Plant Comparison

Chaga vs Fenugreek

A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.

First plant
Second plant
Show:
Plant AChagaInonotus obliquusHymenochaetaceaeFull monograph →
Plant BFenugreekTrigonella foenum-graecumFabaceaeFull monograph →

At a glance

Chaga and Fenugreek: they share 6 indicated uses (arthritis / joint pain, cancer (anticancer research), inflammation (general), …); 3 pharmacological actions in common.

ChagaFenugreek
Constituents34
Pharmacological actions104
Indicated uses118
Safety notes23
Cited sources4117
Indicated uses
Only Chaga
Cold & fluImmune supportInfection (general)WoundsCognitive function
Shared (6)
Arthritis / joint painCancer (anticancer research)Inflammation (general)Metabolic supportSkin irritationCardiovascular / heart health
Only Fenugreek
Blood sugar / diabetes supportFertility
Pharmacological actions
Only Chaga
AntimicrobialAntioxidantImmunomodulator / immune supportNephroprotective (kidney support)Neuroprotective / cognition supportHepatoprotective (liver support)Lipid-lowering
Shared (3)
Anti-inflammatoryAnticancer (preclinical)Antidiabetic (blood-sugar lowering)
Only Fenugreek
Aphrodisiac

Evidence face-off — shared uses

ConditionChagaFenugreekVerdict
Arthritis / joint pain1/108/10Stronger for Fenugreek
Cancer (anticancer research)2/107/10Stronger for Fenugreek
Inflammation (general)1/107/10Stronger for Fenugreek
Metabolic support1/107/10Stronger for Fenugreek
Skin irritation1/107/10Stronger for Fenugreek
Cardiovascular / heart health2/107/10Stronger for Fenugreek

Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.

Key Constituents

Melanin-rich pigments and betulinic acid derivatives[1]

Chaga's dark colour comes from melanin-like pigments; it also concentrates betulinic-acid-type triterpenes absorbed from its birch host, associated with antioxidant and anticancer research interest.

Polysaccharides (beta-glucans)[4]

Immunomodulatory polysaccharides contributing to the traditional tonic and immune-support use.

Polysaccharides
Phenolic compounds[4]

Antioxidant phenolics contributing to chaga's free-radical-scavenging activity.

Phenolic compounds
Steroidal saponins (diosgenin)[12]

Thought to contribute to the antidiabetic and cholesterol-lowering effects.

Saponins
Galactomannan (soluble fiber)[5]

Mucilaginous soluble fiber that slows carbohydrate absorption, a key mechanism behind the blood-sugar-lowering effect.

Polysaccharides
4-hydroxyisoleucine (amino acid)[12]

An unusual amino acid studied for insulin-potentiating activity.

Sotolon (flavor compound)[11]

Aromatic lactone responsible for fenugreek's characteristic maple-syrup smell, including the body-odor effect reported with supplementation.

Pharmacological Actions

Anti-inflammatory[4, 5, 9, 13, 15, 19, 27, 30, 38, 39, 40]
Anticancer (preclinical)[15, 17, 21, 22, 26, 28, 31, 38]
Antimicrobial[38, 39, 40]
Antioxidant[8, 10, 12, 29, 35, 38, 39, 40]
Immunomodulator / immune support[2, 4, 7, 14, 16, 19, 26, 32, 37, 38, 39, 40]
Nephroprotective (kidney support)[20]
Neuroprotective / cognition support[24, 35]
Antidiabetic (blood-sugar lowering)[25, 31, 34, 36]
Hepatoprotective (liver support)[28]
Lipid-lowering[33, 36]
Anti-inflammatory[1, 5, 6, 9, 10, 11, 12]
Anticancer (preclinical)[8]
Antidiabetic (blood-sugar lowering)[4, 5, 6, 11, 12]
Aphrodisiac[3, 5, 11, 12]

Traditional & Indicated Uses

Arthritis / joint pain[38, 39, 40]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Arthritis / joint pain
Cancer (anticancer research)[15, 21, 38]Traditional · 2/10

inferred from anticancer action

Evidence: 2
Label: Cancer (anticancer research)
Cold & flu[38, 39, 40]Traditional · 1/10

inferred from immunomodulator action

Evidence: 1
Label: Cold & flu
Immune support[14, 38, 39, 40]Traditional · 2/10
Evidence: 2
Label: Immune support
Infection (general)[38, 39, 40]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1
Label: Infection (general)
Inflammation (general)[38, 39, 40]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Inflammation (general)
Metabolic support[38, 39, 40]Traditional · 1/10
Evidence: 1
Label: Metabolic support
Skin irritation[38, 39, 40]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Skin irritation
Wounds[38, 39, 40]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1
Label: Wounds
Cognitive function[24, 35]Traditional · 2/10

Chaga-derived 3,4-DHBA protected against Parkinson's-related neurotoxicity (preclinical).

