Omnia SanaPlant Comparison
Common Juniper vs Field restharrow
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Common Juniper and Field restharrow: they share 6 indicated uses (cancer (anticancer research), infection (general), swelling / fluid retention, …); 5 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Common Juniper | Field restharrow | Verdict |
|---|---|---|---|
| Cancer (anticancer research) | 2/10 | 2/10 | Comparable evidence |
| Infection (general) | 1/10 | 2/10 | Comparable evidence |
| Swelling / fluid retention | 1/10 | 7/10 | Stronger for Field restharrow |
| Urinary support | 1/10 | 9/10 | Stronger for Field restharrow |
| Urinary tract infection (UTI) | 1/10 | 2/10 | Comparable evidence |
| Wounds | 1/10 | 2/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Berry essential oil dominated by alpha-pinene, beta-pinene, sabinene and limonene, giving the characteristic aroma and the antimicrobial activity.
Antioxidant and astringent supporting constituents.
Formononetin and its 7-O-glucoside ononin, plus related isoflavones - the signature restharrow constituents (also phytoestrogens).
Pterocarpans and isoflavanones and their glucosides, contributing to antimicrobial and wound-healing activity.
alpha-Onocerin (onocerin), a characteristic triterpene of the genus Ononis.
Caffeic, chlorogenic and p-coumaric acids (antioxidant).
A volatile oil present in the root and aerial parts.
Pharmacological Actions
Aquaretic diuretic; the classic irrigation-therapy action of restharrow root (Ononidis radix), used interchangeably for O. arvensis and O. spinosa.
Aqueous root extract reduced adhesion of uropathogenic E. coli to bladder cells (anti-adhesive).
Inhibits IL-8 release via TLR4/LPS and cytosolic phospholipase A2alpha (restharrow root).
Analgesic activity of Ononis extract in animals (congener O. spinosa).
Protective against ethanol-induced gastric mucosal injury (congener O. spinosa).
Ononis isoflavones showed chemopreventive/antiproliferative activity against breast cancer cells (preclinical).
Traditional & Indicated Uses
inferred from anticancer action
inferred from digestive action
inferred from antimicrobial action
inferred from diuretic action
inferred from diuretic action
inferred from diuretic action
inferred from anticancer action
Aquaretic diuretic for irrigation therapy of the urinary tract.
Anti-adhesive activity against uropathogenic E. coli.
inferred from diuretic / urinary 'gravel' traditional use
inferred from diuretic (aquaretic) action
inferred from antimicrobial action
Isoflavonoid wound-healing agents from restharrow root.
inferred from anti-inflammatory and traditional skin/eczema use
Safety, Cautions & Contraindications
Avoid in pregnancy. Juniper is not recommended during pregnancy (EMA/HMPC, 2023; Health Canada, 2025).Avoid with kidney disorders / serious kidney disease. It’s not recommended if you have kidney disease (EMA/HMPC, 2023; Health Canada, 2025).Adults only (for medicinal use). Use in under-18s is not recommended due to lack of data (EMA/HMPC, 2023).Hydration matters. If you’re using it for urinary “flushing,” you need adequate fluid intake (EMA/HMPC, 2023).Stop and seek help if symptoms look serious. Fever, painful urination, cramps/spasms, or blood in urine = talk to a clinician (EMA/HMPC, 2023).Duration caution. If using it beyond a few weeks, talk to a health professional (Health Canada, 2025).If breastfeeding: ask a health professional first (EMA/HMPC, 2023; Health Canada, 2025).
Duke (2002) rates juniper as + (use with caution), noting diuretic, carminative, and aquaretic activities, primarily at the experimental level (score 1). Traditional use for urinary infections is not supported by strong clinical evidence. The essential oil contains potentially nephrotoxic terpinen-4-ol, and juniper is contraindicated in kidney disease, urinary infections with inflammation, and pregnancy (emmenagogue and potential abortifacient properties). Commission E and PhEur do not recommend medicinal doses for prolonged use exceeding 4–6 weeks (Duke, 2002).
A safety signal exists in the genus: an Ononis spinosa root extract showed hepatotoxic effects at higher doses in animals (alongside analgesic activity). Avoid excessive or prolonged use, and use caution in liver disease.
Used as an aquaretic for irrigation therapy of the urinary tract, restharrow should be taken with a generous fluid intake; it should NOT be used for 'flushing' when there is oedema due to impaired heart or kidney function (standard irrigation-therapy caution).
