Plant Comparison
Lady’s-mantle vs Scots Pine
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Lady’s-mantle and Scots Pine: they share 5 indicated uses (arthritis / joint pain, cancer (anticancer research), inflammation (general), …); 3 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Lady’s-mantle | Scots Pine | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 2/10 | 2/10 | Comparable evidence |
| Cancer (anticancer research) | 2/10 | 2/10 | Comparable evidence |
| Inflammation (general) | 2/10 | 2/10 | Comparable evidence |
| Skin irritation | 2/10 | 2/10 | Comparable evidence |
| Wounds | 1/10 | 2/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Lady's mantle is rich in ellagitannins and other tannins (the basis of its astringency) together with phenolic acids (gallic and caffeic acids) and flavonoids such as quercetin and catechin, which underlie its antioxidant activity.
The needle oil is dominated by monoterpene hydrocarbons, chiefly alpha-pinene, giving the characteristic resinous scent and much of its antimicrobial activity.
The resinous sap/pitch, traditionally used topically for wounds and skin complaints.
The needle is traditionally valued as a source of vitamin C, particularly in winter.
Pharmacological Actions
Alchemilla vulgaris extracts (aerial parts and root) show antioxidant, genoprotective and antitumor activity against multiple human cancer cell lines (preclinical).
Traditional & Indicated Uses
inferred from anti-inflammatory action
Alchemilla vulgaris extracts suppress the growth of MCF-7, A375, A549, HCT116 (aerial parts) and PC-3, MCF-7, Caco-2 (root) cancer cells via caspase-dependent apoptosis and autophagy, while protecting normal cells (preclinical).
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from expectorant action
inferred from anticancer action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from diuretic action
inferred from diuretic action
inferred from diuretic action
Safety, Cautions & Contraindications
Generally considered very safe. One of the gentlest astringent herbs in European herbalism. No significant drug interactions. Tannin content means very high doses should be avoided in sensitive stomachs. Not significantly contraindicated in pregnancy at normal herbal tea doses, but medicinal doses should be used cautiously.
Duke (2002) rates lady's mantle as ++ and notes astringent, angioprotective, anti-inflammatory, and vulnerary activities at the experimental level (score 1). The plant is rich in tannins and is traditionally used for diarrhea, wound healing, and as a mild gynecological tonic. Duke notes its anti-inflammatory and antioxidant properties as experimentally supported. No significant safety concerns are noted at usual herbal doses; the plant is generally well-tolerated (Duke, 2002).
Generally safe in normal amounts. Pine essential oil should not be ingested; topical use only in diluted form. May irritate airways in high concentrations. Allergic reactions to pine pollen and resin are common. Turpentine products are irritant and potentially toxic if ingested.
Duke (2002) rates Scotch pine as + and notes antiseptic, antibacterial (score 1), and bronchospasmolytic activities. Commission E (KOM) and PhEur (PIP) approve pine needle preparations for topical use in rheumatic and neuralgic conditions and for inhalations in upper respiratory catarrh. Duke cautions that pine needle oil should not be inhaled by patients with severe asthma, whooping cough, or laryngospasm. Pine bud preparations are traditionally used for bronchitis and sinus congestion. Dose: 100–200 mg essential oil in ointment or cream for topical use (Duke, 2002).
External Ids
Botanical Description
Low, clump-forming perennial herb with distinctive rounded, softly hairy leaves divided into 7-11 shallow, scalloped, toothed lobes, fanning out like a cloak (giving the genus name Alchemilla, 'little alchemist', after the dew drops that collect in the leaf centre, once prized by alchemists). Tiny, petal-less, yellow-green flowers are borne in loose, branching clusters above the foliage.[14]
Evergreen coniferous tree (Pinaceae), 15-35 m tall, with a long, straight trunk at maturity, distinctive orange-red flaking bark in the upper crown and grey-brown fissured bark at the base. Needles are blue-green, borne in pairs (fascicles of two) with a papery basal sheath. Small yellow male cones release pollen in spring; female cones are woody and mature over two years.[11]
Habitat
Grows in damp meadows, pastures, mountain grassland, streamsides and open woodland, typically on moist, nutrient-rich soils; native to Europe and parts of temperate Asia, favouring cooler upland and northern regions.[14]
Native across northern and central Europe and Siberia - the most widely distributed pine species in the world - forming extensive boreal and montane forests on poor, sandy or peaty, acidic soils; a pioneer species tolerant of dry, nutrient-poor ground.[11]
Harvesting
The leaves and flowering tops are gathered in summer while the plant is in flower, and dried in a warm, shaded, airy place.[14]
Young shoots ('candles') and needles are gathered in spring; bark is stripped from felled or cultivated trees; resin/sap is tapped from the trunk. Needle-bearing twigs can be cut for tea and for steam distillation of the essential oil year-round.[11]
Traditional Uses
Lady's mantle has long been used in European herbal medicine as a gentle astringent for menstrual complaints and as a mild gynaecological tonic, and topically for minor wounds and skin inflammation, reflecting its tannin-rich astringent character.[15]
Scots pine has a long northern European tradition as a source of resinous, aromatic preparations for respiratory complaints (coughs, bronchitis, catarrh) and topical rheumatic/muscular remedies, and pine-needle tea has traditionally been valued as a vitamin-C-rich winter tonic. Modern research on the needle essential oil supports antimicrobial, anti-inflammatory and expectorant activity.[11, 12]
Preparations
Dried leaf and flowering tops infused in hot water, traditionally taken for menstrual complaints and mild digestive upset.
