL. leaf extracts –ex-vivoexperiments confirm experiences from traditional medicine', Natural Product Research. doi:10.1080/14786419.2015.1034714 Preclinical
https://doi.org/10.1080/14786419.2015.1034714
Rad, N. and Shafie, F. and Chaghervand, M.M. and Kashfi, S. and Rashidipour, M. and Chehelcheraghi, F. and Mozaffarpur, S.A. and Rasoulian, B (2018) 'The Wound Healing Effect of Plantago Major Leaf Extract in a Rat Model: An Experimental Confirmation of a Traditional Belief in Persian Medicine', DOAJ (DOAJ: Directory of Open Access Journals). doi:10.22087/hmj.v3i1.702 Preclinical
https://doi.org/10.22087/hmj.v3i1.702
Cardoso, F.D.C.I. and Apolinário, P.P. and Breder, J.D.S.C. and Paranhos, T. and Oliveira, H.C. and Polidoro, A.D. and Oliveira, A.R.D.S. and Lima, M.H.M (2019) 'A protocol for systematic review of Plantago major L. effectiveness in accelerating wound-healing in animal models', Systematic Reviews. doi:10.1186/s13643-019-1255-6 Meta-analysis / review
https://doi.org/10.1186/s13643-019-1255-6
Ringbom, T. and Segura, L. and Noreen, Y. and Perera, P. and Bohlin, L (1998) 'Ursolic Acid fromPlantagomajor, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis', Journal of Natural Products. doi:10.1021/np980088i Preclinical
https://doi.org/10.1021/np980088i
Guillén, M.E.N. and Emim, J.A.D.S. and Souccar, C. and Lapa, A.J (1997) 'Analgesic and Anti-inflammatory Activities of the Aqueous Extract of Plantago major L', International Journal of Pharmacognosy. doi:10.1076/phbi.35.2.99.13288 Preclinical
https://doi.org/10.1076/phbi.35.2.99.13288
Atibayeva, А.E. and Тыныкулов, М (2024) 'ANTI-INFLAMMATORY ACTIVITY OF PLANTAGO MAJOR LEAF EXTRACTS IN VITRO ON EPITHELIAL CELLS OF THE ORAL CAVITY', Vestnik of M Kozybayev North Kazakhstan University. doi:10.54596/2958-0048-2024-2-48-53 Preclinical
https://doi.org/10.54596/2958-0048-2024-2-48-53
Zhakipbekov, K. and Turgumbayeva, A. and Issayeva, R. and Kipchakbayeva, A. and Kadyrbayeva, G. and Tleubayeva, M.I. and Akhayeva, T. and Тастамбек, К. and Sainova, G.A. and Serikbayeva, E. and Tolenova, K. and Махатова, Б. and Anarbayeva, R. and Shimirova, Z. and Tileuberdi, Y (2023) 'Antimicrobial and Other Biomedical Properties of Extracts from Plantago major, Plantaginaceae', Pharmaceuticals. doi:10.3390/ph16081092 Preclinical
https://doi.org/10.3390/ph16081092
Povnitsa, O. and Bilyavska, L. and Pankivska, Y. and Likhanov, A. and Dorovskyh, A. and Лысенко, В.С. and Lokshin, M.M. and Zahorodnia, S (2021) 'In vitro Antiviral Activity of Leaf Extracts Plantago major, Plantago lanceolata, Rubus idaeus', Mikrobiolohichnyi Zhurnal. doi:10.15407/microbiolj84.01.044 Preclinical
https://doi.org/10.15407/microbiolj84.01.044
Han, A.Y. and Nam, M. and Lee, K (2016) 'Plantamajoside Inhibits UVB and Advanced Glycation End Products‐Induced MMP‐1 Expression by Suppressing the MAPK and NF‐κB Pathways in HaCaT Cells', Photochemistry and Photobiology. doi:10.1111/php.12615 Preclinical
https://doi.org/10.1111/php.12615
Shirley, K.P. and Windsor, L.J. and Eckert, G.J. and Gregory, R.L (2015) 'In Vitro Effects of Plantago Major Extract, Aucubin, and Baicalein on Candida albicans Biofilm Formation, Metabolic Activity, and Cell Surface Hydrophobicity', Journal of Prosthodontics. doi:10.1111/jopr.12411 Preclinical
https://doi.org/10.1111/jopr.12411
Samuelsen, A.B (2000) 'The traditional uses, chemical constituents and biological activities of Plantago major L. A review', 8741(00), pp. 1--21. doi:10.1016/s0378-8741(00)00212-9 Traditional / reference
https://doi.org/10.1016/s0378-8741(00)00212-9
