Plant Comparison
Agrimony vs Greater Plantain
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Agrimony and Greater Plantain: they share 8 indicated uses (arthritis / joint pain, bruising, cancer (anticancer research), …); 5 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Agrimony | Greater Plantain | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 2/10 | 1/10 | Comparable evidence |
| Bruising | 2/10 | 1/10 | Comparable evidence |
| Cancer (anticancer research) | 2/10 | 2/10 | Comparable evidence |
| Diarrhoea | 1/10 | 1/10 | Comparable evidence |
| Inflammation (general) | 2/10 | 1/10 | Comparable evidence |
| Skin irritation | 1/10 | 1/10 | Comparable evidence |
| Sore throat | 2/10 | 1/10 | Comparable evidence |
| Wounds | 2/10 | 2/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Responsible for the characteristic astringency.
Antioxidant and anti-inflammatory constituents.
Characteristic iridoids of Plantago major.
Polyphenolic esters contributing to antioxidant and anti-inflammatory activity.
Flavonoid constituents of the leaf.
Pharmacological Actions
Anti-inflammatory gargle (mild inflammation of the mouth and throat / sore throat)
Agrimonia eupatoria ethanolic extract is cytotoxic to breast, colon, lung and cervical cancer cells and inhibits the PI3K/Akt/mTOR pathway (preclinical/in silico).
Traditional & Indicated Uses
inferred from bitter-tonic action
inferred from anti-inflammatory action
Agrimonia eupatoria ethanolic extract shows dose-dependent cytotoxicity against MCF-7 (breast), HT-29 (colon), A549 (lung) and HeLa (cervical) cancer cells and inhibits the PI3K/Akt/mTOR/COX-2/MMP-2 axis (preclinical).
Astringent (relief of mild diarrhoea)
Mild bitter digestive tonic (indigestion)
Anti-inflammatory gargle (mild inflammation of the mouth and throat / sore throat); Vulnerary (minor skin inflammation and small superficial wounds, topical)
inferred from astringent action
Anti-inflammatory gargle (mild inflammation of the mouth and throat / sore throat)
inferred from anti-inflammatory action
inferred from expectorant action
inferred from vulnerary action
Demulcent / expectorant (coughs, catarrh, irritated airways)
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from expectorant action
inferred from anti-inflammatory action
inferred from vulnerary action
P. major extract showed immunomodulatory, antiviral and cytotoxic effects in vitro.
P. major extracts/compounds inhibited proliferation of cancer cell lines (preclinical).
Safety, Cautions & Contraindications
Traditional-use indication only: if diarrhoea persists longer than 3-4 days, or symptoms of mouth/throat inflammation persist beyond about a week, a doctor should be consulted.
Use during pregnancy and breastfeeding is not recommended, as safety has not been established.
Extremely safe; one of the most widely used edible and medicinal plants in the world. Psyllium seeds (closely related) are well-studied as a bulk laxative but should always be taken with adequate water. Allergic reactions are rare but possible. No significant drug interactions documented at normal doses.
Duke (2002) rates plantain as ++ and notes anti-inflammatory, antitussive, antiatherosclerotic, and COX-2-inhibitory activities at the experimental level (score 1). The seeds (psyllium) of related species have clinical evidence for cholesterol reduction and as bulk laxatives, though entries here apply to the leaf. Dose: leaf as tea or poultice for wounds, sore throat, and bronchial conditions. Duke notes the plant is generally safe with anti-inflammatory topical use well-supported in traditional practice. Commission E approved plantain (ribwort species) for catarrh and wound healing (Duke, 2002).
Generally regarded as safe as food and in customary medicinal use; allergic reactions are uncommon, though the abundant wind-borne pollen can aggravate hay fever in sensitive people.
Correct identification is essential and material should be gathered away from roadsides, sprayed lawns and other contaminated ground; deep or infected wounds warrant proper medical care.
