Omnia SanaPlant Comparison
Borage vs Ginger
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Borage and Ginger: they share 9 indicated uses (arthritis / joint pain, back pain, bloating, …); 4 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Borage | Ginger | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 1/10 | 10/10 | Stronger for Ginger |
| Back pain | 1/10 | 10/10 | Stronger for Ginger |
| Bloating | 1/10 | 10/10 | Stronger for Ginger |
| Headache | 1/10 | 10/10 | Stronger for Ginger |
| Indigestion | 1/10 | 10/10 | Stronger for Ginger |
| Inflammation (general) | 1/10 | 10/10 | Stronger for Ginger |
| Pain (general) | 1/10 | 10/10 | Stronger for Ginger |
| Respiratory support | 1/10 | 10/10 | Stronger for Ginger |
| Skin irritation | 1/10 | 10/10 | Stronger for Ginger |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Borage seed oil has one of the highest known GLA contents of any plant oil (typically 20-26%), the basis of its anti-inflammatory reputation.
Unsaturated pyrrolizidine alkaloids present in the whole herb are hepatotoxic and genotoxic on cumulative exposure, limiting internal whole-herb use; the refined seed oil is largely free of them.
Contribute to the plant's traditional demulcent and astringent properties.
The pungent phenolic constituents of the rhizome (notably 6-gingerol, which dehydrates to 6-shogaol on drying) responsible for ginger's antiemetic and anti-inflammatory activity; a standardized regimen of 84 mg/day gingerols/shogaols was effective against chemotherapy-induced nausea.
Pharmacological Actions
Traditional & Indicated Uses
inferred from anti-inflammatory action
inferred from anticancer action
inferred from immunomodulator action
inferred from digestive action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from analgesic action
inferred from digestive action
inferred from analgesic action
inferred from digestive action
inferred from anti-inflammatory action
inferred from antispasmodic action
inferred from antispasmodic action
Safety, Cautions & Contraindications
Pyrrolizidine alkaloids (PAs): Many Boraginaceae can produce PAs; unsaturated PAs are hepatotoxic and genotoxic (risk increases with cumulative exposure). Borage as food/tea: PA presence in borage consumed as herb/tea has been specifically studied; EU has set PA maximum levels for certain foods including borage (context for why sourcing/limits matter). Pregnancy/breastfeeding: avoid internal use of borage herb products due to PA-related concerns and risk uncertainty. Liver disease / long-term use: avoid (PA risk + cumulative exposure logic). Seed oil vs herb: refined/quality-controlled seed oil is generally the preferred form when borage is used medicinally, because the main target compound is GLA; however, product quality and contamination control still matter. Drug interactions (caution): GLA oils have been discussed with anticoagulants (bleeding risk caution is better established for evening primrose oil; borage oil is often grouped in the same “GLA oil” category). Use caution if on anticoagulants/antiplatelets.
Duke (2002) rates borage as a single-plus herb (+) with predominantly folklore-level evidence. Borage seed oil is rich in gamma-linolenic acid (GLA) and has been used for inflammatory conditions such as arthritis and PMS, and for cardiovascular support; typical dose is one 300 mg softgel containing 24% GLA or 2-4 ml liquid leaf extract. Commission E does not approve borage for any indication, and the herb contains hepatotoxic and carcinogenic pyrrolizidine alkaloids, making long-term use inadvisable (Duke, 2002).
Ginger is widely considered safe at culinary and conventional supplemental doses. At high doses (>5 g/day), ginger may cause heartburn, acid reflux, mouth irritation, and mild gastrointestinal discomfort. Ginger may modestly inhibit platelet aggregation and enhance the effects of anticoagulants (e.g., warfarin) — clinical significance at dietary amounts is low, but caution is warranted with high-dose supplementation alongside blood-thinning medications (Shalansky et al., 2007). May lower blood sugar — monitor closely if combining with antidiabetic medications.
Pregnancy: Ginger is among the most studied herbal remedies for pregnancy nausea. At doses up to 1 g/day, it is generally considered safe and effective for nausea and vomiting of pregnancy (NVP), based on multiple RCTs. The EMA monograph supports its use for NVP. Avoid doses >1.5 g/day during pregnancy due to theoretical concern about anticoagulant activity. Breastfeeding: generally considered safe at food amounts; limited data for medicinal doses (European Medicines Agency, 2012a).
