Plant Comparison

Aloe Vera vs Devil's Claw

A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.

First plant
Second plant
Show:
Plant AAloe VeraAloe veraAsphodelaceaeFull monograph →
Plant BDevil's ClawHarpagophytum procumbensPedaliaceaeFull monograph →

At a glance

Aloe Vera and Devil's Claw: they share 6 indicated uses (arthritis / joint pain, back pain, headache, …); 2 pharmacological actions in common.

Aloe VeraDevil's Claw
Constituents32
Pharmacological actions62
Indicated uses116
Safety notes23
Cited sources3215
Indicated uses
Only Aloe Vera
BruisingCancer (anticancer research)EczemaInfection (general)Wounds
Shared (6)
Arthritis / joint painBack painHeadacheInflammation (general)Pain (general)Skin irritation
Only Devil's Claw
none
Pharmacological actions
Only Aloe Vera
Anticancer (preclinical)AntimicrobialEmollient / skin-soothingVulnerary (wound healing)
Shared (2)
Analgesic (pain relief)Anti-inflammatory
Only Devil's Claw
none

Evidence face-off — shared uses

ConditionAloe VeraDevil's ClawVerdict
Arthritis / joint pain1/108/10Stronger for Devil's Claw
Back pain1/109/10Stronger for Devil's Claw
Headache1/108/10Stronger for Devil's Claw
Inflammation (general)1/108/10Stronger for Devil's Claw
Pain (general)1/109/10Stronger for Devil's Claw
Skin irritation1/108/10Stronger for Devil's Claw

Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.

Key Constituents

Polysaccharides (acemannan)[1, 13]

Acemannan and other glucomannans are the principal gel polysaccharides, underlying the emollient and wound-healing effects.

PolysaccharidesMucilage
Anthraquinones (aloin, aloe-emodin)[1]

Found mainly in the leaf latex (not the inner gel); responsible for the traditional laxative effect and requiring caution with prolonged use.

Anthraquinones
Enzymes, vitamins and minerals[1]

Minor bioactive enzymes, vitamins (including C and E) and minerals contribute to the antioxidant and skin-conditioning properties of the gel.

Iridoid glycosides (harpagoside, harpagide, procumbide)[12, 13, 14]

Harpagoside is the main marker compound and anti-inflammatory principle; effective extracts are standardised to it, with the better-quality clinical evidence using preparations delivering roughly 50-60 mg harpagoside per day.

Iridoid glycosidesHarpagosideGlycosides
Phenylethanoids (acteoside/verbascoside) and flavonoids[13]

Antioxidant supporting constituents.

Verbascoside (acteoside)Flavonoids

Pharmacological Actions

Analgesic (pain relief)[13, 14, 15, 16, 17, 18, 19, 20]
Anti-inflammatory[1, 2, 7, 10, 11, 13, 14, 15, 16, 17, 18, 19, 20]
Anticancer (preclinical)[21, 22, 23, 24, 25, 26]

Aloe vera and its anthraquinone aloe-emodin show dose-dependent antiproliferative and pro-apoptotic activity against multiple cancer types in vitro and in vivo (preclinical).

Antimicrobial[1, 3, 9, 11, 13, 14, 15, 16, 17, 18, 19, 20]
Emollient / skin-soothing[4, 13, 14, 15, 16, 17, 18, 19, 20]
Vulnerary (wound healing)[4, 5, 8, 10, 13, 14, 15, 16, 17, 18, 19, 20]
Analgesic (pain relief)[1, 2, 4, 6, 7, 9, 10, 12, 13]

Anti-inflammatory and analgesic for osteoarthritis (hip and knee) pain

Anti-inflammatory[1, 3, 4, 5, 6, 8, 9, 11, 12, 13]

Anti-inflammatory and analgesic for osteoarthritis (hip and knee) pain

Traditional & Indicated Uses

Arthritis / joint pain[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Arthritis / joint pain
Back pain[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from analgesic action

Evidence: 1
Label: Back pain
Bruising[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from vulnerary action

Evidence: 1
Label: Bruising
Cancer (anticancer research)[21, 22, 23, 24, 25, 26]Traditional · 2/10

Aloe-emodin, an Aloe vera anthraquinone, induces apoptosis and inhibits growth of gastric, oral squamous, hepatocellular, lung (incl. xenograft) and glioblastoma cancer cells, modulating caspases, Bcl-2/Bax, PI3K/Akt and MEK/ERK signalling (preclinical).

