Plant Comparison

Greater Burdock vs Hop

A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.

First plant
Second plant
Show:
Plant AGreater BurdockArctium lappaAsteraceaeFull monograph →
Plant BHopHumulus lupulusCannabaceaeFull monograph →

At a glance

Greater Burdock and Hop: they share 5 indicated uses (arthritis / joint pain, bloating, indigestion, …); 3 pharmacological actions in common.

Greater BurdockHop
Constituents13
Pharmacological actions54
Indicated uses76
Safety notes22
Cited sources2421
Indicated uses
Only Greater Burdock
Cancer (anticancer research)Eczema
Shared (5)
Arthritis / joint painBloatingIndigestionInflammation (general)Skin irritation
Only Hop
Insomnia / sleeplessness
Pharmacological actions
Only Greater Burdock
Anticancer (preclinical)Emollient / skin-soothing
Shared (3)
Anti-inflammatoryAntioxidantDigestive aid
Only Hop
Sedative / sleep support

Evidence face-off — shared uses

ConditionGreater BurdockHopVerdict
Arthritis / joint pain2/101/10Comparable evidence
Bloating2/101/10Comparable evidence
Indigestion2/101/10Comparable evidence
Inflammation (general)2/101/10Comparable evidence
Skin irritation2/101/10Comparable evidence

Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.

Key Constituents

Inulin-type fructans and caffeoylquinic acids[1, 4, 6, 8, 10, 11]

Burdock root is a rich source of prebiotic inulin-type fructans (fructooligosaccharides) along with chlorogenic and caffeic acids, the lignans arctiin and arctigenin, cynarine and quercetin, which underlie its antioxidant, anti-inflammatory and gut-supporting activity.

Chlorogenic acidCaffeic acidArctigenin / arctiinQuercetinPolysaccharidesLignansInulin
Bitter acids (humulone, lupulone)[1]

Alpha- and beta-bitter acids responsible for the characteristic bitterness and much of the sedative, GABA-A-receptor-active and antimicrobial activity.

Prenylflavonoids (xanthohumol, 8-prenylnaringenin)[4]

Xanthohumol has antioxidant activity; 8-prenylnaringenin has notable phytoestrogenic activity, the basis of the mild oestrogenic caution.

Flavonoids
Essential oil[1]

Aromatic volatile oil contributing to the characteristic hop aroma.

Essential (volatile) oil

Pharmacological Actions

Anti-inflammatory[1, 2, 3, 5, 6, 9, 10, 11, 13, 14, 15]
Anticancer (preclinical)[9, 16, 17, 18, 19, 20]

Burdock (Arctium lappa) extracts and the lignan arctigenin inhibit proliferation and induce apoptosis in colon, breast, lung and gastric cancer cells, attenuate melanoma progression and reduce preneoplastic colon lesions in vivo (preclinical).

Antioxidant[1, 2, 5, 10, 11, 13, 14, 15, 16]
Digestive aid[4, 11, 13, 14, 15]
Emollient / skin-soothing[1, 2, 13, 14, 15]
Anti-inflammatory[7, 8, 13, 14, 15]
Antioxidant[4, 7, 13, 14, 15]
Digestive aid[13, 14, 15]
Sedative / sleep support[10, 13, 14, 15]

Traditional & Indicated Uses

Arthritis / joint pain[1, 2, 11, 13, 14, 15]Traditional · 2/10

inferred from anti-inflammatory action

Evidence: 2
Label: Arthritis / joint pain
Bloating[4, 11, 13, 14, 15]Traditional · 2/10

inferred from digestive action

Evidence: 2
Label: Bloating
Cancer (anticancer research)[9, 16, 17, 18, 19, 20]Traditional · 2/10

Arctium lappa root reduces diet-induced preneoplastic colon lesions and suppresses melanoma progression; its lignan arctigenin induces apoptosis in colon (HT-29), breast (in vitro/in vivo), lung and gastric cancer cells and chemosensitizes them to doxorubicin (preclinical).