Grieve, M (1931). Available at: https://botanical.com/botanical/mgmh/p/planta14.html Traditional / reference
https://botanical.com/botanical/mgmh/p/planta14.html
Herbal Reality (n.d.) 'Plantain (Plantago major): Benefits, Safety, Uses'. Available at: https://www.herbalreality.com/herb/plantain/ Traditional / reference
https://www.herbalreality.com/herb/plantain/
Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org
Samuelsen, A.B (2000) 'The traditional uses, chemical constituents and biological activities of Plantago major L.: a review', pp. 1--21. Traditional / reference
https://scholar.google.com/scholar?q=The%20traditional%20uses%2C%20chemical%20constituents%20and%20biological%20activities%20of%20Plantago%20major%20L.%3A%20a%20review
World Health Organization (2002) 'WHO Monographs on Selected Medicinal Plants'. Traditional / reference
https://scholar.google.com/scholar?q=WHO%20Monographs%20on%20Selected%20Medicinal%20Plants
Zubair, M., Ekholm, A., Nybom, H., Renvert, S., Widen, C. and Rumpunen, K (2012) 'Effects of Plantago major L. leaf extracts on oral epithelial cells in a scratch assay', 141(3), pp. 825--830. doi:10.1016/j.jep.2012.03.016 Traditional / reference
https://doi.org/10.1016/j.jep.2012.03.016
Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
The Herbal Medic (n.d.) 'Plantain (Plantago lanceolata) - Wound Healing & Respiratory Support Herb'. Available at: https://theherbalmedic.co.uk/plantain-plantago-lanceolate Traditional / reference
https://theherbalmedic.co.uk/plantain-plantago-lanceolate
A Wandering Botanist (2013) 'Plant Story - Plantains (Plantago), Tracking Your Footsteps All Over the World'. Available at: http://khkeeler.blogspot.com/2013/11/plant-story-plantains-plantago-tracking.html Traditional / reference
http://khkeeler.blogspot.com/2013/11/plant-story-plantains-plantago-tracking.html
Edible Wild Food (n.d.) 'Broadleaf Plantain (Plantago major)'. Available at: https://www.ediblewildfood.com/broadleaf-plantain.aspx Traditional / reference
https://www.ediblewildfood.com/broadleaf-plantain.aspx
Florida School of Holistic Living (n.d.). Available at: https://www.holisticlivingschool.org/2020/02/25/march-plantain/ Traditional / reference
https://www.holisticlivingschool.org/2020/02/25/march-plantain/
Living Plant Wisdom (n.d.) 'Living Plant Wisdom Profile: Plantain (Plantago major)'. Available at: https://holisticfarming.substack.com/p/living-plant-wisdom-profile-plantain Traditional / reference
https://holisticfarming.substack.com/p/living-plant-wisdom-profile-plantain
Nine Herbs Charm (n.d.). Available at: https://en.wikipedia.org/wiki/Nine_Herbs_Charm Traditional / reference
https://en.wikipedia.org/wiki/Nine_Herbs_Charm
North Carolina Extension (n.d.) 'Plantago major'. Available at: https://plants.ces.ncsu.edu/plants/plantago-major/ Traditional / reference
https://plants.ces.ncsu.edu/plants/plantago-major/
Royal Botanic Gardens, Kew (n.d.) 'Plantago major L'. Available at: https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:677229-1 Traditional / reference
https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:677229-1
Royal Horticultural Society (n.d.) 'Plantago major (common plantain)'. Available at: https://www.rhs.org.uk/plants/42126/plantago-major/details Traditional / reference
https://www.rhs.org.uk/plants/42126/plantago-major/details
The Wildlife Trusts (n.d.) 'Greater plantain'. Available at: https://www.wildlifetrusts.org/wildlife-explorer/wildflowers/greater-plantain Traditional / reference
https://www.wildlifetrusts.org/wildlife-explorer/wildflowers/greater-plantain