Evidence: 2
Label: Cancer (anticancer research)
Eczema[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from emollient action

Evidence: 1
Label: Eczema
Headache[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from analgesic action

Evidence: 1
Label: Headache
Infection (general)[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1
Label: Infection (general)
Inflammation (general)[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Inflammation (general)
Pain (general)[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10
Evidence: 1
Label: Pain (general)
Skin irritation[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Skin irritation
Wounds[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1
Label: Wounds
Arthritis / joint pain[12, 13]Good · 8/10

Anti-inflammatory and analgesic for osteoarthritis (hip and knee) pain; General joint pain and arthritis support

Evidence: 8
Label: Arthritis / joint pain
Back pain[12, 13, 14, 15]Strong · 9/10

Effective at standardised doses (~50-60 mg harpagoside/day); an aqueous extract was non-inferior to rofecoxib for short-term chronic low back pain; Relief of chronic non-specific low back pain

Evidence: 9
Label: Back pain
Headache[12, 13]Good · 8/10

inferred from analgesic action

Evidence: 8
Label: Headache
Inflammation (general)[12, 13]Good · 8/10

inferred from anti-inflammatory action

Evidence: 8
Label: Inflammation (general)
Pain (general)[12, 13, 14, 15]Strong · 9/10

Anti-inflammatory and analgesic for osteoarthritis (hip and knee) pain; Effective at standardised doses (~50-60 mg harpagoside/day); an aqueous extract was non-inferior to rofecoxib for short-term chronic low back pain; General joint pain and arthritis support; Relief of chronic non-specific low back pain

Evidence: 9
Label: Pain (general)
Skin irritation[12, 13]Good · 8/10

inferred from anti-inflammatory action

Evidence: 8
Label: Skin irritation

Safety, Cautions & Contraindications

Safety note[13, 14, 15, 16, 17, 18, 19, 20]Caution

Topical use of aloe gel is generally safe for most people. Oral use of aloe latex as a laxative is potentially unsafe with prolonged use due to risk of dehydration, electrolyte imbalance, and potential kidney damage. Aloe latex contains anthraquinone glycosides which may cause abdominal cramping and diarrhea. Not recommended during pregnancy or breastfeeding. May interact with diabetes medications, diuretics, and laxatives. Oral aloe gel at typical doses appears safe short-term but long-term safety is unclear. Allergic reactions possible in sensitive individuals.

Safety note[13, 14, 15, 16, 17, 18, 19, 20, 27]Caution

Duke (2002) reports clinical evidence (score 2/3) supporting aloe gel's use in psoriasis, constipation (in adults), and as a vulnerary. Gel preparations have been clinically validated for peptic ulcers (excluding stress-induced), radiation burns, and skin ulcers. Dose: 1 tablespoon gel three times daily or 50–200 mg dried juice equivalent per day as a laxative. An important safety distinction is made: the gel (inner leaf mucilage) is AHPA Class 1 (safe), while the inner leaf juice or dried latex is Class 2b due to anthraquinone content and is contraindicated in intestinal inflammation, colitis, Crohn's disease, appendicitis, and during menstruation (Duke, 2002).

Safety note[13]Caution

Because it is a bitter that increases stomach-acid and bile secretion, it is contraindicated in active peptic ulcer, gastritis and (without medical supervision) gallstones.

Safety note[13]Caution

May add to the effect of anticoagulants (e.g. warfarin) and may influence blood sugar, blood pressure and heart rhythm; use caution with these medicines.

Safety note[13]Caution

Avoid during pregnancy (oxytocic/uterine effect) and while breastfeeding.