Evidence: 2
Label: Cancer (anticancer research)
Eczema[1, 2, 13, 14, 15]Traditional · 2/10

inferred from emollient action

Evidence: 2
Label: Eczema
Indigestion[4, 11, 13, 14, 15]Traditional · 2/10

inferred from digestive action

Evidence: 2
Label: Indigestion
Inflammation (general)[1, 2, 11, 13, 14, 15]Traditional · 2/10

inferred from anti-inflammatory action

Evidence: 2
Label: Inflammation (general)
Skin irritation[1, 2, 11, 13, 14, 15]Traditional · 2/10

inferred from anti-inflammatory action

Evidence: 2
Label: Skin irritation
Arthritis / joint pain[13, 14, 15]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Arthritis / joint pain
Bloating[13, 14, 15]Traditional · 1/10

inferred from digestive action

Evidence: 1
Label: Bloating
Indigestion[13, 14, 15]Traditional · 1/10

inferred from digestive action

Evidence: 1
Label: Indigestion
Inflammation (general)[13, 14, 15]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Inflammation (general)
Insomnia / sleeplessness[13, 14, 15]Traditional · 1/10

inferred from sedative action

Evidence: 1
Label: Insomnia / sleeplessness
Skin irritation[13, 14, 15]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Skin irritation

Safety, Cautions & Contraindications

Safety note[13, 14, 15]Caution

Generally safe as a food plant. Allergic reactions are possible in those sensitive to Asteraceae. Avoid in pregnancy due to uterine-stimulating effects reported in animal studies. The burs (seed heads) can cause mechanical irritation of skin and eyes on contact. Not recommended in biliary obstruction.

Safety note[13, 14, 15, 21]Serious

Duke (2002) rates burdock as +++ and notes antibacterial, antimutagenic, antitumor, choleretic, diuretic, and prebiotic (bifidogenic) activities at the experimental level (score 1). The root is rich in inulin (a prebiotic fructooligosaccharide), which promotes growth of beneficial intestinal bacteria. Dose: 1–2 g dried root in tea three times daily, or 2–4 ml of tincture. Duke notes burdock's general safety, though it belongs to the Asteraceae family and can trigger reactions in sensitive individuals. It should be distinguished from belladonna and similar plants, which resemble it in early growth (Duke, 2002).

Safety note[13, 14, 15]Caution

Generally safe at therapeutic doses for short-term use. Hop preparations may enhance the sedative effects of alcohol, benzodiazepines, and other CNS depressants — avoid combination. Not recommended during pregnancy or breastfeeding. May have mild oestrogenic effects due to 8-prenylnaringenin — caution in hormone-sensitive conditions. Fresh hops can cause contact dermatitis in pickers.

Safety note[13, 14, 15, 16]Caution

Duke (2002) rates hops as +++ and provides clinical evidence (score 2) for sedative activity, consistent with Commission E approval for nervousness, unrest, and sleep disturbances. The primary sedative compound is 2-methyl-3-buten-2-ol, formed from humulone during storage. Duke notes that hop cones have estrogenic activity, explaining occupational menstrual irregularities reported among hop pickers. Dose: 0.5 g dried flower in tea before bed; often combined with valerian. Hops should not be used in depression, as its CNS-depressant effect may worsen depressive symptoms (Duke, 2002).

External Ids

Gbif: 7353729
Wikidata: Q26932
Gbif: 2984535
Powo: urn:lsid:ipni.org:names:303502-2
Wikidata: Q104212

Botanical Description

Robust biennial herb forming a large rosette of huge, heart-shaped (rhubarb-like), long-stalked leaves, dark green above and whitish-woolly beneath, in its first year. In the second year it sends up a tall, branching, grooved flowering stem bearing purple thistle-like flower heads enclosed in a globe of stiff, hooked bracts that ripen into the familiar clinging burrs.[1, 2]

Height: 1-2 m (flowering stem, second year)
Habit: Robust biennial herb; large rosette in year one, tall branching stem in year two
Leaves: Huge, heart-shaped, long-stalked, dark green above and whitish-woolly beneath
Flowers: Purple thistle-like flower heads enclosed in a globe of stiff, hooked bracts
Stem: Tall, branching, grooved flowering stem (second year only)
Root: Long, thick, fleshy first-year taproot
Fruit: Bristly, hooked burr enclosing small achenes, clinging to fur and clothing
Flowering Period: July-September (second year)

