Plant Comparison
Blessed Thistle vs Common yellow woodsorrel
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Blessed Thistle and Common yellow woodsorrel: they share 5 indicated uses (cancer (anticancer research), indigestion, infection (general), …); 3 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Blessed Thistle | Common yellow woodsorrel | Verdict |
|---|---|---|---|
| Cancer (anticancer research) | 2/10 | 2/10 | Comparable evidence |
| Indigestion | 1/10 | 2/10 | Comparable evidence |
| Infection (general) | 1/10 | 2/10 | Comparable evidence |
| Inflammation (general) | 1/10 | 8/10 | Stronger for Common yellow woodsorrel |
| Wounds | 1/10 | 2/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Flavonoid glycosides (e.g. isovitexin, vitexin, quercetin and apigenin derivatives), the main antioxidant constituents.
Caffeic, ferulic and related phenolic acids (antioxidant).
The defining sour constituent - oxalic acid with potassium and calcium oxalates - biosynthesised in part from vitamin C. Responsible for the sour taste and for the kidney-stone/oxalate caution.
High ascorbate content (basis of the traditional antiscorbutic use); also a metabolic precursor of the plant's oxalic acid.
Pharmacological Actions
Appetite stimulant for loss of appetite (approved use under German Commission E)
Bitter digestive / stomachic for indigestion and dyspepsia (stimulates saliva and gastric secretion)
Bitter digestive / stomachic for indigestion and dyspepsia (stimulates saliva and gastric secretion)
Antibacterial and antiparasitic (amoebicidal/giardicidal) activity of woodsorrel extracts/constituents.
Protective against paracetamol-induced liver injury (congener O. corniculata).
Protective against experimental gastric ulceration (congener O. corniculata).
Woodsorrel phytoconstituents (and a green-synthesised nanoparticle made with O. stricta extract) induced apoptosis in breast, colon and Hep2 cancer cells (preclinical).
Alpha-glucosidase and alpha-amylase inhibition by woodsorrel extract (congener O. corniculata).
Anti-Alzheimer's activity of woodsorrel extract in rats (congener O. corniculata).
Promotes wound and fracture healing; traditional topical use for wounds and skin (congener O. corniculata).
Sour, tannin-containing herb; the basis of traditional antidiarrhoeal use.
Traditional astringent remedy for diarrhoea and dysentery (congener O. corniculata).
Traditional & Indicated Uses
Appetite stimulant for loss of appetite (approved use under German Commission E)
inferred from anti-inflammatory action
inferred from anticancer action
Bitter digestive / stomachic for indigestion and dyspepsia (stimulates saliva and gastric secretion)
inferred from antimicrobial action
inferred from anti-inflammatory action
Galactagogue to support breast-milk supply (traditional; no valid clinical-trial evidence)
inferred from anti-inflammatory action
inferred from anticancer action
Hepatoprotective in animal models (congener).
Traditional astringent remedy for diarrhoea and dysentery.
inferred from antimicrobial/antiparasitic action
Promotes wound/fracture healing; traditional topical use.
Alpha-glucosidase/amylase inhibition (congener).
inferred from anti-Alzheimer's / neuroprotective action (congener)
Safety, Cautions & Contraindications
As a member of the daisy family (Asteraceae/ragweed), it can cause allergic reactions in sensitive people; high doses reportedly cause stomach cramps, nausea and vomiting.
Avoid during pregnancy because of a traditional uterine-stimulating reputation.
Although traditionally used to support milk supply, there is no scientifically valid clinical evidence for the galactagogue use.
Yellow woodsorrel is RICH IN OXALIC ACID and soluble oxalates (the source of its sour taste). Avoid large or frequent quantities, and especially avoid it if you are prone to calcium-oxalate kidney stones, have gout, or have kidney disease. Oxalates also bind calcium and iron, reducing their absorption. Use only modest amounts, and cooking reduces soluble oxalate.
Safety in pregnancy and breastfeeding has not been established; avoid medicinal doses during pregnancy and lactation.