Duke (2002) rates ginger as a triple-plus herb (+++) with strong clinical support (score 3) for antiemetic activity, including motion sickness, morning sickness, and postoperative nausea, and score 2 evidence for dyspepsia, diarrhea, and inflammation. Typical doses are 2-4 g dry rhizome per day or 500-1000 mg fresh root three times daily; Commission E approves ginger for dyspepsia and motion sickness. Ginger has antiplatelet properties and should be used with caution alongside anticoagulant medications (Duke, 2002).
External Ids
Botanical Description
Robust, bristly annual herb with hollow, branching stems covered in coarse, stiff hairs. The leaves are large, oval and wrinkled, also coarsely hairy, and smell of cucumber when crushed. The flowers are strikingly bright blue, star-shaped with five pointed petals and a prominent black central cone of anthers, borne in nodding clusters.[1]
Rhizomatous perennial herb with narrow, lance-shaped leaves arising in two ranks from slender, reed-like pseudostems. Pale yellow-green flowers with purple markings are borne in a dense, cone-like spike on a separate short stalk arising directly from the rhizome, though ginger rarely flowers in cultivation. The branching, knobbly rhizome has a pale yellow interior and a characteristic pungent, spicy aroma.[1]
Habitat
Grows readily on disturbed, nutrient-rich ground, gardens, waste places and field margins; native to the Mediterranean region and widely naturalised and cultivated across Europe and elsewhere as a culinary and oil-seed crop.[1]
Believed native to tropical Southeast Asia; cultivated extensively throughout the tropics and subtropics (India, China, Nigeria, the Caribbean) in warm, humid conditions on well-drained, fertile soil.
Harvesting
Leaves and flowers are picked fresh through the growing season, at their best just as the flowers open; the seed is collected in late summer once the seed heads have dried, pressed for its gamma-linolenic-acid-rich oil.[1]
The rhizome is dug 8-10 months after planting, once the leaves have died back, for mature ('old') ginger with the fullest pungency, or earlier for milder young ('green') ginger; cleaned and used fresh or dried and ground.
Traditional Uses
Borage has a long folk reputation, reflected in the old saying 'borage for courage', as a mood-lifting, cooling herb for feverish colds and respiratory complaints, and as a digestive and anti-inflammatory remedy; the fresh leaves and flowers have also been used culinarily. Modern use is centred on the seed oil, rich in gamma-linolenic acid (GLA), for inflammatory and skin conditions.[1]
Ginger rhizome has one of the longest and most widespread medicinal histories of any spice, used across Chinese, Ayurvedic and Western herbal traditions as a warming digestive carminative, an antiemetic for nausea and motion sickness, and an anti-inflammatory remedy for joint pain; this traditional reputation is now supported by an extensive clinical evidence base, particularly for nausea (including pregnancy and chemotherapy-related) and osteoarthritis.[1]
Preparations
Dried rhizome powder or standardised extract, taken as capsules for nausea or joint-pain studies.
Dosage
A phase-two randomised placebo-controlled trial in moderate persistent asthma used Borago officinalis extract at 5 mL three times daily for one month. Because of pyrrolizidine alkaloid content, whole-herb (leaf/flower) preparations should only be used short-term and from PA-controlled sources; avoid in pregnancy, breastfeeding and liver disease. Educational reference only, not a prescription.
Clinical trials for nausea commonly use around 1-1.5 g of dried rhizome powder daily, in divided doses (up to 1 g/day in pregnancy); osteoarthritis studies commonly use similar or somewhat higher doses. Educational reference only, not a prescription.
