Plant Comparison

Aloe Vera vs Greater Celandine

A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.

First plant
Second plant
Show:
Plant AAloe VeraAloe veraAsphodelaceaeFull monograph →
Plant BGreater CelandineChelidonium majusPapaveraceaeFull monograph →

At a glance

Aloe Vera and Greater Celandine: they share 9 indicated uses (arthritis / joint pain, back pain, cancer (anticancer research), …); 4 pharmacological actions in common.

Aloe VeraGreater Celandine
Constituents33
Pharmacological actions66
Indicated uses1115
Safety notes22
Cited sources3214
Indicated uses
Only Aloe Vera
BruisingEczema
Shared (9)
Arthritis / joint painBack painCancer (anticancer research)HeadacheInfection (general)Inflammation (general)Pain (general)Skin irritationWounds
Only Greater Celandine
BloatingIndigestionLiver supportMenstrual crampsMuscle spasmWarts
Pharmacological actions
Only Aloe Vera
Emollient / skin-soothingVulnerary (wound healing)
Shared (4)
Analgesic (pain relief)Anti-inflammatoryAnticancer (preclinical)Antimicrobial
Only Greater Celandine
AntispasmodicCholeretic / cholagogue (bile flow)

Evidence face-off — shared uses

ConditionAloe VeraGreater CelandineVerdict
Arthritis / joint pain1/101/10Comparable evidence
Back pain1/101/10Comparable evidence
Cancer (anticancer research)2/102/10Comparable evidence
Headache1/101/10Comparable evidence
Infection (general)1/101/10Comparable evidence
Inflammation (general)1/101/10Comparable evidence
Pain (general)1/101/10Comparable evidence
Skin irritation1/101/10Comparable evidence
Wounds1/101/10Comparable evidence

Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.

Key Constituents

Polysaccharides (acemannan)[1, 13]

Acemannan and other glucomannans are the principal gel polysaccharides, underlying the emollient and wound-healing effects.

PolysaccharidesMucilage
Anthraquinones (aloin, aloe-emodin)[1]

Found mainly in the leaf latex (not the inner gel); responsible for the traditional laxative effect and requiring caution with prolonged use.

Anthraquinones
Enzymes, vitamins and minerals[1]

Minor bioactive enzymes, vitamins (including C and E) and minerals contribute to the antioxidant and skin-conditioning properties of the gel.

Isoquinoline alkaloids (chelidonine, coptisine, berberine, sanguinarine, chelerythrine)[4]

The biologically active and toxicologically important constituents.

AlkaloidsBerberine
Flavonoids and phenolic acids[4]

Antioxidant constituents.

Phenolic acidsFlavonoids
Orange latex (alkaloid-rich sap)[4]

The caustic sap used traditionally on warts.

Alkaloids

Pharmacological Actions

Analgesic (pain relief)[13, 14, 15, 16, 17, 18, 19, 20]
Anti-inflammatory[1, 2, 7, 10, 11, 13, 14, 15, 16, 17, 18, 19, 20]
Anticancer (preclinical)[21, 22, 23, 24, 25, 26]

Aloe vera and its anthraquinone aloe-emodin show dose-dependent antiproliferative and pro-apoptotic activity against multiple cancer types in vitro and in vivo (preclinical).

Antimicrobial[1, 3, 9, 11, 13, 14, 15, 16, 17, 18, 19, 20]
Emollient / skin-soothing[4, 13, 14, 15, 16, 17, 18, 19, 20]
Vulnerary (wound healing)[4, 5, 8, 10, 13, 14, 15, 16, 17, 18, 19, 20]
Analgesic (pain relief)[4]

Anti-inflammatory, antimicrobial and analgesic (preclinical)

Anti-inflammatory[1, 4, 8]

Anti-inflammatory, antimicrobial and analgesic (preclinical)

Anticancer (preclinical)[6, 7, 12]
Antimicrobial[1, 3, 4, 10]

Anti-inflammatory, antimicrobial and analgesic (preclinical)

Antispasmodic[4]

Antispasmodic / choleretic bitter for upper-abdominal and biliary dyspepsia (indigestion, bloating, cramping) - oral use now restricted for safety

Choleretic / cholagogue (bile flow)[4]