External Ids
Botanical Description
Branching annual herb with a hairy, reddish, ridged stem and spiny, deeply lobed leaves with prominent pale veins. The flower heads are pale yellow, thistle-like, surrounded by a whorl of spiny, leaf-like bracts, giving the plant its 'spotted thistle' appearance.[4]
A small, sour-tasting herbaceous annual to short-lived perennial of the woodsorrel family, 10-40 cm tall. Its bright green leaves are clover-like, palmately divided into three heart-shaped (notched) leaflets that fold down at night and in strong sun. The small five-petalled flowers are bright yellow, borne in little clusters on axillary stalks. The whole plant tastes sharply sour from its oxalic-acid content. It is very similar to the creeping yellow woodsorrel (Oxalis corniculata) but has more upright stems that do not root at the nodes, and generally green (not purplish) foliage.[3]
Habitat
Grows on dry, sunny waste ground, roadsides and rocky slopes; native to the Mediterranean region and Western Asia and naturalised elsewhere as a garden escape.[4]
A common weed of disturbed, open and cultivated ground: gardens, lawns, arable fields, roadsides, footpaths, waste places and greenhouses. It favours moist, fertile, well-lit soils and is excluded by dense established vegetation. Native to North America but now naturalised almost worldwide across temperate and warm regions.[3]
Harvesting
The flowering aerial parts are cut as the plant comes into flower, in summer, and dried in a warm, shaded, airy place to preserve the bitter principle cnicin.[4]
The sour leaves and aerial parts are gathered when actively growing and flowering, used fresh or dried. Because the plant accumulates oxalic acid, harvesting for food or medicine should favour young growth in modest quantities. As a low weed it is easily hand-gathered.[3]
Traditional Uses
Blessed thistle has a long European folk reputation as a bitter digestive tonic for loss of appetite and dyspepsia (an approved use under German Commission E) and, more anecdotally, as a traditional galactagogue to support breast-milk supply, though robust clinical evidence for the latter is lacking.[4, 11]
Yellow woodsorrel (Oxalis stricta and its near-identical relative O. corniculata) has a long folk-medicine history, deepest in South and East Asian traditions. The cooling, sour whole plant has been used as a refrigerant and thirst-quencher, as a sour leafy vegetable/condiment, and as a source of vitamin C against scurvy. Traditional medicinal uses (chiefly documented for O. corniculata) include dysentery and diarrhoea and other digestive complaints, fever, liver complaints, and topical application of the crushed leaves or juice to wounds, insect bites, warts, corns, mouth sores and inflamed skin, as well as use as a mild diuretic. O. stricta shares these uses where the two woodsorrels are not distinguished.[3, 4]
Preparations
Dried flowering herb infused briefly in hot water as a bitter digestive tea, taken before meals.
Crushed fresh leaves or expressed juice applied topically to wounds, insect bites, warts and inflamed skin, or taken in small amounts for its cooling sour effect.
A whole-plant or leaf infusion/decoction used traditionally for fevers, diarrhoea and as a mild diuretic.
Young leaves eaten raw in small quantities as a tart salad green or to add sourness to food (edible 'sourgrass').
Dosage
Traditional herbal references suggest around 1-2 g of dried herb per cup, taken before meals, up to three times daily. Educational reference only, not a prescription.