Evidence: 2
Label: Cognitive function
Cardiovascular / heart health[33]Traditional · 2/10

Chaga polysaccharide lowered lipids in vivo and in vitro.

Evidence: 2
Label: Cardiovascular / heart health
Arthritis / joint pain[1, 5, 11, 12]Good · 8/10

inferred from anti-inflammatory action

Evidence: 8
Label: Arthritis / joint pain
Blood sugar / diabetes support[4, 5, 11, 12]Good · 7/10

inferred from antidiabetic action

Evidence: 7
Label: Blood sugar / diabetes support
Cancer (anticancer research)[8]Good · 7/10

inferred from anticancer action

Evidence: 7
Label: Cancer (anticancer research)
Cardiovascular / heart health[5, 11, 12]Good · 7/10
Evidence: 7
Label: Cardiovascular / heart health
Fertility[3, 5, 11, 12]Good · 8/10
Evidence: 8
Label: Fertility
Inflammation (general)[5, 9, 10, 11, 12]Good · 7/10

inferred from anti-inflammatory action

Evidence: 7
Label: Inflammation (general)
Metabolic support[5, 11, 12]Good · 7/10
Evidence: 7
Label: Metabolic support
Skin irritation[5, 11, 12]Good · 7/10

inferred from anti-inflammatory action

Evidence: 7
Label: Skin irritation

Safety, Cautions & Contraindications

Safety note[38, 39, 40]Caution

Autoimmune conditions: Chaga can stimulate parts of the immune system—people with autoimmune diseases should be cautious.Blood thinners: Chaga contains compounds that may affect clotting—avoid large doses if on anticoagulants.Blood sugar meds: May slightly lower glucose—monitor if taking diabetes medication.Pregnancy & breastfeeding: Limited safety data—best avoided unless guided by a professional.Quality matters: Wild-harvested Chaga can accumulate heavy metals from trees and soil—source from reputable suppliers.

Safety note[38, 39, 40, 41]Info

Duke (2002) does not include a dedicated entry for chaga (Inonotus obliquus) in the Handbook of Medicinal Herbs, Second Edition, as this medicinal fungus was not widely documented in Western herbal literature at that time (Duke, 2002).

Safety note[5, 11, 12]Info

Fenugreek appears https://www.nccih.nih.gov/health/fenugreek for most people.

Safety note[5, 11, 12]Caution

Less serious side effects like diarrhea and indigestion have been reported anecdotally. You may also experience https://pubmed.ncbi.nlm.nih.gov/26251835/, which could be harmful if you have an eating disorder or are trying to https://www.healthline.com/nutrition/how-to-gain-weight. Moreover, some people report a strange and slightly sweet body odor when supplementing, but this is unconfirmed. Given its effect on blood sugar, fenugreek should be used with caution if you’re taking diabetes medication or other supplements that lower blood sugar levels.

Safety note[5, 11, 12, 13]Caution

Duke (2002) provides strong clinical evidence (score 2) for fenugreek's hypoglycemic and hypocholesterolemic activities — among the best-evidenced herbal treatments for blood sugar and lipid management. Anti-inflammatory and demulcent activities also have clinical support. The seed is Commission E approved as an appetite stimulant. Dose: 6–50 g of ground seeds daily for blood sugar management; 1–4 g seeds in tea for digestive use. The plant has lactagogue effects and can cause maple syrup-like body odor due to sotolon content. Contraindicated in pregnancy at medicinal doses due to uterotonic effects (Duke, 2002).

External Ids

Gbif: 2521089
Wikidata: Q1956937
Gbif: 5360475
Wikidata: Q133205

Botanical Description

Parasitic wood-decay fungus (not a true plant) that grows almost entirely inside the trunk of living birch trees, visible externally only as a hard, black, cracked, charcoal-like mass (a sclerotium, sometimes called a 'conk') erupting through the bark. Unlike typical mushrooms, chaga has no true cap, gills or stem; its fertile spore-producing surface develops later, hidden beneath the bark after the tree dies.[1]

Height: External mass 10-40 cm
Habit: Parasitic wood-decay fungus, growing mostly inside the host tree
Leaves: Not applicable (fungus)
Flowers: Not applicable (fungus); reproduces by spores
Stem: No true cap-and-stem structure; visible only as a hard black external mass (sclerotium)
Root: Fungal mycelium spreading through the living wood of the host tree
Fruit: Fertile spore-producing layer develops hidden beneath the bark, typically after the host tree dies
Flowering Period: The visible black mass persists and grows for years; not a seasonal fruiting body