References
Not documented
Lookalikes Review
Dangerous Lookalikes
Not documented
Drug Class Interactions
Not documented
References & Sources
- Slama, M., Slougui, N., Benaissa, A., Nekkaa, A. et al (2024) 'Borago officinalis L.: A Review on Extraction, Phytochemical, and Pharmacological Activities', Chemistry & Biodiversity, 21(5), pp. e202301822. doi:10.1002/cbdv.202301822 Traditional / reference
https://doi.org/10.1002/cbdv.202301822 - Michalak, M., Zagórska-Dziok, M., Klimek-Szczykutowicz, M. and Szopa, A (2023) 'Phenolic Profile and Comparison of the Antioxidant, Anti-Ageing, Anti-Inflammatory, and Protective Activities of Borago officinalis Extracts on Skin Cells', Molecules, 28(2), pp. 868. doi:10.3390/molecules28020868 Preclinical
https://doi.org/10.3390/molecules28020868 - Ghasemian, M., Owlia, S. and Owlia, M.B (2016) 'Review of Anti-Inflammatory Herbal Medicines', Advances in Pharmacological Sciences, 2016, pp. 9130979. doi:10.1155/2016/9130979 Traditional / reference
https://doi.org/10.1155/2016/9130979 - Di Cerbo, A., Carnevale, G., Avallone, R., Zavatti, M. and Corsi, L (2020) 'Protective Effects of Borago officinalis (Borago) on Cold Restraint Stress-Induced Gastric Ulcers in Rats: A Pilot Study', Frontiers in Veterinary Science, 7, pp. 427. doi:10.3389/fvets.2020.00427 Preclinical
https://doi.org/10.3389/fvets.2020.00427 - Seo, S.A., Park, B., Hwang, E., Park, S. and Yi, T (2018) 'Borago officinalis L. attenuates UVB-induced skin photodamage via regulation of AP-1 and Nrf2/ARE pathway in normal human dermal fibroblasts and promotion of collagen synthesis in hairless mice', Experimental Gerontology, 107, pp. 178-186. doi:10.1016/j.exger.2018.02.017 Preclinical
https://doi.org/10.1016/j.exger.2018.02.017 - Mirsadraee, M., Khashkhashi Moghaddam, S., Saeedi, P. and Ghaffari, S (2016) 'Effect of Borago Officinalis Extract on Moderate Persistent Asthma: A Phase two Randomized, Double Blind, Placebo-Controlled Clinical Trial', Tanaffos, 15(3), pp. 168-174. doi:10.1183/13993003.congress-2016.pa4116 Randomized trial
https://doi.org/10.1183/13993003.congress-2016.pa4116 - Lozano-Baena, M., Tasset, I., Munoz-Serrano, A., Alonso-Moraga, A. and de Haro-Bailon, A (2016) 'Cancer Prevention and Health Benefices of Traditionally Consumed Borago officinalis Plants', Nutrients, 8(1), pp. 48. doi:10.3390/nu8010048 Preclinical
https://doi.org/10.3390/nu8010048 - Rodriguez-Magana, M.P., Cordero-Perez, P., Rivas-Morales, C., Oranday-Cardenas, M.A., Moreno-Pena, D.P., Garcia-Hernandez, D.G. and Leos-Rivas, C (2019) 'Hypoglycemic Activity of Tilia americana, Borago officinalis, Chenopodium nuttalliae, and Piper sanctum on Wistar Rats', Journal of Diabetes Research, 2019, pp. 7836820. doi:10.1155/2019/7836820 Preclinical
https://doi.org/10.1155/2019/7836820 - Navarro-Herrera, D., Aranaz, P., Eder-Azanza, L., Zabala, M., Romo-Hualde, A., Hurtado, C., Calavia, D., Lopez-Yoldi, M., Martinez, J.A., Gonzalez-Navarro, C.J. and Vizmanos, J.L (2018) 'Borago officinalis seed oil (BSO), a natural source of omega-6 fatty acids, attenuates fat accumulation by activating peroxisomal beta-oxidation both in C. elegans and in diet-induced obese rats', Food & Function, 9(8), pp. 4340-4351. doi:10.1039/c8fo00423d Preclinical
https://doi.org/10.1039/c8fo00423d - Moliner, C., Casedas, G., Barros, L., Finimundy, T.C., Gomez-Rincon, C. and Lopez, V (2022) 'Neuroprotective Profile of Edible Flowers of Borage (Borago officinalis L.) in Two Different Models: Caenorhabditis elegans and Neuro-2a Cells', Antioxidants, 11(7), pp. 1244. doi:10.3390/antiox11071244 Preclinical
