Omnia SanaPlant Comparison
Cleavers vs Field scabious
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Cleavers and Field scabious: they share 4 indicated uses (eczema, infection (general), skin irritation, …); 2 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Cleavers | Field scabious | Verdict |
|---|---|---|---|
| Eczema | 1/10 | 2/10 | Comparable evidence |
| Infection (general) | 1/10 | 2/10 | Comparable evidence |
| Skin irritation | 1/10 | 2/10 | Comparable evidence |
| Wounds | 1/10 | 2/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Characteristic Rubiaceae iridoids shared with related bedstraws, contributing to the plant's traditional activity.
Antioxidant constituents supporting the plant's antimicrobial and wound-healing activity.
Astringent constituents contributing to the traditional topical use for skin and wounds.
Chlorogenic, cryptochlorogenic and dicaffeoylquinic acids and caffeoylhydrocitric acid (antioxidant).
C-glycosidic flavones such as isovitexin and related flavonoids.
Saponin glycosides (knautiosides) characteristic of the plant and the Caprifoliaceae family.
Pharmacological Actions
Traditional 'blood purifier' (depurative) for skin complaints; the classic use of field scabious.
Knautia and related Caprifoliaceae extracts inhibit inflammatory mediators (COX/LOX).
Traditional & Indicated Uses
inferred from anticancer action
inferred from antimicrobial action
inferred from emollient action
inferred from diuretic action
inferred from diuretic action
inferred from diuretic action
Traditional remedy for eczema, itching and skin complaints; anti-acne activity of Knautia extracts.
Anti-acne activity of Knautia species extracts (antibacterial, anti-inflammatory).
inferred from traditional external use on cuts and sores
Safety, Cautions & Contraindications
Duke (2002) describes cleavers as a diuretic, lymph tonic, and depurative with experimental support (score 1). The plant has been used in traditional medicine for swollen lymph nodes, urinary complaints, and skin conditions. Diuretic and anti-inflammatory activities are supported experimentally. No Commission E approval. Safety rating is ++ (relatively safe), with no known significant contraindications at usual herbal doses (Duke, 2002).
Very little is known about the safety of field scabious and there are no clinical data; avoid medicinal doses in pregnancy and breastfeeding and use only modest amounts.
Most pharmacological data come from closely related Caprifoliaceae (genus Knautia, Scabiosa, Dipsacus) rather than Knautia arvensis itself; apply to field scabious with caution.
External Ids
Botanical Description
Scrambling, sprawling annual herb covered in tiny hooked bristles on its square stems, leaves and seed capsules, allowing it to cling to clothing, fur and neighbouring plants as it climbs ('stickyweed'). The leaves are narrow and lance-shaped, borne in whorls of six to eight. Tiny white, four-petalled flowers give way to small, round, bristly-hooked twin seed capsules ('goosegrass burrs').[6]
A hairy perennial herb of the honeysuckle family (formerly Dipsacaceae), 25-100 cm tall, growing from a stout rootstock. The stems are roughly hairy and bear opposite leaves that are variable - the lower ones often lyre-shaped or pinnately lobed, the upper deeply cut. The flowers are massed into flat, domed pincushion heads about 3-4 cm across, lilac to bluish-violet, with the outer florets enlarged; the heads are carried on long stalks and, unlike true scabious (Scabiosa), the receptacle is hairy rather than scaly. It flowers through summer and is a favourite of bees and butterflies.[1]
Habitat
A common scrambling weed of hedgerows, waste ground, gardens and field margins, climbing over other vegetation for support; native to Europe, Asia and North Africa and widely naturalised elsewhere.[6]
Dry grassland, meadows, pastures, dry hills, roadside banks, field margins and open woods, on well-drained and often calcareous soils across Europe and into western Asia and parts of Africa. A characteristic plant of unimproved dry meadows.[1]
Harvesting
The whole aerial plant (leaf, stem and seed) is cut in spring to early summer, before the fruit fully hardens, and used fresh (as juice) or dried.