Erect annual herb with trifoliate leaves, each leaflet oblong and finely toothed toward the tip. Small, pale yellow to white, pea-like flowers are borne singly or in pairs in the leaf axils, followed by long, slender, curved seed pods.[11]

Height: 30-80 cm
Habit: Erect annual herb
Leaves: Trifoliate, each leaflet oblong, finely toothed toward the tip
Flowers: Small, pale yellow to white, pea-like, borne singly or in pairs in leaf axils
Stem: Erect, branching, slightly hairy
Root: Taproot with nitrogen-fixing nodules
Fruit: Long, slender, curved seed pod (10-15 cm) containing 10-20 hard, angular, yellow-brown seeds
Flowering Period: May-June

Habitat

Grows almost exclusively as a parasite on living birch trees in cold, northern temperate and boreal forests of Europe, Russia, North America and Asia.[1]

Cultivated widely as a food and forage crop; native to the eastern Mediterranean and western Asia, now grown throughout South Asia, the Middle East and North Africa.[11]

Harvesting

The hard black external mass (conk) is chopped or broken away from the living birch trunk, ideally without killing the tree, then dried and broken into pieces or ground for use; sustainable harvesting (leaving part of the conk to regrow) is recommended given the fungus's slow growth.

Parts: Mycelium, Whole Plant

Leaves and young sprouts are harvested throughout the growing season; seed pods are collected when fully mature and dried, then the hard seeds are threshed out.[11]

Parts: Leaf, Seed, Young sprouts
Season: Leaf/sprouts through growing season; seed at maturity

Traditional Uses

Chaga has a long traditional use in Russian, Siberian, Baltic and Scandinavian folk medicine as a tonic remedy for digestive complaints, immune support and general vitality, traditionally taken as a dark, tea-like decoction; this traditional tonic reputation is now studied for its antioxidant, immunomodulatory and anti-inflammatory properties.[1, 4]

Fenugreek seed has an ancient tradition across the Mediterranean, Middle East and South Asia as a digestive and appetite-stimulant remedy and lactation aid, and modern clinical research strongly supports its traditional use for blood sugar and cholesterol management, formalised in Commission E approval as an appetite stimulant.[5, 11, 12]

Preparations

Decoction[1]

Chunks of the dried black conk simmered gently in water for an extended period, producing a dark, tea-like traditional tonic.

Standardised extract[4]

Extract standardised to polysaccharide or polyphenol content, taken as capsules or powder.

Ground seed / seed tea[5]

Ground seeds taken with food, or whole seeds soaked/simmered as a tea, the traditional preparation for digestive and blood sugar support.

Standardized extract (capsule)[5]

Standardized seed extract in capsule form, the form most used in clinical trials on blood sugar and cholesterol.

References

REF-0848, REF-0849, REF-0850, REF-2195, REF-2196, REF-2197, REF-2198, REF-2199, REF-2200, REF-2201, REF-2202, REF-2203, REF-2204, REF-2969, REF-2970, REF-2971, REF-2972, REF-2973, REF-2974, REF-2975, REF-2976, REF-2977, REF-2978, REF-2979, REF-2980, REF-2981, REF-2982, REF-2983, REF-2984, REF-2985, REF-2986, REF-2987, REF-2988, REF-2989, REF-2990, REF-2991, REF-2992
REF-1114, REF-1115, REF-1116, REF-1117, REF-0182, REF-1118, REF-1119, REF-1120, REF-1121, REF-1122

Lookalikes Review

Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07
Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

Dosage

Not documented

Seed[5, 12]

Clinical research and traditional sources suggest around 6-50 g of ground seed daily (higher end for blood sugar management), or 1-4 g in tea for digestive use. Educational reference only, not a prescription.

