Plant Comparison
Andrographis vs Cardamom
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Andrographis and Cardamom: they share 5 indicated uses (arthritis / joint pain, infection (general), inflammation (general), …); 2 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Andrographis | Cardamom | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 5/10 | 1/10 | Stronger for Andrographis |
| Infection (general) | 8/10 | 1/10 | Stronger for Andrographis |
| Inflammation (general) | 5/10 | 1/10 | Stronger for Andrographis |
| Skin irritation | 5/10 | 1/10 | Stronger for Andrographis |
| Wounds | 5/10 | 1/10 | Stronger for Andrographis |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Seed essential oil dominated by 1,8-cineole and alpha-terpinyl acetate, giving the characteristic aroma and much of the carminative, antimicrobial and antioxidant activity.
Additional antioxidant constituents of the seed.
Pharmacological Actions
Andrographolide, the principal diterpene lactone of Andrographis paniculata, suppresses proliferation and induces apoptosis across breast, lung, colon, cervical, hepatic and haematological cancers via NF-kappaB and PI3K/Akt inhibition (preclinical).
Traditional & Indicated Uses
inferred from anti-inflammatory action
Andrographolide (from Andrographis paniculata) acts as a chemopreventive and antitumour agent against breast, lung, colorectal, cervical, prostate and hepatocellular cancers and leukaemia, inducing apoptosis and inhibiting NF-kappaB and PI3K/AKT signalling (preclinical).
Symptomatic relief of the common cold and acute upper respiratory tract infection (reduces symptom severity and duration)
Immunostimulant / immune support
Symptomatic relief of the common cold and acute upper respiratory tract infection (reduces symptom severity and duration)
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from digestive action
inferred from digestive action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
Safety, Cautions & Contraindications
Avoid in pregnancy and when trying to conceive: high doses have shown reproductive toxicity in animals and the herb has a traditional reputation as an abortifacient.
High doses have caused nephrotoxicity and reproductive toxicity in studies; use standardized products at recommended doses and avoid prolonged high-dose use.
Cardamom is generally considered safe for most people when used in culinary amounts. At medicinal doses (supplement form), rare side effects include mild gastrointestinal discomfort and allergic reactions. There are no well-documented serious drug interactions at culinary doses. Cardamom may mildly lower blood pressure — caution if combined with antihypertensive medications. Some sources suggest potential gallstone formation with very high doses, as cardamom may stimulate bile flow. Avoid therapeutic doses during pregnancy until more safety data are available; culinary use is considered safe. Allergy to other Zingiberaceae (ginger, turmeric) may indicate cross-reactivity risk (Korikanthimath and Hiremath, 2002).
Duke (2002) provides clinical support (score 2) for cardamom as a cholagogue, antiviral agent, and appetite stimulant. Commission E and the German PDR (PHR) approve it for loss of appetite and bronchitis (score 2). The essential oil shows antispasmodic and carminative activity. Dose: 1.5 g ground fruit or equivalent preparation three times daily. Duke rates cardamom as generally safe (++), with no significant contraindications at therapeutic doses (Duke, 2002).
External Ids
Botanical Description
Erect, branching annual herb with a slender, quadrangular (square-sectioned), dark green stem. The leaves are opposite, lance-shaped and glabrous, with a short stalk. Small, two-lipped, white flowers with purple-pink markings are borne in loose, spreading axillary and terminal racemes. The whole plant, and especially the leaves, is intensely and characteristically bitter.[11]
Large, rhizomatous perennial herb with tall, reed-like leafy stems (pseudostems) formed by overlapping leaf sheaths, arising from a stout underground rhizome. Small, pale flowers with a violet-veined white lip are borne on separate trailing panicles that grow along the ground from the base of the plant. The fruit is a small, ridged, pale green three-sided capsule (the cardamom pod) containing numerous dark, aromatic seeds.[1]
Habitat
Native to India and Sri Lanka and widely distributed through South and Southeast Asia, growing wild in plains, hillsides, roadsides and cultivated fields; also grown commercially as a medicinal crop.[11]
Native to the moist evergreen forests of the Western Ghats of southern India and Sri Lanka; cultivated in warm, humid, shaded tropical conditions, notably in India, Guatemala and Sri Lanka.[1]
Harvesting
The aerial parts (leaves and tender stems) are cut just before or at the onset of flowering, when andrographolide content is typically highest, and dried in shade to preserve the bitter diterpenoid lactones.[11]
The unripe green pods are hand-picked just before full maturity, then carefully dried (traditionally in the shade or by gentle heat) to preserve the green colour and aromatic oil; the pods are typically used whole or the seeds removed and ground just before use.