Zubair, M (2012). Available at: https://research.slu.se/en/publications/genetic-variation-biochemical-contents-and-wound-healing-activity/ Traditional / reference
https://research.slu.se/en/publications/genetic-variation-biochemical-contents-and-wound-healing-activity/

Ngangom, L., Venugopal, D. and Pandey, N (2024) 'Investigation of Trifolium repens L. from the Indian Himalayan region as a phyto-therapeutic agent', Natural Product Research, 38(24), pp. 4468-4478. doi:10.1080/14786419.2023.2299319 Meta-analysis / review
https://doi.org/10.1080/14786419.2023.2299319
Ahmad, S. and Zeb, A (2020) 'Phytochemical profile and pharmacological properties of Trifolium repens', Journal of Basic and Clinical Physiology and Pharmacology, 32(3), pp. 20200015. doi:10.1515/jbcpp-2020-0015 Meta-analysis / review
https://doi.org/10.1515/jbcpp-2020-0015
Sarno, F., Pepe, G., Termolino, P., Carafa, V. and others (2020) 'Trifolium repens Blocks Proliferation in Chronic Myelogenous Leukemia via the BCR-ABL/STAT5 Pathway', Cells, 9(2), pp. 379. doi:10.3390/cells9020379 Preclinical
https://doi.org/10.3390/cells9020379
Ahmad, S. and Zeb, A (2020) 'Nephroprotective property of Trifolium repens leaf extract against paracetamol-induced kidney damage in mice', 3 Biotech, 10(12), pp. 541. doi:10.1007/s13205-020-02539-0 Preclinical
https://doi.org/10.1007/s13205-020-02539-0
Kolodziejczyk-Czepas, J (2012) 'Trifolium species-derived substances and extracts--biological activity and prospects for medicinal applications', Journal of Ethnopharmacology, 143(1), pp. 14-23. doi:10.1016/j.jep.2012.06.048 Meta-analysis / review
https://doi.org/10.1016/j.jep.2012.06.048
Chen, Y.H., Chen, P., Wang, Y., Yang, C.H., Wu, X., Wu, C.J., Luo, L., Wang, Q., Niu, C. and Yao, J.Y (2019) 'Structural characterization and anti-inflammatory activity evaluation of chemical constituents in the extract of Trifolium repens L', Journal of Food Biochemistry, 43(9), pp. e12981. doi:10.1111/jfbc.12981 Preclinical
https://doi.org/10.1111/jfbc.12981
Habibi Zadeh, S.K., Farahpour, M.R. and Kar, H.H (2020) 'The effect of topical administration of an ointment prepared from Trifolium repens hydroethanolic extract on the acceleration of excisional cutaneous wound healing', Wounds, 32(9), pp. 253-261. doi:10.25270/wnds/2020.253261 Preclinical
https://doi.org/10.25270/wnds/2020.253261
Kicel, A. and Wolbis, M (2012) 'Study on the phenolic constituents of the flowers and leaves of Trifolium repens L', Natural Product Research, 26(21), pp. 2050-2054. doi:10.1080/14786419.2011.637217 Preclinical
https://doi.org/10.1080/14786419.2011.637217
Ahmad, S. and Zeb, A (2019) 'Effects of phenolic compounds from aqueous extract of Trifolium repens against acetaminophen-induced hepatotoxicity in mice', Journal of Food Biochemistry, 43(9), pp. e12963. doi:10.1111/jfbc.12963 Preclinical
https://doi.org/10.1111/jfbc.12963
Borczak, B. and Szewczyk, A. and Domagała, D. and Kapusta-Duch, J. and Leszczyńska, T. and Kotuła, M. and Grulova, D (2024) 'Potential Antidiabetic, Antioxidative and Antiproliferative Properties of Functional Wheat Flour Muffins Enriched with White Clover Flowers (Trifolium repens L.)', Int J Mol Sci, 25(18). doi:10.3390/ijms25189909 Preclinical
https://doi.org/10.3390/ijms25189909
Rawat, P. and Kumar, B. and Misra, A. and Singh, S.P. and Singh, S.P. and Srivastava, S (2025) 'Effect of hydrolysed Trifolium repens L. extract on menopause-induced obesity and depressive symptoms: an in vitro and in vivo approach', Nat Prod Res, pp. 1-8. doi:10.1080/14786419.2025.2560636 Preclinical
https://doi.org/10.1080/14786419.2025.2560636