Drug Class Interactions

Not documented

Safety note[14, 15]Caution
Drug Class: antidiabetics
Mechanism: Fenugreek seed lowers fasting and post-meal blood sugar (confirmed by a meta-analysis of randomised trials in type 2 diabetes and prediabetes), so taken with diabetes medicines it may add to their effect and increase the risk of hypoglycaemia; monitor blood glucose.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

Pairings

Not documented

Fenugreek and bitter melon can each lower blood sugar, so taking them together — especially alongside diabetes medicines — may add up and increase the risk of hypoglycaemia. Monitor your blood glucose.[15, 16]

Partner Id: momordica-charantia
Type: caution
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

Fenugreek and black seed (Nigella sativa) can each lower blood sugar, so taking them together — especially alongside diabetes medicines — may add up and increase the risk of hypoglycaemia. Monitor your blood glucose.[15, 17]

Partner Id: nigella-sativa
Type: caution
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

References & Sources

  1. Camilleri, E., Blundell, R., Baral, B., Karpinski, T.M. et al (2024) 'A brief overview of the medicinal and nutraceutical importance of Inonotus obliquus (chaga) mushrooms', Heliyon, 10(15), pp. e35638. doi:10.1016/j.heliyon.2024.e35638 Traditional / reference
    https://doi.org/10.1016/j.heliyon.2024.e35638
  2. Lu, Y., Jia, Y., Xue, Z., Li, N. et al (2021) 'Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application', Polymers (Basel), 13(9), pp. 1441. doi:10.3390/polym13091441 Traditional / reference
    https://doi.org/10.3390/polym13091441
  3. Kobus, Z., Krzywicka, M., Blicharz-Kania, A., Bosacka, A. et al (2024) 'Impact of Incorporating Dried Chaga Mushroom (Inonotus obliquus) into Gluten-Free Bread on Its Antioxidant and Sensory Characteristics', Molecules, 29(16), pp. 3801. doi:10.3390/molecules29163801 Preclinical
    https://doi.org/10.3390/molecules29163801
  4. Szychowski, K.A., Skora, B., Pomianek, T. and Gminski, J (2020) 'Inonotus obliquus - from folk medicine to clinical use', Journal of Traditional and Complementary Medicine, 11(4), pp. 293-302. doi:10.1016/j.jtcme.2020.08.003 Meta-analysis / review
    https://doi.org/10.1016/j.jtcme.2020.08.003
  5. Javed, S., Mitchell, K., Sidsworth, D., Sellers, S.L., Reutens-Hernandez, J., Massicotte, H.B., Egger, K.N., Lee, C.H. and Payne, G.W (2019) 'Inonotus obliquus attenuates histamine-induced microvascular inflammation', PLoS One, 14(8), pp. e0220776. doi:10.1371/journal.pone.0220776 Preclinical
    https://doi.org/10.1371/journal.pone.0220776
  6. Zou, C., Hou, Z., Bai, M., Guo, R., Lin, B., Wang, X., Huang, X. and Song, S (2020) 'Highly modified steroids from Inonotus obliquus', Organic & Biomolecular Chemistry, 18(20), pp. 3908-3916. doi:10.1039/d0ob00474j Preclinical
    https://doi.org/10.1039/d0ob00474j
  7. Zhong, X.H., Ren, K., Lu, S.J., Yang, S.Y. and Sun, D.Z (2009) 'Progress of research on Inonotus obliquus', Chinese Journal of Integrative Medicine, 15(2), pp. 156-160. doi:10.1007/s11655-009-0156-2 Meta-analysis / review
    https://doi.org/10.1007/s11655-009-0156-2
  8. Burmasova, M.A., Utebaeva, A.A., Sysoeva, E.V. and Sysoeva, M.A (2019) 'Melanins of Inonotus obliquus: bifidogenic and antioxidant properties', Biomolecules, 9(6), pp. 248. doi:10.3390/biom9060248 Preclinical
    https://doi.org/10.3390/biom9060248
  9. Sun, Y., Deng, X., Li, Z., Dong, Y., Jiang, W., Ma, Y., Zhou, W., Zhu, T., Wang, G., Liu, S. and Hu, B (2022) 'Polysaccharide derived from Inonotus obliquus inhibits lipopolysaccharide-induced acute endometritis in mice', American Journal of Translational Research, 14(11), pp. 8332-8342. Preclinical
    https://scholar.google.com/scholar?q=Polysaccharide%20derived%20from%20Inonotus%20obliquus%20inhibits%20lipopolysaccharide-induced%20acute%20endometritis%20in%20mice