External Ids
Botanical Description
Slender, downy perennial herb with a basal rosette of pinnately compound leaves and a single, unbranched, upright flowering stem. The leaflets are toothed, alternating large and small, and silvery-downy beneath. Small, five-petalled, bright yellow flowers are borne closely along a slender terminal spike (raceme), opening a few at a time from the base upwards, giving the old name 'church steeples'. After flowering, small bristly, hooked burrs form that cling to clothing and animal fur for dispersal.[13, 14]
Low, rosette-forming perennial herb (Plantaginaceae) with broad, oval to rounded leaves marked by 5-9 prominent parallel ribs, borne on long, channelled petioles. Slender, leafless flowering spikes rise from the rosette bearing tiny, densely packed greenish flowers, followed by small seed capsules.[36]
Habitat
Native to Europe and temperate Asia and now one of the most widespread naturalised weeds worldwide (the name 'waybread', or historically 'white man's foot', reflects its spread along paths and trails); thrives on compacted, disturbed ground such as paths, lawns and roadsides.[36]
Harvesting
The flowering aerial parts are cut in summer, at the start of flowering, and dried promptly in a warm, airy, shaded place.[13]
Leaves are gathered fresh throughout the growing season, especially for poultice use; seed is collected in autumn once ripe.[36]
Traditional Uses
Agrimony has a long folk history as an astringent remedy for mild diarrhoea, as a gargle for sore throats and mild mouth/throat inflammation, and as a mild bitter digestive tonic; it has also been applied topically to minor wounds and skin inflammation. It is officially recognised in the European Union herbal monograph for traditional use in mild diarrhoea and mild inflammation of the mouth or throat.[13, 14]
Greater plantain is one of the most widely used wound herbs across world folk-medicine traditions, applied fresh as a poultice to cuts, stings and insect bites, and taken as a tea for cough, digestive upset and mild diarrhoea. Modern reviews confirm broad anti-inflammatory, antimicrobial, antioxidant and wound-healing activity supporting these traditional uses.[1, 36]
Preparations
Crushed or chewed fresh leaf applied directly to wounds, stings and insect bites - the classic traditional first-aid use.
Dried leaf steeped in hot water for cough, digestive complaints and mild diarrhoea.
The mucilaginous seed, related to psyllium, used traditionally as a mild bulk laxative.
Dosage
The EU herbal monograph gives 1.5-4 g of the comminuted herb in 250 mL (or less) of boiling water as an infusion, 2-3 times daily, in adolescents, adults and elderly. As a gargle for mild oral or throat inflammation, 1.5 g in 150 mL of boiling water 2-4 times daily, or a decoction of 3-4.5 g in 250 mL 2-3 times daily. Educational reference only, not a prescription.
The EU herbal monograph gives 1-4 mL three times daily (orally, or as a gargle for oral and throat use). Educational reference only, not a prescription.
References
Lookalikes Review
References & Sources
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https://doi.org/10.1076/phbi.35.2.99.13288 - Atibayeva, А.E. and Тыныкулов, М (2024) 'ANTI-INFLAMMATORY ACTIVITY OF PLANTAGO MAJOR LEAF EXTRACTS IN VITRO ON EPITHELIAL CELLS OF THE ORAL CAVITY', Vestnik of M Kozybayev North Kazakhstan University. doi:10.54596/2958-0048-2024-2-48-53 Preclinical
https://doi.org/10.54596/2958-0048-2024-2-48-53 - Zhakipbekov, K. and Turgumbayeva, A. and Issayeva, R. and Kipchakbayeva, A. and Kadyrbayeva, G. and Tleubayeva, M.I. and Akhayeva, T. and Тастамбек, К. and Sainova, G.A. and Serikbayeva, E. and Tolenova, K. and Махатова, Б. and Anarbayeva, R. and Shimirova, Z. and Tileuberdi, Y (2023) 'Antimicrobial and Other Biomedical Properties of Extracts from Plantago major, Plantaginaceae', Pharmaceuticals. doi:10.3390/ph16081092 Preclinical