Vigorous, twining perennial climbing vine with rough, hairy stems and deeply lobed, opposite leaves resembling grape leaves. The plant is dioecious; female plants bear the characteristic papery, cone-like flower clusters ('hops'), covered in yellow, resinous lupulin glands, that are the medicinal and brewing part.[1]

Height: Climbing vine to 6-8 m
Habit: Vigorous, twining, dioecious perennial climbing vine
Leaves: Deeply lobed, opposite, rough-textured, resembling grape leaves
Flowers: Papery, cone-like female flower clusters covered in yellow resinous lupulin glands
Stem: Rough, hairy, twining, climbing without tendrils
Root: Perennial rootstock (rhizome) sending up new climbing stems each year
Fruit: Small achene within the papery cone
Flowering Period: Late summer

Habitat

A common weed of disturbed ground, waste places, roadsides, field margins and riverbanks on rich, moist soils; native to Europe and temperate Asia and naturalised in North America and elsewhere.[2]

Grows in hedgerows, woodland edges and damp thickets, climbing over other vegetation; native to Europe, Western Asia and North America, and widely cultivated for brewing.

Harvesting

The root is dug at the end of the first growing season (autumn) or early in the second spring, before the flowering stem develops, when it is at its most tender and richest in inulin; leaves are picked through the first year, and the seed/fruit is collected from the dried burrs in the second autumn. Careful identification against deadly nightshade, whose root can resemble burdock, is essential before digging.[11]

Parts: Leaf, Root, Seed
Season: Root at the end of year one or start of year two; leaf through year one; seed in year-two autumn

The female flower cones are picked in late summer once mature (when the lupulin glands are fully developed and sticky), then dried quickly to preserve the volatile oils and bitter resins.[1]

Parts: Flower
Season: Late summer, at cone maturity

Traditional Uses

Burdock root is a classic 'alterative' or blood-purifying herb of European and East Asian (gobo) traditional medicine, used for chronic skin conditions, as a mild diuretic supporting elimination, and as a digestive bitter; the root is also eaten as a root vegetable (gobo) in Japanese cuisine.[1, 2]

Hop cones have a long European tradition as a calming, sedative herb for nervous tension, restlessness and insomnia, and as a bitter digestive tonic; the sedative reputation, historically noted among hop-pickers who became drowsy from handling the cones, is now linked to GABA-A receptor-active bitter resins.[1]

Preparations

Decoction (root)[2]

Dried or fresh root simmered in water as a traditional alterative and digestive decoction.

Tincture[12]

Tincture of the dried root, ethanol 45% V/V or 25% V/V, 8-12 ml three times daily per the EU herbal monograph. The monograph states the ethanol strength but no drug-extract ratio, so no 1:5 ratio is claimed here. Educational reference only, not a prescription.

Fresh root (culinary)[11]

Fresh root peeled and cooked as a root vegetable (gobo), continuing the traditional food-medicine use.

Infusion[12]

Dried flower cones infused in hot water as a herbal tea, 500-1000 mg in 150-200 ml, taken 30-60 minutes before bedtime per the EU herbal monograph. Educational reference only, not a prescription.

Tincture[12]

Tincture (1:5) of the dried cones, 1-2 ml up to three times daily per the EU herbal monograph. Educational reference only, not a prescription.

Standardised extract[1]

Concentrated extract standardised to xanthohumol/humulone content, studied for sleep-enhancing activity via GABA-A receptor modulation.

Dosage

Root decoction[12]

The EU herbal monograph on Arctium lappa L., radix gives, for adults and elderly, a single dose of 2-6 g of the comminuted root as an infusion, 3 times daily; a powdered herbal substance at 350 mg 3-5 times daily, a liquid extract at 2-8 mL 3 times daily and a soft extract at 0.2 g per dose (1-2 g daily) are also listed. Not recommended under 18 years, and a practitioner should be consulted if symptoms persist beyond 2 weeks. Educational reference only, not a prescription.

Tincture[12]

The EU herbal monograph gives 8-12 mL three times daily, for tinctures in either 45% V/V or 25% V/V ethanol, in adults and elderly. Educational reference only, not a prescription.