Parić, A. and Mesic, A. and Mahmutović-Dizdarević, I. and Jerković-Mujkić, A. and Žujo, B. and Bašić, N. and Pustahija, F (2024) 'Bioactive potential of Trifolium repens L. essential oil', J Environ Sci Health B, 59(9), pp. 584-594. doi:10.1080/03601234.2024.2396730 Preclinical
https://doi.org/10.1080/03601234.2024.2396730
Renda, G. and Yalçın, F.N. and Nemutlu, E. and Akkol, E.K. and Süntar, I. and Keleş, H. and Ina, H. and Çalış, I. and Ersöz, T (2013) 'Comparative assessment of dermal wound healing potentials of various Trifolium L. extracts and determination of their isoflavone contents as potential active ingredients', J Ethnopharmacol, 148(2), pp. 423-32. doi:10.1016/j.jep.2013.04.031 Preclinical
https://doi.org/10.1016/j.jep.2013.04.031
Ahmed, I.A.M. and Matthäus, B. and Özcan, M.M. and Juhaimi, F.A. and Ghafoor, K. and Babiker, E.E. and Osman, M.A. and Alqah, H.A.S (2020) 'Determination of Bioactive Lipid and Antioxidant Activity of Onobrychis, Pimpinella, Trifolium, and Phleum spp. Seed and Oils', J Oleo Sci, 69(11), pp. 1367-1371. doi:10.5650/jos.ess20153 Preclinical
https://doi.org/10.5650/jos.ess20153
Harlow, B.E. and Flythe, M.D. and Goodman, J.P. and Ji, H. and Aiken, G.E (2022) 'Isoflavone Containing Legumes Mitigate Ergot Alkaloid-Induced Vasoconstriction in Goats (Capra hircus)', Animals (Basel), 12(6). doi:10.3390/ani12060750 Preclinical
https://doi.org/10.3390/ani12060750
Shang, H. and Li, R. and Wu, H. and Sun, Z (2019) 'Polysaccharides from Trifolium repens L. extracted by different methods and extraction condition optimization', Sci Rep, 9(1), pp. 6353. doi:10.1038/s41598-019-42877-5 Preclinical
https://doi.org/10.1038/s41598-019-42877-5
Prati, S. and Baravelli, V. and Fabbri, D. and Schwarzinger, C. and Brandolini, V. and Maietti, A. and Tedeschi, P. and Benvenuti, S. and Macchia, M. and Marotti, I. and Bonetti, A. and Catizone, P. and Dinelli, G (2007) 'Composition and content of seed flavonoids in forage and grain legume crops', J Sep Sci, 30(4), pp. 491-501. doi:10.1002/jssc.200600383 Preclinical
https://doi.org/10.1002/jssc.200600383
Woolsey, I.D. and Zeller, W.E. and Blomstrand, B.M. and Øines, Ø. and Enemark, H.L (2022) 'Effects of selected condensed tannins on Cryptosporidium parvum growth and proliferation in HCT-8 cell cultures', Exp Parasitol, 241, pp. 108353. doi:10.1016/j.exppara.2022.108353 Preclinical
https://doi.org/10.1016/j.exppara.2022.108353
Hou, K. and Xue, Q. and Shi, L. and Liu, S. and Zhong, X. and Liu, Y. and Wang, C (2026) 'Identification of Trifolium repens as a New Source of Glycyrrhetinic Acid: Pathway Elucidation and Heterologous Reconstruction in Yeast', J Agric Food Chem, 74(19), pp. 15182-15194. doi:10.1021/acs.jafc.6c02001 Preclinical
https://doi.org/10.1021/acs.jafc.6c02001
Tundis, R. and Marrelli, M. and Conforti, F. and Tenuta, M.C. and Bonesi, M. and Menichini, F. and Loizzo, M.R (2015) 'Trifolium pratense and T. repens (Leguminosae): Edible Flower Extracts as Functional Ingredients', Foods, 4(3), pp. 338-348. doi:10.3390/foods4030338 Preclinical
https://doi.org/10.3390/foods4030338
Başar, Y. and Yıldız, İ. and HOSAFLIOĞLU, İ. and Azeroual, A. and Erenler, R (2026) 'The Phytochemical Content and DPPH Activity of Trifolium repens L. Methanol Extract, and In Silico Studies', Adıyaman üniversitesi fen bilimleri dergisi, 16(1), pp. 61-76. doi:10.37094/adyujsci.1813336 Preclinical
https://doi.org/10.37094/adyujsci.1813336
