Plant Comparison
Greater Burdock vs Hop
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Greater Burdock and Hop: they share 5 indicated uses (arthritis / joint pain, bloating, indigestion, …); 3 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Greater Burdock | Hop | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 2/10 | 1/10 | Comparable evidence |
| Bloating | 2/10 | 1/10 | Comparable evidence |
| Indigestion | 2/10 | 1/10 | Comparable evidence |
| Inflammation (general) | 2/10 | 1/10 | Comparable evidence |
| Skin irritation | 2/10 | 1/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Burdock root is a rich source of prebiotic inulin-type fructans (fructooligosaccharides) along with chlorogenic and caffeic acids, the lignans arctiin and arctigenin, cynarine and quercetin, which underlie its antioxidant, anti-inflammatory and gut-supporting activity.
Alpha- and beta-bitter acids responsible for the characteristic bitterness and much of the sedative, GABA-A-receptor-active and antimicrobial activity.
Xanthohumol has antioxidant activity; 8-prenylnaringenin has notable phytoestrogenic activity, the basis of the mild oestrogenic caution.
Aromatic volatile oil contributing to the characteristic hop aroma.
Pharmacological Actions
Burdock (Arctium lappa) extracts and the lignan arctigenin inhibit proliferation and induce apoptosis in colon, breast, lung and gastric cancer cells, attenuate melanoma progression and reduce preneoplastic colon lesions in vivo (preclinical).
Traditional & Indicated Uses
inferred from anti-inflammatory action
inferred from digestive action
Arctium lappa root reduces diet-induced preneoplastic colon lesions and suppresses melanoma progression; its lignan arctigenin induces apoptosis in colon (HT-29), breast (in vitro/in vivo), lung and gastric cancer cells and chemosensitizes them to doxorubicin (preclinical).
inferred from digestive action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from digestive action
inferred from anti-inflammatory action
inferred from sedative action
Safety, Cautions & Contraindications
Generally safe as a food plant. Allergic reactions are possible in those sensitive to Asteraceae. Avoid in pregnancy due to uterine-stimulating effects reported in animal studies. The burs (seed heads) can cause mechanical irritation of skin and eyes on contact. Not recommended in biliary obstruction.
Duke (2002) rates burdock as +++ and notes antibacterial, antimutagenic, antitumor, choleretic, diuretic, and prebiotic (bifidogenic) activities at the experimental level (score 1). The root is rich in inulin (a prebiotic fructooligosaccharide), which promotes growth of beneficial intestinal bacteria. Dose: 1–2 g dried root in tea three times daily, or 2–4 ml of tincture. Duke notes burdock's general safety, though it belongs to the Asteraceae family and can trigger reactions in sensitive individuals. It should be distinguished from belladonna and similar plants, which resemble it in early growth (Duke, 2002).
Generally safe at therapeutic doses for short-term use. Hop preparations may enhance the sedative effects of alcohol, benzodiazepines, and other CNS depressants — avoid combination. Not recommended during pregnancy or breastfeeding. May have mild oestrogenic effects due to 8-prenylnaringenin — caution in hormone-sensitive conditions. Fresh hops can cause contact dermatitis in pickers.
Duke (2002) rates hops as +++ and provides clinical evidence (score 2) for sedative activity, consistent with Commission E approval for nervousness, unrest, and sleep disturbances. The primary sedative compound is 2-methyl-3-buten-2-ol, formed from humulone during storage. Duke notes that hop cones have estrogenic activity, explaining occupational menstrual irregularities reported among hop pickers. Dose: 0.5 g dried flower in tea before bed; often combined with valerian. Hops should not be used in depression, as its CNS-depressant effect may worsen depressive symptoms (Duke, 2002).