  10. Ishfaq, P.M., Mishra, S., Mishra, A., Ahmad, Z., Gayen, S., Jain, S.K., Tripathi, S. and Mishra, S.K (2022) 'Inonotus obliquus aqueous extract prevents histopathological alterations in liver induced by environmental toxicant Microcystin', Current Research in Pharmacology and Drug Discovery, 3, pp. 100118. doi:10.1016/j.crphar.2022.100118 Preclinical
    https://doi.org/10.1016/j.crphar.2022.100118
  11. Peng, A., Liu, S., Fang, L., Zhu, Z., Zhou, Y., Yue, S., Ma, Z., Liu, X., Xue, S., Qiu, Y. and Qi, R (2022) 'Inonotus obliquus and its bioactive compounds alleviate non-alcoholic fatty liver disease via regulating FXR/SHP/SREBP-1c axis', European Journal of Pharmacology, 921, pp. 174841. doi:10.1016/j.ejphar.2022.174841 Preclinical
    https://doi.org/10.1016/j.ejphar.2022.174841
  12. Zhang, Y., Liu, Q., Sun, Y. and Jiang, J (2023) 'Inonotus obliquus sclerotia epidermis were different from internal tissues in compound composition, antioxidant activity, and associated fungi', FEMS Microbiology Letters, 370, pp. fnad126. doi:10.1093/femsle/fnad126 Preclinical
    https://doi.org/10.1093/femsle/fnad126
  13. Yu, S., Lai, Z., Xue, H., Zhu, J., Yue, G., Wang, J. and Jin, L.H (2024) 'Inonotus obliquus aqueous extract inhibits intestinal inflammation and insulin metabolism defects in Drosophila', Toxicology Mechanisms and Methods, 34(9), pp. 970-984. doi:10.1080/15376516.2024.2368795 Preclinical
    https://doi.org/10.1080/15376516.2024.2368795
  14. Wold, C.W. and Christopoulos, P. and Arias, M. and Dzovor, D.E. and Øynebråten, I. and Corthay, A. and Inngjerdingen, K.T (2024) 'Fungal polysaccharides from Inonotus obliquus are agonists for Toll-like receptors and induce macrophage anti-cancer activity', Communications Biology. doi:10.1038/s42003-024-05853-y Preclinical
    https://doi.org/10.1038/s42003-024-05853-y
  15. Li, J. and Qu, C. and Li, F. and Chen, Y. and Zheng, J. and Xiao, Y. and Jin, Q. and Jin, G. and Huang, X. and Jin, D (2021) 'Inonotus obliquus Polysaccharide Ameliorates Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Cancer in Mice via Activation of the NLRP3 Inflammasome', Frontiers in Pharmacology. doi:10.3389/fphar.2020.621835 Preclinical
    https://doi.org/10.3389/fphar.2020.621835
  16. Wold, C.W. and Gerwick, W.H. and Wangensteen, H. and Inngjerdingen, K.T (2020) 'Bioactive triterpenoids and water-soluble melanin from Inonotus obliquus (Chaga) with immunomodulatory activity', Journal of Functional Foods. doi:10.1016/j.jff.2020.104025 Preclinical
    https://doi.org/10.1016/j.jff.2020.104025
  17. Kim, J. and Yang, S. and Hwang, A.Y. and Cho, H. and Hwang, K.T (2020) 'Composition of Triterpenoids in Inonotus obliquus and Their Anti-Proliferative Activity on Cancer Cell Lines', Molecules. doi:10.3390/molecules25184066 Preclinical
    https://doi.org/10.3390/molecules25184066
  18. Duru, K.C. and Kovaleva, E.G. and Данилова, И.Г. and Bijl, P.V.D (2019) 'The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies', Phytotherapy Research. doi:10.1002/ptr.6384 Preclinical
    https://doi.org/10.1002/ptr.6384
  19. Hu, Y. and Teng, C. and Yu, S. and Wang, X. and Liang, J. and Bai, X. and Dong, L. and Song, T. and Yu, M. and Qu, J (2017) 'Inonotus obliquus polysaccharide regulates gut microbiota of chronic pancreatitis in mice', AMB Express. doi:10.1186/s13568-017-0341-1 Preclinical
    https://doi.org/10.1186/s13568-017-0341-1
  20. Chou, Y. and Kan, W. and Chang, C. and Peng, Y. and Wang, H. and Yu, W. and Cheng, Y. and Jhang, Y. and Liu, H. and Chuu, J (2016) 'Renal Protective Effects of Low Molecular Weight of Inonotus obliquus Polysaccharide (LIOP) on HFD/STZ-Induced Nephropathy in Mice', International Journal of Molecular Sciences. doi:10.3390/ijms17091535 Preclinical
    https://doi.org/10.3390/ijms17091535