External Ids

Gbif: 2777724
Powo: urn:lsid:ipni.org:names:530017-1
Wikidata: Q80079
Gbif: 3585335
Powo: urn:lsid:ipni.org:names:675824-1
Wikidata: Q386675

Botanical Description

Succulent, rosette-forming perennial with thick, fleshy, lance-shaped leaves edged with soft, pale teeth, each leaf filled with a clear, slippery, mucilaginous gel beneath a tougher green rind. In favourable conditions it produces a tall flowering spike bearing tubular yellow (sometimes orange) flowers.[1]

Height: Leaves 40-80 cm; flower spike to about 1 m
Habit: Succulent, rosette-forming perennial
Leaves: Thick, fleshy, lance-shaped, edged with soft pale teeth, filled with clear mucilaginous gel
Flowers: Tubular yellow (occasionally orange) flowers on a tall, unbranched or sparsely branched spike
Stem: Very short, often inconspicuous, below the leaf rosette
Root: Shallow, fibrous roots
Fruit: Capsule (rarely produced in cultivation)
Flowering Period: Varies with climate; typically under warm, dry conditions

Low-growing, sprawling perennial herb with trailing stems and deeply lobed, greyish-green leaves arising from a large, fleshy primary taproot bearing smaller secondary storage tubers (the part used medicinally). Striking funnel-shaped, purplish-pink to violet flowers give way to a distinctive woody fruit covered in long, hooked spines - the origin of the common name.[13]

Height: Trailing stems to 1.5 m, low-growing
Habit: Low-growing, sprawling perennial herb
Leaves: Deeply lobed, greyish-green
Flowers: Funnel-shaped, purplish-pink to violet
Stem: Trailing, sprawling stems
Root: Large primary taproot with smaller secondary storage tubers (the medicinal part)
Fruit: Woody capsule covered in long, hooked spines ('devil's claw')
Flowering Period: Summer (during the rainy season)

Habitat

Believed native to the Arabian Peninsula, and now cultivated and naturalised throughout arid and semi-arid tropical and subtropical regions worldwide as a garden, medicinal and commercial crop.[1]

Native to the dry savannas and semi-desert regions of southern Africa, particularly the Kalahari Desert region of Namibia, Botswana and South Africa.[13]

Harvesting

Outer, mature leaves are cut close to the base as needed; the clear inner gel (mucilage) is separated from the outer rind and from the bitter yellow latex (aloin-containing exudate) just under the rind, since the gel and the latex have different uses and safety profiles.[1]

Parts: Leaf
Season: Year-round where climate permits, from mature outer leaves

The secondary root tubers are dug by hand, sliced and dried in the sun, traditionally by local harvesters in southern Africa; sustainable wild-harvesting practices are important given the plant's slow growth and habitat sensitivity.

Parts: Secondary root tuber

Traditional Uses

Aloe vera has an ancient reputation, recorded from ancient Egypt onward, as a topical remedy for burns, wounds and skin inflammation (the 'burn plant' / 'first aid plant'), and the bitter leaf latex has been used traditionally as a stimulant laxative. It remains one of the most widely used topical botanicals for skin care and minor wound healing.[1]

Devil's claw has a long southern African traditional-medicine history as a remedy for fever, pain and digestive complaints, and is now one of the most clinically studied herbal analgesics for osteoarthritis and chronic low back pain, with standardised extracts showing efficacy comparable to some conventional analgesics in trials.[13]

Preparations

Fresh gel[1]

Clear inner leaf gel applied fresh, or as a stabilised commercial gel, directly to the skin for burns, minor wounds and skin irritation.

Oral juice/gel[1]

Inner leaf gel (latex-free) taken orally, used traditionally for digestive support.

Standardised extract[13, 14]

Root tuber extract standardised to harpagoside content, taken as capsules or tablets; the best-studied clinical form for osteoarthritis and back pain.

Dosage

Topical gel[12]

The WHO monograph on Aloe Vera Gel specifies fresh gel, or preparations containing 10-70% fresh gel, applied to the affected skin area. Educational reference only, not a prescription.