Antispasmodic / choleretic bitter for upper-abdominal and biliary dyspepsia (indigestion, bloating, cramping) - oral use now restricted for safety

Traditional & Indicated Uses

Arthritis / joint pain[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Arthritis / joint pain
Back pain[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from analgesic action

Evidence: 1
Label: Back pain
Bruising[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from vulnerary action

Evidence: 1
Label: Bruising
Cancer (anticancer research)[21, 22, 23, 24, 25, 26]Traditional · 2/10

Aloe-emodin, an Aloe vera anthraquinone, induces apoptosis and inhibits growth of gastric, oral squamous, hepatocellular, lung (incl. xenograft) and glioblastoma cancer cells, modulating caspases, Bcl-2/Bax, PI3K/Akt and MEK/ERK signalling (preclinical).

Evidence: 2
Label: Cancer (anticancer research)
Eczema[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from emollient action

Evidence: 1
Label: Eczema
Headache[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from analgesic action

Evidence: 1
Label: Headache
Infection (general)[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1
Label: Infection (general)
Inflammation (general)[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Inflammation (general)
Pain (general)[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10
Evidence: 1
Label: Pain (general)
Skin irritation[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Skin irritation
Wounds[13, 14, 15, 16, 17, 18, 19, 20]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1
Label: Wounds
Arthritis / joint pain[4]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Arthritis / joint pain
Back pain[4]Traditional · 1/10

inferred from analgesic action

Evidence: 1
Label: Back pain
Bloating[4]Traditional · 1/10

Antispasmodic / choleretic bitter for upper-abdominal and biliary dyspepsia (indigestion, bloating, cramping) - oral use now restricted for safety

Evidence: 1
Label: Bloating
Cancer (anticancer research)[6, 7, 12]Traditional · 2/10

inferred from anticancer action

Evidence: 2
Label: Cancer (anticancer research)
Headache[4]Traditional · 1/10

inferred from analgesic action

Evidence: 1
Label: Headache
Indigestion[4]Traditional · 1/10

Antispasmodic / choleretic bitter for upper-abdominal and biliary dyspepsia (indigestion, bloating, cramping) - oral use now restricted for safety

Evidence: 1
Label: Indigestion
Infection (general)[4]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1
Label: Infection (general)
Inflammation (general)[4]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Inflammation (general)
Liver support[4]Traditional · 1/10

inferred from choleretic action

Evidence: 1
Label: Liver support
Menstrual cramps[4]Traditional · 1/10

inferred from antispasmodic action

Evidence: 1
Label: Menstrual cramps
Muscle spasm[4]Traditional · 1/10

inferred from antispasmodic action

Evidence: 1
Label: Muscle spasm
Pain (general)[4]Traditional · 1/10

inferred from analgesic action

Evidence: 1
Label: Pain (general)
Skin irritation[4]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Skin irritation
Warts[4]Traditional · 1/10

Fresh orange latex traditionally dabbed on warts

Evidence: 1
Label: Warts
Wounds[4]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1
Label: Wounds

Safety, Cautions & Contraindications

Safety note[13, 14, 15, 16, 17, 18, 19, 20]Caution

Topical use of aloe gel is generally safe for most people. Oral use of aloe latex as a laxative is potentially unsafe with prolonged use due to risk of dehydration, electrolyte imbalance, and potential kidney damage. Aloe latex contains anthraquinone glycosides which may cause abdominal cramping and diarrhea. Not recommended during pregnancy or breastfeeding. May interact with diabetes medications, diuretics, and laxatives. Oral aloe gel at typical doses appears safe short-term but long-term safety is unclear. Allergic reactions possible in sensitive individuals.

Safety note[13, 14, 15, 16, 17, 18, 19, 20, 27]Caution

Duke (2002) reports clinical evidence (score 2/3) supporting aloe gel's use in psoriasis, constipation (in adults), and as a vulnerary. Gel preparations have been clinically validated for peptic ulcers (excluding stress-induced), radiation burns, and skin ulcers. Dose: 1 tablespoon gel three times daily or 50–200 mg dried juice equivalent per day as a laxative. An important safety distinction is made: the gel (inner leaf mucilage) is AHPA Class 1 (safe), while the inner leaf juice or dried latex is Class 2b due to anthraquinone content and is contraindicated in intestinal inflammation, colitis, Crohn's disease, appendicitis, and during menstruation (Duke, 2002).