External Ids
Botanical Description
Evergreen coniferous shrub or small tree, often low and sprawling, with sharp, needle-like leaves in whorls of three, each bearing a single white band on the upper surface. The plant is dioecious; female plants bear small, round, fleshy, berry-like cones ('juniper berries') that take two to three years to ripen from green to blue-black.[1]
A tough, deep-rooted perennial herb or low subshrub of the pea family, 30-80 cm tall, sometimes bearing soft spines. It has a very long, woody, tenacious taproot - so strong it was said to stop (arrest) the harrow, giving 'rest-harrow' its name. The stems are hairy and sticky, often reddish, and clothed in small trifoliolate (clover-like) leaves with toothed leaflets. The flowers are typical pea flowers, pink to purplish-pink (occasionally white), borne singly or in pairs in the leaf axils. Field restharrow (O. arvensis) is generally less spiny than its close relative spiny restharrow (O. spinosa).[8, 10]
Habitat
Grows on heath, moorland, rocky hillsides and open coniferous woodland on poor, often calcareous soils; one of the most widely distributed conifers, native across the Northern Hemisphere from Europe and Asia to North America.
Rough grassland, field margins, roadsides, dunes and dry, sandy or calcareous waste ground across Europe, western Asia and parts of North Africa. As a deep-rooted, nitrogen-fixing legume it colonises poor, disturbed soils and was historically a troublesome weed of arable fields (hence 'restharrow').[8]
Harvesting
The ripe, blue-black berry-like cones are hand-picked in autumn, typically in their second or third year of ripening (a mix of ages is often present on the same shrub); leaves and young stems can be gathered through the growing season.
The root (Ononidis radix) is the principal medicinal part, dug in autumn from the second year onward and dried; the aerial flowering parts are also gathered in summer. The long woody taproot is cleaned and cut before drying for decoctions and infusions.[8]
Traditional Uses
Juniper berry has a long European tradition as a diuretic and urinary antiseptic for minor urinary complaints, a warming digestive carminative for indigestion and bloating, and a flavouring for gin and other spirits; the leaf and wood have also been burned or used topically for their antimicrobial properties.[1]
Restharrow root has a long place in European herbal medicine as a gentle aquaretic diuretic used for 'irrigation therapy' of the urinary tract - to increase urine flow in cystitis, urinary gravel and stones, and to flush the bladder. Field restharrow (Ononis arvensis) is used interchangeably with the officinal spiny restharrow (O. spinosa, Ononidis radix). The root and flowering herb have also been used as a mild anti-inflammatory, for skin complaints and eczema, for rheumatic conditions, and (as a decoction or gargle) for the mouth and throat. The isoflavone-rich root is a folk remedy in central and eastern European traditions.[8, 13]
Preparations
Comminuted juniper cone berries infused in 150 ml boiling water, 2.0-2.5 g as a single dose 1-3 times daily per the current revision of the EU herbal monograph. Educational reference only, not a prescription.
Steam-distilled from the berries; used in small internal doses for short periods or diluted for topical/aromatic use.
The dried root simmered in water and taken as an aquaretic diuretic for irrigation of the urinary tract; the classic restharrow preparation.
The flowering aerial parts infused as a milder diuretic and anti-inflammatory tea.
A root decoction used traditionally as a mouth/throat gargle and as a wash for skin complaints.
Dosage
The EU herbal monograph gives 2.0-2.5 g of the comminuted cone berries in 150 mL of boiling water as an infusion, 1-3 times daily (single dose 2-2.5 g, daily dose 2.5-6 g), for adults and elderly. Use is limited to short courses - if symptoms persist beyond 2 weeks a healthcare practitioner should be consulted - with adequate fluid intake; contraindicated in severe renal disease and not recommended in pregnancy. Educational reference only, not a prescription.