Standardised extract[14]

Clinical trials for osteoarthritis and back pain commonly use extracts providing around 50-60 mg harpagoside daily. Educational reference only, not a prescription.

References

REF-2234, REF-2235, REF-2236, REF-2237, REF-2238, REF-2239, REF-2240, REF-2241, REF-2242, REF-2243, REF-2244
REF-1829, REF-1830, REF-1831, REF-1832, REF-1833, REF-1834, REF-1835, REF-1836, REF-1837, REF-1838, REF-1839

Drug Class Interactions

Safety note[28, 29]Caution
Drug Class: antidiabetics
Mechanism: Aloe vera (taken internally) can lower blood sugar - a meta-analysis found improved fasting glucose in prediabetes and improved HbA1c in type 2 diabetes - so combining it with diabetes medicines may increase the risk of hypoglycaemia; monitor blood glucose.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

Not documented

Lookalikes Review

Outcome: has-lookalikes
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07
Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

Dangerous Lookalikes

Safety note[30, 31, 32]Irritant
Dangerous Plant: agave-americana
Confused Part: Fleshy leaves harvested for their soothing gel; agave forms a very similar large rosette of thick, pointed succulent leaves.
Confusion Context: Aloe vera is grown and harvested for the clear soothing gel inside its fleshy leaves. Agave (Agave americana and relatives) forms a very similar rosette of thick, pointed succulent leaves and, as Gardening Know How notes, the two are easily confused if you have not grown both. But agave is not soothing: its sap contains calcium oxalate raphides, steroidal saponins and acrid oils, and peer-reviewed dermatology reports document painful irritant contact dermatitis (even purpura) from agave sap. Applying or ingesting agave sap in mistake for aloe gel can burn the skin, mouth and gut. Because both are common houseplants and garden succulents, this is a realistic mix-up.
Distinguishing Features: Inside the leaf (decisive): snap or cut a leaf. Aloe leaves are soft and filled with clear, slippery gel. Agave leaves are tough and fibrous/stringy with no gel - you cannot easily snap them by hand., Leaf tip and edge: agave leaves end in one hard, sharp terminal spine and often have stiff sharp teeth; aloe has softer, more pliable leaves with soft whitish teeth and no rigid terminal spike., Whole plant over time: aloe flowers repeatedly on a branched stalk and lives on; agave typically flowers only once, on a huge tall stalk, then dies.
Key Test: Cut a leaf. Clear, slippery gel inside a soft leaf = aloe (safe gel). A tough, fibrous leaf with no gel, ending in a hard sharp spine = agave - its sap is an irritant that can burn skin, mouth and gut, so do not use it. When in doubt, do not apply or consume it unless you are certain it is aloe.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

