Plant Comparison
Coriander vs Perforate St John’s-wort
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Coriander and Perforate St John’s-wort: they share 5 indicated uses (arthritis / joint pain, infection (general), inflammation (general), …); 2 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Coriander | Perforate St John’s-wort | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 1/10 | 1/10 | Comparable evidence |
| Infection (general) | 1/10 | 1/10 | Comparable evidence |
| Inflammation (general) | 1/10 | 1/10 | Comparable evidence |
| Skin irritation | 1/10 | 1/10 | Comparable evidence |
| Wounds | 1/10 | 1/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Seed essential oil dominated by linalool, giving the characteristic aroma and much of the antimicrobial and carminative activity.
Antioxidant flavonoids and phenolics, notably quercetin derivatives, identified across leaf and seed extracts.
Red pigments historically used to standardise extracts; contribute to antiviral activity and are the compounds responsible for photosensitivity risk.
Considered the principal compound behind the antidepressant activity and the main driver of the herb's potent CYP3A4/P-glycoprotein induction and drug-interaction profile.
Antioxidant flavonoids contributing to overall activity.
Pharmacological Actions
Traditional & Indicated Uses
inferred from anti-inflammatory action
inferred from digestive action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from antispasmodic action
inferred from antispasmodic action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from antiviral action
inferred from anti-inflammatory action
inferred from sedative action
inferred from anti-inflammatory action
Safety, Cautions & Contraindications
• Food use is generally safe for most people (leaf in salads, seed as spice) (Burdock & Carabin, 2009). • Allergy is the main “big warning.” Coriander can trigger reactions ranging from mild oral itching to more serious allergy in sensitive people, especially those with pollen allergies (e.g., birch/mugwort) or other Apiaceae spice allergies (Thermo Fisher/Phadia, n.d.; Berghea et al., 2025). • If you use supplements (capsules/powder) and you take diabetes medication, be cautious: coriander seed powder has shown blood-sugar improvements in a small human trial, so it may add to the effect of glucose-lowering meds (Zamany et al., 2025). • Essential oil is not the same as the spice. Coriander essential oil is highly concentrated and should not be taken internally in “DIY doses.” It can be irritating, and safety data are discussed mainly for food-flavouring levels—not self-prescribed medicinal dosing (Burdock & Carabin, 2009). • Pregnancy / breastfeeding: normal culinary amounts are generally considered fine; “medicinal-dose” supplements or essential oil are best avoided unless guided by a qualified professional because safety data at higher doses is limited (Burdock & Carabin, 2009).
Duke (2002) provides clinical evidence (score 2) for coriander's role as an aperitif (appetite stimulant) and digestive tonic, consistent with Commission E approval. It demonstrates antispasmodic, carminative, and antifungal activities at the experimental level. Dose: 1–3 g crushed fruits (seeds) three times daily, or equivalent preparations. Duke notes mild hypoglycemic activity and a potential antiimplantation effect in high doses — use with caution in women attempting pregnancy (Duke, 2002).
Significant drug interactions: strongly induces CYP3A4 and P-glycoprotein, reducing plasma levels of many drugs including oral contraceptives, antiretrovirals, cyclosporine, warfarin, and digoxin. May cause photosensitivity (fair-skinned individuals). Do not combine with SSRIs, SNRIs, or MAOIs (serotonin syndrome risk). Avoid in bipolar disorder.
Duke (2002) rates St. John's wort as ++ (raised from earlier editions) and notes antidepressant, antiviral, antibacterial, and wound-healing activities at experimental and clinical levels. Hypericin and hyperforin are identified as key active constituents. Clinical evidence (score 2) confirms antidepressant efficacy in mild-to-moderate depression, and WHO/Commission E provide approval for this indication. Dose: 300 mg standardized extract (0.3% hypericin, 3–5% hyperforin) three times daily. Duke emphasizes the critical drug interaction: St. John's wort is a potent CYP3A4 inducer and can significantly reduce blood levels of many medications including oral contraceptives, cyclosporine, antiretrovirals, and warfarin. Avoid combined use with SSRIs (serotonin syndrome risk) and pharmaceutical antidepressants (Duke, 2002).