Traditional Uses
Andrographis, the 'king of bitters', is a cornerstone bitter tonic of Ayurvedic and traditional Chinese medicine (Chuan xin lian), used for fevers, colds, sore throat, infections and liver complaints. This traditional reputation for treating the common cold and upper respiratory infections is now supported by clinical trials of standardised extracts.[10, 12]
Cardamom has a long Ayurvedic, Middle Eastern and Asian tradition as a warming digestive carminative for indigestion and bloating, a remedy for respiratory complaints such as asthma and bronchitis, and a valued spice for tea, coffee and cooking.[1]
Preparations
Dosage
Clinical trials for upper respiratory infection commonly use extracts standardised to around 60-120 mg andrographolide daily, in divided doses, for up to 5-7 days. Educational reference only, not a prescription.
The WHO monograph on Herba Andrographidis gives, by indication - for the common cold, 1.5-3.0 g of the powdered crude drug three times daily, after meals and at bedtime; for pyrexia, a decoction from 3 g of the crude drug twice daily; for diarrhoea, a decoction from 3-9 g as a single dose as needed, or two 500 mg tablets four times daily. Note that the EMA HMPC assessed this herb and issued a public statement rather than a monograph, so there is no EU posology. Educational reference only, not a prescription.
The WHO monograph on Semen Cardamomi gives an average DAILY dosage of 1.5 g of the drug, or equivalent preparations; for tincture, a daily dosage equivalent to 12 g. Note the 1.5 g is a daily total, not a per-dose amount. Educational reference only, not a prescription.
References
Lookalikes Review
References & Sources
- Okonogi, R. and others (2023) 'Efficacy of Andrographis paniculata spray in acute pharyngitis: A randomized controlled trial', Drug Discoveries & Therapeutics, 17(5), pp. 315-321. doi:10.5582/ddt.2023.01053 Randomized trial
https://doi.org/10.5582/ddt.2023.01053 - Hossain, S., Urbi, Z., Karuniawati, H., Mohiuddin, R.B. and others (2018) 'Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide', Critical Reviews in Food Science and Nutrition, 61(10), pp. 1635-1652. doi:10.1080/10408398.2018.1501657 Meta-analysis / review
https://doi.org/10.1080/10408398.2018.1501657 - Worakunphanich, W. and others (2021) 'Andrographis paniculata Formulations: Impact on Diterpene Lactone Oral Bioavailability', European Journal of Drug Metabolism and Pharmacokinetics, 46(5), pp. 565-581. doi:10.1007/s13318-021-00736-7 Meta-analysis / review
https://doi.org/10.1007/s13318-021-00736-7 - Worakunphanich, W., Thavorncharoensap, M., Youngkong, S., Thakkinstian, A. and Chaikledkaew, U (2021) 'Safety of Andrographis paniculata: A systematic review and meta-analysis', Pharmacoepidemiology and Drug Safety, 30(6), pp. 727-739. doi:10.1002/pds.5190 Meta-analysis / review
https://doi.org/10.1002/pds.5190 - Kumar, S., Singh, B. and Bajpai, V (2021) 'Andrographis paniculata (Burm.f.) Nees and its major constituent andrographolide as potential antiviral agents', Journal of Ethnopharmacology, 274, pp. 113954. doi:10.1016/j.jep.2021.113954 Meta-analysis / review
https://doi.org/10.1016/j.jep.2021.113954 - Barbosa, F.L. and others (2021) 'Andrographis paniculata (Burm. f.) Wall. ex Nees: An Updated Review of Phytochemistry, Antimicrobial Pharmacology, and Clinical Safety and Efficacy', Life, 11(4), pp. 348. doi:10.3390/life11040348 Meta-analysis / review
https://doi.org/10.3390/life11040348 - Singh, P. and others (2022) 'Andrographis paniculata mitigates first-line anti-tubercular drugs-induced nephrotoxicity in Wistar rats', Biomarkers, 27(4), pp. 385-394. doi:10.1080/1354750X.2022.2043444 Preclinical
https://doi.org/10.1080/1354750X.2022.2043444 - Coon, J.T. and Ernst, E (2004) 'Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials', Journal of Clinical Pharmacy and Therapeutics, 29(1), pp. 37-45. doi:10.1046/j.1365-2710.2003.00534.x Meta-analysis / review
