Plant Comparison
Midland Hawthorn vs Raspberry Leaf
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Midland Hawthorn and Raspberry Leaf: both belong to the Rosaceae family; they share 2 indicated uses (menstrual cramps, skin irritation).
Evidence face-off — shared uses
| Condition | Midland Hawthorn | Raspberry Leaf | Verdict |
|---|---|---|---|
| Menstrual cramps | 1/10 | 5/10 | Stronger for Raspberry Leaf |
| Skin irritation | 1/10 | 6/10 | Stronger for Raspberry Leaf |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
The principal cardioactive and antioxidant constituents, the basis for extract standardisation.
Additional antioxidant constituents of the flower, leaf and fruit.
Pharmacological Actions
Astringent for mild diarrhoea (tannins)
Astringent for menstrual cramps (traditional); Astringent for mild diarrhoea (tannins)
Traditional uterine tonic taken in late pregnancy to tone the uterus and support labour - one small double-blind RCT found a shorter second stage of labour and fewer forceps deliveries (no effect on the first stage), alongside observational signals; robust proof is still lacking
Traditional & Indicated Uses
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from sedative action
inferred from antispasmodic action
inferred from antispasmodic action
Astringent for menstrual cramps (traditional)
inferred from emmenagogue action
inferred from astringent action
Safety, Cautions & Contraindications
Generally safe and well tolerated. High doses may cause low blood pressure and sedation. May interact with cardiac glycosides (digoxin) and antihypertensive drugs. Consult a physician before using with existing heart medications.
Duke (2002) rates hawthorn (Crataegus spp., including C. laevigata) as a triple-plus herb (+++) with Commission E approval (score 2-3) for decreasing cardiac output in functional Stage II heart insufficiency (NYHA). Clinical evidence supports hawthorn standardized extracts (80-500 mg, standardized to flavonoids or procyanidins) for angina, arrhythmia, atherosclerosis, and hypertension. Hawthorn may potentiate digitalis and other cardiac medications and is not considered suitable for self-medication without professional guidance (Duke, 2002).
External Ids
Botanical Description
Small deciduous tree or large shrub with thorny branches and glossy, shallowly lobed leaves (less deeply cut than common hawthorn). Clusters of small, five-petalled white (occasionally pink) flowers with a strong scent appear in spring, followed by small red berries (haws), each usually containing two seeds (nutlets).[1]
Deciduous, thicket-forming shrub (Rosaceae), 1-2 m tall, with upright, prickly, biennial canes (vegetative in the first year, fruiting in the second). Leaves are pinnate with 3-7 toothed leaflets, whitish-felted beneath. Small white, five-petalled flowers are followed by the aggregate red raspberry fruit, a cluster of drupelets.[2]
Habitat
Grows in woodland, woodland edges, hedgerows and scrub, typically on richer, damper soils than common hawthorn; native to western and central Europe.[1]
Native to Europe and northern Asia, widely cultivated as a fruit crop and naturalised on woodland edges, hedgerows and disturbed ground in temperate regions.[2]
Harvesting
Flowers are picked as they open in spring, leaves are picked with the young flowering shoots, and the ripe red berries (haws) are gathered in autumn; all three parts are used, often combined, in hawthorn preparations.[1]
Leaves are picked fresh during the growing season - before or during flowering is considered optimal - and dried; fruit is picked when fully ripe in summer.[2]
Traditional Uses
Hawthorn flower, leaf and berry have a long European tradition, and substantial modern clinical study, as a cardiovascular tonic - supporting heart function, mild circulatory complaints and calming nervous tension - reflected in its traditional use for 'heart strengthening' and its modern standing as a well-studied botanical for mild heart failure symptoms.[1]
Raspberry leaf has a long, very widely known folk tradition as a 'pregnancy tea', taken in the final weeks of pregnancy as a uterine tonic to prepare for labour. Observational studies and a small randomised controlled trial suggest a possible modest effect on labour duration, though robust proof is still lacking.[1, 13]
Preparations
Leaf-and-flower extract standardised to flavonoid or oligomeric proanthocyanidin content, taken as tablets or capsules; the best-studied clinical form.
Dosage
The EU herbal monograph on Crataegus spp., folium cum flore gives dry extracts in divided daily doses of 240-900 mg (single dose 80-450 mg) or, for one quantified extract, 570-1750 mg daily (single dose 190-350 mg), in adults and elderly. If symptoms persist longer than 2 weeks a doctor should be consulted, and hawthorn is never used as a substitute for prescribed heart medication without medical supervision. Educational reference only, not a prescription.