External Ids
Botanical Description
Slender annual herb with delicate, broad, lobed lower leaves and finely divided, feathery upper leaves - a marked contrast within the same plant. Small white or pale pink flowers are borne in flat compound umbels, followed by round, ridged, aromatic seeds. The fresh leaf ('cilantro') has a distinctive citrusy aroma, often described as soapy by those with a genetic sensitivity to it.[4]
Erect, branching perennial herb with paired, oval leaves dotted with tiny translucent oil glands that look like pinpricks when held to the light (giving the species name 'perforatum'). Bright yellow, five-petalled flowers with numerous stamens and black dots along the petal edges are borne in flat-topped clusters, and release a reddish pigment when crushed.[4]
Habitat
Believed native to the Mediterranean region and Western Asia; cultivated worldwide as a culinary herb and spice crop on well-drained, sunny sites.[4]
Grows in grassland, roadsides, woodland clearings and waste ground on well-drained soils; native to Europe, Western Asia and North Africa and widely naturalised elsewhere, including North America and Australia.[4]
Harvesting
Leaves are picked fresh through the growing season, before the plant bolts (flowers), when the flavour is best; the seed is harvested in late summer once the umbels have browned and dried, then threshed; the root can be dug at the same time as young leaves.
The flowering tops (flower and upper leaf) are cut in summer as the flowers open, around the traditional St John's Day period, and dried quickly in a warm, shaded, airy place to preserve the hypericin and hyperforin content.[4]
Traditional Uses
Coriander seed and leaf have a very long culinary and medicinal history across the Mediterranean, Middle East and Asia as a digestive carminative for indigestion, bloating and cramping, and, more recently, studied for calming/anxiolytic effects on the central nervous system alongside cardiovascular and metabolic benefits.[1, 4]
St John's wort has a centuries-long European folk reputation as a wound-healing and nerve tonic herb, traditionally used for mild wounds, burns and nerve pain and to lift low mood; this traditional mood-supporting use is now one of the most extensively clinically studied applications of any herbal medicine, with standardised extracts shown comparable to conventional antidepressants for mild-to-moderate depression.[1, 4]
Preparations
Seed powder or extract studied for glycaemic and psychiatric-symptom support in clinical and preclinical work.
Flowering-top extract standardised to hypericin and/or hyperforin content, taken as tablets or capsules; the best-studied clinical form for mood support.
References
Lookalikes Review
Dangerous Lookalikes
Not documented
Dosage
Not documented
Clinical trials for mild-to-moderate depression commonly use around 300 mg of standardised extract three times daily (900 mg/day total); given extensive drug interactions, use should be discussed with a healthcare provider, especially alongside other medicines. Educational reference only, not a prescription.
Drug Class Interactions
Not documented
Pairings
Not documented
St John's wort raises serotonin activity and can cause serotonin syndrome when combined with other serotonin-boosting agents; pairing it with another mood-active, serotonergic herb such as saffron may add to this risk.[30]
St John's wort is a strong enzyme inducer and increases serotonin activity; combining it with another antidepressant-type herb such as rhodiola may add to serotonergic effects and unpredictably change how each is handled by the body.[30]
St John's wort speeds up the breakdown of many substances and also raises serotonin activity; pairing it with a sedative herb such as valerian may add to drowsiness and can unpredictably change how each is handled by the body.[30, 31]