Not documented

References & Sources

  1. Sanchez, M., Gonzalez-Burgos, E., Iglesias, I. and Gomez-Serranillos, M.P (2020) 'Pharmacological update properties of Aloe vera and its major active constituents', Molecules, 25(6), pp. 1324. doi:10.3390/molecules25061324 Meta-analysis / review
    https://doi.org/10.3390/molecules25061324
  2. Kaur, S. and Bains, K (2023) 'Aloe barbadensis Miller (Aloe vera)', International Journal for Vitamin and Nutrition Research, 94(3-4), pp. 308-321. doi:10.1024/0300-9831/a000797 Meta-analysis / review
    https://doi.org/10.1024/0300-9831/a000797
  3. Catalano, A., Ceramella, J., Iacopetta, D., Marra, M., Conforti, F., Lupi, F.R., Gabriele, D., Borges, F. and Sinicropi, M.S (2024) 'Aloe vera - an extensive review focused on recent studies', Foods, 13(13), pp. 2155. doi:10.3390/foods13132155 Meta-analysis / review
    https://doi.org/10.3390/foods13132155
  4. Surjushe, A., Vasani, R. and Saple, D.G (2008) 'Aloe vera: a short review', Indian Journal of Dermatology, 53(4), pp. 163-166. doi:10.4103/0019-5154.44785 Meta-analysis / review
    https://doi.org/10.4103/0019-5154.44785
  5. Liang, J., Cui, L., Li, J., Guan, S., Zhang, K. and Li, J (2020) 'Aloe vera: a medicinal plant used in skin wound healing', Tissue Engineering Part B: Reviews, 27(5), pp. 455-474. doi:10.1089/ten.TEB.2020.0236 Meta-analysis / review
    https://doi.org/10.1089/ten.TEB.2020.0236
  6. Guo, X. and Mei, N (2016) 'Aloe vera: a review of toxicity and adverse clinical effects', Journal of Environmental Science and Health Part C, 34(2), pp. 77-96. doi:10.1080/10590501.2016.1166826 Meta-analysis / review
    https://doi.org/10.1080/10590501.2016.1166826
  7. Boyapati, R., Peeta, J., Dhulipalla, R., Kolaparthy, L., Adurty, C. and Cheruvu, R.N.S (2024) 'Comparative evaluation of the efficacy of probiotic, Aloe vera, povidine-iodine, and chlorhexidine mouthwashes in the treatment of gingival inflammation: a randomized controlled trial', Dental and Medical Problems, 61(2), pp. 181-190. doi:10.17219/dmp/156425 Randomized trial
    https://doi.org/10.17219/dmp/156425
  8. Hekmatpou, D., Mehrabi, F., Rahzani, K. and Aminiyan, A (2019) 'The effect of Aloe vera clinical trials on prevention and healing of skin wound: a systematic review', Iranian Journal of Medical Sciences, 44(1), pp. 1-9. Meta-analysis / review
    https://scholar.google.com/scholar?q=The%20effect%20of%20Aloe%20vera%20clinical%20trials%20on%20prevention%20and%20healing%20of%20skin%20wound%3A%20a%20systematic%20review
  9. Gao, Y., Kuok, K.I., Jin, Y. and Wang, R (2018) 'Biomedical applications of Aloe vera', Critical Reviews in Food Science and Nutrition, 59(sup1), pp. S244-S256. doi:10.1080/10408398.2018.1496320 Meta-analysis / review
    https://doi.org/10.1080/10408398.2018.1496320
  10. Feily, A. and Namazi, M.R (2009) 'Aloe vera in dermatology: a brief review', Giornale Italiano di Dermatologia e Venereologia, 144(1), pp. 85-91. Meta-analysis / review
    https://scholar.google.com/scholar?q=Aloe%20vera%20in%20dermatology%3A%20a%20brief%20review
  11. Sierra-Garcia, G.D., Castro-Rios, R., Gonzalez-Horta, A., Lara-Arias, J. and Chavez-Montes, A (2014) 'Acemannan, an extracted polysaccharide from Aloe vera: a literature review', Natural Product Communications, 9(8), pp. 1217-1221. doi:10.1177/1934578x1400900836 Meta-analysis / review
    https://doi.org/10.1177/1934578x1400900836
  12. World Health Organization (1999) 'Aloe Vera Gel'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
    https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37