Safety note[13, 14]Serious

SERIOUS: oral greater celandine can cause acute idiosyncratic liver injury (hepatocellular hepatotoxicity with jaundice). Multiple reported cases - dozens of herb-induced liver injury reports in the literature, with continuing recent case reports - led regulators to restrict or suspend oral products. Do not take internally if you have any liver disease, and stop immediately and seek care at any sign of liver problems (jaundice, dark urine, upper-abdominal pain).

Safety note[4, 13]Caution

Avoid in pregnancy and breastfeeding. The fresh orange latex is irritant and caustic - keep it away from the eyes and broken skin.

External Ids

Gbif: 2777724
Powo: urn:lsid:ipni.org:names:530017-1
Wikidata: Q80079
Gbif: 5334186
Wikidata: Q156807

Botanical Description

Succulent, rosette-forming perennial with thick, fleshy, lance-shaped leaves edged with soft, pale teeth, each leaf filled with a clear, slippery, mucilaginous gel beneath a tougher green rind. In favourable conditions it produces a tall flowering spike bearing tubular yellow (sometimes orange) flowers.[1]

Height: Leaves 40-80 cm; flower spike to about 1 m
Habit: Succulent, rosette-forming perennial
Leaves: Thick, fleshy, lance-shaped, edged with soft pale teeth, filled with clear mucilaginous gel
Flowers: Tubular yellow (occasionally orange) flowers on a tall, unbranched or sparsely branched spike
Stem: Very short, often inconspicuous, below the leaf rosette
Root: Shallow, fibrous roots
Fruit: Capsule (rarely produced in cultivation)
Flowering Period: Varies with climate; typically under warm, dry conditions

Branching perennial herb with soft, brittle, hairy stems that exude a distinctive bright orange-yellow latex (sap) when cut or broken. The leaves are deeply lobed, pale bluish-green beneath, giving a delicate, almost fern-like appearance. Small, four-petalled, bright yellow flowers are borne in loose umbel-like clusters.[4]

Height: 30-90 cm
Habit: Branching, brittle-stemmed perennial herb
Leaves: Deeply lobed, pale bluish-green beneath
Flowers: Small, four-petalled, bright yellow, in loose umbel-like clusters
Stem: Soft, brittle, hairy, exuding bright orange-yellow latex when broken
Root: Branching taproot, also exuding orange latex
Fruit: Slender, curved capsule
Flowering Period: April-September

Habitat

Believed native to the Arabian Peninsula, and now cultivated and naturalised throughout arid and semi-arid tropical and subtropical regions worldwide as a garden, medicinal and commercial crop.[1]

Grows in shaded, nutrient-rich ground - hedgerows, walls, waste ground and woodland edges, often near old buildings; native to Europe and Western Asia and naturalised in North America.[4]

Harvesting

Outer, mature leaves are cut close to the base as needed; the clear inner gel (mucilage) is separated from the outer rind and from the bitter yellow latex (aloin-containing exudate) just under the rind, since the gel and the latex have different uses and safety profiles.[1]

Parts: Leaf
Season: Year-round where climate permits, from mature outer leaves

The flowering aerial parts are cut in spring to summer; the fresh orange latex is collected by breaking a stem or leaf as needed for topical (wart) use. Given the documented hepatotoxicity of oral preparations, harvesting for internal use is not recommended.[4]

Parts: Aerial parts (and fresh orange latex)
Season: Spring to summer, while flowering

Traditional Uses

Aloe vera has an ancient reputation, recorded from ancient Egypt onward, as a topical remedy for burns, wounds and skin inflammation (the 'burn plant' / 'first aid plant'), and the bitter leaf latex has been used traditionally as a stimulant laxative. It remains one of the most widely used topical botanicals for skin care and minor wound healing.[1]

Greater celandine has a long European folk history, reflected in its name 'tetterwort', as a topical remedy for warts and skin blemishes (the fresh orange latex dabbed directly on), and internally as a bitter choleretic digestive remedy for biliary and upper-abdominal dyspepsia - though oral use is now medically restricted because of documented liver injury.[4]

Preparations

Fresh gel[1]

Clear inner leaf gel applied fresh, or as a stabilised commercial gel, directly to the skin for burns, minor wounds and skin irritation.