Not documented
References
Lookalikes Review
Dangerous Lookalikes
Not documented
Synonyms
Not documented
Drug Class Interactions
Not documented
Pairings
Not documented
Classic urinary irrigation-therapy pairing: both are aquaretic diuretics used to increase urine flow in cystitis and urinary gravel.[13]
Both are traditional diuretic 'flushing' herbs for irrigation therapy of the urinary tract.[13]
Both are Fabaceae rich in the isoflavone phytoestrogen formononetin; combined use adds to phytoestrogen exposure - use caution in hormone-sensitive conditions.[1]
References & Sources
- Pepeljnjak, S., Kosalec, I., Kalodera, Z. and Blazević, N (2005) 'Antimicrobial activity of juniper berry essential oil (Juniperus communis L., Cupressaceae)', Acta Pharmaceutica, 55(4), pp. 417-422. Available at: https://pubmed.ncbi.nlm.nih.gov/16375831/ Preclinical
https://pubmed.ncbi.nlm.nih.gov/16375831/ - Peruč, D., Tićac, B., Broznić, D., Maglica, Ž. et al (2020) 'Juniperus communis essential oil limits the biofilm formation of Mycobacterium avium and Mycobacterium intracellulare on polystyrene in a temperature-dependent manner', International Journal of Environmental Health Research, 32(1), pp. 141-154. doi:10.1080/09603123.2020.1741519 Preclinical
https://doi.org/10.1080/09603123.2020.1741519 - Marković, T., Popović, S., Matić, S., Mitrović, M. et al (2024) 'Insights into Molecular Mechanisms of Anticancer Activity of Juniperus communis Essential Oil in HeLa and HCT 116 Cells', Plants (Basel), 13(17), pp. 2351. doi:10.3390/plants13172351 Preclinical
https://doi.org/10.3390/plants13172351 - Goncalves, A.C., Flores-Felix, J.D., Coutinho, P., Alves, G. and Silva, L.R (2022) 'Zimbro (Juniperus communis L.) as a Promising Source of Bioactive Compounds and Biomedical Activities: A Review on Recent Trends', International Journal of Molecular Sciences, 23(6), pp. 3197. doi:10.3390/ijms23063197 Meta-analysis / review
https://doi.org/10.3390/ijms23063197 - Bais, S., Gill, N.S., Rana, N. and Shandil, S (2014) 'A Phytopharmacological Review on a Medicinal Plant: Juniperus communis', International Scholarly Research Notices, 2014, pp. 634723. doi:10.1155/2014/634723 Meta-analysis / review
https://doi.org/10.1155/2014/634723 - Raina, R., Verma, P.K., Peshin, R. and Kour, H (2019) 'Potential of Juniperus communis L as a nutraceutical in human and veterinary medicine', Heliyon, 5(8), pp. e02376. doi:10.1016/j.heliyon.2019.e02376 Meta-analysis / review
https://doi.org/10.1016/j.heliyon.2019.e02376 - Gordien, A.Y., Gray, A.I., Franzblau, S.G. and Seidel, V (2009) 'Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae)', Journal of Ethnopharmacology, 126(3), pp. 500-505. doi:10.1016/j.jep.2009.09.007 Preclinical
https://doi.org/10.1016/j.jep.2009.09.007 - Klancnik, A., Zorko, S., Toplak, N., Kovac, M., Bucar, F., Jersek, B. and Smole Mozina, S (2017) 'Antiadhesion activity of juniper (Juniperus communis L.) preparations against Campylobacter jejuni evaluated with PCR-based methods', Phytotherapy Research, 32(3), pp. 542-550. doi:10.1002/ptr.6005 Preclinical
https://doi.org/10.1002/ptr.6005 - Maurya, A.K., Devi, R., Kumar, A., Koundal, R., Thakur, S., Sharma, A., Kumar, D., Kumar, R., Padwad, Y.S., Chand, G., Singh, B. and Agnihotri, V.K (2018) 'Chemical Composition, Cytotoxic and Antibacterial Activities of Essential Oils of Cultivated Clones of Juniperus communis and Wild Juniperus Species', Chemistry & Biodiversity, 15(9), pp. e1800183. doi:10.1002/cbdv.201800183 Preclinical