The EU herbal monograph gives 1-2 g of the comminuted leaf and flower in 150 mL of boiling water as an infusion, up to 4 times daily (maximum 6 g daily), in adults and elderly. Educational reference only, not a prescription.
Popular guidance and observational studies generally describe starting raspberry-leaf tea or tablets in the last few weeks of pregnancy, at roughly 1-3 cups of tea daily; use should be discussed with a midwife or doctor given the lack of robust trial evidence. Educational reference only, not a prescription.
References
Drug Class Interactions
Not documented
Lookalikes Review
References & Sources
- Fong, H.H.S. and Bauman, J.L (2002) 'Hawthorn', Journal of Cardiovascular Nursing, 16(4), pp. 1-8. doi:10.1097/00005082-200207000-00002 Traditional / reference
https://doi.org/10.1097/00005082-200207000-00002 - Orhan, I.E (2018) 'Phytochemical and Pharmacological Activity Profile of Crataegus oxyacantha L. (Hawthorn) - A Cardiotonic Herb', Current Medicinal Chemistry, 25(37), pp. 4854-4865. doi:10.2174/0929867323666160919095519 Traditional / reference
https://doi.org/10.2174/0929867323666160919095519 - Ahmadipour, B., Kalantar, M., Abaszadeh, S. and Hassanpour, H (2024) 'Antioxidant and antihyperlipidemic effects of hawthorn extract (Crataegus oxyacantha) in broiler chickens', Veterinary Medicine and Science, 10(3), pp. e1414. doi:10.1002/vms3.1414 Preclinical
https://doi.org/10.1002/vms3.1414 - Rigelsky, J.M. and Sweet, B.V (2002) 'Hawthorn: pharmacology and therapeutic uses', American Journal of Health-System Pharmacy, 59(5), pp. 417-422. doi:10.1093/ajhp/59.5.417 Meta-analysis / review
https://doi.org/10.1093/ajhp/59.5.417 - Saeedi, G., Jeivad, F., Goharbari, M., Gheshlaghi, G.H. and Sabzevari, O (2018) 'Ethanol Extract of Crataegus Oxyacantha L. Ameliorate Dietary Non-Alcoholic Fatty Liver Disease in Rat', Drug Research, 68(10), pp. 553-559. doi:10.1055/a-0579-7532 Preclinical
https://doi.org/10.1055/a-0579-7532 - Mecheri, A., Benabderrahmane, W., Amrani, A., Boubekri, N., Benayache, F., Benayache, S. and Zama, D (2019) 'Hepatoprotective Effects of Algerian Crataegus oxyacantha Leaves', Recent Patents on Food, Nutrition & Agriculture, 10(1), pp. 70-75. doi:10.2174/2212798410666180730095456 Preclinical
https://doi.org/10.2174/2212798410666180730095456 - Benabderrahmane, W., Lores, M., Benaissa, O., Lamas, J.P., de Miguel, T., Amrani, A., Benayache, F. and Benayache, S (2019) 'Polyphenolic content and bioactivities of Crataegus oxyacantha L. (Rosaceae)', Natural Product Research, 35(4), pp. 627-632. doi:10.1080/14786419.2019.1582044 Preclinical
https://doi.org/10.1080/14786419.2019.1582044 - Ali, M., Muhammad, S., Shah, M.R., Khan, A., Rashid, U., Farooq, U., Ullah, F., Sadiq, A., Ayaz, M., Ali, M., Ahmad, M. and Latif, A (2017) 'Neurologically Potent Molecules from Crataegus oxyacantha; Isolation, Anticholinesterase Inhibition, and Molecular Docking', Frontiers in Pharmacology, 8, pp. 327. doi:10.3389/fphar.2017.00327 Preclinical
https://doi.org/10.3389/fphar.2017.00327 - Cuevas-Duran, R.E., Medrano-Rodriguez, J.C., Sanchez-Aguilar, M., Soria-Castro, E., Rubio-Ruiz, M.E., Del Valle-Mondragon, L., Sanchez-Mendoza, A., Torres-Narvaez, J.C., Pastelin-Hernandez, G. and Ibarra-Lara, L (2017) 'Extracts of Crataegus oxyacantha and Rosmarinus officinalis Attenuate Ischemic Myocardial Damage by Decreasing Oxidative Stress and Regulating the Production of Cardiac Vasoactive Agents', International Journal of Molecular Sciences, 18(11), pp. 2412. doi:10.3390/ijms18112412 Preclinical
https://doi.org/10.3390/ijms18112412 - Alp, H., Soner, B.C., Baysal, T. and Sahin, A.S (2014) 'Protective effects of Hawthorn (Crataegus oxyacantha) extract against digoxin-induced arrhythmias in rats', Anatolian Journal of Cardiology, 15(12), pp. 970-975. doi:10.5152/akd.2014.5869 Preclinical