Ayoubi, S.A. and Abdelwahab, I. and Ela, M.A. and Lakany, A.E. and Raafat, K (2026) 'Advanced Hybrid-Green Ultrasound–Infrared–Microwave Trifolium repens Essential oil Isolation with Multi-Target Ethnomedicine Bioactivity against Neuropathy, Inflammation and Multidrug-Resistant Infection', Journal of Food and Drug Analysis, 34(2). doi:10.38212/2224-6614.3595 Preclinical
https://doi.org/10.38212/2224-6614.3595
Ahmad, S. and Zeb, A. and Ayaz, M. and Murkovic, M (2019) 'Characterization of phenolic compounds using UPLC–HRMS and HPLC–DAD and anti-cholinesterase and anti-oxidant activities of Trifolium repens L. leaves', European Food Research and Technology, 246(3), pp. 485-496. doi:10.1007/s00217-019-03416-8 Preclinical
https://doi.org/10.1007/s00217-019-03416-8
Petrović, M. and Stanković, M. and Anđelković, B. and Babić, S. and Zornić, V. and Vasiljević, S. and Stevanović, Z.D (2016) 'Quality Parameters and Antioxidant Activity of Three Clover Species in Relation to the Livestock Diet', Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 44(1), pp. 201-208. doi:10.15835/nbha44110144 Preclinical
https://doi.org/10.15835/nbha44110144
Jakubczyk, K. and Łukomska, A. and Gutowska, I. and Kochman, J. and Janił, J. and Janda, K (2021) 'Edible Flowers Extracts as a Source of Bioactive Compounds with Antioxidant Properties—In Vitro Studies', Applied Sciences, 11(5), pp. 2120-2120. doi:10.3390/app11052120 Preclinical
https://doi.org/10.3390/app11052120
Ngangom, L. and Venugopal, D. and Pandey, N. and Kumar, N (2022) 'In-silico screening and identification of potential bioactive compounds of Trifolium repens against pathogenic bacterial target proteins', Materials Today Proceedings, 73, pp. 142-150. doi:10.1016/j.matpr.2022.09.501 Preclinical
https://doi.org/10.1016/j.matpr.2022.09.501
Amer, B. and Juul, L. and Møller, A.H. and Møller, H.S. and Dalsgaard, T.K (2020) 'Improved solubility of proteins from white and red clover – inhibition of redox enzymes', International Journal of Food Science & Technology, 56(1), pp. 302-311. doi:10.1111/ijfs.14632 Preclinical
https://doi.org/10.1111/ijfs.14632
Pap, N. and Granato, D. and Järvenpää, E. and Tienaho, J. and Marnila, P. and Hellström, J. and Pihlava, J. and Franco, M. and Stefański, T. and Rinne, M (2024) 'Biorefining of legume and grass biomasses: Technological properties and bioactivities of the green juice', Future Foods, 9, pp. 100331-100331. doi:10.1016/j.fufo.2024.100331 Preclinical
https://doi.org/10.1016/j.fufo.2024.100331
Ahn, C. and Lee, J. and Park, M.J. and Kim, J. and Yang, J. and Yoo, Y. and Jeung, E (2020) 'Cytostatic effects of plant essential oils on human skin and lung cells', Experimental and Therapeutic Medicine, 19(3), pp. 2008-2018. doi:10.3892/etm.2020.8460 Preclinical
https://doi.org/10.3892/etm.2020.8460
Bhattacharya, S. et al (2013) 'Review of the botanical, phytochemical, pharmacological and toxicological properties of white clover (Trifolium repens L.)', 7(7), pp. 583--588. Traditional / reference
https://scholar.google.com/scholar?q=Review%20of%20the%20botanical%2C%20phytochemical%2C%20pharmacological%20and%20toxicological%20properties%20of%20white%20clover%20%28Trifolium%20repens%20L.%29
Grieve, M (1931) 'A Modern Herbal'. Traditional / reference
https://scholar.google.com/scholar?q=A%20Modern%20Herbal
Klaiber, I. et al (2002) 'Health benefits of isoflavones from clover species', 16(1), pp. 1--8. Traditional / reference
https://scholar.google.com/scholar?q=Health%20benefits%20of%20isoflavones%20from%20clover%20species
Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition

Greater Plantain monograph White clover monograph Compare other plants

Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.