Infusion[12]

The EU herbal monograph distinguishes two uses, in adolescents, adults and elderly. To aid sleep - 500-1000 mg of the comminuted flower in 150-200 mL of boiling water as an infusion, 30-60 minutes before bedtime. In mental stress - 500 mg in 150-200 mL as an infusion, up to 4 times daily. A 1:5 tincture at 1-2 mL up to 3 times daily is also listed. Educational reference only, not a prescription.

References

REF-0709, REF-0705, REF-2338, REF-0707, REF-2339, REF-0722, REF-2340, REF-2341, REF-2342, REF-2343, REF-0706
REF-0839, REF-0840, REF-0841, REF-1726, REF-1727, REF-1728, REF-1729, REF-1730, REF-1731, REF-1732, REF-1733

Lookalikes Review

Outcome: has-lookalikes
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07
Outcome: has-lookalikes
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

Dangerous Lookalikes

Safety note[22, 23, 24]Fatal
Dangerous Plant: atropa-belladonna
Confused Part: First-year taproots dug for use as food or 'burdock root tea'; the root of deadly nightshade closely resembles a burdock root and the two grow as weeds in the same rough ground.
Confusion Context: Greater burdock (Arctium lappa) is dug for its long first-year taproot, used as a vegetable and as 'burdock root tea.' Deadly nightshade (Atropa belladonna) grows as a weed in the same disturbed ground and its root closely resembles a burdock root, so belladonna root can be gathered or processed in mistake for burdock. This has caused real poisonings: a JAMA case report (Bryson et al., 1978) describes atropine poisoning from a commercial burdock root tea, and belladonna-contaminated herbal teas have caused severe anticholinergic poisoning from as little as a few milligrams of atropine. Belladonna contains tropane alkaloids (atropine, hyoscyamine, scopolamine); poisoning causes dry flushed skin, widely dilated pupils, blurred vision, fever, a racing heart, agitation, hallucinations, seizures and can be fatal, especially in children.
Distinguishing Features: Whole plant: only dig burdock when you can match the whole living plant - burdock has huge rhubarb-like heart-shaped leaves that are whitish-woolly underneath and, in its second year, the familiar hooked burrs. Deadly nightshade is a branching plant with dull green oval pointed leaves, solitary purple-brown bell-shaped flowers and shiny black cherry-sized berries., Berries (decisive if present): burdock never bears berries - it makes bristly burrs. A plant near your 'burdock' bearing shiny black berries in green star-shaped calyces is deadly nightshade - do not dig roots from that ground., Best practice: because the roots alone are hard to tell apart, do not wild-harvest burdock root unless an expert has confirmed the living plant - buy it from a reputable supplier instead.
Key Test: Identify the whole living plant before digging any root. Confirm large rhubarb-like leaves that are woolly-white underneath (and hooked burrs in the second year) for burdock. If there are shiny black berries, purple-brown bell-shaped flowers or oval pointed leaves among the plants, deadly nightshade may be present - do not dig or brew root tea from there. When in doubt, buy burdock rather than foraging the root.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07
Safety note[21]Dangerous
Dangerous Plant: bryonia-dioica
Confused Part: Young climbing spring shoots gathered and cooked like asparagus; toxic bryony vines send up similar shoots in the same hedgerows.
Confusion Context: Hop (Humulus lupulus) shoots are foraged in spring and cooked like asparagus. As Totally Wild UK warns, they can be confused with other climbing plants such as white bryony (Bryonia dioica) and black bryony (Dioscorea communis), which are poisonous and often scramble through the same hedgerows, sometimes twined around the hops themselves. White bryony contains cucurbitacins that cause severe vomiting, diarrhoea and colic, and a few of its berries can seriously poison a child. Because the young shoots are gathered before the tell-tale hop cones form, careful leaf checking is essential.
Distinguishing Features: Leaves (decisive): hop leaves have a nettle-like toothed margin and are lobed, and hops have NO tendrils. The bryony lookalikes do not have that toothed, lobed hop-leaf and white bryony climbs by curling tendrils., Leaf arrangement: hop leaves are opposite (in pairs); white bryony leaves are alternate., Later signs: only hops produce the papery green cones; white bryony bears red berries and black bryony shiny red berries - never gather shoots from a vine that carries or grew red berries.
Key Test: Check every shoot for true hop leaves - toothed, lobed, in opposite pairs, with no tendrils. Any shoot with untoothed leaves, curling tendrils, alternate leaves, or that grew red berries is not hops and may be toxic bryony - discard it.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

