Plant Comparison
Wormwood vs Common yellow woodsorrel
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Wormwood and Common yellow woodsorrel: they share 6 indicated uses (blood sugar / diabetes support, cancer (anticancer research), indigestion, …); 5 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Wormwood | Common yellow woodsorrel | Verdict |
|---|---|---|---|
| Blood sugar / diabetes support | 1/10 | 2/10 | Comparable evidence |
| Cancer (anticancer research) | 2/10 | 2/10 | Comparable evidence |
| Indigestion | 1/10 | 2/10 | Comparable evidence |
| Infection (general) | 1/10 | 2/10 | Comparable evidence |
| Inflammation (general) | 1/10 | 8/10 | Stronger for Common yellow woodsorrel |
| Wounds | 1/10 | 2/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Intensely bitter sesquiterpene lactones responsible for the classic digestive-bitter action.
Volatile oil containing thujone (alpha- and beta-isomers), the neurotoxic ketone that limits safe internal use, along with other monoterpenes.
Antioxidant constituents contributing to the plant's antioxidant activity.
Flavonoid glycosides (e.g. isovitexin, vitexin, quercetin and apigenin derivatives), the main antioxidant constituents.
Caffeic, ferulic and related phenolic acids (antioxidant).
The defining sour constituent - oxalic acid with potassium and calcium oxalates - biosynthesised in part from vitamin C. Responsible for the sour taste and for the kidney-stone/oxalate caution.
High ascorbate content (basis of the traditional antiscorbutic use); also a metabolic precursor of the plant's oxalic acid.
Pharmacological Actions
Artemisia absinthium (wormwood) total flavonoids and its constituent alpha/beta-thujone induce ROS- and caspase-mediated apoptosis in cervical and choriocarcinoma cancer cells (preclinical).
Antibacterial and antiparasitic (amoebicidal/giardicidal) activity of woodsorrel extracts/constituents.
Protective against paracetamol-induced liver injury (congener O. corniculata).
Protective against experimental gastric ulceration (congener O. corniculata).
Woodsorrel phytoconstituents (and a green-synthesised nanoparticle made with O. stricta extract) induced apoptosis in breast, colon and Hep2 cancer cells (preclinical).
Alpha-glucosidase and alpha-amylase inhibition by woodsorrel extract (congener O. corniculata).
Anti-Alzheimer's activity of woodsorrel extract in rats (congener O. corniculata).
Promotes wound and fracture healing; traditional topical use for wounds and skin (congener O. corniculata).
Sour, tannin-containing herb; the basis of traditional antidiarrhoeal use.
Traditional astringent remedy for diarrhoea and dysentery (congener O. corniculata).
Traditional & Indicated Uses
inferred from anti-inflammatory action
inferred from antidiabetic action
Artemisia absinthium (wormwood) total flavonoids (cynaroside, astragalin) inhibit HeLa cervical cancer cells via ROS-mediated apoptosis, and its terpenoid alpha,beta-thujone induces caspase-dependent apoptosis in choriocarcinoma cells and sensitizes them to paclitaxel (preclinical).
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from antispasmodic action
inferred from antidiabetic action
inferred from antispasmodic action
inferred from anti-inflammatory action
inferred from anticancer action
Hepatoprotective in animal models (congener).
Traditional astringent remedy for diarrhoea and dysentery.
inferred from antimicrobial/antiparasitic action
Promotes wound/fracture healing; traditional topical use.
Alpha-glucosidase/amylase inhibition (congener).
inferred from anti-Alzheimer's / neuroprotective action (congener)
Safety, Cautions & Contraindications
CAUTION: Contains thujone, which is neurotoxic in significant amounts. Internal use should be limited in duration and dose — short-term use only (under 4 weeks). Contraindicated in pregnancy (powerful uterine stimulant). Avoid in epilepsy, renal disease, and in children. The small amounts present in properly prepared bitter tinctures and vermouth are generally considered safe. The thujone content of absinthe was historically exaggerated.
Duke (2002) rates wormwood as + (use with caution) and provides clinical evidence (score 2) for use as an aperitif and bitter digestive tonic, consistent with Commission E approval for dyspeptic complaints and loss of appetite. The plant contains absinthin and artabsin (bitter sesquiterpene lactones) responsible for digestive stimulation, and also thujone — a neurotoxic ketone that is the active agent responsible for 'absinthism' (historical neurological syndrome linked to absinthe consumption). Duke strongly cautions that thujone content limits safe long-term use, and wormwood should not be taken internally for more than 4 weeks at a time. Strictly contraindicated in pregnancy (abortifacient, neurotoxic) and epilepsy (Duke, 2002).