  21. Arata, S. and Watanabe, J. and Maeda, M. and Yamamoto, M. and Matsuhashi, H. and Mochizuki, M. and Kagami, N. and Honda, K. and Inagaki, M (2016) 'Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice', Heliyon. doi:10.1016/j.heliyon.2016.e00111 Preclinical
    https://doi.org/10.1016/j.heliyon.2016.e00111
  22. Lee, K.R. and Lee, J.S. and Kim, Y.R. and Song, I.G. and Hong, E.K (2014) 'Polysaccharide from Inonotus obliquus inhibits migration and invasion in B16-F10 cells by suppressing MMP-2 and MMP-9 via downregulation of NF-κB signaling pathway', Oncology Reports. doi:10.3892/or.2014.3103 Preclinical
    https://doi.org/10.3892/or.2014.3103
  23. Song, F. and Liu, Y. and Kong, X. and Chang, W. and Song, G (2013) 'Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom: Inonotus Obliquus', Asian Pacific Journal of Cancer Prevention. doi:10.7314/apjcp.2013.14.3.1571 Preclinical
    https://doi.org/10.7314/apjcp.2013.14.3.1571
  24. Gunjima, K. and Tomiyama, R. and Takakura, K. and Yamada, T. and Hashida, K. and Nakamura, Y. and Konishi, T. and Matsugo, S. and Hori, O (2013) '3,4‐Dihydroxybenzalacetone Protects Against Parkinson's Disease‐Related Neurotoxin 6‐OHDA Through Akt/Nrf2/Glutathione Pathway', Journal of Cellular Biochemistry. doi:10.1002/jcb.24643 Preclinical
    https://doi.org/10.1002/jcb.24643
  25. Geng, Y. and Lu, Z. and Huang, W. and Xu, H. and Shi, J. and Xu, Z (2013) 'Bioassay-Guided Isolation of DPP-4 Inhibitory Fractions from Extracts of Submerged Cultured of Inonotus obliquus', Molecules. doi:10.3390/molecules18011150 Preclinical
    https://doi.org/10.3390/molecules18011150
  26. Zhang, L. and Fan, C. and Liu, S. and Zang, Z. and Jiao, L. and Zhang, L (2011) 'Chemical composition and antitumor activity of polysaccharide from Inonotus obliquus', Journal of Medicinal Plants Research. doi:10.5897/jmpr.9000346 Preclinical
    https://doi.org/10.5897/jmpr.9000346
  27. Choi, S. and Hur, S.J. and An, C.S. and Jeon, Y.H. and Jeoung, Y.J. and Bak, J.P. and Lim, B.O (2010) 'Anti-Inflammatory Effects ofInonotus obliquusin Colitis Induced by Dextran Sodium Sulfate', Journal of Biomedicine and Biotechnology. doi:10.1155/2010/943516 Preclinical
    https://doi.org/10.1155/2010/943516
  28. Youn, M. and Kim, J. and Park, S. and Kim, Y. and Kim, S. and Lee, J.S. and Chai, K.Y. and Kim, H. and Cui, M. and So, H.S. and Kim, K. and Park, R (2008) 'Chaga mushroom (Inonotus obliquus ) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells', World Journal of Gastroenterology. doi:10.3748/wjg.14.511 Preclinical
    https://doi.org/10.3748/wjg.14.511
  29. Nakajima, Y. and Sato, Y. and Konishi, T (2007) 'Antioxidant Small Phenolic Ingredients in Inonotus obliquus (persoon) Pilat (Chaga)', Chemical and Pharmaceutical Bulletin. doi:10.1248/cpb.55.1222 Preclinical
    https://doi.org/10.1248/cpb.55.1222
  30. Kim, H. and Yoon, D. and Kim, C. and Shrestha, B. and Chang, W. and Lim, S. and Lee, W. and Han, S. and Lee, J. and Lim, M. and Kim, G. and Choi, S. and Song, W.O. and Sung, J. and Hwang, K (2007) 'Ethanol Extract of Inonotus obliquus Inhibits Lipopolysaccharide-Induced Inflammation in RAW 264.7 Macrophage Cells', Journal of Medicinal Food. doi:10.1089/jmf.2006.156 Preclinical
    https://doi.org/10.1089/jmf.2006.156
  31. Mizuno, T. and Zhuang, C. and Abe, K. and Okamoto, H. and Kiho, T. and Ukai, S. and Leclerc, S. and Meijer, L (1999) 'Antitumor and Hypoglycemic Activities of Polysaccharides from the Sclerotia and Mycelia of Inonotus obliquus (Pers.: Fr.) Pil. (Aphyllophoromycetideae)', International journal of medicinal mushrooms. doi:10.1615/intjmedmushr.v1.i4.20 Preclinical
    https://doi.org/10.1615/intjmedmushr.v1.i4.20
  32. Su, L. and Xin, C. and Yang, J. and Dong, L. and Mei, H. and Dai, X. and Wang, Q (2022) 'A polysaccharide from Inonotus obliquus ameliorates intestinal barrier dysfunction in mice with type 2 diabetes mellitus', International Journal of Biological Macromolecules. doi:10.1016/j.ijbiomac.2022.06.071 Preclinical