https://doi.org/10.5152/akd.2014.5869 - Rothfuss, M.A., Pascht, U. and Kissling, G (2001) 'Effect of long-term application of Crataegus oxyacantha on ischemia and reperfusion induced arrhythmias in rats', Arzneimittel-Forschung, 51(1), pp. 24-28. doi:10.1055/s-0031-1299998 Preclinical
https://doi.org/10.1055/s-0031-1299998 - Khan, A., Akram, M., Thiruvengadam, M., Daniyal, M., Zakki, S.A., Munir, N., Zainab, R., Heydari, M., Mosavat, S.H., Rebezov, M. and Shariati, M.A (2022) 'Anti-anxiety Properties of Selected Medicinal Plants', Current Pharmaceutical Biotechnology, 23(8), pp. 1041-1060. doi:10.2174/1389201022666210122125131 Meta-analysis / review
https://doi.org/10.2174/1389201022666210122125131 - Rastogi, S., Pandey, M.M. and Rawat, A.K.S (2015) 'Traditional herbs: a remedy for cardiovascular disorders', Phytomedicine, 23(11), pp. 1082-1089. doi:10.1016/j.phymed.2015.10.012 Meta-analysis / review
https://doi.org/10.1016/j.phymed.2015.10.012 - European Medicines Agency (2016) 'European Union herbal monograph on Crataegus spp., folium cum flore'. Traditional / reference
https://scholar.google.com/scholar?q=European%20Union%20herbal%20monograph%20on%20Crataegus%20spp.%2C%20folium%20cum%20flore - Hendel, N. and Hendel, M (2014) 'Hedgerow Medicine'. Traditional / reference
https://scholar.google.com/scholar?q=Hedgerow%20Medicine - Pittler, M.H., Guo, R. and Ernst, E (2008) 'Hawthorn extract for treating chronic heart failure'. Traditional / reference
https://scholar.google.com/scholar?q=Hawthorn%20extract%20for%20treating%20chronic%20heart%20failure - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Tankanow, R., Tamer, H.R., Streetman, D.S., Smith, S.G., Welton, J.L., Annesley, T., Aaronson, K.D. and Bleske, B.E (2003) 'Interaction study between digoxin and a preparation of hawthorn (Crataegus oxyacantha)', Journal of Clinical Pharmacology, 43(6), pp. 637-642. doi:10.1177/0091270003253417 Randomized trial
https://doi.org/10.1177/0091270003253417 - Pittler, M.H., Guo, R. and Ernst, E (2008) 'Hawthorn extract for treating chronic heart failure', Cochrane Database of Systematic Reviews, 2008(1), pp. CD005312. doi:10.1002/14651858.CD005312.pub2 Meta-analysis / review
https://doi.org/10.1002/14651858.CD005312.pub2 - Pittler, M.H., Guo, R. and Ernst, E (2008) 'Hawthorn extract for treating chronic heart failure', Cochrane Database of Systematic Reviews, 2008(1), pp. CD005312. doi:10.1002/14651858.CD005312.pub2 Meta-analysis / review
https://doi.org/10.1002/14651858.CD005312.pub2 - Ghasemzadeh Rahbardar, M. and Hosseinzadeh, H (2024) 'Therapeutic potential of hypnotic herbal medicines: A comprehensive review', Phytotherapy Research, 38(6), pp. 3037-3059. doi:10.1002/ptr.8201 Meta-analysis / review
https://doi.org/10.1002/ptr.8201 - Block, K.I., Gyllenhaal, C. and Mead, M.N (2004) 'Safety and efficacy of herbal sedatives in cancer care', Integrative Cancer Therapies, 3(2), pp. 128-148. doi:10.1177/1534735404265003 Meta-analysis / review
https://doi.org/10.1177/1534735404265003
- Bowman, R.L., Taylor, J. and Davis, D.L (2024) 'Raspberry leaf (Rubus idaeus) use in pregnancy: a prospective observational study', BMC Complementary Medicine and Therapies. doi:10.1186/s12906-024-04465-7 Randomized trial
https://doi.org/10.1186/s12906-024-04465-7 - Mostafa, H.S. and others (2020) 'Phenolic Composition, Mineral Content, and Beneficial Bioactivities of Leaf Extracts from Black Currant (Ribes nigrum L.), Raspberry (Rubus idaeus), and Aronia (Aronia melanocarpa)', Nutrients, 12(2), pp. 463. doi:10.3390/nu12020463 Meta-analysis / review
