Omnia SanaPlant Comparison
Hop vs Ginger
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Hop and Ginger: they share 5 indicated uses (arthritis / joint pain, bloating, indigestion, …); 3 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Hop | Ginger | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 1/10 | 10/10 | Stronger for Ginger |
| Bloating | 1/10 | 10/10 | Stronger for Ginger |
| Indigestion | 1/10 | 10/10 | Stronger for Ginger |
| Inflammation (general) | 1/10 | 10/10 | Stronger for Ginger |
| Skin irritation | 1/10 | 10/10 | Stronger for Ginger |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Alpha- and beta-bitter acids responsible for the characteristic bitterness and much of the sedative, GABA-A-receptor-active and antimicrobial activity.
Xanthohumol has antioxidant activity; 8-prenylnaringenin has notable phytoestrogenic activity, the basis of the mild oestrogenic caution.
Aromatic volatile oil contributing to the characteristic hop aroma.
The pungent phenolic constituents of the rhizome (notably 6-gingerol, which dehydrates to 6-shogaol on drying) responsible for ginger's antiemetic and anti-inflammatory activity; a standardized regimen of 84 mg/day gingerols/shogaols was effective against chemotherapy-induced nausea.
Pharmacological Actions
Traditional & Indicated Uses
inferred from anti-inflammatory action
inferred from digestive action
inferred from anti-inflammatory action
inferred from sedative action
inferred from anti-inflammatory action
inferred from analgesic action
inferred from digestive action
inferred from analgesic action
inferred from digestive action
inferred from anti-inflammatory action
inferred from antispasmodic action
inferred from antispasmodic action
Safety, Cautions & Contraindications
Generally safe at therapeutic doses for short-term use. Hop preparations may enhance the sedative effects of alcohol, benzodiazepines, and other CNS depressants — avoid combination. Not recommended during pregnancy or breastfeeding. May have mild oestrogenic effects due to 8-prenylnaringenin — caution in hormone-sensitive conditions. Fresh hops can cause contact dermatitis in pickers.
Duke (2002) rates hops as +++ and provides clinical evidence (score 2) for sedative activity, consistent with Commission E approval for nervousness, unrest, and sleep disturbances. The primary sedative compound is 2-methyl-3-buten-2-ol, formed from humulone during storage. Duke notes that hop cones have estrogenic activity, explaining occupational menstrual irregularities reported among hop pickers. Dose: 0.5 g dried flower in tea before bed; often combined with valerian. Hops should not be used in depression, as its CNS-depressant effect may worsen depressive symptoms (Duke, 2002).
Ginger is widely considered safe at culinary and conventional supplemental doses. At high doses (>5 g/day), ginger may cause heartburn, acid reflux, mouth irritation, and mild gastrointestinal discomfort. Ginger may modestly inhibit platelet aggregation and enhance the effects of anticoagulants (e.g., warfarin) — clinical significance at dietary amounts is low, but caution is warranted with high-dose supplementation alongside blood-thinning medications (Shalansky et al., 2007). May lower blood sugar — monitor closely if combining with antidiabetic medications.
Pregnancy: Ginger is among the most studied herbal remedies for pregnancy nausea. At doses up to 1 g/day, it is generally considered safe and effective for nausea and vomiting of pregnancy (NVP), based on multiple RCTs. The EMA monograph supports its use for NVP. Avoid doses >1.5 g/day during pregnancy due to theoretical concern about anticoagulant activity. Breastfeeding: generally considered safe at food amounts; limited data for medicinal doses (European Medicines Agency, 2012a).
Duke (2002) rates ginger as a triple-plus herb (+++) with strong clinical support (score 3) for antiemetic activity, including motion sickness, morning sickness, and postoperative nausea, and score 2 evidence for dyspepsia, diarrhea, and inflammation. Typical doses are 2-4 g dry rhizome per day or 500-1000 mg fresh root three times daily; Commission E approves ginger for dyspepsia and motion sickness. Ginger has antiplatelet properties and should be used with caution alongside anticoagulant medications (Duke, 2002).