External Ids
Botanical Description
Robust biennial herb forming a large rosette of huge, heart-shaped (rhubarb-like), long-stalked leaves, dark green above and whitish-woolly beneath, in its first year. In the second year it sends up a tall, branching, grooved flowering stem bearing purple thistle-like flower heads enclosed in a globe of stiff, hooked bracts that ripen into the familiar clinging burrs.[1, 2]
Vigorous, twining perennial climbing vine with rough, hairy stems and deeply lobed, opposite leaves resembling grape leaves. The plant is dioecious; female plants bear the characteristic papery, cone-like flower clusters ('hops'), covered in yellow, resinous lupulin glands, that are the medicinal and brewing part.[1]
Habitat
A common weed of disturbed ground, waste places, roadsides, field margins and riverbanks on rich, moist soils; native to Europe and temperate Asia and naturalised in North America and elsewhere.[2]
Grows in hedgerows, woodland edges and damp thickets, climbing over other vegetation; native to Europe, Western Asia and North America, and widely cultivated for brewing.
Harvesting
The root is dug at the end of the first growing season (autumn) or early in the second spring, before the flowering stem develops, when it is at its most tender and richest in inulin; leaves are picked through the first year, and the seed/fruit is collected from the dried burrs in the second autumn. Careful identification against deadly nightshade, whose root can resemble burdock, is essential before digging.[11]
The female flower cones are picked in late summer once mature (when the lupulin glands are fully developed and sticky), then dried quickly to preserve the volatile oils and bitter resins.[1]
Traditional Uses
Hop cones have a long European tradition as a calming, sedative herb for nervous tension, restlessness and insomnia, and as a bitter digestive tonic; the sedative reputation, historically noted among hop-pickers who became drowsy from handling the cones, is now linked to GABA-A receptor-active bitter resins.[1]
Preparations
Dried or fresh root simmered in water as a traditional alterative and digestive decoction.
Tincture of the dried root, ethanol 45% V/V or 25% V/V, 8-12 ml three times daily per the EU herbal monograph. The monograph states the ethanol strength but no drug-extract ratio, so no 1:5 ratio is claimed here. Educational reference only, not a prescription.
Fresh root peeled and cooked as a root vegetable (gobo), continuing the traditional food-medicine use.
Dried flower cones infused in hot water as a herbal tea, 500-1000 mg in 150-200 ml, taken 30-60 minutes before bedtime per the EU herbal monograph. Educational reference only, not a prescription.
Tincture (1:5) of the dried cones, 1-2 ml up to three times daily per the EU herbal monograph. Educational reference only, not a prescription.
Concentrated extract standardised to xanthohumol/humulone content, studied for sleep-enhancing activity via GABA-A receptor modulation.
Dosage
The EU herbal monograph on Arctium lappa L., radix gives, for adults and elderly, a single dose of 2-6 g of the comminuted root as an infusion, 3 times daily; a powdered herbal substance at 350 mg 3-5 times daily, a liquid extract at 2-8 mL 3 times daily and a soft extract at 0.2 g per dose (1-2 g daily) are also listed. Not recommended under 18 years, and a practitioner should be consulted if symptoms persist beyond 2 weeks. Educational reference only, not a prescription.
The EU herbal monograph gives 8-12 mL three times daily, for tinctures in either 45% V/V or 25% V/V ethanol, in adults and elderly. Educational reference only, not a prescription.
The EU herbal monograph distinguishes two uses, in adolescents, adults and elderly. To aid sleep - 500-1000 mg of the comminuted flower in 150-200 mL of boiling water as an infusion, 30-60 minutes before bedtime. In mental stress - 500 mg in 150-200 mL as an infusion, up to 4 times daily. A 1:5 tincture at 1-2 mL up to 3 times daily is also listed. Educational reference only, not a prescription.