Yellow woodsorrel is RICH IN OXALIC ACID and soluble oxalates (the source of its sour taste). Avoid large or frequent quantities, and especially avoid it if you are prone to calcium-oxalate kidney stones, have gout, or have kidney disease. Oxalates also bind calcium and iron, reducing their absorption. Use only modest amounts, and cooking reduces soluble oxalate.
Safety in pregnancy and breastfeeding has not been established; avoid medicinal doses during pregnancy and lactation.
External Ids
Botanical Description
Aromatic, silvery-grey perennial herb with finely divided, silky-hairy leaves and numerous small, pale yellow, drooping, globe-shaped flower heads borne in loose branched panicles. The whole plant has a characteristic intensely bitter taste and a pungent, sage-like aroma.[4]
A small, sour-tasting herbaceous annual to short-lived perennial of the woodsorrel family, 10-40 cm tall. Its bright green leaves are clover-like, palmately divided into three heart-shaped (notched) leaflets that fold down at night and in strong sun. The small five-petalled flowers are bright yellow, borne in little clusters on axillary stalks. The whole plant tastes sharply sour from its oxalic-acid content. It is very similar to the creeping yellow woodsorrel (Oxalis corniculata) but has more upright stems that do not root at the nodes, and generally green (not purplish) foliage.[3]
Habitat
Grows on dry, sunny, stony or waste ground, roadsides and field margins; native to Europe, North Africa and temperate Asia, and naturalised in North America.[4]
A common weed of disturbed, open and cultivated ground: gardens, lawns, arable fields, roadsides, footpaths, waste places and greenhouses. It favours moist, fertile, well-lit soils and is excluded by dense established vegetation. Native to North America but now naturalised almost worldwide across temperate and warm regions.[3]
Harvesting
The flowering aerial parts (leaf, stem and flower) are cut as flowering begins, in mid- to late summer, and dried in a warm, shaded, airy place.[4]
The sour leaves and aerial parts are gathered when actively growing and flowering, used fresh or dried. Because the plant accumulates oxalic acid, harvesting for food or medicine should favour young growth in modest quantities. As a low weed it is easily hand-gathered.[3]
Traditional Uses
Yellow woodsorrel (Oxalis stricta and its near-identical relative O. corniculata) has a long folk-medicine history, deepest in South and East Asian traditions. The cooling, sour whole plant has been used as a refrigerant and thirst-quencher, as a sour leafy vegetable/condiment, and as a source of vitamin C against scurvy. Traditional medicinal uses (chiefly documented for O. corniculata) include dysentery and diarrhoea and other digestive complaints, fever, liver complaints, and topical application of the crushed leaves or juice to wounds, insect bites, warts, corns, mouth sores and inflamed skin, as well as use as a mild diuretic. O. stricta shares these uses where the two woodsorrels are not distinguished.[3, 4]
Preparations
Dried flowering herb infused briefly in hot water as a very bitter digestive tea, taken before meals to stimulate appetite.
Crushed fresh leaves or expressed juice applied topically to wounds, insect bites, warts and inflamed skin, or taken in small amounts for its cooling sour effect.
A whole-plant or leaf infusion/decoction used traditionally for fevers, diarrhoea and as a mild diuretic.
Young leaves eaten raw in small quantities as a tart salad green or to add sourness to food (edible 'sourgrass').
Dosage
Because of its thujone content, traditional herbal references limit internal use to small bitter doses (around 0.5-1 g dried herb per cup) for no more than about 4 weeks at a time. Educational reference only, not a prescription.