St John's wort is a strong enzyme inducer and kava is a liver-metabolised sedative; combining them may add to central-nervous-system effects and alter how kava is processed, so combined use warrants caution.[30, 31]
References & Sources
- Santibáñez, A., Jiménez-Ferrer, E., Angulo-Bejarano, P.I., Sharma, A. and Herrera-Ruiz, M (2023) 'Coriandrum sativum and Its Utility in Psychiatric Disorders', Molecules, 28(14), pp. 5314. doi:10.3390/molecules28145314 Traditional / reference
https://doi.org/10.3390/molecules28145314 - Wei, J.N., Liu, Z.H., Zhao, Y.P., Zhao, L.L. et al (2019) 'Phytochemical and bioactive profile of Coriandrum sativum L', Food Chemistry, 286, pp. 260-267. doi:10.1016/j.foodchem.2019.01.171 Traditional / reference
https://doi.org/10.1016/j.foodchem.2019.01.171 - Hosseini, M., Boskabady, M.H. and Khazdair, M.R (2021) 'Neuroprotective effects of Coriandrum sativum and its constituent, linalool: A review', Avicenna Journal of Phytomedicine, 11(5), pp. 436-450. doi:10.22038/AJP.2021.55681.2786 Traditional / reference
https://doi.org/10.22038/AJP.2021.55681.2786 - Mahleyuddin, N.N., Moshawih, S., Ming, L.C., Zulkifly, H.H., Kifli, N. and Loy, M.J (2021) 'Coriandrum sativum L.: A Review on Ethnopharmacology, Phytochemistry, and Cardiovascular Benefits', Molecules, 27(1), pp. 209. doi:10.3390/molecules27010209 Meta-analysis / review
https://doi.org/10.3390/molecules27010209 - Prachayasittikul, V., Prachayasittikul, S., Ruchirawat, S. and Prachayasittikul, V (2017) 'Coriander (Coriandrum sativum): A promising functional food toward the well-being', Food Research International, 105, pp. 305-323. doi:10.1016/j.foodres.2017.11.019 Meta-analysis / review
https://doi.org/10.1016/j.foodres.2017.11.019 - Laribi, B., Kouki, K., M'Hamdi, M. and Bettaieb, T (2015) 'Coriander (Coriandrum sativum L.) and its bioactive constituents', Fitoterapia, 103, pp. 9-26. doi:10.1016/j.fitote.2015.03.012 Meta-analysis / review
https://doi.org/10.1016/j.fitote.2015.03.012 - Sahib, N.G., Anwar, F., Gilani, A.H., Hamid, A.A., Saari, N. and Alkharfy, K.M (2012) 'Coriander (Coriandrum sativum L.): a potential source of high-value components for functional foods and nutraceuticals - a review', Phytotherapy Research, 27(10), pp. 1439-1456. doi:10.1002/ptr.4897 Meta-analysis / review
https://doi.org/10.1002/ptr.4897 - Scandar, S., Zadra, C. and Marcotullio, M.C (2023) 'Coriander (Coriandrum sativum) Polyphenols and Their Nutraceutical Value against Obesity and Metabolic Syndrome', Molecules, 28(10), pp. 4187. doi:10.3390/molecules28104187 Meta-analysis / review
https://doi.org/10.3390/molecules28104187 - Al-Khayri, J.M., Banadka, A., Nandhini, M., Nagella, P., Al-Mssallem, M.Q. and Alessa, F.M (2023) 'Coriandrum sativum Essential Oil: A review on Its Phytochemistry and Biological Activity', Molecules, 28(2), pp. 696. doi:10.3390/molecules28020696 Meta-analysis / review
https://doi.org/10.3390/molecules28020696 - Kukner, A., Soyler, G., Toros, P., Dede, G., Mericli, F. and Isik, S (2020) 'Protective effect of Coriandrum sativum extract against inflammation and apoptosis in liver ischaemia/reperfusion injury', Folia Morphologica, 80(2), pp. 363-371. doi:10.5603/FM.a2020.0060 Preclinical
https://doi.org/10.5603/FM.a2020.0060 - Liu, Q.F., Jeong, H., Lee, J.H., Hong, Y.K., Oh, Y. and Kim, Y.M (2016) 'Coriandrum sativum Suppresses Abeta42-Induced ROS Increases, Glial Cell Proliferation, and ERK Activation', American Journal of Chinese Medicine, 44(7), pp. 1325-1347. doi:10.1142/S0192415X16500749 Preclinical
https://doi.org/10.1142/S0192415X16500749 - Koppula, S., Alluri, R. and Kopalli, S.R (2021) 'Coriandrum sativum attenuates microglia mediated neuroinflammation and MPTP-induced behavioral and oxidative changes in Parkinson's disease mouse model', EXCLI Journal, 20, pp. 835-850. doi:10.17179/excli2021-3668 Preclinical