https://doi.org/10.1002/cbdv.201800183 - Jegal, J., Park, S., Chung, K., Chung, H.Y., Lee, J., Jeong, E.J., Kim, K.H. and Yang, M.H (2016) 'Tyrosinase inhibitory flavonoid from Juniperus communis fruits', Bioscience, Biotechnology, and Biochemistry, 80(12), pp. 2311-2317. doi:10.1080/09168451.2016.1217146 Preclinical
https://doi.org/10.1080/09168451.2016.1217146 - Lin, T., Lu, C., Chang, K. and Lee, C (2022) 'Juniperus communis extract ameliorates lipopolysaccharide-induced acute kidney injury through the adenosine monophosphate-activated protein kinase pathway', Food Science & Nutrition, 10(10), pp. 3405-3414. doi:10.1002/fsn3.2941 Preclinical
https://doi.org/10.1002/fsn3.2941 - Gao, H., Huang, X., Yang, T., Chang, K., Yeh, L., Hsieh, M., Weng, J. and Tsai, N (2019) 'Juniperus communis Suppresses Melanoma Tumorigenesis by Inhibiting Tumor Growth and Inducing Apoptosis', The American Journal of Chinese Medicine, 47(5), pp. 1171-1191. doi:10.1142/S0192415X19500605 Preclinical
https://doi.org/10.1142/S0192415X19500605 - Huang, N., Huang, R., Huang, X., Chang, K., Lee, C., Hsiao, C., Lee, S. and Tsai, N (2021) 'Evaluation of anticancer effects of Juniperus communis extract on hepatocellular carcinoma cells in vitro and in vivo', Bioscience Reports, 41(7), pp. BSR20211143. doi:10.1042/BSR20211143 Preclinical
https://doi.org/10.1042/BSR20211143 - Lai, W., Lee, S., Chang, K., Huang, X., Li, C., Lee, C., Wu, C., Hsu, H. and Tsai, N (2021) 'Juniperus communis extract induces cell cycle arrest and apoptosis of colorectal adenocarcinoma in vitro and in vivo', Brazilian Journal of Medical and Biological Research, 54(10), pp. e10891. doi:10.1590/1414-431X2020e10891 Preclinical
https://doi.org/10.1590/1414-431X2020e10891 - Peruc, D., Ticac, B., Abram, M., Broznic, D., Stifter, S., Staver, M.M. and Gobin, I (2019) 'Synergistic potential of Juniperus communis and Helichrysum italicum essential oils against nontuberculous mycobacteria', Journal of Medical Microbiology, 68(5), pp. 703-710. doi:10.1099/jmm.0.000962 Preclinical
https://doi.org/10.1099/jmm.0.000962 - European Medicines Agency (HMPC) (2023) 'European Union herbal monograph on Juniperus communis L., galbulus (pseudo-fructus), Revision 1'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-juniperus-communis-l-pseudo-fructus-galbulus-revision-1_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-juniperus-communis-l-pseudo-fructus-galbulus-revision-1_en.pdf - European Medicines Agency (2010) 'European Union herbal monograph on Juniperus communis L., pseudo-fructus'. Traditional / reference
https://scholar.google.com/scholar?q=European%20Union%20herbal%20monograph%20on%20Juniperus%20communis%20L.%2C%20pseudo-fructus - British Herbal Medicine Association (1983) 'British Herbal Pharmacopoeia'. Traditional / reference
https://scholar.google.com/scholar?q=British%20Herbal%20Pharmacopoeia - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Four Season Foraging (2025) 'Is Juniper Toxic?'. Available at: https://www.fourseasonforaging.com/blog/2025/4/17/is-juniper-toxic Traditional / reference
https://www.fourseasonforaging.com/blog/2025/4/17/is-juniper-toxic - Zheljazkov, V.D. and Cantrell, C.L. and Semerdjieva, I. and Radoukova, T. and Stoyanova, A. and Maneva, V. and Kacaniova, M. and Astatkie, T. and Borisova, D. and Dincheva, I. and Salamon, I (2021) 'Essential Oil Composition and Bioactivity of Two Juniper Species from Bulgaria and Slovakia', Molecules, 26(12), pp. 3659. doi:10.3390/molecules26123659 Preclinical
https://doi.org/10.3390/molecules26123659