Not documented
References
Lookalikes Review
Synonyms
Not documented
Drug Class Interactions
Not documented
References & Sources
- Batiha, G.E.S., Olatunde, A., El-Mleeh, A., Hetta, H.F., Al-Rejaie, S. et al (2020) 'Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Wormwood (Artemisia absinthium)', Antibiotics (Basel), 9(6), pp. 353. doi:10.3390/antibiotics9060353 Traditional / reference
https://doi.org/10.3390/antibiotics9060353 - Wubuli, A., Abdulla, R., Zhao, J., Wu, T. and Aisa, H.A (2024) 'Exploring anti-inflammatory and antioxidant-related quality markers of Artemisia absinthium L. based on spectrum-effect relationship', Phytochemical Analysis, 35(5), pp. 1152-1173. doi:10.1002/pca.3350 Preclinical
https://doi.org/10.1002/pca.3350 - Rashidi, R., Akaberi, M., Gholoobi, A., Ghazavi, H. and Forouzanfar, F (2023) 'Artemisia absinthium Extract Attenuates the Quinolinic Acid-Induced Cell Injury in OLN-93 Cells', Current Drug Discovery Technologies, 20(4), pp. e300323215213. doi:10.2174/1570163820666230330105331 Preclinical
https://doi.org/10.2174/1570163820666230330105331 - Szopa, A., Pajor, J., Klin, P., Rzepiela, A., Elansary, H.O., Al-Mana, F.A., Mattar, M.A. and Ekiert, H (2020) 'Artemisia absinthium L. - Importance in the History of Medicine, the Latest Advances in Phytochemistry and Therapeutical, Cosmetological and Culinary Uses', Plants, 9(9), pp. 1063. doi:10.3390/plants9091063 Meta-analysis / review
https://doi.org/10.3390/plants9091063 - Hbika, A., Daoudi, N.E., Bouyanzer, A., Bouhrim, M., Mohti, H., Loukili, E.H., Mechchate, H., Al-Salahi, R., Nasr, F.A., Bnouham, M. and Zaid, A (2022) 'Artemisia absinthium L. Aqueous and Ethyl Acetate Extracts: Antioxidant Effect and Potential Activity In Vitro and In Vivo against Pancreatic alpha-Amylase and Intestinal alpha-Glucosidase', Pharmaceutics, 14(3), pp. 481. doi:10.3390/pharmaceutics14030481 Preclinical
https://doi.org/10.3390/pharmaceutics14030481 - Bagheri, F., Amri, J., Salehi, M., Karami, H., Alimoradian, A. and Latifi, S.A (2020) 'Effect of Artemisia absinthium ethanolic extract on oxidative stress markers and the TLR4, S100A4, Bax and Bcl-2 genes expression in the kidney of STZ-induced diabetic rats', Hormone Molecular Biology and Clinical Investigation, 41(4), pp. 20200028. doi:10.1515/hmbci-2020-0028 Preclinical
https://doi.org/10.1515/hmbci-2020-0028 - Al-Malki, A.L (2018) 'Shikimic acid from Artemisia absinthium inhibits protein glycation in diabetic rats', International Journal of Biological Macromolecules, 122, pp. 1212-1216. doi:10.1016/j.ijbiomac.2018.09.072 Preclinical
https://doi.org/10.1016/j.ijbiomac.2018.09.072 - Boeing, T., de Souza, J., Vilhena da Silva, R.C., Mariano, L.N.B., Mota da Silva, L., Gerhardt, G.M., Cretton, S., Klein-Junior, L.C. and de Souza, P (2023) 'Gastroprotective effect of Artemisia absinthium L.: A medicinal plant used in the treatment of digestive disorders', Journal of Ethnopharmacology, 312, pp. 116488. doi:10.1016/j.jep.2023.116488 Preclinical
https://doi.org/10.1016/j.jep.2023.116488 - Liu, Z., Li, X., Jin, Y., Nan, T., Zhao, Y., Huang, L. and Yuan, Y (2023) 'New Evidence for Artemisia absinthium as an Alternative to Classical Antibiotics: Chemical Analysis of Phenolic Compounds, Screening for Antimicrobial Activity', International Journal of Molecular Sciences, 24(15), pp. 12044. doi:10.3390/ijms241512044 Preclinical
https://doi.org/10.3390/ijms241512044 - Moaca, E., Pavel, I.Z., Danciu, C., Crainiceanu, Z., Minda, D., Ardelean, F., Antal, D.S., Ghiulai, R., Cioca, A., Derban, M., Simu, S., Chioibas, R., Szuhanek, C. and Dehelean, C (2019) 'Romanian Wormwood (Artemisia absinthium L.): Physicochemical and Nutraceutical Screening', Molecules, 24(17), pp. 3087. doi:10.3390/molecules24173087 Preclinical
https://doi.org/10.3390/molecules24173087 - Turak, A., Shi, S., Jiang, Y. and Tu, P (2014) 'Dimeric guaianolides from Artemisia absinthium', Phytochemistry, 105, pp. 109-114. doi:10.1016/j.phytochem.2014.06.016 Preclinical
https://doi.org/10.1016/j.phytochem.2014.06.016 - Correa-Ferreira, M.L., Noleto, G.R. and Oliveira Petkowicz, C.L (2013) 'Artemisia absinthium and Artemisia vulgaris: a comparative study of infusion polysaccharides', Carbohydrate Polymers, 102, pp. 738-745. doi:10.1016/j.carbpol.2013.10.096 Preclinical
https://doi.org/10.1016/j.carbpol.2013.10.096 - Grieve, M (1931) 'A Modern Herbal'. Traditional / reference