Not documented
References
Lookalikes Review
Synonyms
Not documented
Drug Class Interactions
Not documented
References & Sources
- Rezig, K., Benkaci-Ali, F., Foucaunier, M.L., Laurent, S. et al (2023) 'HPLC/ESI-MS Characterization of Phenolic Compounds from Cnicus benedictus L. Roots: A Study of Antioxidant, Antibacterial, Anti-Inflammatory, and Anti-Alzheimer's Activity', Chemistry & Biodiversity, 21(1), pp. e202300724. doi:10.1002/cbdv.202300724 Preclinical
https://doi.org/10.1002/cbdv.202300724 - Ahmadimoghaddam, D., Sadeghian, R., Ranjbar, A., Izadidastenaei, Z. and Mohammadi, S (2020) 'Antinociceptive activity of Cnicus benedictus L. leaf extract: a mechanistic evaluation', Research in Pharmaceutical Sciences, 15(5), pp. 463-472. doi:10.4103/1735-5362.297849 Preclinical
https://doi.org/10.4103/1735-5362.297849 - Zhang, J., Shen, S., Zhu, S., Jia, F. et al (2024) 'Cnicus benedictus extract-loaded electrospun gelatin wound dressing for treating diabetic wounds: An in vitro and in vivo study', Journal of Applied Biomaterials & Functional Materials, 22, pp. 22808000241245298. doi:10.1177/22808000241245298 Preclinical
https://doi.org/10.1177/22808000241245298 - Zietal, K., Mirowska-Guzel, D., Nowaczyk, A. and Blecharz-Klin, K (2024) 'Cnicus benedictus: Folk Medicinal Uses, Biological Activities, and In Silico Screening of Main Phytochemical Constituents', Planta Medica. doi:10.1055/a-2401-6049 Traditional / reference
https://doi.org/10.1055/a-2401-6049 - Jalil, D.M., Al-Mahdawi, T.T., Jameel, M.G. and Talal, M (2024) 'In Vitro Evaluate the Antiproliferative Impact of Cnicus Benedictus L. Leaves Methanolic Extract on Cervical Cancer', Asian Pacific Journal of Cancer Prevention, 25(10), pp. 3643-3649. doi:10.31557/APJCP.2024.25.10.3643 Preclinical
https://doi.org/10.31557/APJCP.2024.25.10.3643 - Peng, Y., Jian, Y., Zulfiqar, A., Li, B., Zhang, K., Long, F., Peng, C., Cai, X., Khan, I.A. and Wang, W (2017) 'Two new sesquiterpene lactone glycosides from Cnicus benedictus', Natural Product Research, 31(19), pp. 2211-2217. doi:10.1080/14786419.2017.1295239 Preclinical
https://doi.org/10.1080/14786419.2017.1295239 - Paun, G., Neagu, E., Moroeanu, V., Albu, C., Savin, S. and Lucian Radu, G (2019) 'Chemical and Bioactivity Evaluation of Cnicus benedictus and Eryngium planum Polyphenolic-Rich Extracts', BioMed Research International, 2019, pp. 3692605. doi:10.1155/2019/3692605 Preclinical
https://doi.org/10.1155/2019/3692605 - Gobrecht, P., Gebel, J., Leibinger, M., Zeitler, C., Chen, Z., Grundemann, D. and Fischer, D (2024) 'Cnicin promotes functional nerve regeneration', Phytomedicine, 129, pp. 155641. doi:10.1016/j.phymed.2024.155641 Preclinical
https://doi.org/10.1016/j.phymed.2024.155641 - Avula, B., Katragunta, K., Wang, Y.H., Ali, Z. and Khan, I.A (2022) 'Simultaneous determination and characterization of flavonoids, sesquiterpene lactone, and other phenolics from Centaurea benedicta and dietary supplements using UHPLC-PDA-MS and LC-DAD-QToF', Journal of Pharmaceutical and Biomedical Analysis, 216, pp. 114806. doi:10.1016/j.jpba.2022.114806 Preclinical