Fresh or dried young needles steeped in hot water - the traditional vitamin-C-rich tonic tea. Only use needles from a certainly identified pine, never yew (see dangerous look-alikes).
Steam-distilled from the needles; used diluted in ointments, chest rubs or steam inhalation for respiratory complaints.
References
Lookalikes Review
Dosage
Dangerous Lookalikes
Not documented
References & Sources
- Jelaca, S., Jovanovic, I., Bovan, D., Jovanovic, M.Z., Jurisevic, M.M., Dundjerovic, D. and others (2024) 'Dual Role of Alchemilla vulgaris L. Extract in Breast Cancer Regression: Reestablishment of Effective Immune Response', Pharmaceuticals, 17(3). doi:10.3390/ph17030286 Preclinical
https://doi.org/10.3390/ph17030286 - Jelaca, S., Jovanovic, I., Bovan, D., Pavlovic, S., Gajovic, N., Dundjerovic, D. and others (2024) 'Antimelanoma Effects of Alchemilla vulgaris: A Comprehensive In Vitro and In Vivo Study', Diseases, 12(6). doi:10.3390/diseases12060125 Preclinical
https://doi.org/10.3390/diseases12060125 - Kanak, S., Krzeminska, B., Celinski, R., Bakalczuk, M. and Dos Santos Szewczyk, K (2022) 'Phenolic composition and antioxidant activity of Alchemilla species', Plants, 11(20), pp. 2709. doi:10.3390/plants11202709 Meta-analysis / review
https://doi.org/10.3390/plants11202709 - Jakimiuk, K. and Tomczyk, M (2023) 'A review of the traditional uses, phytochemistry, pharmacology, and clinical evidence for the use of the genus Alchemilla (Rosaceae)', Journal of Ethnopharmacology, 320, pp. 117439. doi:10.1016/j.jep.2023.117439 Meta-analysis / review
https://doi.org/10.1016/j.jep.2023.117439 - Jelaca, S., Dajic-Stevanovic, Z., Vukovic, N., Kolasinac, S., Trendafilova, A., Nedialkov, P. and others (2022) 'Beyond Traditional Use of Alchemilla vulgaris: Genoprotective and Antitumor Activity In Vitro', Molecules, 27(23). doi:10.3390/molecules27238113 Traditional / reference
https://doi.org/10.3390/molecules27238113 - Anajirih, N., Abdeen, A., Taher, E.S., Abdelkader, A., Abd-Ellatieff, H.A., Gewaily, M.S. and others (2024) 'Alchemilla vulgaris modulates isoproterenol-induced cardiotoxicity: interplay of oxidative stress, inflammation, autophagy, and apoptosis', Frontiers in Pharmacology. doi:10.3389/fphar.2024.1394557 Preclinical
https://doi.org/10.3389/fphar.2024.1394557 - Karaoglan, E.S., Bayir, Y., Albayrak, A., Toktay, E., Ozgen, U., Kazaz, C., Kahramanlar, A. and Cadirci, E (2020) 'Isolation of major compounds and gastroprotective activity of Alchemilla on indomethacin induced gastric ulcers in rats', Eurasian Journal of Medicine, 52(3), pp. 249-253. doi:10.5152/eurasianjmed.2020.19243 Preclinical
https://doi.org/10.5152/eurasianjmed.2020.19243 - Vlaisavljevic, S., Jelaca, S., Zengin, G., Mimica-Dukic, N., Berezni, S., Miljic, M. and Dajic Stevanovic, Z (2019) 'Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties', RSC Advances, 9(64), pp. 37474--37483. doi:10.1039/c9ra08231j Preclinical
https://doi.org/10.1039/c9ra08231j - Kupeli Akkol, E., Demirel, M.A., Bahadir Acikara, O., Suntar, I., Ergene, B., Ilhan, M., Ozbilgin, S., Saltan, G., Keles, H. and Tekin, M (2015) 'Phytochemical analyses and effects of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in rat endometriosis model', Archives of Gynecology and Obstetrics, 292(3), pp. 619-628. doi:10.1007/s00404-015-3665-6 Preclinical
https://doi.org/10.1007/s00404-015-3665-6 - Dos Santos Szewczyk, K., Pietrzak, W., Klimek, K., Grzywa-Celinska, A., Celinski, R. and Gogacz, M (2022) 'LC-ESI-MS/MS identification of biologically active phenolics in different extracts of Alchemilla acutiloba Opiz', Molecules, 27(3), pp. 621. doi:10.3390/molecules27030621 Preclinical