External Ids
Botanical Description
Vigorous, twining perennial climbing vine with rough, hairy stems and deeply lobed, opposite leaves resembling grape leaves. The plant is dioecious; female plants bear the characteristic papery, cone-like flower clusters ('hops'), covered in yellow, resinous lupulin glands, that are the medicinal and brewing part.[1]
Rhizomatous perennial herb with narrow, lance-shaped leaves arising in two ranks from slender, reed-like pseudostems. Pale yellow-green flowers with purple markings are borne in a dense, cone-like spike on a separate short stalk arising directly from the rhizome, though ginger rarely flowers in cultivation. The branching, knobbly rhizome has a pale yellow interior and a characteristic pungent, spicy aroma.[1]
Habitat
Grows in hedgerows, woodland edges and damp thickets, climbing over other vegetation; native to Europe, Western Asia and North America, and widely cultivated for brewing.
Believed native to tropical Southeast Asia; cultivated extensively throughout the tropics and subtropics (India, China, Nigeria, the Caribbean) in warm, humid conditions on well-drained, fertile soil.
Harvesting
The female flower cones are picked in late summer once mature (when the lupulin glands are fully developed and sticky), then dried quickly to preserve the volatile oils and bitter resins.[1]
The rhizome is dug 8-10 months after planting, once the leaves have died back, for mature ('old') ginger with the fullest pungency, or earlier for milder young ('green') ginger; cleaned and used fresh or dried and ground.
Traditional Uses
Hop cones have a long European tradition as a calming, sedative herb for nervous tension, restlessness and insomnia, and as a bitter digestive tonic; the sedative reputation, historically noted among hop-pickers who became drowsy from handling the cones, is now linked to GABA-A receptor-active bitter resins.[1]
Ginger rhizome has one of the longest and most widespread medicinal histories of any spice, used across Chinese, Ayurvedic and Western herbal traditions as a warming digestive carminative, an antiemetic for nausea and motion sickness, and an anti-inflammatory remedy for joint pain; this traditional reputation is now supported by an extensive clinical evidence base, particularly for nausea (including pregnancy and chemotherapy-related) and osteoarthritis.[1]
Preparations
Dried flower cones infused in hot water as a herbal tea, 500-1000 mg in 150-200 ml, taken 30-60 minutes before bedtime per the EU herbal monograph. Educational reference only, not a prescription.
Tincture (1:5) of the dried cones, 1-2 ml up to three times daily per the EU herbal monograph. Educational reference only, not a prescription.
Concentrated extract standardised to xanthohumol/humulone content, studied for sleep-enhancing activity via GABA-A receptor modulation.
Dried rhizome powder or standardised extract, taken as capsules for nausea or joint-pain studies.
Dosage
The EU herbal monograph distinguishes two uses, in adolescents, adults and elderly. To aid sleep - 500-1000 mg of the comminuted flower in 150-200 mL of boiling water as an infusion, 30-60 minutes before bedtime. In mental stress - 500 mg in 150-200 mL as an infusion, up to 4 times daily. A 1:5 tincture at 1-2 mL up to 3 times daily is also listed. Educational reference only, not a prescription.
Clinical trials for nausea commonly use around 1-1.5 g of dried rhizome powder daily, in divided doses (up to 1 g/day in pregnancy); osteoarthritis studies commonly use similar or somewhat higher doses. Educational reference only, not a prescription.