https://scholar.google.com/scholar?q=A%20Modern%20Herbal - Hoffmann, D (2003) 'Medical Herbalism'. Traditional / reference
https://scholar.google.com/scholar?q=Medical%20Herbalism - Lee, J.-Y. and Park, H. and Lim, W. and Song, G (2020) 'alpha,beta-Thujone suppresses human placental choriocarcinoma cells via metabolic disruption', Reproduction, 159(6), pp. 745-756. doi:10.1530/REP-20-0018 Preclinical
https://doi.org/10.1530/REP-20-0018 - He, M. and Yasin, K. and Yu, S. and Li, J. and Xia, L (2023) 'Total Flavonoids in Artemisia absinthium L. and Evaluation of Its Anticancer Activity', International Journal of Molecular Sciences, 24(22), pp. 16348. doi:10.3390/ijms242216348 Preclinical
https://doi.org/10.3390/ijms242216348 - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
- Yang, J.C. and Loewus, F.A (1975) 'Metabolic Conversion of L-Ascorbic Acid to Oxalic Acid in Oxalate-accumulating Plants', Plant Physiology, 56(2), pp. 283-285. doi:10.1104/pp.56.2.283 Preclinical
https://doi.org/10.1104/pp.56.2.283 - Chandramohan, S. and Nair, A.S. and Das, R. and Bhat, S.A. and Krishna, G.S. and Yadav, N. and Archana, V.K. and Rajagopalan, R (2025) 'Biogenic synthesis of zinc oxide nanoparticles using leaf extract of Oxalis stricta and its effect on colon cancer: an in vitro and in silico approach', Biometals, 38(4), pp. 1355-1380. doi:10.1007/s10534-025-00710-9 Preclinical
https://doi.org/10.1007/s10534-025-00710-9 - Majumdar, A. and Kumar Saraf, S. and Baghel, M. and Rao, S.P (2025) 'Chemical Diversity and Biomedical Relevance of Oxalis corniculata L.: A Review of Nutritional and Pharmacological Aspects', Chemistry and Biodiversity, 23(1), pp. e02154. doi:10.1002/cbdv.202502154 Meta-analysis / review
https://doi.org/10.1002/cbdv.202502154 - Sarfraz, I. and Rasul, A. and Hussain, G. and Shah, M.A. and Nageen, B. and Jabeen, F. and Selamoglu, Z. and Ucak, I. and Asrar, M. and Adem, S (2022) 'A Review on Phyto-pharmacology of Oxalis corniculata', Combinatorial Chemistry and High Throughput Screening, 25(7), pp. 1181-1186. doi:10.2174/1386207324666210813121431 Meta-analysis / review
https://doi.org/10.2174/1386207324666210813121431 - Sreejith, G. and Jayasree, M. and Latha, P.G. and Suja, S.R. and Shyamal, S. and Shine, V.J. and Anuja, G.I. and Sini, S. and Shikha, P. and Krishnakumar, N.M. and Vilash, V. and Shoumya, S. and Rajasekharan, S (2014) 'Hepatoprotective activity of Oxalis corniculata L. ethanolic extract against paracetamol induced hepatotoxicity in Wistar rats and its in vitro antioxidant effects', Indian Journal of Experimental Biology, 52(2), pp. 147-152. Preclinical
https://scholar.google.com/scholar?q=Hepatoprotective%20activity%20of%20Oxalis%20corniculata%20L.%20ethanolic%20extract%20against%20paracetamol%20induced%20hepatotoxicity%20in%20Wistar%20rats%20and%20its%20in%20vitro%20antioxidant%20effects - Sakat, S.S. and Tupe, P. and Juvekar, A (2012) 'Gastroprotective Effect of Oxalis corniculata (Whole Plant) on Experimentally Induced Gastric Ulceration in Wistar Rats', Indian Journal of Pharmaceutical Sciences, 74(1), pp. 48-53. doi:10.4103/0250-474X.102543 Preclinical
https://doi.org/10.4103/0250-474X.102543 - Gholipour, A.R. and Jafari, L. and Ramezanpour, M. and Evazalipour, M. and Chavoshi, M. and Yousefbeyk, F. and Kargar Moghaddam, S.J. and Yekta Kooshali, M.H. and Ramezanpour, N. and Daei, P. and Ghasemi, S. and Hamidi, M (2022) 'Apoptosis Effects of Oxalis corniculata L. Extract on Human MCF-7 Breast Cancer Cell Line', Galen Medical Journal, 11, pp. e2484. doi:10.31661/gmj.v11i.2484 Preclinical
https://doi.org/10.31661/gmj.v11i.2484 - Zhang, J. and Zhao, X. and Long, X. and Zhang, Y. and Luo, X. and Shen, W (2026) 'Oxalis corniculata L. Ethanol Extract Promotes Fracture Healing: Integrated Omics and Experimental Validation', Food Science and Nutrition, 14, pp. e71896. doi:10.1002/fsn3.71896 Preclinical
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https://doi.org/10.1155/2021/9981915 - Manna, D. and Dutta, P.K. and Achari, B. and Lohia, A (2010) 'A novel galacto-glycerolipid from Oxalis corniculata kills Entamoeba histolytica and Giardia lamblia', Antimicrobial Agents and Chemotherapy, 54(11), pp. 4825-4832. doi:10.1128/AAC.00546-10 Preclinical
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Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.