Drug Class Interactions

Not documented

Safety note[17, 18, 19]Caution
Drug Class: sedatives-cns-depressants
Mechanism: Hops has calming, sedative effects (a controlled trial found a valerian-hops combination shortened the time to fall asleep); taken with sedatives, sleeping tablets or other central-nervous-system depressants (including alcohol) it may add to drowsiness and slowed reactions.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

Pairings

Not documented

Hops and passionflower are both GABA-acting sedative herbs commonly combined in sleep blends; together they may enhance relaxation and additive drowsiness.[17, 20]

Partner Id: passiflora-incarnata
Type: synergy
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

Hops and lemon balm are both mild sedative, sleep-supporting herbs often combined in calming blends; used together they may reinforce each other's relaxing effect.[17, 18]

Partner Id: melissa-officinalis
Type: synergy
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

References & Sources

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  2. de Souza, A.R.C., de Oliveira, T.L., Fontana, P.D., Carneiro, M.C., Corazza, M.L., de Messias Reason, I.J. and Bavia, L (2022) 'Phytochemicals and Biological Activities of Burdock (Arctium lappa L.) Extracts: A Review', Chemistry and Biodiversity, 19(11). doi:10.1002/cbdv.202200615 Preclinical
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  3. Yosri, N., Alsharif, S.M., Xiao, J., Musharraf, S.G., Zhao, C., Saeed, A., Gao, R., Said, N.S., Di Minno, A., Daglia, M., Guo, Z., Khalifa, S.A.M. and El-Seedi, H.R (2023) 'Arctium lappa (burdock): insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine', Biomedicine & Pharmacotherapy, 158, pp. 114104. doi:10.1016/j.biopha.2022.114104 Meta-analysis / review
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  4. Mondal, S.C. and Eun, J.B (2022) 'Mechanistic insights on burdock (Arctium lappa L.) extract effects on diabetes mellitus', Food Science and Biotechnology, 31(8), pp. 999--1008. doi:10.1007/s10068-022-01091-2 Preclinical
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  5. Shyam, M. and Sabina, E.P (2024) 'Harnessing the power of Arctium lappa root: a review of its pharmacological properties and therapeutic applications', Natural Products and Bioprospecting, 14(1), pp. 49. doi:10.1007/s13659-024-00466-8 Meta-analysis / review
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  6. Gao, Q., Yang, M. and Zuo, Z (2018) 'Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L', Acta Pharmacologica Sinica, 39(5), pp. 787-801. doi:10.1038/aps.2018.32 Traditional / reference
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  7. Jin, X., Liu, S., Chen, S., Wang, L., Cui, Y., He, J., Fang, S., Li, J. and Chang, Y (2023) 'A systematic review on botany, ethnopharmacology, quality control, phytochemistry, pharmacology and toxicity of Arctium lappa L. fruit', Journal of Ethnopharmacology, 308, pp. 116223. doi:10.1016/j.jep.2023.116223 Meta-analysis / review
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  8. Shukla, S., Kakade, M., Cherian, S., Alagarasu, K. and Parashar, D (2024) 'Arctigenin from Arctium lappa L. inhibits chikungunya virus by affecting its entry and replication', Phytomedicine, 128, pp. 155491. doi:10.1016/j.phymed.2024.155491 Preclinical
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  9. Nascimento, B.A.C., Gardinassi, L.G., Silveira, I.M.G., Gallucci, M.G., Tome, M.A., Oliveira, J.F.D., Moreira, M.R.A., Meirelles, A.F.G., Faccioli, L.H., Tefe-Silva, C. and Zoccal, K.F (2019) 'Arctium lappa extract suppresses inflammation and inhibits melanoma progression', Medicines, 6(3), pp. 81. doi:10.3390/medicines6030081 Preclinical