The flowering aerial parts (leaves, stems, flower heads) are gathered in summer while in flower and dried; the root is also used. Best cut from established plants in dry grassland.[1]
Traditional Uses
Cleavers has a long European folk history as a lymphatic and diuretic 'spring tonic' herb, traditionally used to support the urinary system and lymphatic drainage, and topically as a soothing, emollient wash or poultice for skin irritation, wounds and minor swellings.[6]
Field scabious has a European folk-medicine reputation chiefly as a remedy for skin complaints - eczema, itching, scabies (the name 'scabious' comes from its use against 'the scab'), cuts and sores - taken internally as a 'blood purifier' (alterative/depurative) and applied externally as a wash or poultice. It has also been used for coughs and sore throats. The plant is rich in phenolic acids, flavonoids and saponins; the closely related genera Knautia, Scabiosa and Dipsacus in the honeysuckle family share this chemistry and a tradition of use in skin disease and inflammation.[3, 4]
Preparations
References
Lookalikes Review
Synonyms
Not documented
References & Sources
- Laanet, P.R., Saar-Reismaa, P., Jõul, P., Bragina, O. and Vaher, M (2023) 'Phytochemical Screening and Antioxidant Activity of Selected Estonian Galium Species', Molecules, 28(6), pp. 2867. doi:10.3390/molecules28062867 Preclinical
https://doi.org/10.3390/molecules28062867 - Antoniak, K., Studzińska-Sroka, E., Szymański, M., Dudek-Makuch, M. et al (2023) 'Antiangiogenic, Anti-Inflammatory and Antioxidant Properties of Bidens tripartita Herb, Galium verum Herb and Rumex hydrolapathum Root', Molecules, 28(13), pp. 4966. doi:10.3390/molecules28134966 Preclinical
https://doi.org/10.3390/molecules28134966 - Razzivina, V., Vasiljeva, A., Kronberga, A., Skudrins, G. et al (2024) 'Phenolic Content and Anti-Inflammatory Activity of Cultivated and Wild-Type Galium odoratum Extracts in Murine Bone Marrow-Derived Macrophages', Antioxidants (Basel), 13(12), pp. 1447. doi:10.3390/antiox13121447 Preclinical
https://doi.org/10.3390/antiox13121447 - Sahin, B., Karabulut, S., Filiz, A.K., Ozkaraca, M., Gezer, A. and Akpulat, H.A (2022) 'Galium aparine L. protects against acetaminophen-induced hepatotoxicity in rats', Chemico-Biological Interactions, 366, pp. 110119. doi:10.1016/j.cbi.2022.110119 Preclinical
https://doi.org/10.1016/j.cbi.2022.110119 - Lee, S.Y., Park, S.Y. and Park, H.J (2024) 'Immuno-Enhancing Effects of Galium aparine L. in Cyclophosphamide-Induced Immunosuppressed Animal Models', Nutrients, 16(5), pp. 597. doi:10.3390/nu16050597 Preclinical
https://doi.org/10.3390/nu16050597 - Beirami, A.D., Akhtari, N., Noroozi, R., Hatamabadi, D., Hasan, S.M.F. and Ayatollahi, S.A (2024) 'Bringing back Galium aparine L. from forgotten corners of traditional wound treatment procedures: an antimicrobial, antioxidant, and in-vitro wound healing assay along with HPTLC fingerprinting study', BMC Complementary Medicine and Therapies, 24(1), pp. 279. doi:10.1186/s12906-024-04355-y Preclinical
https://doi.org/10.1186/s12906-024-04355-y - Ilina, T., Kashpur, N., Granica, S., Bazylko, A., Shinkovenko, I. and Kovalyova, A (2019) 'Phytochemical Profiles and In Vitro Immunomodulatory Activity of Ethanolic Extracts from Galium aparine L', Plants, 8(12), pp. 541. doi:10.3390/plants8120541 Preclinical
https://doi.org/10.3390/plants8120541 - Atmaca, H., Bozkurt, E., Cittan, M. and Dilek Tepe, H (2016) 'Effects of Galium aparine extract on the cell viability, cell cycle and cell death in breast cancer cell lines', Journal of Ethnopharmacology, 186, pp. 305-310. doi:10.1016/j.jep.2016.04.007 Preclinical