- Gampe, N. and Darcsi, A. and Nagyne Nedves, A. and Boldizsar, I. and Kursinszki, L. and Beni, S (2019) 'Phytochemical analysis of Ononis arvensis L. by liquid chromatography coupled with mass spectrometry', Journal of Mass Spectrometry, 54(2), pp. 121-133. doi:10.1002/jms.4308 Preclinical
https://doi.org/10.1002/jms.4308 - Denes, T. and Bartha, S.G. and Kerenyi, M. and Varga, E. and Balazs, V.L. and Csepregi, R. and Papp, N (2017) 'Histological and antimicrobial study of Ononis arvensis L', Acta Biologica Hungarica, 68(3), pp. 321-333. doi:10.1556/018.68.2017.3.9 Preclinical
https://doi.org/10.1556/018.68.2017.3.9 - Gampe, N. and Nagy, E. and Kursinszki, L. and Beni, S (2021) 'Quantitative determination of isoflavonoids in Ononis species by UPLC-UV-DAD', Phytochemical Analysis, 32(4), pp. 474-481. doi:10.1002/pca.2995 Preclinical
https://doi.org/10.1002/pca.2995 - Gampe, N. and Szakacs, Z. and Darcsi, A. and Boldizsar, I. and Szoke, E. and Kuzovkina, I. and Kursinszki, L. and Beni, S (2021) 'Qualitative and Quantitative Phytochemical Analysis of Ononis arvensis Hairy Root Cultures', Frontiers in Plant Science, 11, pp. 622585. doi:10.3389/fpls.2020.622585 Preclinical
https://doi.org/10.3389/fpls.2020.622585 - Pazdziora, W. and Grabowska, K. and Zagrodzki, P. and Pasko, P. and Prochownik, E. and Podolak, I. and Galanty, A (2025) 'Quantitative Analysis of Isoflavones from Ononis Species and Their Chemopreventive Potential on Breast Cancer Cells', Molecules, 30(11), pp. 2379. doi:10.3390/molecules30112379 Preclinical
https://doi.org/10.3390/molecules30112379 - Spilkova, J. and Bednar, P. and Stroblikova, R (2001) 'Capillary electrophoretic analysis of hydroxycinnamic acids from Ononis arvensis L', Die Pharmazie, 56(5), pp. 424-425. Preclinical
https://scholar.google.com/scholar?q=Capillary%20electrophoretic%20analysis%20of%20hydroxycinnamic%20acids%20from%20Ononis%20arvensis%20L. - Spilkova, J. and Hubik, J (1982) 'Pharmacognosy study of Ononis arvensis L. II. Flavonoids and onocerin in the drug', Ceskoslovenska Farmacie, 31(1), pp. 24-26. Preclinical
https://scholar.google.com/scholar?q=Pharmacognosy%20study%20of%20Ononis%20arvensis%20L.%20II.%20Flavonoids%20and%20onocerin%20in%20the%20drug - Rezacova, A. and Spilkova, J. and Hubik, J (1978) 'A pharmacognostic study of the species Ononis arvensis L', Ceskoslovenska Farmacie, 27(10), pp. 452-455. Traditional / reference
https://scholar.google.com/scholar?q=A%20pharmacognostic%20study%20of%20the%20species%20Ononis%20arvensis%20L. - Felsberg, A.A. and Rosentsveig, P.E (1965) 'A comparative phytochemical study of the roots of Ononis arvensis L. and Ononis spinosa L', Aptechnoe Delo, 14(6), pp. 26-32. Preclinical
https://scholar.google.com/scholar?q=A%20comparative%20phytochemical%20study%20of%20the%20roots%20of%20Ononis%20arvensis%20L.%20and%20Ononis%20spinosa%20L. - Sichinava, M.B. and Mchelidze, K.Z. and Churadze, M.V. and Alaniia, M.D. and Aneli, D.N (2014) 'Chemical composition and microstructural peculiarities of overground and underground vegetative organs of field restharrow (Ononis arvensis L.)', Georgian Medical News, (231), pp. 88-94. Preclinical
https://scholar.google.com/scholar?q=Chemical%20composition%20and%20microstructural%20peculiarities%20of%20overground%20and%20underground%20vegetative%20organs%20of%20field%20restharrow%20%28Ononis%20arvensis%20L.%29 - Dedio, I. and Kozlowski, J (1977) 'Comparative morphological and phytochemical studies of Ononis spinosa L. and Ononis arvensis L. I. Biometric and chromatographic studies of methanolic extracts', Acta Poloniae Pharmaceutica, 34(1), pp. 97-102. Preclinical