Oral juice/gel[1]

Inner leaf gel (latex-free) taken orally, used traditionally for digestive support.

Fresh latex (topical, warts only)[4]

Fresh orange latex from a broken stem dabbed directly onto warts, the classic external folk use; kept well away from eyes, mucous membranes and broken skin.

Infusion/tincture (historical, oral - restricted)[13]

Historically taken as an infusion or tincture for biliary dyspepsia, but oral use is now restricted in several jurisdictions due to hepatotoxicity risk and should only be considered under professional supervision, if at all.

Dosage

Topical gel[12]

The WHO monograph on Aloe Vera Gel specifies fresh gel, or preparations containing 10-70% fresh gel, applied to the affected skin area. Educational reference only, not a prescription.

All internal preparations[13, 14]

Because of a documented risk of acute liver injury, no internal dose is given here; oral use should be avoided, especially by anyone with liver disease, and any sign of jaundice, dark urine or upper-abdominal pain warrants immediate medical attention. Educational reference only, not a prescription.

References

REF-2234, REF-2235, REF-2236, REF-2237, REF-2238, REF-2239, REF-2240, REF-2241, REF-2242, REF-2243, REF-2244
REF-0770, REF-0771, REF-0772, REF-0460, REF-2264, REF-2265, REF-2266, REF-2267, REF-2268, REF-2269, REF-2270, REF-2271

Drug Class Interactions

Safety note[28, 29]Caution
Drug Class: antidiabetics
Mechanism: Aloe vera (taken internally) can lower blood sugar - a meta-analysis found improved fasting glucose in prediabetes and improved HbA1c in type 2 diabetes - so combining it with diabetes medicines may increase the risk of hypoglycaemia; monitor blood glucose.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

Not documented

Lookalikes Review

Outcome: has-lookalikes
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07
Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

Dangerous Lookalikes

Safety note[30, 31, 32]Irritant
Dangerous Plant: agave-americana
Confused Part: Fleshy leaves harvested for their soothing gel; agave forms a very similar large rosette of thick, pointed succulent leaves.
Confusion Context: Aloe vera is grown and harvested for the clear soothing gel inside its fleshy leaves. Agave (Agave americana and relatives) forms a very similar rosette of thick, pointed succulent leaves and, as Gardening Know How notes, the two are easily confused if you have not grown both. But agave is not soothing: its sap contains calcium oxalate raphides, steroidal saponins and acrid oils, and peer-reviewed dermatology reports document painful irritant contact dermatitis (even purpura) from agave sap. Applying or ingesting agave sap in mistake for aloe gel can burn the skin, mouth and gut. Because both are common houseplants and garden succulents, this is a realistic mix-up.
Distinguishing Features: Inside the leaf (decisive): snap or cut a leaf. Aloe leaves are soft and filled with clear, slippery gel. Agave leaves are tough and fibrous/stringy with no gel - you cannot easily snap them by hand., Leaf tip and edge: agave leaves end in one hard, sharp terminal spine and often have stiff sharp teeth; aloe has softer, more pliable leaves with soft whitish teeth and no rigid terminal spike., Whole plant over time: aloe flowers repeatedly on a branched stalk and lives on; agave typically flowers only once, on a huge tall stalk, then dies.
Key Test: Cut a leaf. Clear, slippery gel inside a soft leaf = aloe (safe gel). A tough, fibrous leaf with no gel, ending in a hard sharp spine = agave - its sap is an irritant that can burn skin, mouth and gut, so do not use it. When in doubt, do not apply or consume it unless you are certain it is aloe.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