References
Lookalikes Review
Dangerous Lookalikes
Drug Class Interactions
Not documented
Pairings
References & Sources
- Chan, Y.S., Cheng, L.N., Wu, J.H., Chan, E., Kwan, Y.W., Lee, S.M.Y., Leung, G.P.H., Yu, P.H.F. and Chan, S.W (2010) 'A review of the pharmacological effects of Arctium lappa (burdock)', Inflammopharmacology, 19(5), pp. 245--254. doi:10.1007/s10787-010-0062-4 Preclinical
https://doi.org/10.1007/s10787-010-0062-4 - de Souza, A.R.C., de Oliveira, T.L., Fontana, P.D., Carneiro, M.C., Corazza, M.L., de Messias Reason, I.J. and Bavia, L (2022) 'Phytochemicals and Biological Activities of Burdock (Arctium lappa L.) Extracts: A Review', Chemistry and Biodiversity, 19(11). doi:10.1002/cbdv.202200615 Preclinical
https://doi.org/10.1002/cbdv.202200615 - Yosri, N., Alsharif, S.M., Xiao, J., Musharraf, S.G., Zhao, C., Saeed, A., Gao, R., Said, N.S., Di Minno, A., Daglia, M., Guo, Z., Khalifa, S.A.M. and El-Seedi, H.R (2023) 'Arctium lappa (burdock): insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine', Biomedicine & Pharmacotherapy, 158, pp. 114104. doi:10.1016/j.biopha.2022.114104 Meta-analysis / review
https://doi.org/10.1016/j.biopha.2022.114104 - Mondal, S.C. and Eun, J.B (2022) 'Mechanistic insights on burdock (Arctium lappa L.) extract effects on diabetes mellitus', Food Science and Biotechnology, 31(8), pp. 999--1008. doi:10.1007/s10068-022-01091-2 Preclinical
https://doi.org/10.1007/s10068-022-01091-2 - Shyam, M. and Sabina, E.P (2024) 'Harnessing the power of Arctium lappa root: a review of its pharmacological properties and therapeutic applications', Natural Products and Bioprospecting, 14(1), pp. 49. doi:10.1007/s13659-024-00466-8 Meta-analysis / review
https://doi.org/10.1007/s13659-024-00466-8 - Gao, Q., Yang, M. and Zuo, Z (2018) 'Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L', Acta Pharmacologica Sinica, 39(5), pp. 787-801. doi:10.1038/aps.2018.32 Traditional / reference
https://doi.org/10.1038/aps.2018.32 - Jin, X., Liu, S., Chen, S., Wang, L., Cui, Y., He, J., Fang, S., Li, J. and Chang, Y (2023) 'A systematic review on botany, ethnopharmacology, quality control, phytochemistry, pharmacology and toxicity of Arctium lappa L. fruit', Journal of Ethnopharmacology, 308, pp. 116223. doi:10.1016/j.jep.2023.116223 Meta-analysis / review
https://doi.org/10.1016/j.jep.2023.116223 - Shukla, S., Kakade, M., Cherian, S., Alagarasu, K. and Parashar, D (2024) 'Arctigenin from Arctium lappa L. inhibits chikungunya virus by affecting its entry and replication', Phytomedicine, 128, pp. 155491. doi:10.1016/j.phymed.2024.155491 Preclinical
https://doi.org/10.1016/j.phymed.2024.155491 - Nascimento, B.A.C., Gardinassi, L.G., Silveira, I.M.G., Gallucci, M.G., Tome, M.A., Oliveira, J.F.D., Moreira, M.R.A., Meirelles, A.F.G., Faccioli, L.H., Tefe-Silva, C. and Zoccal, K.F (2019) 'Arctium lappa extract suppresses inflammation and inhibits melanoma progression', Medicines, 6(3), pp. 81. doi:10.3390/medicines6030081 Preclinical
https://doi.org/10.3390/medicines6030081 - Lu, N., Wei, J., Gong, X., Tang, X., Zhang, X., Xiang, W., Liu, S., Luo, C. and Wang, X (2023) 'Preventive effect of Arctium lappa polysaccharides on acute lung injury through anti-inflammatory and antioxidant activities', Nutrients, 15(23), pp. 4946. doi:10.3390/nu15234946 Preclinical
https://doi.org/10.3390/nu15234946 - Moro, T.M.A. and Clerici, M.T.P.S (2020) 'Burdock (Arctium lappa L) roots as a source of inulin-type fructans and other bioactive compounds: Current knowledge and future perspectives for food and non-food applications', Food Research International. doi:10.1016/j.foodres.2020.109889 Preclinical