https://doi.org/10.1046/j.1365-2710.2003.00534.x - Rondee, N. and others (2023) 'The Effects of Andrographis paniculata (Burm.F.) Wall. Ex Nees and Andrographolide on Neuroinflammation in the Treatment of Neurodegenerative Diseases', Nutrients, 15(15), pp. 3428. doi:10.3390/nu15153428 Meta-analysis / review
https://doi.org/10.3390/nu15153428 - Zeng, B., Wei, A., Zhou, Q., Yuan, M., Lei, K., Liu, Y., Song, J., Guo, L. and Ye, Q (2021) 'Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches', Phytotherapy Research. doi:10.1002/ptr.7324 Randomized trial
https://doi.org/10.1002/ptr.7324 - Gonde, D.P., Bhole, B.K. and Kakad, K.S (2023) 'Andrographolide, diterpenoid constituent of Andrographis paniculata: Review on botany, phytochemistry, molecular docking analysis, and pharmacology', Annales Pharmaceutiques Francaises. doi:10.1016/j.pharma.2023.10.001 Preclinical
https://doi.org/10.1016/j.pharma.2023.10.001 - Hu, X.Y., Wu, R.H., Logue, M., Blondel, C., Lai, L.Y.W., Stuart, B., Flower, A., Fei, Y.T., Moore, M., Shepherd, J., Liu, J.P. and Lewith, G (2017) 'Andrographis paniculata (Chuan Xin Lian) for symptomatic relief of acute respiratory tract infections in adults and children: A systematic review and meta-analysis', PLoS ONE. doi:10.1371/journal.pone.0181780 Meta-analysis / review
https://doi.org/10.1371/journal.pone.0181780 - World Health Organization (2002) 'Herba Andrographidis'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 - Tundis, R. and Patra, J.K. and Bonesi, M. and Das, S. and Nath, R. and Das Talukdar, A. and Das, G. and Loizzo, M.R (2023) 'Anti-Cancer Agent: The Labdane Diterpenoid-Andrographolide', Plants, 12(10), pp. 1969. doi:10.3390/plants12101969 Preclinical
https://doi.org/10.3390/plants12101969 - Mishra, S.K. and Tripathi, S. and Shukla, A. and Oh, S.H. and Kim, H.M (2015) 'Andrographolide and analogues in cancer prevention', Frontiers in Bioscience (Elite Edition), 7(2), pp. 255-266. doi:10.2741/E732 Preclinical
https://doi.org/10.2741/E732 - Paul, S. and Roy, D. and Pati, S. and Sa, G (2021) 'The Adroitness of Andrographolide as a Natural Weapon Against Colorectal Cancer', Frontiers in Pharmacology, 12, pp. 731492. doi:10.3389/fphar.2021.731492 Preclinical
https://doi.org/10.3389/fphar.2021.731492 - Memorial Sloan Kettering Cancer Center (n.d.) 'Andrographis (About Herbs)'. Available at: https://www.mskcc.org/cancer-care/integrative-medicine/herbs/andrographis Traditional / reference
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/andrographis
- Ashokkumar, K., Murugan, M., Dhanya, M.K. and Warkentin, T.D (2019) 'Botany, traditional uses, phytochemistry and biological activities of cardamom [Elettaria cardamomum (L.) Maton] - A critical review', Journal of Ethnopharmacology, 246, pp. 112244. doi:10.1016/j.jep.2019.112244 Meta-analysis / review
https://doi.org/10.1016/j.jep.2019.112244 - Jamal, A., Javed, K., Aslam, M. and Jafri, M.A (2006) 'Gastroprotective effect of cardamom, Elettaria cardamomum Maton. fruits in rats', Journal of Ethnopharmacology, 103(2), pp. 149-153. doi:10.1016/j.jep.2005.07.016 Preclinical
https://doi.org/10.1016/j.jep.2005.07.016 - Yahyazadeh, R., Ghasemzadeh Rahbardar, M., Razavi, B.M., Karimi, G. and Hosseinzadeh, H (2021) 'The effect of Elettaria cardamomum (cardamom) on the metabolic syndrome: Narrative review', Iranian Journal of Basic Medical Sciences, 24(11), pp. 1462-1469. doi:10.22038/IJBMS.2021.54417.12228 Meta-analysis / review
https://doi.org/10.22038/IJBMS.2021.54417.12228 - Cardenas Garza, G.R., Elizondo Luevano, J.H., Bazaldua Rodriguez, A.F., Chavez Montes, A., Perez Hernandez, R.A. and Martinez Delgado, A.J (2021) 'Benefits of Cardamom (Elettaria cardamomum (L.) Maton) and Turmeric (Curcuma longa L.) Extracts for Their Applications as Natural Anti-Inflammatory Adjuvants', Plants, 10(9), pp. 1908. doi:10.3390/plants10091908 Preclinical