Not documented

References & Sources

  1. Sanchez, M., Gonzalez-Burgos, E., Iglesias, I. and Gomez-Serranillos, M.P (2020) 'Pharmacological update properties of Aloe vera and its major active constituents', Molecules, 25(6), pp. 1324. doi:10.3390/molecules25061324 Meta-analysis / review
    https://doi.org/10.3390/molecules25061324
  2. Kaur, S. and Bains, K (2023) 'Aloe barbadensis Miller (Aloe vera)', International Journal for Vitamin and Nutrition Research, 94(3-4), pp. 308-321. doi:10.1024/0300-9831/a000797 Meta-analysis / review
    https://doi.org/10.1024/0300-9831/a000797
  3. Catalano, A., Ceramella, J., Iacopetta, D., Marra, M., Conforti, F., Lupi, F.R., Gabriele, D., Borges, F. and Sinicropi, M.S (2024) 'Aloe vera - an extensive review focused on recent studies', Foods, 13(13), pp. 2155. doi:10.3390/foods13132155 Meta-analysis / review
    https://doi.org/10.3390/foods13132155
  4. Surjushe, A., Vasani, R. and Saple, D.G (2008) 'Aloe vera: a short review', Indian Journal of Dermatology, 53(4), pp. 163-166. doi:10.4103/0019-5154.44785 Meta-analysis / review
    https://doi.org/10.4103/0019-5154.44785
  5. Liang, J., Cui, L., Li, J., Guan, S., Zhang, K. and Li, J (2020) 'Aloe vera: a medicinal plant used in skin wound healing', Tissue Engineering Part B: Reviews, 27(5), pp. 455-474. doi:10.1089/ten.TEB.2020.0236 Meta-analysis / review
    https://doi.org/10.1089/ten.TEB.2020.0236
  6. Guo, X. and Mei, N (2016) 'Aloe vera: a review of toxicity and adverse clinical effects', Journal of Environmental Science and Health Part C, 34(2), pp. 77-96. doi:10.1080/10590501.2016.1166826 Meta-analysis / review
    https://doi.org/10.1080/10590501.2016.1166826
  7. Boyapati, R., Peeta, J., Dhulipalla, R., Kolaparthy, L., Adurty, C. and Cheruvu, R.N.S (2024) 'Comparative evaluation of the efficacy of probiotic, Aloe vera, povidine-iodine, and chlorhexidine mouthwashes in the treatment of gingival inflammation: a randomized controlled trial', Dental and Medical Problems, 61(2), pp. 181-190. doi:10.17219/dmp/156425 Randomized trial
    https://doi.org/10.17219/dmp/156425
  8. Hekmatpou, D., Mehrabi, F., Rahzani, K. and Aminiyan, A (2019) 'The effect of Aloe vera clinical trials on prevention and healing of skin wound: a systematic review', Iranian Journal of Medical Sciences, 44(1), pp. 1-9. Meta-analysis / review
    https://scholar.google.com/scholar?q=The%20effect%20of%20Aloe%20vera%20clinical%20trials%20on%20prevention%20and%20healing%20of%20skin%20wound%3A%20a%20systematic%20review
  9. Gao, Y., Kuok, K.I., Jin, Y. and Wang, R (2018) 'Biomedical applications of Aloe vera', Critical Reviews in Food Science and Nutrition, 59(sup1), pp. S244-S256. doi:10.1080/10408398.2018.1496320 Meta-analysis / review
    https://doi.org/10.1080/10408398.2018.1496320
  10. Feily, A. and Namazi, M.R (2009) 'Aloe vera in dermatology: a brief review', Giornale Italiano di Dermatologia e Venereologia, 144(1), pp. 85-91. Meta-analysis / review
    https://scholar.google.com/scholar?q=Aloe%20vera%20in%20dermatology%3A%20a%20brief%20review
  11. Sierra-Garcia, G.D., Castro-Rios, R., Gonzalez-Horta, A., Lara-Arias, J. and Chavez-Montes, A (2014) 'Acemannan, an extracted polysaccharide from Aloe vera: a literature review', Natural Product Communications, 9(8), pp. 1217-1221. doi:10.1177/1934578x1400900836 Meta-analysis / review
    https://doi.org/10.1177/1934578x1400900836
  12. World Health Organization (1999) 'Aloe Vera Gel'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