https://doi.org/10.1016/j.foodres.2020.109889 - European Medicines Agency (HMPC) (2011) 'Community herbal monograph on Arctium lappa L., radix'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-arctium-lappa-l-radix_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-arctium-lappa-l-radix_en.pdf - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - World Health Organization (2002) 'WHO Monographs on Selected Medicinal Plants'. Traditional / reference
https://scholar.google.com/scholar?q=WHO%20Monographs%20on%20Selected%20Medicinal%20Plants - Xu, Z., Li, Y., Jiang, D. and Deng, L (2008) 'Arctium lappa L.: A review of its traditional uses, phytochemistry, and pharmacology', 121(2), pp. 167--184. Traditional / reference
https://scholar.google.com/scholar?q=Arctium%20lappa%20L.%3A%20A%20review%20of%20its%20traditional%20uses%2C%20phytochemistry%2C%20and%20pharmacology - Romualdo, G.R., Silva, E.D.A., Da Silva, T.C., Aloia, T.P.A., Nogueira, M.S., De Castro, I.A. and others (2019) 'Burdock (Arctium lappa L.) root attenuates preneoplastic lesion development in a diet and thioacetamide-induced model of steatohepatitis-associated hepatocarcinogenesis', Environmental Toxicology, 35(4), pp. 518--527. doi:10.1002/tox.22887 Preclinical
https://doi.org/10.1002/tox.22887 - Chen, Y.-F. and Liu, R.-Z. and Ying, W.-W. and Yang, Y.-N. and Xiang, S.-F. and Shao, X.-J. and Cao, J. and Zhang, Y.-Q. and Yang, B. and He, Q.-J. and Ying, M.-D (2022) 'Arctigenin impairs UBC12 enzyme activity and cullin neddylation to attenuate cancer cells', Acta Pharmacologica Sinica, 44(3), pp. 661-669. doi:10.1038/s41401-022-00992-6 Preclinical
https://doi.org/10.1038/s41401-022-00992-6 - Shi, H. and Zhao, L. and Guo, X. and Fang, R. and Zhang, H. and Dong, G. and Fu, J. and Yan, F. and Zhang, J. and Ning, Z. and Ma, Q. and Li, Z. and Li, C. and Dai, J. and Si, C. and Xiong, H (2020) 'Arctigenin Attenuates Breast Cancer Progression through Decreasing GM-CSF/TSLP/STAT3/beta-Catenin Signaling', International Journal of Molecular Sciences, 21(17), pp. 6357. doi:10.3390/ijms21176357 Preclinical
https://doi.org/10.3390/ijms21176357 - Li, Q.-C. and Liang, Y. and Tian, Y. and Hu, G.-R (2016) 'Arctigenin induces apoptosis in colon cancer cells through ROS/p38MAPK pathway', Journal of BUON, 21(1), pp. 87-94. Preclinical
https://scholar.google.com/scholar?q=Arctigenin%20induces%20apoptosis%20in%20colon%20cancer%20cells%20through%20ROS/p38MAPK%20pathway - Lee, K.-S. and Lee, M.-G. and Kwon, Y.-S. and Nam, K.-S (2020) 'Arctigenin Enhances the Cytotoxic Effect of Doxorubicin in MDA-MB-231 Breast Cancer Cells', International Journal of Molecular Sciences, 21(8), pp. 2997. doi:10.3390/ijms21082997 Preclinical
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https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Bryson, P.D. and Watanabe, A.S. and Rumack, B.H. and Murphy, R.C (1978) 'Burdock root tea poisoning. Case report involving a commercial preparation', JAMA, 239(20), pp. 2157. Available at: https://pubmed.ncbi.nlm.nih.gov/642161/ Clinical study
https://pubmed.ncbi.nlm.nih.gov/642161/ - Berdai, M.A. and Labib, S. and Chetouani, K. and Harandou, M (2012) 'Atropa belladonna intoxication: a case report', Pan African Medical Journal, 11, pp. 72. Available at: https://pubmed.ncbi.nlm.nih.gov/22655106/ Clinical study