https://doi.org/10.3390/plants10091908 - Sreedharan, S., Nair, V. and Cisneros-Zevallos, L (2023) 'Protective Role of Phenolic Compounds from Whole Cardamom (Elettaria cardamomum (L.) Maton) against LPS-Induced Inflammation in Colon and Macrophage Cells', Nutrients, 15(13), pp. 2965. doi:10.3390/nu15132965 Preclinical
https://doi.org/10.3390/nu15132965 - Almeer, R.S., Alnasser, M., Aljarba, N. and AlBasher, G.I (2021) 'Effects of Green cardamom (Elettaria cardamomum Maton) and its combination with cyclophosphamide on Ehrlich solid tumors', BMC Complementary Medicine and Therapies, 21(1), pp. 133. doi:10.1186/s12906-021-03305-2 Preclinical
https://doi.org/10.1186/s12906-021-03305-2 - Almohammed, H.I., Alkhaibari, A.M. and Alanazi, A.D (2022) 'Antiparasitic effects of Elettaria cardamomum L. essential oil and its main compounds, 1,8-Cineole alone and in combination with albendazole against Echinococcus granulosus protoscoleces', Saudi Journal of Biological Sciences, 29(4), pp. 2811-2818. doi:10.1016/j.sjbs.2022.01.005 Preclinical
https://doi.org/10.1016/j.sjbs.2022.01.005 - Pavarino, M., Marengo, A., Cagliero, C., Bicchi, C., Rubiolo, P. and Sgorbini, B (2023) 'Elettaria cardamomum (L.) Maton Essential Oil: An Interesting Source of Bioactive Specialized Metabolites as Inhibitors of Acetylcholinesterase and Butyrylcholinesterase', Plants, 12(19), pp. 3463. doi:10.3390/plants12193463 Preclinical
https://doi.org/10.3390/plants12193463 - Masoumi-Ardakani, Y., Mahmoudvand, H., Mirzaei, A., Esmaeilpour, K., Ghazvini, H. and Khalifeh, S (2017) 'The effect of Elettaria cardamomum extract on anxiety-like behavior in a rat model of post-traumatic stress disorder', Biomedicine & Pharmacotherapy, 87, pp. 489-495. doi:10.1016/j.biopha.2016.12.116 Preclinical
https://doi.org/10.1016/j.biopha.2016.12.116 - Delgadillo-Puga, C., Torre-Villalvazo, I., Carino-Cervantes, Y.Y., Garcia-Luna, C., Soberanes-Chavez, P. and de Gortari, P (2023) 'Cardamom (Elettaria cardamomum (L.) Maton) Seeds Intake Increases Energy Expenditure and Reduces Fat Mass in Mice by Modulating Neural Circuits That Regulate Adipose Tissue Lipolysis and Mitochondrial Oxidative Metabolism in Liver and Skeletal Muscle', International Journal of Molecular Sciences, 24(4), pp. 3909. doi:10.3390/ijms24043909 Preclinical
https://doi.org/10.3390/ijms24043909 - World Health Organization (2009) 'Semen Cardamomi'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 - Bhilave, M.P., Bhosale, S.V. and Nadaf, S.B (2013) 'Evaluation of antibacterial activity of cardamom seeds of Elettaria cardamomum', 4(1), pp. 66--69. Traditional / reference
https://scholar.google.com/scholar?q=Evaluation%20of%20antibacterial%20activity%20of%20cardamom%20seeds%20of%20Elettaria%20cardamomum - Jamal, A., Javed, K., Aslam, M. and Jafri, M.A (2006) 'Gastroprotective effect of cardamom, Elettaria cardamomum (Maton) Fruits in Rats', 103(2), pp. 149--153. doi:10.1016/j.jep.2005.09.040 Traditional / reference
https://doi.org/10.1016/j.jep.2005.09.040 - Korikanthimath, V.S. and Hiremath, G.M (2002) 'Cardamom (Elettaria cardamomum Maton)', pp. 144--157. Traditional / reference
https://scholar.google.com/scholar?q=Cardamom%20%28Elettaria%20cardamomum%20Maton%29 - Royal Botanic Gardens, Kew (n.d.) 'Elettaria cardamomum (L.) Maton'. Available at: https://powo.science.kew.org/taxon/urn:lsid:http://ipni.org:names:796793-1 Traditional / reference
https://powo.science.kew.org/taxon/urn:lsid:http://ipni.org:names:796793-1 - Verma, S.K., Jain, V. and Katewa, S.S (2009) 'Blood pressure lowering, fibrinolysis enhancing and antioxidant activities of cardamom (Elettaria cardamomum)', 46(6), pp. 503--506. Traditional / reference
https://scholar.google.com/scholar?q=Blood%20pressure%20lowering%2C%20fibrinolysis%20enhancing%20and%20antioxidant%20activities%20of%20cardamom%20%28Elettaria%20cardamomum%29 - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.