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  10. Lu, N., Wei, J., Gong, X., Tang, X., Zhang, X., Xiang, W., Liu, S., Luo, C. and Wang, X (2023) 'Preventive effect of Arctium lappa polysaccharides on acute lung injury through anti-inflammatory and antioxidant activities', Nutrients, 15(23), pp. 4946. doi:10.3390/nu15234946 Preclinical
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  11. Moro, T.M.A. and Clerici, M.T.P.S (2020) 'Burdock (Arctium lappa L) roots as a source of inulin-type fructans and other bioactive compounds: Current knowledge and future perspectives for food and non-food applications', Food Research International. doi:10.1016/j.foodres.2020.109889 Preclinical
    https://doi.org/10.1016/j.foodres.2020.109889
  12. European Medicines Agency (HMPC) (2011) 'Community herbal monograph on Arctium lappa L., radix'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-arctium-lappa-l-radix_en.pdf Traditional / reference
    https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-arctium-lappa-l-radix_en.pdf
  13. Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
    https://powo.science.kew.org
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  15. Xu, Z., Li, Y., Jiang, D. and Deng, L (2008) 'Arctium lappa L.: A review of its traditional uses, phytochemistry, and pharmacology', 121(2), pp. 167--184. Traditional / reference
    https://scholar.google.com/scholar?q=Arctium%20lappa%20L.%3A%20A%20review%20of%20its%20traditional%20uses%2C%20phytochemistry%2C%20and%20pharmacology
  16. Romualdo, G.R., Silva, E.D.A., Da Silva, T.C., Aloia, T.P.A., Nogueira, M.S., De Castro, I.A. and others (2019) 'Burdock (Arctium lappa L.) root attenuates preneoplastic lesion development in a diet and thioacetamide-induced model of steatohepatitis-associated hepatocarcinogenesis', Environmental Toxicology, 35(4), pp. 518--527. doi:10.1002/tox.22887 Preclinical
    https://doi.org/10.1002/tox.22887
  17. Chen, Y.-F. and Liu, R.-Z. and Ying, W.-W. and Yang, Y.-N. and Xiang, S.-F. and Shao, X.-J. and Cao, J. and Zhang, Y.-Q. and Yang, B. and He, Q.-J. and Ying, M.-D (2022) 'Arctigenin impairs UBC12 enzyme activity and cullin neddylation to attenuate cancer cells', Acta Pharmacologica Sinica, 44(3), pp. 661-669. doi:10.1038/s41401-022-00992-6 Preclinical
    https://doi.org/10.1038/s41401-022-00992-6
  18. Shi, H. and Zhao, L. and Guo, X. and Fang, R. and Zhang, H. and Dong, G. and Fu, J. and Yan, F. and Zhang, J. and Ning, Z. and Ma, Q. and Li, Z. and Li, C. and Dai, J. and Si, C. and Xiong, H (2020) 'Arctigenin Attenuates Breast Cancer Progression through Decreasing GM-CSF/TSLP/STAT3/beta-Catenin Signaling', International Journal of Molecular Sciences, 21(17), pp. 6357. doi:10.3390/ijms21176357 Preclinical
    https://doi.org/10.3390/ijms21176357
  19. Li, Q.-C. and Liang, Y. and Tian, Y. and Hu, G.-R (2016) 'Arctigenin induces apoptosis in colon cancer cells through ROS/p38MAPK pathway', Journal of BUON, 21(1), pp. 87-94. Preclinical
    https://scholar.google.com/scholar?q=Arctigenin%20induces%20apoptosis%20in%20colon%20cancer%20cells%20through%20ROS/p38MAPK%20pathway
  20. Lee, K.-S. and Lee, M.-G. and Kwon, Y.-S. and Nam, K.-S (2020) 'Arctigenin Enhances the Cytotoxic Effect of Doxorubicin in MDA-MB-231 Breast Cancer Cells', International Journal of Molecular Sciences, 21(8), pp. 2997. doi:10.3390/ijms21082997 Preclinical
    https://doi.org/10.3390/ijms21082997
  21. Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
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  22. Bryson, P.D. and Watanabe, A.S. and Rumack, B.H. and Murphy, R.C (1978) 'Burdock root tea poisoning. Case report involving a commercial preparation', JAMA, 239(20), pp. 2157. Available at: https://pubmed.ncbi.nlm.nih.gov/642161/ Clinical study
    https://pubmed.ncbi.nlm.nih.gov/642161/
  23. Berdai, M.A. and Labib, S. and Chetouani, K. and Harandou, M (2012) 'Atropa belladonna intoxication: a case report', Pan African Medical Journal, 11, pp. 72. Available at: https://pubmed.ncbi.nlm.nih.gov/22655106/ Clinical study