References
Not documented
Drug Class Interactions
Pairings
Lookalikes Review
Dangerous Lookalikes
Not documented
References & Sources
- Lee, H., Chung, S.H., Kwon, D.J., Nam, M.J. et al (2024) 'Sleep-enhancing effect of Hongcheon-hop (Humulus lupulus L.) extract containing xanthohumol and humulone through GABA-A receptor', Journal of Ethnopharmacology, 338(Pt 2), pp. 119019. doi:10.1016/j.jep.2024.119019 Preclinical
https://doi.org/10.1016/j.jep.2024.119019 - Kenda, M., Glavač, N.K., Nagy, M. and Sollner Dolenc, M (2021) 'Herbal Products Used in Menopause and for Gynecological Disorders', Molecules, 26(24), pp. 7421. doi:10.3390/molecules26247421 Traditional / reference
https://doi.org/10.3390/molecules26247421 - Dietz, B.M., Hajirahimkhan, A., Dunlap, T.L. and Bolton, J.L (2016) 'Botanicals and Their Bioactive Phytochemicals for Women's Health', Pharmacological Reviews, 68(4), pp. 1026-1073. doi:10.1124/pr.115.010843 Traditional / reference
https://doi.org/10.1124/pr.115.010843 - Sun, X.L., Xia, T.S., Jiang, Y.P., Wang, N.N., Xu, L.C. and Han, T (2022) 'Humulus lupulus L. extract and its active constituent xanthohumol attenuate oxidative stress and nerve injury induced by iron overload via activating AKT/GSK3beta and Nrf2/NQO1 pathways', Journal of Natural Medicines, 76(4), pp. 801-814. doi:10.1007/s11418-022-01642-1 Preclinical
https://doi.org/10.1007/s11418-022-01642-1 - Karbalaei, N., Sadeghi, N., Nekoeian, A. and Malekzadeh, A (2019) 'Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats', Chinese Journal of Integrative Medicine, 25(9), pp. 1-8. doi:10.1007/s11655-019-3025-7 Preclinical
https://doi.org/10.1007/s11655-019-3025-7 - Xia, T.S., Lin, L.Y., Zhang, Q.Y., Jiang, Y.P., Li, C.H. and Liu, X.Y (2019) 'Humulus lupulus L. Extract Prevents Ovariectomy-Induced Osteoporosis in Mice and Regulates Activities of Osteoblasts and Osteoclasts', Chinese Journal of Integrative Medicine, 27(1), pp. 31-38. doi:10.1007/s11655-019-2700-z Preclinical
https://doi.org/10.1007/s11655-019-2700-z - Hurth, Z., Faber, M.L., Gendrisch, F., Holzer, M., Haarhaus, B. and Cawelius, A (2022) 'The Anti-Inflammatory Effect of Humulus lupulus Extract In Vivo Depends on the Galenic System of the Topical Formulation', Pharmaceuticals, 15(3), pp. 350. doi:10.3390/ph15030350 Preclinical
https://doi.org/10.3390/ph15030350 - Caban, M., Chojnacka, K., Owczarek, K., Laskowska, J., Fichna, J. and Podsedek, A (2020) 'Spent hops (Humulus Lupulus L.) extract as modulator of the inflammatory response in lipopolysaccharide stimulated RAW 264.7 macrophages', Journal of Physiology and Pharmacology, 71(1). doi:10.26402/jpp.2020.1.05 Preclinical
https://doi.org/10.26402/jpp.2020.1.05 - Wang, S., Dunlap, T.L., Howell, C.E., Mbachu, O.C., Rue, E.A. and Phansalkar, R (2016) 'Hop (Humulus lupulus L.) Extract and 6-Prenylnaringenin Induce P450 1A1 Catalyzed Estrogen 2-Hydroxylation', Chemical Research in Toxicology, 29(7), pp. 1142-1150. doi:10.1021/acs.chemrestox.6b00112 Preclinical
https://doi.org/10.1021/acs.chemrestox.6b00112 - Kyrou, I., Christou, A., Panagiotakos, D., Stefanaki, C., Skenderi, K. and Katsana, K (2017) 'Effects of a hops (Humulus lupulus L.) dry extract supplement on self-reported depression, anxiety and stress levels in apparently healthy young adults: a randomized, placebo-controlled, double-blind, crossover pilot study', Hormones, 16(2), pp. 171-180. doi:10.14310/horm.2002.1738 Randomized trial