    https://doi.org/10.1016/j.ijbiomac.2022.06.071
  33. Yang, M. and Hu, D. and Cui, Z. and Li, H. and Man, C. and Jiang, Y (2021) 'Lipid-Lowering Effects of Inonotus obliquus Polysaccharide In Vivo and In Vitro', Foods. doi:10.3390/foods10123085 Preclinical
    https://doi.org/10.3390/foods10123085
  34. Wang, J. and Hu, W. and Li, L. and Huang, X. and Liu, Y. and Wang, D. and Teng, L (2017) 'Antidiabetic activities of polysaccharides separated from Inonotus obliquus via the modulation of oxidative stress in mice with streptozotocin-induced diabetes', PLoS ONE. doi:10.1371/journal.pone.0180476 Preclinical
    https://doi.org/10.1371/journal.pone.0180476
  35. Giridharan, V.V. and Thandavarayan, R.A. and Konishi, T (2011) 'Amelioration of scopolamine induced cognitive dysfunction and oxidative stress by Inonotus obliquus– a medicinal mushroom', Food & Function. doi:10.1039/c1fo10037h Preclinical
    https://doi.org/10.1039/c1fo10037h
  36. Lee, J. and Hyun, C (2014) 'Insulin‐Sensitizing and Beneficial Lipid‐Metabolic Effects of the Water‐Soluble Melanin Complex Extracted from Inonotus obliquus', Phytotherapy Research. doi:10.1002/ptr.5131 Preclinical
    https://doi.org/10.1002/ptr.5131
  37. Kim, Y (2005) 'Immunomodulatory Activity of the Water Extract from Medicinal MushroomInonotus obliquus', Mycobiology. doi:10.4489/myco.2005.33.3.158 Preclinical
    https://doi.org/10.4489/myco.2005.33.3.158
  38. Géry, A., Dubreule, C., André, V., Rioult, J.P., Bouchart, V., Heutte, N., Eldin de Pécoulas, P., Krivomaz, T. and Garon, D (2018) 'Chaga (Inonotus obliquus), a future potential medicinal fungus in oncology? A chemical study and a comparison of the cytotoxicity against human lung adenocarcinoma cells (A549) and human bronchial epithelial cells (BEAS-2B)', 17(3), pp. 832--843. doi:10.1177/1534735418757912 Traditional / reference
    https://doi.org/10.1177/1534735418757912
  39. Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
    https://powo.science.kew.org
  40. Shashkina, M.Ya., Shashkin, P.N. and Sergeev, A.V (2006) 'Chemical and medicobiological properties of chaga', 40(10), pp. 560--568. Traditional / reference
    https://scholar.google.com/scholar?q=Chemical%20and%20medicobiological%20properties%20of%20chaga
  41. Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
    https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
  1. Faghfoori, Z., Javadivala, Z., Khalili, Y. and Malek Mahdavi, A (2023) 'Effects of Trigonella foenum-graecum (fenugreek) on rheumatoid arthritis: a systematic review', Immunopharmacology and Immunotoxicology, 45(5), pp. 626-634. doi:10.1080/08923973.2023.2202298 Meta-analysis / review
    https://doi.org/10.1080/08923973.2023.2202298
  2. Ouzir, M., El Bairi, K. and Amzazi, S (2016) 'Toxicological properties of fenugreek (Trigonella foenum graecum)', Food and Chemical Toxicology, 96, pp. 145-154. doi:10.1016/j.fct.2016.08.003 Meta-analysis / review
    https://doi.org/10.1016/j.fct.2016.08.003
  3. Rao, A., Steels, E., Inder, W.J., Abraham, S. and others (2016) 'Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a double-blind randomised clinical study', The Aging Male, 19(2), pp. 134-142. doi:10.3109/13685538.2015.1135323 Randomized trial
    https://doi.org/10.3109/13685538.2015.1135323
  4. Avalos-Soriano, A., De la Cruz-Cordero, R., Rosado, J.L. and Garcia-Gasca, T (2016) '4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity', Molecules, 21(11), pp. 1596. doi:10.3390/molecules21111596 Preclinical
    https://doi.org/10.3390/molecules21111596
  5. Neelakantan, N., Narayanan, M., de Souza, R.J. and van Dam, R.M (2014) 'Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials', pp. 7. Meta-analysis / review
    https://scholar.google.com/scholar?q=Effect%20of%20fenugreek%20%28Trigonella%20foenum-graecum%20L.%29%20intake%20on%20glycemia%3A%20a%20meta-analysis%20of%20clinical%20trials