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- Lee, H., Chung, S.H., Kwon, D.J., Nam, M.J. et al (2024) 'Sleep-enhancing effect of Hongcheon-hop (Humulus lupulus L.) extract containing xanthohumol and humulone through GABA-A receptor', Journal of Ethnopharmacology, 338(Pt 2), pp. 119019. doi:10.1016/j.jep.2024.119019 Preclinical
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https://doi.org/10.1124/pr.115.010843 - Sun, X.L., Xia, T.S., Jiang, Y.P., Wang, N.N., Xu, L.C. and Han, T (2022) 'Humulus lupulus L. extract and its active constituent xanthohumol attenuate oxidative stress and nerve injury induced by iron overload via activating AKT/GSK3beta and Nrf2/NQO1 pathways', Journal of Natural Medicines, 76(4), pp. 801-814. doi:10.1007/s11418-022-01642-1 Preclinical
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https://doi.org/10.3390/ph15030350 - Caban, M., Chojnacka, K., Owczarek, K., Laskowska, J., Fichna, J. and Podsedek, A (2020) 'Spent hops (Humulus Lupulus L.) extract as modulator of the inflammatory response in lipopolysaccharide stimulated RAW 264.7 macrophages', Journal of Physiology and Pharmacology, 71(1). doi:10.26402/jpp.2020.1.05 Preclinical
https://doi.org/10.26402/jpp.2020.1.05 - Wang, S., Dunlap, T.L., Howell, C.E., Mbachu, O.C., Rue, E.A. and Phansalkar, R (2016) 'Hop (Humulus lupulus L.) Extract and 6-Prenylnaringenin Induce P450 1A1 Catalyzed Estrogen 2-Hydroxylation', Chemical Research in Toxicology, 29(7), pp. 1142-1150. doi:10.1021/acs.chemrestox.6b00112 Preclinical
https://doi.org/10.1021/acs.chemrestox.6b00112 - Kyrou, I., Christou, A., Panagiotakos, D., Stefanaki, C., Skenderi, K. and Katsana, K (2017) 'Effects of a hops (Humulus lupulus L.) dry extract supplement on self-reported depression, anxiety and stress levels in apparently healthy young adults: a randomized, placebo-controlled, double-blind, crossover pilot study', Hormones, 16(2), pp. 171-180. doi:10.14310/horm.2002.1738 Randomized trial
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https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-humulus-lupulus-l-flos-revision-1_en.pdf - Becker, A., Felgentreff, F., Schröder, H., Meier, B. and Brattstrom, A (2014) 'The anxiolytic effects of a Valerian extract is based on valerenic acid', pp. 267. Traditional / reference
https://scholar.google.com/scholar?q=The%20anxiolytic%20effects%20of%20a%20Valerian%20extract%20is%20based%20on%20valerenic%20acid - Koetter, U. and Blumenthal, M (2010) 'Valerian and hops for insomnia: overview of clinical data', pp. 44--50. Traditional / reference
https://scholar.google.com/scholar?q=Valerian%20and%20hops%20for%20insomnia%3A%20overview%20of%20clinical%20data - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Ghasemzadeh Rahbardar, M. and Hosseinzadeh, H (2024) 'Therapeutic potential of hypnotic herbal medicines: A comprehensive review', Phytotherapy Research, 38(6), pp. 3037-3059. doi:10.1002/ptr.8201 Meta-analysis / review
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https://doi.org/10.1002/ptr.2167 - Ngan, A. and Conduit, R (2011) 'A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality', Phytotherapy Research, 25(8), pp. 1153-1159. doi:10.1002/ptr.3400 Randomized trial
https://doi.org/10.1002/ptr.3400 - Totally Wild UK 'Hops (Humulus lupulus) Identification Guide'. Available at: https://totallywilduk.co.uk/2022/12/08/hops-humulus-lupulus-identification-guide/ Traditional / reference
https://totallywilduk.co.uk/2022/12/08/hops-humulus-lupulus-identification-guide/
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.