https://doi.org/10.1016/j.jpba.2022.114806 - Paun, G., Neagu, E., Albu, C. and Radu, G.L (2015) 'Inhibitory potential of some Romanian medicinal plants against enzymes linked to neurodegenerative diseases and their antioxidant activity', Pharmacognosy Magazine, 11(Suppl 1), pp. S110-S116. doi:10.4103/0973-1296.157709 Preclinical
https://doi.org/10.4103/0973-1296.157709 - Drugs.com (n.d.) 'Blessed Thistle Uses, Benefits & Dosage'. Available at: https://www.drugs.com/npp/blessed-thistle.html Traditional / reference
https://www.drugs.com/npp/blessed-thistle.html - Drugs and Lactation Database (LactMed) (2021) 'Blessed Thistle'. Available at: https://www.ncbi.nlm.nih.gov/books/NBK501775/ Traditional / reference
https://www.ncbi.nlm.nih.gov/books/NBK501775/
- Yang, J.C. and Loewus, F.A (1975) 'Metabolic Conversion of L-Ascorbic Acid to Oxalic Acid in Oxalate-accumulating Plants', Plant Physiology, 56(2), pp. 283-285. doi:10.1104/pp.56.2.283 Preclinical
https://doi.org/10.1104/pp.56.2.283 - Chandramohan, S. and Nair, A.S. and Das, R. and Bhat, S.A. and Krishna, G.S. and Yadav, N. and Archana, V.K. and Rajagopalan, R (2025) 'Biogenic synthesis of zinc oxide nanoparticles using leaf extract of Oxalis stricta and its effect on colon cancer: an in vitro and in silico approach', Biometals, 38(4), pp. 1355-1380. doi:10.1007/s10534-025-00710-9 Preclinical
https://doi.org/10.1007/s10534-025-00710-9 - Majumdar, A. and Kumar Saraf, S. and Baghel, M. and Rao, S.P (2025) 'Chemical Diversity and Biomedical Relevance of Oxalis corniculata L.: A Review of Nutritional and Pharmacological Aspects', Chemistry and Biodiversity, 23(1), pp. e02154. doi:10.1002/cbdv.202502154 Meta-analysis / review
https://doi.org/10.1002/cbdv.202502154 - Sarfraz, I. and Rasul, A. and Hussain, G. and Shah, M.A. and Nageen, B. and Jabeen, F. and Selamoglu, Z. and Ucak, I. and Asrar, M. and Adem, S (2022) 'A Review on Phyto-pharmacology of Oxalis corniculata', Combinatorial Chemistry and High Throughput Screening, 25(7), pp. 1181-1186. doi:10.2174/1386207324666210813121431 Meta-analysis / review
https://doi.org/10.2174/1386207324666210813121431 - Sreejith, G. and Jayasree, M. and Latha, P.G. and Suja, S.R. and Shyamal, S. and Shine, V.J. and Anuja, G.I. and Sini, S. and Shikha, P. and Krishnakumar, N.M. and Vilash, V. and Shoumya, S. and Rajasekharan, S (2014) 'Hepatoprotective activity of Oxalis corniculata L. ethanolic extract against paracetamol induced hepatotoxicity in Wistar rats and its in vitro antioxidant effects', Indian Journal of Experimental Biology, 52(2), pp. 147-152. Preclinical
https://scholar.google.com/scholar?q=Hepatoprotective%20activity%20of%20Oxalis%20corniculata%20L.%20ethanolic%20extract%20against%20paracetamol%20induced%20hepatotoxicity%20in%20Wistar%20rats%20and%20its%20in%20vitro%20antioxidant%20effects - Sakat, S.S. and Tupe, P. and Juvekar, A (2012) 'Gastroprotective Effect of Oxalis corniculata (Whole Plant) on Experimentally Induced Gastric Ulceration in Wistar Rats', Indian Journal of Pharmaceutical Sciences, 74(1), pp. 48-53. doi:10.4103/0250-474X.102543 Preclinical
https://doi.org/10.4103/0250-474X.102543 - Gholipour, A.R. and Jafari, L. and Ramezanpour, M. and Evazalipour, M. and Chavoshi, M. and Yousefbeyk, F. and Kargar Moghaddam, S.J. and Yekta Kooshali, M.H. and Ramezanpour, N. and Daei, P. and Ghasemi, S. and Hamidi, M (2022) 'Apoptosis Effects of Oxalis corniculata L. Extract on Human MCF-7 Breast Cancer Cell Line', Galen Medical Journal, 11, pp. e2484. doi:10.31661/gmj.v11i.2484 Preclinical