  13. Femenia A, Sánchez ES, Simal S, Rosselló C. Compositional features of polysaccharides from Aloe vera (1999) ';39(2):109-117', 39(2). Traditional / reference
    https://scholar.google.com/scholar?q=%3B39%282%29%3A109-117.
  14. Catalano A, Iacopetta D, Ceramella J, et al. Aloe vera - An extensive review focused on recent studies. Foods. 2024;13 (2024) ';13(13):2155', 13(13). Traditional / reference
    https://scholar.google.com/scholar?q=%3B13%2813%29%3A2155.
  15. Hekmatpou D, Mehrabi F, Rahzani K, Aminiyan A. The effect of Aloe vera clinical trials on prevention and healing of skin wound: A systematic review. Iran J Med Sci. 2019;44 (2019) ';44(1):1-9', 44(1). Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC6330525/ Traditional / reference
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6330525/
  16. National Center for Complementary and Integrative Health. Aloe vera. NIH. 2020. https://www.nccih.nih.gov/health/aloe-vera (2020) 'https://www.nccih.nih.gov/health/aloe-vera'. Available at: https://www.nccih.nih.gov/health/aloe-vera Traditional / reference
    https://www.nccih.nih.gov/health/aloe-vera
  17. Sahu PK, Giri DD, Singh R, et al. Therapeutic and medicinal uses of Aloe vera: A review. Pharmacol Pharm. 2013;4:599-610 (2013) ';4:599-610'. Traditional / reference
    https://scholar.google.com/scholar?q=%3B4%3A599-610.
  18. Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological update properties of Aloe vera and its major active constituents. Molecules. 2020;25 (2020) ';25(6):1324', 25(6). Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC7144722/ Traditional / reference
    https://pmc.ncbi.nlm.nih.gov/articles/PMC7144722/
  19. Surjushe A, Vasani R, Saple DG. Aloe vera: A short review. Indian J Dermatol. 2008;53 (2008) ';53(4):163-166', 53(4). Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC2763764/ Traditional / reference
    https://pmc.ncbi.nlm.nih.gov/articles/PMC2763764/
  20. Ulbricht C, Armstrong J, Basch E, et al. An evidence-based systematic review of Aloe vera by the Natural Standard Research Collaboration. J Herb Pharmacother. 2008;7 (2008) ';7(3-4):279-323'. Available at: https://www.ncbi.nlm.nih.gov/books/NBK92765/ Traditional / reference
    https://www.ncbi.nlm.nih.gov/books/NBK92765/
  21. Haroon, N. and Amjad, A. and Maaz, M. and Noman, A.M. and Anees, N. and Muhammad, Z. and Shah, M. and Al Abdulmonem, W (2026) 'Phytochemistry, Bioavailability, and Molecular Mechanisms Underlying Multitarget Anticancer Activity of Aloe vera', Nutrients, 18(12), pp. 2034. doi:10.3390/nu18122034 Preclinical
    https://doi.org/10.3390/nu18122034
  22. Chen, S.-H. and Lin, K.-Y. and Chang, C.-C. and Fang, C.-L. and Lin, C.-P (2007) 'Aloe-emodin-induced apoptosis in human gastric carcinoma cells', Food and Chemical Toxicology, 45(11), pp. 2296-2303. doi:10.1016/j.fct.2007.06.005 Preclinical
    https://doi.org/10.1016/j.fct.2007.06.005
  23. Li, Q. and Wen, J. and Yu, K. and Shu, Y. and He, W. and Chu, H. and Zhang, B. and Ge, C (2018) 'Aloe-emodin induces apoptosis in human oral squamous cell carcinoma SCC15 cells', BMC Complementary and Alternative Medicine, 18(1), pp. 296. doi:10.1186/s12906-018-2353-z Preclinical
    https://doi.org/10.1186/s12906-018-2353-z
  24. Arcella, A. and Sanchez, M (2021) 'Natural substances to potentiate canonical glioblastoma chemotherapy', Journal of Chemotherapy, 33(5), pp. 276-287. doi:10.1080/1120009X.2021.1873633 Preclinical
    https://doi.org/10.1080/1120009X.2021.1873633
  25. Zhu, M. and He, Q. and Wang, Y. and Duan, L. and Rong, K. and Wu, Y. and Ding, Y. and Mi, Y. and Ge, X. and Yang, X. and Yu, Y (2023) 'Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments', Frontiers in Pharmacology, 14, pp. 1238841. doi:10.3389/fphar.2023.1238841 Preclinical