https://scholar.google.com/scholar?q=Comparative%20morphological%20and%20phytochemical%20studies%20of%20Ononis%20spinosa%20L.%20and%20Ononis%20arvensis%20L.%20I.%20Biometric%20and%20chromatographic%20studies%20of%20methanolic%20extracts - Felsberg, A.A. and Rozentsveig, P.E (1965) 'Photochemical examination of Ononis arvensis. I', Aptechnoe Delo, 14(3), pp. 25-27. Preclinical
https://scholar.google.com/scholar?q=Photochemical%20examination%20of%20Ononis%20arvensis.%20I - Nechita, V. and Tarau, A. and Suster, A. and Nechita, M. and Toiu, A. and Benedec, D. and Hanganu, D. and Siserman, C. and Drugan, C. and Oniga, I (2026) 'Phytochemical Constituents and Biological Activities of Ononis spinosa: A Comprehensive Review', Plants (Basel), 15(9), pp. 1409. doi:10.3390/plants15091409 Meta-analysis / review
https://doi.org/10.3390/plants15091409 - Spiegler, V. and Gierlikowska, B. and Saenger, T. and Addotey, J.N. and Sendker, J. and Jose, J. and Kiss, A.K. and Hensel, A (2020) 'Root Extracts From Ononis spinosa Inhibit IL-8 Release Via Interactions With Toll-Like Receptor 4 and Lipopolysaccharide', Frontiers in Pharmacology, 11, pp. 889. doi:10.3389/fphar.2020.00889 Preclinical
https://doi.org/10.3389/fphar.2020.00889 - Deipenbrock, M. and Sendker, J. and Hensel, A (2020) 'Aqueous Root Extract from Ononis spinosa Exerts Anti-adhesive Activity against Uropathogenic Escherichia coli', Planta Medica, 86(4), pp. 247-254. doi:10.1055/a-1089-8645 Preclinical
https://doi.org/10.1055/a-1089-8645 - Ergene Oz, B. and Saltan Iscan, G. and Kupeli Akkol, E. and Suntar, I. and Bahadir Acikara, O (2017) 'Isoflavonoids as wound healing agents from Ononidis Radix', Journal of Ethnopharmacology, 211, pp. 384-393. doi:10.1016/j.jep.2017.09.029 Preclinical
https://doi.org/10.1016/j.jep.2017.09.029 - Arnold, E. and Benz, T. and Zapp, C. and Wink, M (2015) 'Inhibition of Cytosolic Phospholipase A2alpha (cPLA2alpha) by Medicinal Plants in Relation to Their Phenolic Content', Molecules, 20(8), pp. 15033-15048. doi:10.3390/molecules200815033 Preclinical
https://doi.org/10.3390/molecules200815033 - Yilmaz, B.S. and Ozbek, H. and Citoglu, G.S. and Ugras, S. and Bayram, I. and Erdogan, E (2006) 'Analgesic and hepatotoxic effects of Ononis spinosa L', Phytotherapy Research, 20(6), pp. 500-503. doi:10.1002/ptr.1891 Preclinical
https://doi.org/10.1002/ptr.1891 - Manal Ahmad, A. and Yasser Ibrahim, K. and Manal Mohammad, A (2021) 'Efficacy of extract from Ononis spinosa L. on ethanol-induced gastric mucosal injury in rats', Journal of Traditional Chinese Medicine, 41(2), pp. 270-275. Preclinical
https://scholar.google.com/scholar?q=Efficacy%20of%20extract%20from%20Ononis%20spinosa%20L.%20on%20ethanol-induced%20gastric%20mucosal%20injury%20in%20rats - Addotey, J.N. and Lengers, I. and Jose, J. and Gampe, N. and Beni, S. and Petereit, F. and Hensel, A (2018) 'Isoflavonoids with inhibiting effects on human hyaluronidase-1 and norneolignan clitorienolactone B from Ononis spinosa L. root extract', Fitoterapia, 130, pp. 169-174. doi:10.1016/j.fitote.2018.08.013 Preclinical
https://doi.org/10.1016/j.fitote.2018.08.013 - Stojković, D. and Drakulić, D. and Gašić, U. and Zengin, G. and Stevanović, M. and Rajčević, N. and Sokóvić, M (2020) 'Ononis spinosa L., an edible and medicinal plant: UHPLC-LTQ-Orbitrap/MS chemical profiling and biological activities of the herbal extract', Food & Function. doi:10.1039/d0fo01595d Preclinical