https://doi.org/10.31661/gmj.v11i.2484 - Zhang, J. and Zhao, X. and Long, X. and Zhang, Y. and Luo, X. and Shen, W (2026) 'Oxalis corniculata L. Ethanol Extract Promotes Fracture Healing: Integrated Omics and Experimental Validation', Food Science and Nutrition, 14, pp. e71896. doi:10.1002/fsn3.71896 Preclinical
https://doi.org/10.1002/fsn3.71896 - Ullah, I. and Shad Bibi, N. and Sadiq, A. and Niazy, B. and Hesam, A.M (2026) 'In vitro studies of phytochemical, antioxidant, antibacterial and enzymatic inhibition of Oxalis corniculata whole plant from South Waziristan, Pakistan', PLoS One, 21(5), pp. e0335026. doi:10.1371/journal.pone.0335026 Preclinical
https://doi.org/10.1371/journal.pone.0335026 - Gao, T. and Hu, W. and Zhang, Z. and Tang, Z. and Chen, Y. and Zhang, Z. and Yuan, S. and Chen, T. and Huang, Y. and Feng, S. and Zhou, L. and Ding, C. and Yuan, M (2022) 'An acidic polysaccharide from Oxalis corniculata L. and the preliminary study on its antioxidant activity', Journal of Food Biochemistry, 46(9), pp. e14235. doi:10.1111/jfbc.14235 Preclinical
https://doi.org/10.1111/jfbc.14235 - Golbarg, H. and Mehdipour Moghaddam, M.J (2021) 'Antibacterial Potency of Medicinal Plants Including Oxalis corniculata against Multi-Drug Resistant Bacteria', BioMed Research International, 2021, pp. 9981915. doi:10.1155/2021/9981915 Preclinical
https://doi.org/10.1155/2021/9981915 - Manna, D. and Dutta, P.K. and Achari, B. and Lohia, A (2010) 'A novel galacto-glycerolipid from Oxalis corniculata kills Entamoeba histolytica and Giardia lamblia', Antimicrobial Agents and Chemotherapy, 54(11), pp. 4825-4832. doi:10.1128/AAC.00546-10 Preclinical
https://doi.org/10.1128/AAC.00546-10 - Abu-Elfotuh, K. and Hamdan, A.M.E. and Mohamed, S.A. and Bakr, R.O. and Ahmed, A.H. and Atwa, A.M. and Hamdan, A.M. and Alanzai, A.G. and Alnahhas, R.K. and Gowifel, A.M.H. and Salem, M.A (2024) 'The potential anti-Alzheimer's activity of Oxalis corniculata Linn. methanolic extract in experimental rats', Journal of Ethnopharmacology, 324, pp. 117731. doi:10.1016/j.jep.2024.117731 Preclinical
https://doi.org/10.1016/j.jep.2024.117731 - Nguyen, T. and Quy, D.Q. and Tung, N.T. and Huyen, N.T. and Minh, P.L. and Huyen, N.T.M. and Ho, T. and Ha, N.T.T. and Casanola-Martin, G.M. and Rasulev, B. and Pham-The, H (2026) 'Integrated In Vitro and In Silico Insights into the Antidiabetic and Antioxidant Mechanisms of Oxalis corniculata L. Aerial Parts', Molecules, 31(4), pp. 630. doi:10.3390/molecules31040630 Preclinical
https://doi.org/10.3390/molecules31040630 - Salahuddin, H. and Mansoor, Q. and Batool, R. and Farooqi, A.A. and Mahmood, T. and Ismail, M (2016) 'Anticancer activity of Cynodon dactylon and Oxalis corniculata on Hep2 cell line', Cellular and Molecular Biology, 62(5), pp. 60-63. Preclinical
https://scholar.google.com/scholar?q=Anticancer%20activity%20of%20Cynodon%20dactylon%20and%20Oxalis%20corniculata%20on%20Hep2%20cell%20line
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.