https://doi.org/10.3390/antiox11071244 - Samy, M.N., Hamed, A.N.E., Sugimoto, S., Otsuka, H., Kamel, M.S. and Matsunami, K (2015) 'Officinalioside, a new lignan glucoside from Borago officinalis L', Natural Product Research, 30(8), pp. 967-972. doi:10.1080/14786419.2015.1088540 Preclinical
https://doi.org/10.1080/14786419.2015.1088540 - Yue, Y., Jin, F. and Yue, X (2021) 'The effect of Borago officinalis on the signaling pathway of the NLRP3 inflammasome complex, TLR4 and some inflammatory cytokines in type II diabetic patients with acute respiratory distress syndrome', Cellular and Molecular Biology, 67(3), pp. 178-183. doi:10.14715/cmb/2021.67.3.28 Clinical study
https://doi.org/10.14715/cmb/2021.67.3.28 - Fernandes, L., Pereira, J.A., Saraiva, J.A., Ramalhosa, E. and Casal, S (2019) 'Phytochemical characterization of Borago officinalis L. and Centaurea cyanus L. during flower development', Food Research International, 123, pp. 771-778. doi:10.1016/j.foodres.2019.05.014 Preclinical
https://doi.org/10.1016/j.foodres.2019.05.014 - European Medicines Agency (HMPC) (2021) 'Public statement on the use of herbal medicinal products containing toxic, unsaturated pyrrolizidine alkaloids (PAs), including recommendations regarding contamination of herbal medicinal products with PAs, Revision 1'. Available at: https://www.ema.europa.eu/en/documents/public-statement/public-statement-use-herbal-medicinal-products-containing-toxic-unsaturated-pyrrolizidine-alkaloids-pas-including-recommendations-regarding-contamination-herbal-medicinal-products-pyrrolizidine_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/public-statement/public-statement-use-herbal-medicinal-products-containing-toxic-unsaturated-pyrrolizidine-alkaloids-pas-including-recommendations-regarding-contamination-herbal-medicinal-products-pyrrolizidine_en.pdf - Kapoor, R. and Huang, Y.S (2006) 'Gamma linolenic acid: an antiinflammatory omega-6 fatty acid', 7(6), pp. 531--534. doi:10.2174/138920106779116874 Traditional / reference
https://doi.org/10.2174/138920106779116874 - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - World Health Organization (2002) 'WHO Monographs on Selected Medicinal Plants'. Traditional / reference
https://scholar.google.com/scholar?q=WHO%20Monographs%20on%20Selected%20Medicinal%20Plants - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Negroni, M.S., Marengo, A., Caruso, D., et al (2019) 'A case report of accidental intoxication following ingestion of foxglove confused with borage: high digoxinemia without major complications', Case Reports in Cardiology, 2019, pp. 9707428. doi:10.1155/2019/9707428 Clinical study
https://doi.org/10.1155/2019/9707428 - Iraci, F. and Herdeg, C. and Holzwarth, M. and Storz, M.A (2023) 'Of mixed vegetables and cardiac arrhythmias - Digitalis purpurea confused with Borago officinalis: a case series of accidental digitoxin intoxications', Journal of Cardiology Cases, 28(2), pp. 86-90. doi:10.1016/j.jccase.2023.04.007 Clinical study
https://doi.org/10.1016/j.jccase.2023.04.007
- Crichton, M., Marshall, S., Isenring, E., Lohning, A., McCarthy, A.L., Molassiotis, A. and others (2023) 'Effect of a Standardized Ginger Root Powder Regimen on Chemotherapy-Induced Nausea and Vomiting: A Multicenter, Double-Blind, Placebo-Controlled Randomized Trial', Journal of the Academy of Nutrition and Dietetics, 124(3), pp. 313--330. doi:10.1016/j.jand.2023.09.003 Randomized trial
https://doi.org/10.1016/j.jand.2023.09.003 - Mathieu, S., Soubrier, M., Peirs, C., Monfoulet, L.E., Boirie, Y. and Tournadre, A (2022) 'A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms', Nutrients, 14(8). doi:10.3390/nu14081607 Meta-analysis / review
https://doi.org/10.3390/nu14081607 - Ali, B.H., Blunden, G., Tanira, M.O. and Nemmar, A (2008) 'Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research', 46(2), pp. 409--420. doi:10.1016/j.fct.2007.09.085 Clinical study