https://doi.org/10.1039/d0fo01595d - Stojković, D. and Días, M.I. and Drakulić, D. and Barros, L. and Stevanović, M. and Ferreira, I.C. and Sokóvić, M (2020) 'Methanolic Extract of the Herb Ononis spinosa L. Is an Antifungal Agent with no Cytotoxicity to Primary Human Cells', Pharmaceuticals. doi:10.3390/ph13040078 Preclinical
https://doi.org/10.3390/ph13040078 - Kırmızıgül, S. and Gören, N. and Yang, S. and Cordell, G.A. and Bozok-Johansson, C (1997) 'Spinonin, a Novel Glycoside from Ononis spinosa subsp. leiosperma', Journal of Natural Products. doi:10.1021/np9605652 Preclinical
https://doi.org/10.1021/np9605652 - Mladenova, S.G. and Savova, M.S. and Marchev, A.S. and Ferrante, C. and Orlando, G. and Wabitsch, M. and Georgiev, M.I (2022) 'Anti-adipogenic activity of maackiain and ononin is mediated via inhibition of PPARγ in human adipocytes', Biomedicine & Pharmacotherapy. doi:10.1016/j.biopha.2022.112908 Preclinical
https://doi.org/10.1016/j.biopha.2022.112908 - Лужанин, В.Г. and Whaley, A.K. and Ponkratova, A.O. and Grishukova, E.A. and Suloev, I.S. and Смирнов, С.Н. and Serebryakov, E.B (2021) 'Isolation of Individual Compounds from the Terrestrial Parts of Ononis Arvensis L. and Solidago Canadensis L', Drug development & registration. doi:10.33380/2305-2066-2021-10-1-83-89 Preclinical
https://doi.org/10.33380/2305-2066-2021-10-1-83-89 - Bogoutdinova, A. and Whaley, A.K. and Ponkratova, A.O. and Orlova, A. and Goncharov, M.Y. and Shpakova, V. and Farmanova, N.T. and Nurullaeva, D.K. and Sharipov, A. and Gambaryan, S. and Повыдыш, М.Н (2021) 'Isolation of formononetin-7-O-β-D-glucopyranoside from the grass of Ononis arvensis L. and the assessment of its effect on induced platelet activation', Drug development & registration. doi:10.33380/2305-2066-2021-10-4(1)-14-19 Preclinical
https://doi.org/10.33380/2305-2066-2021-10-4(1)-14-19 - Paździora, W. and Grabowska, K. and Paśko, P. and Prochownik, E. and Podolak, I. and Galanty, A (2026) 'Multifaceted Evaluation of Isoflavone-Rich Fabaceae Species in Prostate Cancer In Vitro Models', Applied Sciences. doi:10.3390/app16136289 Preclinical
https://doi.org/10.3390/app16136289 - Gallo, G. and Cicione, A. and Nacchia, A. and Lombardo, R. and Riolo, S. and Guercio, A. and Fiasconaro, D. and Nunzio, C.D (2026) 'A randomized controlled trial comparing alpha-blocker (tamsulosin) and a phyto-complex (Solidago virga-aurea, Phyllantus niruri, Epilobium angustifolium, Peumus boldus and Ononis spinosa) in the treatment of ureteral stent-related symptoms', Urologia Journal. doi:10.1177/03915603261454171 Randomized trial
https://doi.org/10.1177/03915603261454171 - Ismailov, E. and Рогожникова, Е. and Марданлы, С.Г. and Мизина, П. and Kalinina, T.S (2024) 'COMPARATIVE STUDY OF SETTINGS FROM WILD SPECIES OF STEELWORM', Problems of Biological Medical and Pharmaceutical Chemistry. doi:10.29296/25877313-2024-12-02 Preclinical
https://doi.org/10.29296/25877313-2024-12-02 - Mauro, E.D. and Saldutto, P. and Rocca, R.L. and Sangiorgi, G. and Patelli, G. and Barone, B. and Verratti, V. and Castellucci, R. and Napolitano, L. and Iacono, F. and Altieri, V (2024) 'Efficacy and Safety of Boldine Combined with Phyllanthus niruri and Ononis spinosa in Medical Expulsive Therapy for Distal Ureteral Stones with Renal Colic: A Single-Center, Retrospective Cohort Study', Medicina. doi:10.3390/medicina60091455 Clinical study
https://doi.org/10.3390/medicina60091455 - DÉNES, T (2022) 'PHYTOCHEMICAL INVESTIGATION AND ANTIOXIDANT POTENTIAL OF ONONIS ARVENSIS L', FARMACIA. doi:10.31925/farmacia.2022.3.20 Preclinical