  6. Nagulapalli Venkata, K.C., Swaroop, A., Bagchi, D. and Bishayee, A (2017) 'A small plant with big benefits: Fenugreek (Trigonella foenum-graecum Linn.) for disease prevention and health promotion', Molecular Nutrition & Food Research, 61(6), pp. 1600950. doi:10.1002/mnfr.201600950 Meta-analysis / review
    https://doi.org/10.1002/mnfr.201600950
  7. Ulbricht, C., Basch, E., Burke, D., Cheung, L. and others (2007) 'Fenugreek (Trigonella foenum-graecum L. Leguminosae): an evidence-based systematic review by the natural standard research collaboration', Journal of Herbal Pharmacotherapy, 7(3-4), pp. 143-177. doi:10.1080/15228940802142852 Meta-analysis / review
    https://doi.org/10.1080/15228940802142852
  8. El Bairi, K., Ouzir, M., Agnieszka, N. and Khalki, L (2017) 'Anticancer potential of Trigonella foenum graecum: Cellular and molecular targets', Biomedicine & Pharmacotherapy, 90, pp. 479-491. doi:10.1016/j.biopha.2017.03.071 Meta-analysis / review
    https://doi.org/10.1016/j.biopha.2017.03.071
  9. Piao, C.H., Bui, T.T., Song, C.H., Shin, H.S. and others (2017) 'Trigonella foenum-graecum alleviates airway inflammation of allergic asthma in ovalbumin-induced mouse model', Biochemical and Biophysical Research Communications, 482(4), pp. 1284-1288. doi:10.1016/j.bbrc.2016.12.029 Preclinical
    https://doi.org/10.1016/j.bbrc.2016.12.029
  10. Asif, M., Yousaf, H.M., Saleem, M., Saadullah, M. and others (2021) 'Trigonella foenum-graecum Seeds Oil Attenuated Inflammation and Angiogenesis in vivo through Down-Regulation of TNF-alpha', Anti-Cancer Agents in Medicinal Chemistry, 21(11), pp. 1460-1471. doi:10.2174/1871520620666201005100132 Preclinical
    https://doi.org/10.2174/1871520620666201005100132
  11. World Health Organization (1999) 'WHO Monographs on Selected Medicinal Plants'. Traditional / reference
    https://scholar.google.com/scholar?q=WHO%20Monographs%20on%20Selected%20Medicinal%20Plants
  12. Kumar, P. and Bhandari, U (2013) 'Protective effect of fenugreek (Trigonella foenum-graecum L.) seeds in experimentally-induced myocardial infarction', 23(2), pp. 255--261. Traditional / reference
    https://scholar.google.com/scholar?q=Protective%20effect%20of%20fenugreek%20%28Trigonella%20foenum-graecum%20L.%29%20seeds%20in%20experimentally-induced%20myocardial%20infarction
  13. Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
    https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
  14. Neelakantan, N., Narayanan, M., de Souza, R.J. and van Dam, R.M (2014) 'Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials', Nutrition Journal, 13, pp. 7. doi:10.1186/1475-2891-13-7 Meta-analysis / review
    https://doi.org/10.1186/1475-2891-13-7
  15. Kim, J., Noh, W., Kim, A., Choi, Y. and Kim, Y.S (2023) 'The effect of fenugreek in type 2 diabetes and prediabetes: a systematic review and meta-analysis of randomized controlled trials', International Journal of Molecular Sciences, 24(18), pp. 13999. doi:10.3390/ijms241813999 Meta-analysis / review
    https://doi.org/10.3390/ijms241813999
  16. Zhang, X., Zhao, Y., Song, Y. and Miao, M (2024) 'Effects of Momordica charantia L. supplementation on glycemic control and lipid profile in type 2 diabetes mellitus patients: a systematic review and meta-analysis of randomized controlled trials', Heliyon, 10(10), pp. e31126. doi:10.1016/j.heliyon.2024.e31126 Meta-analysis / review
    https://doi.org/10.1016/j.heliyon.2024.e31126
  17. Daryabeygi-Khotbehsara, R., Golzarand, M., Ghaffari, M.P. and Djafarian, K (2017) 'Nigella sativa improves glucose homeostasis and serum lipids in type 2 diabetes: a systematic review and meta-analysis', Complementary Therapies in Medicine, 35, pp. 6-13. doi:10.1016/j.ctim.2017.08.016 Meta-analysis / review
    https://doi.org/10.1016/j.ctim.2017.08.016

Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.