    https://pubmed.ncbi.nlm.nih.gov/22655106/
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  3. Dietz, B.M., Hajirahimkhan, A., Dunlap, T.L. and Bolton, J.L (2016) 'Botanicals and Their Bioactive Phytochemicals for Women's Health', Pharmacological Reviews, 68(4), pp. 1026-1073. doi:10.1124/pr.115.010843 Traditional / reference
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  4. Sun, X.L., Xia, T.S., Jiang, Y.P., Wang, N.N., Xu, L.C. and Han, T (2022) 'Humulus lupulus L. extract and its active constituent xanthohumol attenuate oxidative stress and nerve injury induced by iron overload via activating AKT/GSK3beta and Nrf2/NQO1 pathways', Journal of Natural Medicines, 76(4), pp. 801-814. doi:10.1007/s11418-022-01642-1 Preclinical
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  5. Karbalaei, N., Sadeghi, N., Nekoeian, A. and Malekzadeh, A (2019) 'Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats', Chinese Journal of Integrative Medicine, 25(9), pp. 1-8. doi:10.1007/s11655-019-3025-7 Preclinical
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  6. Xia, T.S., Lin, L.Y., Zhang, Q.Y., Jiang, Y.P., Li, C.H. and Liu, X.Y (2019) 'Humulus lupulus L. Extract Prevents Ovariectomy-Induced Osteoporosis in Mice and Regulates Activities of Osteoblasts and Osteoclasts', Chinese Journal of Integrative Medicine, 27(1), pp. 31-38. doi:10.1007/s11655-019-2700-z Preclinical
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  7. Hurth, Z., Faber, M.L., Gendrisch, F., Holzer, M., Haarhaus, B. and Cawelius, A (2022) 'The Anti-Inflammatory Effect of Humulus lupulus Extract In Vivo Depends on the Galenic System of the Topical Formulation', Pharmaceuticals, 15(3), pp. 350. doi:10.3390/ph15030350 Preclinical
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  8. Caban, M., Chojnacka, K., Owczarek, K., Laskowska, J., Fichna, J. and Podsedek, A (2020) 'Spent hops (Humulus Lupulus L.) extract as modulator of the inflammatory response in lipopolysaccharide stimulated RAW 264.7 macrophages', Journal of Physiology and Pharmacology, 71(1). doi:10.26402/jpp.2020.1.05 Preclinical
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  9. Wang, S., Dunlap, T.L., Howell, C.E., Mbachu, O.C., Rue, E.A. and Phansalkar, R (2016) 'Hop (Humulus lupulus L.) Extract and 6-Prenylnaringenin Induce P450 1A1 Catalyzed Estrogen 2-Hydroxylation', Chemical Research in Toxicology, 29(7), pp. 1142-1150. doi:10.1021/acs.chemrestox.6b00112 Preclinical
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  10. Kyrou, I., Christou, A., Panagiotakos, D., Stefanaki, C., Skenderi, K. and Katsana, K (2017) 'Effects of a hops (Humulus lupulus L.) dry extract supplement on self-reported depression, anxiety and stress levels in apparently healthy young adults: a randomized, placebo-controlled, double-blind, crossover pilot study', Hormones, 16(2), pp. 171-180. doi:10.14310/horm.2002.1738 Randomized trial
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  11. Hege, M., Jung, F., Sellmann, C., Jin, C., Ziegenhardt, D. and Hellerbrand, C (2017) 'An iso-alpha-acid-rich extract from hops (Humulus lupulus) attenuates acute alcohol-induced liver steatosis in mice', Nutrition, 41, pp. 70-77. doi:10.1016/j.nut.2017.07.010 Preclinical
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  12. European Medicines Agency (HMPC) (2014) 'Community herbal monograph on Humulus lupulus L., flos, Revision 1'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-humulus-lupulus-l-flos-revision-1_en.pdf Traditional / reference
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  13. Becker, A., Felgentreff, F., Schröder, H., Meier, B. and Brattstrom, A (2014) 'The anxiolytic effects of a Valerian extract is based on valerenic acid', pp. 267. Traditional / reference
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Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.