    https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37
  13. Femenia A, Sánchez ES, Simal S, Rosselló C. Compositional features of polysaccharides from Aloe vera (1999) ';39(2):109-117', 39(2). Traditional / reference
    https://scholar.google.com/scholar?q=%3B39%282%29%3A109-117.
  14. Catalano A, Iacopetta D, Ceramella J, et al. Aloe vera - An extensive review focused on recent studies. Foods. 2024;13 (2024) ';13(13):2155', 13(13). Traditional / reference
    https://scholar.google.com/scholar?q=%3B13%2813%29%3A2155.
  15. Hekmatpou D, Mehrabi F, Rahzani K, Aminiyan A. The effect of Aloe vera clinical trials on prevention and healing of skin wound: A systematic review. Iran J Med Sci. 2019;44 (2019) ';44(1):1-9', 44(1). Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC6330525/ Traditional / reference
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6330525/
  16. National Center for Complementary and Integrative Health. Aloe vera. NIH. 2020. https://www.nccih.nih.gov/health/aloe-vera (2020) 'https://www.nccih.nih.gov/health/aloe-vera'. Available at: https://www.nccih.nih.gov/health/aloe-vera Traditional / reference
    https://www.nccih.nih.gov/health/aloe-vera
  17. Sahu PK, Giri DD, Singh R, et al. Therapeutic and medicinal uses of Aloe vera: A review. Pharmacol Pharm. 2013;4:599-610 (2013) ';4:599-610'. Traditional / reference
    https://scholar.google.com/scholar?q=%3B4%3A599-610.
  18. Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological update properties of Aloe vera and its major active constituents. Molecules. 2020;25 (2020) ';25(6):1324', 25(6). Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC7144722/ Traditional / reference
    https://pmc.ncbi.nlm.nih.gov/articles/PMC7144722/
  19. Surjushe A, Vasani R, Saple DG. Aloe vera: A short review. Indian J Dermatol. 2008;53 (2008) ';53(4):163-166', 53(4). Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC2763764/ Traditional / reference
    https://pmc.ncbi.nlm.nih.gov/articles/PMC2763764/
  20. Ulbricht C, Armstrong J, Basch E, et al. An evidence-based systematic review of Aloe vera by the Natural Standard Research Collaboration. J Herb Pharmacother. 2008;7 (2008) ';7(3-4):279-323'. Available at: https://www.ncbi.nlm.nih.gov/books/NBK92765/ Traditional / reference
    https://www.ncbi.nlm.nih.gov/books/NBK92765/
  21. Haroon, N. and Amjad, A. and Maaz, M. and Noman, A.M. and Anees, N. and Muhammad, Z. and Shah, M. and Al Abdulmonem, W (2026) 'Phytochemistry, Bioavailability, and Molecular Mechanisms Underlying Multitarget Anticancer Activity of Aloe vera', Nutrients, 18(12), pp. 2034. doi:10.3390/nu18122034 Preclinical
    https://doi.org/10.3390/nu18122034
  22. Chen, S.-H. and Lin, K.-Y. and Chang, C.-C. and Fang, C.-L. and Lin, C.-P (2007) 'Aloe-emodin-induced apoptosis in human gastric carcinoma cells', Food and Chemical Toxicology, 45(11), pp. 2296-2303. doi:10.1016/j.fct.2007.06.005 Preclinical
    https://doi.org/10.1016/j.fct.2007.06.005
  23. Li, Q. and Wen, J. and Yu, K. and Shu, Y. and He, W. and Chu, H. and Zhang, B. and Ge, C (2018) 'Aloe-emodin induces apoptosis in human oral squamous cell carcinoma SCC15 cells', BMC Complementary and Alternative Medicine, 18(1), pp. 296. doi:10.1186/s12906-018-2353-z Preclinical
    https://doi.org/10.1186/s12906-018-2353-z
  24. Arcella, A. and Sanchez, M (2021) 'Natural substances to potentiate canonical glioblastoma chemotherapy', Journal of Chemotherapy, 33(5), pp. 276-287. doi:10.1080/1120009X.2021.1873633 Preclinical
    https://doi.org/10.1080/1120009X.2021.1873633