https://doi.org/10.3390/molecules27030621 - Ozbek, H., Acikara, O.B., Keskin, I., Kirmizi, N.I., Ozbilgin, S., Oz, B.E., Kurtul, E., Ozrenk, B.C., Tekin, M. and Saltan, G (2016) 'Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis', Biomedicine & Pharmacotherapy, 86, pp. 172-176. doi:10.1016/j.biopha.2016.12.005 Preclinical
https://doi.org/10.1016/j.biopha.2016.12.005 - Krivokuca, M., Niketic, M., Milenkovic, M., Golic, N., Masia, C., Scaltrito, M.M., Sisto, F. and Kundakovic, T (2015) 'Anti-Helicobacter pylori activity of four Alchemilla species (Rosaceae)', Natural Product Communications, 10(8), pp. 1369-1371. doi:10.1177/1934578x1501000814 Preclinical
https://doi.org/10.1177/1934578x1501000814 - Duckstein, S.M., Lotter, E.M., Meyer, U., Lindequist, U. and Stintzing, F.C (2013) 'Phenolic constituents from Alchemilla vulgaris L. and Alchemilla mollis (Buser) Rothm. at different dates of harvest', Zeitschrift fur Naturforschung C, 68(1-2), pp. 529-540. doi:10.1515/znc-2012-11-1201 Preclinical
https://doi.org/10.1515/znc-2012-11-1201 - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - Hoffmann, D (2003) 'Medical Herbalism: The Science and Practice of Herbal Medicine'. Traditional / reference
https://scholar.google.com/scholar?q=Medical%20Herbalism%3A%20The%20Science%20and%20Practice%20of%20Herbal%20Medicine - Pauli, A. and Schilcher, H (2012) 'In vitro antimicrobial activities of essential oils monographed in the European Pharmacopoeia 6th edition'. Traditional / reference
https://scholar.google.com/scholar?q=In%20vitro%20antimicrobial%20activities%20of%20essential%20oils%20monographed%20in%20the%20European%20Pharmacopoeia%206th%20edition - Ibrahim, O.H.M. and Abo-Elyousr, K.A.M. and Asiry, K.A. and Alhakamy, N.A. and Mousa, M.A.A (2022) 'Phytochemical Characterization, Antimicrobial Activity and In Vitro Antiproliferative Potential of Alchemilla vulgaris Auct Root Extract against Prostate (PC-3), Breast (MCF-7) and Colorectal Adenocarcinoma (Caco-2) Cancer Cell Lines', Plants, 11(16), pp. 2140. doi:10.3390/plants11162140 Preclinical
https://doi.org/10.3390/plants11162140 - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
- Jurado, P., Uruen, C., Martinez, S., Lain, E. and others (2023) 'Essential oils of Pinus sylvestris, Citrus limon and Origanum vulgare exhibit high bactericidal and anti-biofilm activities against Neisseria gonorrhoeae and Streptococcus suis', Biomedicine & Pharmacotherapy, 168, pp. 115703. doi:10.1016/j.biopha.2023.115703 Preclinical
https://doi.org/10.1016/j.biopha.2023.115703 - Csikos, E., Cseko, K., Kemeny, A., Draskoczi, L. and others (2022) 'Pinus sylvestris L. and Syzygium aromaticum (L.) Merr. & L. M. Perry Essential Oils Inhibit Endotoxin-Induced Airway Hyperreactivity despite Aggravated Inflammatory Mechanisms in Mice', Molecules, 27(12), pp. 3868. doi:10.3390/molecules27123868 Preclinical
https://doi.org/10.3390/molecules27123868 - Allenspach, M., Valder, C., Flamm, D., Grisoni, F. and others (2020) 'Verification of Chromatographic Profile of Primary Essential Oil of Pinus sylvestris L. Combined with Chemometric Analysis', Molecules, 25(13), pp. 2973. doi:10.3390/molecules25132973 Preclinical
https://doi.org/10.3390/molecules25132973 - Allenspach, M., Valder, C., Flamm, D. and Steuer, C (2021) 'Authenticity control of Pinus sylvestris essential oil by chiral gas chromatographic analysis of alpha-pinene', Scientific Reports, 11(1), pp. 16923. doi:10.1038/s41598-021-96356-x Preclinical