    https://doi.org/10.3389/fphar.2023.1238841
  26. Kim, H.J. and Choi, J.W. and Ree, J. and Lim, J.S. and Lee, J. and Kim, J.I. and Thapa, S.B. and Sohng, J.K. and Park, Y.I (2022) 'Aloe emodin 3-O-glucoside inhibits cell growth and migration and induces apoptosis of non-small-cell lung cancer cells via suppressing MEK/ERK and Akt signalling pathways', Life Sciences, 300, pp. 120495. doi:10.1016/j.lfs.2022.120495 Preclinical
    https://doi.org/10.1016/j.lfs.2022.120495
  27. Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
    https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
  28. Suksomboon, N., Poolsup, N. and Punthanitisarn, S (2016) 'Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis', Journal of Clinical Pharmacy and Therapeutics, 41(2), pp. 180-188. doi:10.1111/jcpt.12382 Meta-analysis / review
    https://doi.org/10.1111/jcpt.12382
  29. Suksomboon, N., Poolsup, N. and Punthanitisarn, S (2016) 'Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis', Journal of Clinical Pharmacy and Therapeutics, 41(2), pp. 180-188. doi:10.1111/jcpt.12382 Meta-analysis / review
    https://doi.org/10.1111/jcpt.12382
  30. Gardening Know How 'Aloe Vs. Agave Plants: What's The Difference Between Aloe And Agave'. Available at: https://www.gardeningknowhow.com/ornamental/cacti-succulents/scgen/how-to-tell-agave-and-aloe-apart.htm Traditional / reference
    https://www.gardeningknowhow.com/ornamental/cacti-succulents/scgen/how-to-tell-agave-and-aloe-apart.htm
  31. Ricks, M.R. and Vogel, P.S. and Elston, D.M. and Hivnor, C (1999) 'Purpuric agave dermatitis', Journal of the American Academy of Dermatology, 40(2 Pt 2), pp. 356-8. doi:10.1016/s0190-9622(99)70485-8 Clinical study
    https://doi.org/10.1016/s0190-9622(99)70485-8
  32. Genillier-Foin, N. and Avenel-Audran, M (2007) 'Purpuric contact dermatitis from Agave americana', Annales de Dermatologie et de Venereologie, 134(5 Pt 1), pp. 477-8. doi:10.1016/s0151-9638(07)89218-0 Clinical study
    https://doi.org/10.1016/s0151-9638(07)89218-0
  1. Mncwangi, N., Chen, W., Vermaak, I., Viljoen, A.M. and Gericke, N (2012) 'Devil's Claw - a review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens', Journal of Ethnopharmacology, 143(3), pp. 755-771. doi:10.1016/j.jep.2012.08.013 Meta-analysis / review
    https://doi.org/10.1016/j.jep.2012.08.013
  2. Parenti, C., Arico, G., Pennisi, M., Venditti, A. and Scoto, G.M (2015) 'Harpagophytum procumbens extract potentiates morphine antinociception in neuropathic rats', Natural Product Research, 30(11), pp. 1248-1255. doi:10.1080/14786419.2015.1052069 Preclinical
    https://doi.org/10.1080/14786419.2015.1052069
  3. Mariano, A., Bigioni, I., Mattioli, R., Di Sotto, A., Leopizzi, M., Garzoli, S., Mariani, P.F., Dalla Vedova, P., Ammendola, S. and Scotto d'Abusco, A (2022) 'Harpagophytum procumbens Root Extract Mediates Anti-Inflammatory Effects in Osteoarthritis Synoviocytes through CB2 Activation', Pharmaceuticals, 15(4), pp. 457. doi:10.3390/ph15040457 Preclinical
    https://doi.org/10.3390/ph15040457
  4. Gxaba, N. and Manganyi, M.C (2022) 'The Fight against Infection and Pain: Devil's Claw (Harpagophytum procumbens) a Rich Source of Anti-Inflammatory Activity: 2011-2022', Molecules, 27(11), pp. 3637. doi:10.3390/molecules27113637 Meta-analysis / review
    https://doi.org/10.3390/molecules27113637
  5. Menghini, L., Recinella, L., Leone, S., Chiavaroli, A., Cicala, C., Brunetti, L., Vladimir-Knezevic, S., Orlando, G. and Ferrante, C (2019) 'Devil's claw (Harpagophytum procumbens) and chronic inflammatory diseases: A concise overview on preclinical and clinical data', Phytotherapy Research, 33(9), pp. 2152-2162. doi:10.1002/ptr.6395 Meta-analysis / review