https://doi.org/10.1016/j.fct.2007.09.085 - European Medicines Agency (2012) 'European Union herbal monograph on Zingiber officinale Roscoe, rhizoma (Zingiberis rhizoma)'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-zingiber-officinale-roscoe-rhizoma_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-zingiber-officinale-roscoe-rhizoma_en.pdf - Huang, F.Y., Deng, T., Meng, L.X. and Ma, X.L (2019) 'Dietary ginger as a traditional therapy for blood sugar control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis', 98(13). doi:10.1097/MD.0000000000015054 Meta-analysis / review
https://doi.org/10.1097/MD.0000000000015054 - Marx, W., McCarthy, A.L., Ried, K. et al (2017) 'Can ginger ameliorate chemotherapy-induced nausea? Protocol of a randomized double blind, placebo-controlled trial', pp. 65. doi:10.1186/s12906-017-1571-z Randomized trial
https://doi.org/10.1186/s12906-017-1571-z - Mashhadi, N.S., Ghiasvand, R., Askari, G., Hariri, M., Darvishi, L. and Mofid, M.R (2013) 'Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: a review', pp. S36--S42. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC3665023/ Traditional / reference
https://pmc.ncbi.nlm.nih.gov/articles/PMC3665023/ - Royal Botanic Gardens, Kew (n.d.) 'Zingiber officinale Roscoe'. Available at: https://powo.science.kew.org/taxon/urn:lsid:http://ipni.org:names:798372-1 Traditional / reference
https://powo.science.kew.org/taxon/urn:lsid:http://ipni.org:names:798372-1 - Shalansky, S., Lynd, L., Richardson, K., Ingaszewski, A. and Kerr, C (2007) 'Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with complementary and alternative medicine', 27(9), pp. 1237--1247. doi:10.1592/phco.27.9.1237 Clinical study
https://doi.org/10.1592/phco.27.9.1237 - Viljoen, E., Visser, J., Koen, N. and Musekiwa, A (2014) 'A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting', 13(1), pp. 20. doi:10.1186/1475-2891-13-20 Meta-analysis / review
https://doi.org/10.1186/1475-2891-13-20 - Xu, Y., Yang, Q. and Wang, X (2020) 'Efficacy of herbal medicine (cinnamon/fennel/ginger) for primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials', Journal of International Medical Research, 48(6). doi:10.1177/0300060520936179 Meta-analysis / review
https://doi.org/10.1177/0300060520936179 - Zhang, Y., Gui, Y., Adams, R., Farragher, J., Itsiopoulos, C., Bow, K. and others (2025) 'Comparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis', Nutrients, 17(15). doi:10.3390/nu17152547 Meta-analysis / review
https://doi.org/10.3390/nu17152547 - Hu, Y., Amoah, A.N., Zhang, H., Fu, R., Qiu, Y., Cao, Y. and others (2020) 'Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis', Journal of Maternal-Fetal and Neonatal Medicine, 35(1), pp. 187--196. doi:10.1080/14767058.2020.1712714 Meta-analysis / review
https://doi.org/10.1080/14767058.2020.1712714 - Huang, F.Y., Deng, T., Meng, L.X. and Ma, X.L (2019) 'Dietary ginger as a traditional therapy for blood sugar control in patients with type 2 diabetes mellitus: A systematic review and meta-analysis', Medicine (Baltimore), 98(13). doi:10.1097/MD.0000000000015054 Meta-analysis / review
https://doi.org/10.1097/MD.0000000000015054 - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Jiang, X., Williams, K.M., Liauw, W.S., Ammit, A.J., Roufogalis, B.D., Duke, C.C., Day, R.O. and McLachlan, A.J (2005) 'Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects', British Journal of Clinical Pharmacology, 59(4), pp. 425-432. doi:10.1111/j.1365-2125.2005.02322.x Randomized trial
https://doi.org/10.1111/j.1365-2125.2005.02322.x
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.