https://doi.org/10.14310/horm.2002.1738 - Hege, M., Jung, F., Sellmann, C., Jin, C., Ziegenhardt, D. and Hellerbrand, C (2017) 'An iso-alpha-acid-rich extract from hops (Humulus lupulus) attenuates acute alcohol-induced liver steatosis in mice', Nutrition, 41, pp. 70-77. doi:10.1016/j.nut.2017.07.010 Preclinical
https://doi.org/10.1016/j.nut.2017.07.010 - European Medicines Agency (HMPC) (2014) 'Community herbal monograph on Humulus lupulus L., flos, Revision 1'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-humulus-lupulus-l-flos-revision-1_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-humulus-lupulus-l-flos-revision-1_en.pdf - Becker, A., Felgentreff, F., Schröder, H., Meier, B. and Brattstrom, A (2014) 'The anxiolytic effects of a Valerian extract is based on valerenic acid', pp. 267. Traditional / reference
https://scholar.google.com/scholar?q=The%20anxiolytic%20effects%20of%20a%20Valerian%20extract%20is%20based%20on%20valerenic%20acid - Koetter, U. and Blumenthal, M (2010) 'Valerian and hops for insomnia: overview of clinical data', pp. 44--50. Traditional / reference
https://scholar.google.com/scholar?q=Valerian%20and%20hops%20for%20insomnia%3A%20overview%20of%20clinical%20data - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Ghasemzadeh Rahbardar, M. and Hosseinzadeh, H (2024) 'Therapeutic potential of hypnotic herbal medicines: A comprehensive review', Phytotherapy Research, 38(6), pp. 3037-3059. doi:10.1002/ptr.8201 Meta-analysis / review
https://doi.org/10.1002/ptr.8201 - Block, K.I., Gyllenhaal, C. and Mead, M.N (2004) 'Safety and efficacy of herbal sedatives in cancer care', Integrative Cancer Therapies, 3(2), pp. 128-148. doi:10.1177/1534735404265003 Meta-analysis / review
https://doi.org/10.1177/1534735404265003 - Koetter, U., Schrader, E., Kaeufeler, R. and Brattstroem, A (2007) 'A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder', Phytotherapy Research, 21(9), pp. 847-851. doi:10.1002/ptr.2167 Randomized trial
https://doi.org/10.1002/ptr.2167 - Ngan, A. and Conduit, R (2011) 'A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality', Phytotherapy Research, 25(8), pp. 1153-1159. doi:10.1002/ptr.3400 Randomized trial
https://doi.org/10.1002/ptr.3400 - Totally Wild UK 'Hops (Humulus lupulus) Identification Guide'. Available at: https://totallywilduk.co.uk/2022/12/08/hops-humulus-lupulus-identification-guide/ Traditional / reference
https://totallywilduk.co.uk/2022/12/08/hops-humulus-lupulus-identification-guide/
- Crichton, M., Marshall, S., Isenring, E., Lohning, A., McCarthy, A.L., Molassiotis, A. and others (2023) 'Effect of a Standardized Ginger Root Powder Regimen on Chemotherapy-Induced Nausea and Vomiting: A Multicenter, Double-Blind, Placebo-Controlled Randomized Trial', Journal of the Academy of Nutrition and Dietetics, 124(3), pp. 313--330. doi:10.1016/j.jand.2023.09.003 Randomized trial
https://doi.org/10.1016/j.jand.2023.09.003 - Mathieu, S., Soubrier, M., Peirs, C., Monfoulet, L.E., Boirie, Y. and Tournadre, A (2022) 'A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms', Nutrients, 14(8). doi:10.3390/nu14081607 Meta-analysis / review
https://doi.org/10.3390/nu14081607 - Ali, B.H., Blunden, G., Tanira, M.O. and Nemmar, A (2008) 'Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research', 46(2), pp. 409--420. doi:10.1016/j.fct.2007.09.085 Clinical study