  25. Zhu, M. and He, Q. and Wang, Y. and Duan, L. and Rong, K. and Wu, Y. and Ding, Y. and Mi, Y. and Ge, X. and Yang, X. and Yu, Y (2023) 'Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments', Frontiers in Pharmacology, 14, pp. 1238841. doi:10.3389/fphar.2023.1238841 Preclinical
    https://doi.org/10.3389/fphar.2023.1238841
  26. Kim, H.J. and Choi, J.W. and Ree, J. and Lim, J.S. and Lee, J. and Kim, J.I. and Thapa, S.B. and Sohng, J.K. and Park, Y.I (2022) 'Aloe emodin 3-O-glucoside inhibits cell growth and migration and induces apoptosis of non-small-cell lung cancer cells via suppressing MEK/ERK and Akt signalling pathways', Life Sciences, 300, pp. 120495. doi:10.1016/j.lfs.2022.120495 Preclinical
    https://doi.org/10.1016/j.lfs.2022.120495
  27. Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
    https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
  28. Suksomboon, N., Poolsup, N. and Punthanitisarn, S (2016) 'Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis', Journal of Clinical Pharmacy and Therapeutics, 41(2), pp. 180-188. doi:10.1111/jcpt.12382 Meta-analysis / review
    https://doi.org/10.1111/jcpt.12382
  29. Suksomboon, N., Poolsup, N. and Punthanitisarn, S (2016) 'Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis', Journal of Clinical Pharmacy and Therapeutics, 41(2), pp. 180-188. doi:10.1111/jcpt.12382 Meta-analysis / review
    https://doi.org/10.1111/jcpt.12382
  30. Gardening Know How 'Aloe Vs. Agave Plants: What's The Difference Between Aloe And Agave'. Available at: https://www.gardeningknowhow.com/ornamental/cacti-succulents/scgen/how-to-tell-agave-and-aloe-apart.htm Traditional / reference
    https://www.gardeningknowhow.com/ornamental/cacti-succulents/scgen/how-to-tell-agave-and-aloe-apart.htm
  31. Ricks, M.R. and Vogel, P.S. and Elston, D.M. and Hivnor, C (1999) 'Purpuric agave dermatitis', Journal of the American Academy of Dermatology, 40(2 Pt 2), pp. 356-8. doi:10.1016/s0190-9622(99)70485-8 Clinical study
    https://doi.org/10.1016/s0190-9622(99)70485-8
  32. Genillier-Foin, N. and Avenel-Audran, M (2007) 'Purpuric contact dermatitis from Agave americana', Annales de Dermatologie et de Venereologie, 134(5 Pt 1), pp. 477-8. doi:10.1016/s0151-9638(07)89218-0 Clinical study
    https://doi.org/10.1016/s0151-9638(07)89218-0
  1. Li, X.L., Sun, Y.P., Wang, M., Wang, Z.B. and Kuang, H.X (2024) 'Alkaloids in Chelidonium majus L.: a review of its phytochemistry, pharmacology and toxicology', Frontiers in Pharmacology, 15, pp. 1440979. doi:10.3389/fphar.2024.1440979 Traditional / reference
    https://doi.org/10.3389/fphar.2024.1440979
  2. Koriem, K.M.M., Arbid, M.S. and Asaad, G.F (2012) 'Chelidonium majus leaves methanol extract and its chelidonine alkaloid ingredient reduce cadmium-induced nephrotoxicity in rats', Journal of Natural Medicines, 67(1), pp. 159-167. doi:10.1007/s11418-012-0667-6 Preclinical
    https://doi.org/10.1007/s11418-012-0667-6
  3. Nawrot, R (2017) 'Defense-related Proteins from Chelidonium majus L. as Important Components of its Latex', Current Protein & Peptide Science, 18(8), pp. 864-880. doi:10.2174/1389203718666170406124013 Traditional / reference
    https://doi.org/10.2174/1389203718666170406124013
  4. Gilca, M., Gaman, L., Panait, E., Stoian, I. and Atanasiu, V (2010) 'Chelidonium majus - an integrative review: traditional knowledge versus modern findings', Forschende Komplementarmedizin. doi:10.1159/000321397 Traditional / reference
    https://doi.org/10.1159/000321397