https://doi.org/10.1016/j.jep.2016.04.007 - Bokhari, J., Khan, M.R., Shabbir, M., Rashid, U., Jan, S. and Zai, J.A (2012) 'Evaluation of diverse antioxidant activities of Galium aparine', Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 102, pp. 24-29. doi:10.1016/j.saa.2012.09.056 Preclinical
https://doi.org/10.1016/j.saa.2012.09.056 - Shi, G., Liu, J., Zhao, W., Liu, Y. and Tian, X (2016) 'Separation and purification and in vitro anti-proliferative activity of leukemia cell K562 of Galium aparine L. petroleum ether phase', Saudi Pharmaceutical Journal, 24(3), pp. 241-247. doi:10.1016/j.jsps.2016.04.005 Preclinical
https://doi.org/10.1016/j.jsps.2016.04.005 - Quinlan, F.J (1883) 'Galium Aparine as a Remedy for Chronic Ulcers', British Medical Journal, 1(1172), pp. 1173-1174. doi:10.1136/bmj.1.1172.1173 Traditional / reference
https://doi.org/10.1136/bmj.1.1172.1173 - British Herbal Medicine Association (1983) 'British Herbal Pharmacopoeia'. Traditional / reference
https://scholar.google.com/scholar?q=British%20Herbal%20Pharmacopoeia - Hoffmann, D (2003) 'Medical Herbalism: The Science and Practice of Herbal Medicine'. Traditional / reference
https://scholar.google.com/scholar?q=Medical%20Herbalism%3A%20The%20Science%20and%20Practice%20of%20Herbal%20Medicine - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
- Karalija, E. and Muratovic, E. and Tarkowski, P. and Zeljkovic, S.C (2017) 'Variation in Phenolic Composition of Knautia arvensis in Correlation with Geographic Area and Plant Organ', Natural Product Communications, 12(4), pp. 545-548. doi:10.1177/1934578x1701200421 Preclinical
https://doi.org/10.1177/1934578x1701200421 - Moldoch, J. and Szajwaj, B. and Masullo, M. and Pecio, L. and Oleszek, W. and Piacente, S. and Stochmal, A (2011) 'Phenolic constituents of Knautia arvensis aerial parts', Natural Product Communications, 6(11), pp. 1627-1630. doi:10.1177/1934578x1100601117 Preclinical
https://doi.org/10.1177/1934578x1100601117 - Plouvier, V (1971) 'Research on heterosides: knautioside and saponosides from Knautia arvensis and related glycosides', Comptes Rendus de l'Academie des Sciences, Serie D, 272(10), pp. 1443-1446. Preclinical
https://scholar.google.com/scholar?q=Research%20on%20heterosides%3A%20knautioside%20and%20saponosides%20from%20Knautia%20arvensis%20and%20related%20glycosides - Chrzaszcz, M. and Miazga-Karska, M. and Klimek, K. and Dybowski, M.P. and Typek, R. and Tchorzewska, D. and Dos Santos Szewczyk, K (2023) 'The Anti-Acne Potential and Chemical Composition of Knautia Species (Caprifoliaceae) Extracts', International Journal of Molecular Sciences, 24(11), pp. 9188. doi:10.3390/ijms24119188 Preclinical
https://doi.org/10.3390/ijms24119188 - Skala, E. and Szopa, A (2023) 'Dipsacus and Scabiosa Species - The Source of Specialized Metabolites with High Biological Relevance: A Review', Molecules, 28(9), pp. 3754. doi:10.3390/molecules28093754 Meta-analysis / review
https://doi.org/10.3390/molecules28093754 - Pinto, D.C.G.A. and Rahmouni, N. and Beghidja, N. and Silva, A.M.S (2018) 'Scabiosa Genus: A Rich Source of Bioactive Metabolites', Medicines (Basel), 5(4), pp. 110. doi:10.3390/medicines5040110 Meta-analysis / review
https://doi.org/10.3390/medicines5040110 - Albayrak, S. and Aksoy, A. and Yilmaz, M.A. and Beyzi, E (2024) 'Investigation of Phytochemical, Antioxidant and Antidiabetic Potentials of Scabiosa L. (Caprifoliaceae) Species with Chemometric Methods', Chemistry and Biodiversity, 21(2), pp. e202301652. doi:10.1002/cbdv.202301652 Preclinical
https://doi.org/10.1002/cbdv.202301652 - Saar-Reismaa, P. and Koel, M. and Tarto, R. and Vaher, M (2022) 'Extraction of bioactive compounds from Dipsacus fullonum leaves using deep eutectic solvents', Journal of Chromatography A, 1677, pp. 463330. doi:10.1016/j.chroma.2022.463330 Preclinical
https://doi.org/10.1016/j.chroma.2022.463330
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.