https://doi.org/10.31925/farmacia.2022.3.20 - Zarga, M.H.A. and Al‐Jaber, H.I. and Al‐Qudah, M.A. and Al-Aboudi, A.M (2021) 'A new cyclic polyketide and other constituents from Ononis spinosa growing wildly in Jordan and their antioxidant activity', Journal of Asian Natural Products Research. doi:10.1080/10286020.2021.1914597 Preclinical
https://doi.org/10.1080/10286020.2021.1914597 - Abbas, M.A. and Jaffal, S.M (2019) 'ANTINOCICEPTIVE ACTION OF ONONIS SPINOSA LEAF EXTRACT IN MOUSE PAIN MODELS', Acta Poloniae Pharmaceutica - Drug Research. doi:10.32383/appdr/99291 Preclinical
https://doi.org/10.32383/appdr/99291 - (2009) 'Radical scavenger and Antioxidant activities of extracts and fractions from Bulgarian Ononis spinosa L. and GC-MS analysis of Ethanol extract', The Internet Journal of Alternative Medicine. doi:10.5580/121d Preclinical
https://doi.org/10.5580/121d - Davitavyan, N. and Е.Б., Н. and Pogulyay, Y. and Khochava, M. and Мизина, П. and Адамов, Г (2024) 'STUDYING THE HYPOLYPIDEMIC ACTIVITY OF FLAVONOIDS AND ISOFLAVONOIDS OF THE ONONIS ARVENSIS L. METHODS BY IN SILICO', Problems of Biological Medical and Pharmaceutical Chemistry. doi:10.29296/25877313-2024-05-01 Preclinical
https://doi.org/10.29296/25877313-2024-05-01 - Gampe, N. and Dávid, D.N. and Takács‐Novák, K. and Backlund, A. and Béni, S (2022) 'In vitro and in silico evaluation of Ononis isoflavonoids as molecules targeting the central nervous system', PLoS ONE. doi:10.1371/journal.pone.0265639 Preclinical
https://doi.org/10.1371/journal.pone.0265639 - Pauli, G.F (2000) 'Comprehensive Spectroscopic Investigation of α-Onocerin', Planta Medica. doi:10.1055/s-2000-14895 Preclinical
https://doi.org/10.1055/s-2000-14895 - Köster, J. and Strack, D. and Barz, W (1983) 'High Performance Liquid Chromatographic Separation of Isoflavones and Structural Elucidation of Isoflavone 7-O-glucoside 6″-malonates from Cicer arietinum', Planta Medica. doi:10.1055/s-2007-969907 Preclinical
https://doi.org/10.1055/s-2007-969907 - Spiegler, V. and Michalak, B. and Addotey, J.N. and Saenger, T. and Jose, J. and Kiss, A.K. and Hensel, A (2019) 'Root extracts from Ononis spinosa exert anti-inflammatory activity in vitro on IL-8 and TNF-α release by inhibition of TLR-4 receptor', Planta Medica. doi:10.1055/s-0039-3399691 Preclinical
https://doi.org/10.1055/s-0039-3399691 - Çoban, T. and Çitoğlu, G.S. and Yılmaz, B.S. and İşcan, M (2003) 'Antioxidant Activities of Plants Used in Traditional Medicine in Turkey', Pharmaceutical Biology. doi:10.1080/13880200390501974 Preclinical
https://doi.org/10.1080/13880200390501974 - Obiștioiu, D. and Cocan, I. and Tîrziu, E. and Herman, V. and Negrea, M. and Ban-Cucerzan, A. and Neacşu, A. and Cozma, A. and Nichita, I. and Hulea, A. and Radulov, I. and Alexa, E (2021) 'Phytochemical Profile and Microbiological Activity of Some Plants Belonging to the Fabaceae Family', Antibiotics. doi:10.3390/antibiotics10060662 Preclinical
https://doi.org/10.3390/antibiotics10060662 - Orlando, G. and Chiavaroli, A. and Ferrante, C. and Recinella, L. and Leone, S. and Brunetti, L. and Simone, S.C.D. and Menghini, L. and Petrucci, M. and Zengin, G. and Cesaroni, F. and Pontarelli, G. and Cindolo, L. and Neri, F (2021) 'Protective effects induced by the food supplement Fluxonorm® in the lower urinary tract', PubMed. doi:10.26355/eurrev_202104_25562 Preclinical
https://doi.org/10.26355/eurrev_202104_25562
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.