https://doi.org/10.1038/s41598-021-96356-x - Rodrigues, A.M., Mendes, M.D., Lima, A.S., Barbosa, P.M. and others (2017) 'Pinus halepensis, Pinus pinaster, Pinus pinea and Pinus sylvestris Essential Oils Chemotypes and Monoterpene Hydrocarbon Enantiomers', Chemistry & Biodiversity, 14(1), pp. e1600153. doi:10.1002/cbdv.201600153 Preclinical
https://doi.org/10.1002/cbdv.201600153 - Judzentiene, A., Stikliene, A. and Kupcinskiene, E (2007) 'Changes in the essential oil composition in the needles of Scots pine (Pinus sylvestris L.) under anthropogenic stress', The Scientific World Journal, 7(Suppl 1), pp. 141-150. doi:10.1100/tsw.2007.36 Preclinical
https://doi.org/10.1100/tsw.2007.36 - Hoai, N.T., Duc, H.V., Thao, D.T., Orav, A. and others (2015) 'Selectivity of Pinus sylvestris extract and essential oil to estrogen-insensitive breast cancer cells', Pharmacognosy Magazine, 11(Suppl 2), pp. S290-S295. doi:10.4103/0973-1296.166052 Preclinical
https://doi.org/10.4103/0973-1296.166052 - Fayemiwo, K.A., Adeleke, M.A., Okoro, O.P., Awojide, S.H. and others (2014) 'Larvicidal efficacies and chemical composition of essential oils of Pinus sylvestris and Syzygium aromaticum against mosquitoes', Asian Pacific Journal of Tropical Biomedicine, 4(1), pp. 30-34. doi:10.1016/S2221-1691(14)60204-5 Preclinical
https://doi.org/10.1016/S2221-1691(14)60204-5 - Scalas, D., Mandras, N., Roana, J., Tardugno, R. and others (2018) 'Use of Pinus sylvestris L. (Pinaceae), Origanum vulgare L. (Lamiaceae), and Thymus vulgaris L. (Lamiaceae) essential oils and their main components to enhance itraconazole activity against azole susceptible/not-susceptible Cryptococcus neoformans strains', BMC Complementary and Alternative Medicine, 18(1), pp. 143. doi:10.1186/s12906-018-2219-4 Preclinical
https://doi.org/10.1186/s12906-018-2219-4 - Suntar, I., Tumen, I., Ustun, O., Keles, H. and others (2012) 'Appraisal on the wound healing and anti-inflammatory activities of the essential oils obtained from the cones and needles of Pinus species by in vivo and in vitro experimental models', Journal of Ethnopharmacology, 139(2), pp. 533-540. doi:10.1016/j.jep.2011.11.045 Preclinical
https://doi.org/10.1016/j.jep.2011.11.045 - Grieve, M (1931) 'A Modern Herbal'. Traditional / reference
https://scholar.google.com/scholar?q=A%20Modern%20Herbal - Bakkali, F. et al (2008) 'Biological effects of essential oils — a review', 46(2), pp. 446--475. doi:10.1016/j.fct.2007.09.106 Preclinical
https://doi.org/10.1016/j.fct.2007.09.106 - Sousa, A. et al (2010) 'Proanthocyanidins from Pinus pinaster bark', 71(1), pp. 64--72. Traditional / reference
https://scholar.google.com/scholar?q=Proanthocyanidins%20from%20Pinus%20pinaster%20bark - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Missouri Poison Center 'Pine Needles'. Available at: https://missouripoisoncenter.org/is-this-a-poison/pine-needles/ Traditional / reference
https://missouripoisoncenter.org/is-this-a-poison/pine-needles/ - Arens, A.M. and Anaebere, T.C. and Horng, H. and Olson, K (2016) 'Fatal Taxus baccata ingestion with perimortem serum taxine B quantification', Clinical Toxicology (Philadelphia, Pa.), 54(9), pp. 878-880. doi:10.1080/15563650.2016.1209765 Clinical study
https://doi.org/10.1080/15563650.2016.1209765 - Froldi, R. and Croci, P.F. and Dell'Acqua, L. and Fare, F. and Tassoni, G. and Gambaro, V (2010) 'Preliminary gas chromatography with mass spectrometry determination of 3,5-dimethoxyphenol in biological specimens as evidence of taxus poisoning', Journal of Analytical Toxicology, 34(1), pp. 53-6. doi:10.1093/jat/34.1.53 Clinical study
https://doi.org/10.1093/jat/34.1.53
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.