https://doi.org/10.3390/nu12020463 - Bijak, M., Saluk-Bijak, J. and others (2016) 'The influence of Rubus idaeus and Rubus caesius leaf extracts on platelet aggregation in whole blood. Cross-talk of platelets and neutrophils', Platelets, 27(5), pp. 433-439. doi:10.3109/09537104.2015.1131254 Preclinical
https://doi.org/10.3109/09537104.2015.1131254 - Valdes, M. and others (2022) 'Rubus idaeus extract improves symptoms in knee osteoarthritis patients: results from a phase II double-blind randomized controlled trial', BMC Musculoskeletal Disorders, 23(1), pp. 650. doi:10.1186/s12891-022-05612-2 Randomized trial
https://doi.org/10.1186/s12891-022-05612-2 - Campos, P.M. and others (2020) 'Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial', Journal of Cosmetic Dermatology, 19(3), pp. 671-676. doi:10.1111/jocd.13305 Randomized trial
https://doi.org/10.1111/jocd.13305 - Bednarski, M. and others (2014) 'CD39/NTPDase-1 expression and activity in human umbilical vein endothelial cells are differentially regulated by leaf extracts from Rubus caesius and Rubus idaeus', Cellular & Molecular Biology Letters, 19(2), pp. 291-304. doi:10.2478/s11658-014-0202-8 Preclinical
https://doi.org/10.2478/s11658-014-0202-8 - Rojas-Vera, J., Patel, A.V. and Dacke, C.G (2002) 'Relaxant activity of raspberry (Rubus idaeus) leaf extract in guinea-pig ileum in vitro', Phytotherapy Research, 16(7), pp. 665-668. doi:10.1002/ptr.1040 Preclinical
https://doi.org/10.1002/ptr.1040 - Raudone, L. and others (2022) 'In Vitro Antioxidant and Prooxidant Activities of Red Raspberry (Rubus idaeus L.) Stem Extracts', Molecules, 27(13), pp. 4073. doi:10.3390/molecules27134073 Preclinical
https://doi.org/10.3390/molecules27134073 - Cugnetto, M.L. and others (2015) 'An oil-soluble extract of Rubus idaeus cells enhances hydration and water homeostasis in skin cells', International Journal of Cosmetic Science, 37(4), pp. 428-433. doi:10.1111/ics.12236 Preclinical
https://doi.org/10.1111/ics.12236 - Socha, M.W., Flis, W., Wartega, M., Szambelan, M., Pietrus, M. and Kazdepka-Zieminska, A (2023) 'Raspberry Leaves and Extracts-Molecular Mechanism of Action and Its Effectiveness on Human Cervical Ripening and the Induction of Labor', Nutrients, 15(14), pp. 3206. doi:10.3390/nu15143206 Clinical study
https://doi.org/10.3390/nu15143206 - Jianu, E.M., Pop, R.M., Gherman, L.M., Ranga, F., Levai, A.M., Rus, V., Bolboaca, S.D., Stefan, R.A., Onofrei, M.M., Nati, I.D., Stoia, I.A., Stefan, P.A., Mihu, C. and Mihu, C.M (2024) 'The Effect of Rubus idaeus Polyphenols Extract in Induced Endometriosis in Rats', Molecules, 29(4), pp. 778. doi:10.3390/molecules29040778 Preclinical
https://doi.org/10.3390/molecules29040778 - Cyboran-Mikolajczyk, S., Meczarska, K., Solarska-Sciuk, K., Ratajczak-Wielgomas, K., Oszmianski, J., Jencova, V. and Bonarska-Kujawa, D (2022) 'Protection of Erythrocytes and Microvascular Endothelial Cells against Oxidative Damage by Fragaria vesca L. and Rubus idaeus L. Leaves Extracts - The Mechanism of Action', Molecules, 27(18), pp. 5865. doi:10.3390/molecules27185865 Preclinical
https://doi.org/10.3390/molecules27185865 - Farnaghi, S. and Braniff, K (2022) 'Survey of Raspberry Leaf Tea in pregnancy', Australian and New Zealand Journal of Obstetrics and Gynaecology. doi:10.1111/ajo.13496 Randomized trial
https://doi.org/10.1111/ajo.13496 - Simpson, M., Parsons, M., Greenwood, J. and Wade, K (2001) 'Raspberry leaf in pregnancy: its safety and efficacy in labor', Journal of Midwifery & Women's Health, 46(2), pp. 51--59. doi:10.1016/s1526-9523(01)00095-2 Randomized trial
https://doi.org/10.1016/s1526-9523(01)00095-2
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.