https://doi.org/10.17179/excli2021-3668 - Laribi, B., Kouki, K., M'Hamdi, M. and Bettaieb, T (2015) 'Coriander (Coriandrum sativum L.) and its bioactive constituents', pp. 9--26. Traditional / reference
https://scholar.google.com/scholar?q=Coriander%20%28Coriandrum%20sativum%20L.%29%20and%20its%20bioactive%20constituents - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
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- Ng, Q.X., Venkatanarayanan, N. and Ho, C.Y.X (2017) 'Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis', Journal of Affective Disorders, 210, pp. 211-221. doi:10.1016/j.jad.2016.12.048 Meta-analysis / review
https://doi.org/10.1016/j.jad.2016.12.048 - Kholghi, G., Arjmandi-Rad, S., Zarrindast, M.R. and Vaseghi, S (2022) 'St. John's wort (Hypericum perforatum) and depression: what happens to the neurotransmitter systems?', Naunyn-Schmiedeberg's Archives of Pharmacology, 395(6), pp. 629-642. doi:10.1007/s00210-022-02229-z Traditional / reference
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https://doi.org/10.22038/IJBMS.2022.65112.14338 - Jiang, Z., Wang, F., Zhao, Y., Lu, L., Jiang, X., Huang, T., Lin, Y., Guo, L., Weng, Z. and Liu, E (2024) 'Hypericum perforatum L. attenuates depression by regulating Akkermansia muciniphila, tryptophan metabolism and NFkB-NLRP2-Caspase1-IL1beta pathway', Phytomedicine, 132, pp. 155847. doi:10.1016/j.phymed.2024.155847 Preclinical
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https://doi.org/10.1345/aph.10088 - Murphy, P.A., Kern, S.E., Stanczyk, F.Z. and Westhoff, C.L (2005) 'Interaction of St. John's Wort with oral contraceptives: effects on the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding', Contraception, 71(6), pp. 402-408. doi:10.1016/j.contraception.2004.11.004 Clinical study
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https://doi.org/10.1016/j.contraception.2004.11.004 - Pfrunder, A., Schiesser, M., Gerber, S., Haschke, M., Bitzer, J. and Drewe, J (2003) 'Interaction of St John's wort with low-dose oral contraceptive therapy: a randomized controlled trial', British Journal of Clinical Pharmacology, 56(6), pp. 683-690. doi:10.1046/j.1365-2125.2003.02005.x Randomized trial
https://doi.org/10.1046/j.1365-2125.2003.02005.x - Johne, A., Brockmoller, J., Bauer, S., Maurer, A., Langheinrich, M. and Roots, I (1999) 'Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)', Clinical Pharmacology and Therapeutics, 66(4), pp. 338-345. doi:10.1053/cp.1999.v66.a101944 Clinical study
https://doi.org/10.1053/cp.1999.v66.a101944 - Mathijssen, R.H.J., Verweij, J., de Bruijn, P., Loos, W.J. and Sparreboom, A (2002) 'Effects of St. John's wort on irinotecan metabolism', Journal of the National Cancer Institute, 94(16), pp. 1247-1249. doi:10.1093/jnci/94.16.1247 Randomized trial
https://doi.org/10.1093/jnci/94.16.1247 - Smith, P., Bullock, J.M., Booker, B.M., Haas, C.E., Berenson, C.S. and Jusko, W.J (2004) 'The influence of St. John's wort on the pharmacokinetics and protein binding of imatinib mesylate', Pharmacotherapy, 24(11), pp. 1508-1514. doi:10.1592/phco.24.16.1508.50958 Clinical study
https://doi.org/10.1592/phco.24.16.1508.50958 - Izzo, A.A (2004) 'Drug interactions with St. John's Wort (Hypericum perforatum): a review of the clinical evidence', International Journal of Clinical Pharmacology and Therapeutics, 42(3), pp. 139-148. doi:10.5414/cpp42139 Meta-analysis / review
https://doi.org/10.5414/cpp42139 - Caus, M.N., Lupoae, M. and Chitescu, C.L (2026) 'Efficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks', Pharmaceuticals, 19(3), pp. 399. doi:10.3390/ph19030399 Meta-analysis / review
https://doi.org/10.3390/ph19030399
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.