    https://doi.org/10.1002/ptr.6395
  6. Brien, S., Lewith, G.T. and McGregor, G (2006) 'Devil's Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: a review of efficacy and safety', Journal of Alternative and Complementary Medicine, 12(10), pp. 981-993. doi:10.1089/acm.2006.12.981 Meta-analysis / review
    https://doi.org/10.1089/acm.2006.12.981
  7. Ungerer, G., Cui, J., Ndam, T., Bekemeier, M., Song, H., Li, R., Siedhoff, H.R., Yang, B., Appenteng, M.K., Greenlief, C.M., Miller, D.K., Sun, G.Y., Folk, W.R. and Gu, Z (2020) 'Harpagophytum procumbens Extract Ameliorates Allodynia and Modulates Oxidative and Antioxidant Stress Pathways in a Rat Model of Spinal Cord Injury', Neuromolecular Medicine, 22(2), pp. 278-292. doi:10.1007/s12017-019-08585-z Preclinical
    https://doi.org/10.1007/s12017-019-08585-z
  8. Recinella, L., Chiavaroli, A., Ronci, M., Menghini, L., Brunetti, L., Leone, S., Tirillini, B., Angelini, P., Covino, S., Venanzoni, R., Zengin, G., Di Simone, S., Ciferri, M.C., di Giacomo, V., Cataldi, A., Rapino, M., Valerio, V.D., Orlando, G. and Ferrante, C (2020) 'Multidirectional Pharma-Toxicological Study on Harpagophytum procumbens DC. ex Meisn.: An IBD-Focused Investigation', Antioxidants, 9(2), pp. 168. doi:10.3390/antiox9020168 Preclinical
    https://doi.org/10.3390/antiox9020168
  9. Baghdikian, B., Lanhers, M.C., Fleurentin, J., Ollivier, E., Maillard, C., Balansard, G. and Mortier, F (1997) 'An analytical study, anti-inflammatory and analgesic effects of Harpagophytum procumbens and Harpagophytum zeyheri', Planta Medica, 63(2), pp. 171-176. doi:10.1055/s-2006-957638 Preclinical
    https://doi.org/10.1055/s-2006-957638
  10. Lim, D.W., Kim, J.G., Han, D. and Kim, Y.T (2014) 'Analgesic effect of Harpagophytum procumbens on postoperative and neuropathic pain in rats', Molecules, 19(1), pp. 1060-1068. doi:10.3390/molecules19011060 Preclinical
    https://doi.org/10.3390/molecules19011060
  11. Jang, M., Lim, S., Han, S., Park, H., Shin, I., Kim, J., Kim, N., Lee, J., Kim, K. and Kim, C (2003) 'Harpagophytum procumbens suppresses lipopolysaccharide-stimulated expressions of cyclooxygenase-2 and inducible nitric oxide synthase in fibroblast cell line L929', Journal of Pharmacological Sciences, 93(3), pp. 367-371. doi:10.1254/jphs.93.367 Preclinical
    https://doi.org/10.1254/jphs.93.367
  12. Chrubasik, S (2004) 'Devil's claw extract as an example of the effectiveness of herbal analgesics', Der Orthopade. doi:10.1007/s00132-004-0675-7 Clinical study
    https://doi.org/10.1007/s00132-004-0675-7
  13. Brendler, T., Gruenwald, J., Ulbricht, C. and Basch, E (2006) 'Devil's Claw (Harpagophytum procumbens DC): an evidence-based systematic review by the Natural Standard Research Collaboration', Journal of Herbal Pharmacotherapy. doi:10.1080/j157v06n01_09 Meta-analysis / review
    https://doi.org/10.1080/j157v06n01_09
  14. Chrubasik, S., Conradt, C. and Roufogalis, B.D (2004) 'Effectiveness of Harpagophytum extracts and clinical efficacy', Phytotherapy Research, 18(2), pp. 187--189. doi:10.1002/ptr.1416 Preclinical
    https://doi.org/10.1002/ptr.1416
  15. Gagnier, J.J., Chrubasik, S. and Manheimer, E (2004) 'Harpagophytum procumbens for osteoarthritis and low back pain: a systematic review', BMC Complementary and Alternative Medicine. doi:10.1186/1472-6882-4-13 Meta-analysis / review
    https://doi.org/10.1186/1472-6882-4-13

Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.