  5. Popovic, A., Deljanin, M., Popovic, S., Todorovic, D., Djurdjevic, P., Matic, S., Stankovic, M., Avramovic, D. and Baskic, D (2021) 'Chelidonium majus crude extract induces activation of peripheral blood mononuclear cells and enhances their cytotoxic effect toward HeLa cells', International Journal of Environmental Health Research, 32(7), pp. 1554-1566. doi:10.1080/09603123.2021.1897534 Preclinical
    https://doi.org/10.1080/09603123.2021.1897534
  6. Shen, L., Lee, S.A., Joo, J.C., Hong, E., Cui, Z.Y., Jo, E., Park, S.J. and Jang, H.J (2022) 'Chelidonium majus induces apoptosis of human ovarian cancer cells via ATF3-mediated regulation of Foxo3a by Tip60', Journal of Microbiology and Biotechnology, 32(4), pp. 493-503. doi:10.4014/jmb.2109.09030 Preclinical
    https://doi.org/10.4014/jmb.2109.09030
  7. Deljanin, M., Nikolic, M., Baskic, D., Todorovic, D., Djurdjevic, P., Zaric, M., Stankovic, M., Todorovic, M., Avramovic, D. and Popovic, S (2016) 'Chelidonium majus crude extract inhibits migration and induces cell cycle arrest and apoptosis in tumor cell lines', Journal of Ethnopharmacology, 190, pp. 362-371. doi:10.1016/j.jep.2016.06.056 Preclinical
    https://doi.org/10.1016/j.jep.2016.06.056
  8. Warowicka, A., Qasem, B., Dera-Szymanowska, A., Wolun-Cholewa, M., Florczak, P., Horst, N., Napierala, M., Szymanowski, K., Popenda, L., Bartkowiak, G., Florek, E., Gozdzicka-Jozefiak, A. and Mlynarz, P (2021) 'Effect of protoberberine-rich fraction of Chelidonium majus L. on endometriosis regression', Pharmaceutics, 13(7), pp. 931. doi:10.3390/pharmaceutics13070931 Preclinical
    https://doi.org/10.3390/pharmaceutics13070931
  9. Kadan, G., Gozler, T. and Hesse, M (1992) '(+)-Norchelidonine from Chelidonium majus', Planta Medica, 58(5), pp. 477. doi:10.1055/s-2006-961523 Preclinical
    https://doi.org/10.1055/s-2006-961523
  10. Musidlak, O., Warowicka, A., Broniarczyk, J., Adamczyk, D., Gozdzicka-Jozefiak, A. and Nawrot, R (2022) 'The activity of Chelidonium majus L. latex and its components on HPV reveal insights into the antiviral molecular mechanism', International Journal of Molecular Sciences, 23(16), pp. 9241. doi:10.3390/ijms23169241 Preclinical
    https://doi.org/10.3390/ijms23169241
  11. Zhang, W., You, C., Wang, C., Fan, L., Wang, Y., Su, Y., Deng, Z. and Du, S (2014) 'One new alkaloid from Chelidonium majus L', Natural Product Research, 28(21), pp. 1873-1878. doi:10.1080/14786419.2014.953497 Preclinical
    https://doi.org/10.1080/14786419.2014.953497
  12. Capistrano I, R., Wouters, A., Lardon, F., Gravekamp, C., Apers, S. and Pieters, L (2015) 'In vitro and in vivo investigations on the antitumour activity of Chelidonium majus', Phytomedicine, 22(14), pp. 1279-1287. doi:10.1016/j.phymed.2015.10.013 Preclinical
    https://doi.org/10.1016/j.phymed.2015.10.013
  13. Teschke, R., Frenzel, C., Glass, X., Schulze, J. and Eickhoff, A (2012) 'Greater Celandine hepatotoxicity: a clinical review', Annals of Hepatology. doi:10.1016/s1665-2681(19)31408-5 Clinical study
    https://doi.org/10.1016/s1665-2681(19)31408-5
  14. Ciornolutchii, V., Ismaiel, A., Sabo, C.M., Al Hajjar, N., Seicean, A. and Dumitrascu, D.L (2024) 'A Hidden Cause of Hypertransaminasemia: Liver Toxicity Caused by Chelidonium Majus L. Report of Two Cases of Herb-Induced Liver Injury and Literature Review', American Journal of Therapeutics, 31(4), pp. e382--e387. doi:10.1097/MJT.0000000000001708 Clinical study
    https://doi.org/10.1097/MJT.0000000000001708

Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.