https://doi.org/10.1016/j.fct.2007.09.085 - European Medicines Agency (2012) 'European Union herbal monograph on Zingiber officinale Roscoe, rhizoma (Zingiberis rhizoma)'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-zingiber-officinale-roscoe-rhizoma_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-zingiber-officinale-roscoe-rhizoma_en.pdf - Huang, F.Y., Deng, T., Meng, L.X. and Ma, X.L (2019) 'Dietary ginger as a traditional therapy for blood sugar control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis', 98(13). doi:10.1097/MD.0000000000015054 Meta-analysis / review
https://doi.org/10.1097/MD.0000000000015054 - Marx, W., McCarthy, A.L., Ried, K. et al (2017) 'Can ginger ameliorate chemotherapy-induced nausea? Protocol of a randomized double blind, placebo-controlled trial', pp. 65. doi:10.1186/s12906-017-1571-z Randomized trial
https://doi.org/10.1186/s12906-017-1571-z - Mashhadi, N.S., Ghiasvand, R., Askari, G., Hariri, M., Darvishi, L. and Mofid, M.R (2013) 'Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: a review', pp. S36--S42. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC3665023/ Traditional / reference
https://pmc.ncbi.nlm.nih.gov/articles/PMC3665023/ - Royal Botanic Gardens, Kew (n.d.) 'Zingiber officinale Roscoe'. Available at: https://powo.science.kew.org/taxon/urn:lsid:http://ipni.org:names:798372-1 Traditional / reference
https://powo.science.kew.org/taxon/urn:lsid:http://ipni.org:names:798372-1 - Shalansky, S., Lynd, L., Richardson, K., Ingaszewski, A. and Kerr, C (2007) 'Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with complementary and alternative medicine', 27(9), pp. 1237--1247. doi:10.1592/phco.27.9.1237 Clinical study
https://doi.org/10.1592/phco.27.9.1237 - Viljoen, E., Visser, J., Koen, N. and Musekiwa, A (2014) 'A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting', 13(1), pp. 20. doi:10.1186/1475-2891-13-20 Meta-analysis / review
https://doi.org/10.1186/1475-2891-13-20 - Xu, Y., Yang, Q. and Wang, X (2020) 'Efficacy of herbal medicine (cinnamon/fennel/ginger) for primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials', Journal of International Medical Research, 48(6). doi:10.1177/0300060520936179 Meta-analysis / review
https://doi.org/10.1177/0300060520936179 - Zhang, Y., Gui, Y., Adams, R., Farragher, J., Itsiopoulos, C., Bow, K. and others (2025) 'Comparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis', Nutrients, 17(15). doi:10.3390/nu17152547 Meta-analysis / review
https://doi.org/10.3390/nu17152547 - Hu, Y., Amoah, A.N., Zhang, H., Fu, R., Qiu, Y., Cao, Y. and others (2020) 'Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis', Journal of Maternal-Fetal and Neonatal Medicine, 35(1), pp. 187--196. doi:10.1080/14767058.2020.1712714 Meta-analysis / review
https://doi.org/10.1080/14767058.2020.1712714 - Huang, F.Y., Deng, T., Meng, L.X. and Ma, X.L (2019) 'Dietary ginger as a traditional therapy for blood sugar control in patients with type 2 diabetes mellitus: A systematic review and meta-analysis', Medicine (Baltimore), 98(13). doi:10.1097/MD.0000000000015054 Meta-analysis / review
https://doi.org/10.1097/MD.0000000000015054 - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Jiang, X., Williams, K.M., Liauw, W.S., Ammit, A.J., Roufogalis, B.D., Duke, C.C., Day, R.O. and McLachlan, A.J (2005) 'Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects', British Journal of Clinical Pharmacology, 59(4), pp. 425-432. doi:10.1111/j.1365-2125.2005.02322.x Randomized trial
https://doi.org/10.1111/j.1365-2125.2005.02322.x
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.