https://doi.org/10.3390/ph16081092 - Povnitsa, O. and Bilyavska, L. and Pankivska, Y. and Likhanov, A. and Dorovskyh, A. and Лысенко, В.С. and Lokshin, M.M. and Zahorodnia, S (2021) 'In vitro Antiviral Activity of Leaf Extracts Plantago major, Plantago lanceolata, Rubus idaeus', Mikrobiolohichnyi Zhurnal. doi:10.15407/microbiolj84.01.044 Preclinical
https://doi.org/10.15407/microbiolj84.01.044 - Han, A.Y. and Nam, M. and Lee, K (2016) 'Plantamajoside Inhibits UVB and Advanced Glycation End Products‐Induced MMP‐1 Expression by Suppressing the MAPK and NF‐κB Pathways in HaCaT Cells', Photochemistry and Photobiology. doi:10.1111/php.12615 Preclinical
https://doi.org/10.1111/php.12615 - Shirley, K.P. and Windsor, L.J. and Eckert, G.J. and Gregory, R.L (2015) 'In Vitro Effects of Plantago Major Extract, Aucubin, and Baicalein on Candida albicans Biofilm Formation, Metabolic Activity, and Cell Surface Hydrophobicity', Journal of Prosthodontics. doi:10.1111/jopr.12411 Preclinical
https://doi.org/10.1111/jopr.12411 - Samuelsen, A.B (2000) 'The traditional uses, chemical constituents and biological activities of Plantago major L. A review', 8741(00), pp. 1--21. doi:10.1016/s0378-8741(00)00212-9 Traditional / reference
https://doi.org/10.1016/s0378-8741(00)00212-9 - Grieve, M (1931). Available at: https://botanical.com/botanical/mgmh/p/planta14.html Traditional / reference
https://botanical.com/botanical/mgmh/p/planta14.html - Herbal Reality (n.d.) 'Plantain (Plantago major): Benefits, Safety, Uses'. Available at: https://www.herbalreality.com/herb/plantain/ Traditional / reference
https://www.herbalreality.com/herb/plantain/ - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - Samuelsen, A.B (2000) 'The traditional uses, chemical constituents and biological activities of Plantago major L.: a review', pp. 1--21. Traditional / reference
https://scholar.google.com/scholar?q=The%20traditional%20uses%2C%20chemical%20constituents%20and%20biological%20activities%20of%20Plantago%20major%20L.%3A%20a%20review - World Health Organization (2002) 'WHO Monographs on Selected Medicinal Plants'. Traditional / reference
https://scholar.google.com/scholar?q=WHO%20Monographs%20on%20Selected%20Medicinal%20Plants - Zubair, M., Ekholm, A., Nybom, H., Renvert, S., Widen, C. and Rumpunen, K (2012) 'Effects of Plantago major L. leaf extracts on oral epithelial cells in a scratch assay', 141(3), pp. 825--830. doi:10.1016/j.jep.2012.03.016 Traditional / reference
https://doi.org/10.1016/j.jep.2012.03.016 - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - The Herbal Medic (n.d.) 'Plantain (Plantago lanceolata) - Wound Healing & Respiratory Support Herb'. Available at: https://theherbalmedic.co.uk/plantain-plantago-lanceolate Traditional / reference
https://theherbalmedic.co.uk/plantain-plantago-lanceolate - A Wandering Botanist (2013) 'Plant Story - Plantains (Plantago), Tracking Your Footsteps All Over the World'. Available at: http://khkeeler.blogspot.com/2013/11/plant-story-plantains-plantago-tracking.html Traditional / reference
http://khkeeler.blogspot.com/2013/11/plant-story-plantains-plantago-tracking.html - Edible Wild Food (n.d.) 'Broadleaf Plantain (Plantago major)'. Available at: https://www.ediblewildfood.com/broadleaf-plantain.aspx Traditional / reference
https://www.ediblewildfood.com/broadleaf-plantain.aspx - Florida School of Holistic Living (n.d.). Available at: https://www.holisticlivingschool.org/2020/02/25/march-plantain/ Traditional / reference
https://www.holisticlivingschool.org/2020/02/25/march-plantain/ - Living Plant Wisdom (n.d.) 'Living Plant Wisdom Profile: Plantain (Plantago major)'. Available at: https://holisticfarming.substack.com/p/living-plant-wisdom-profile-plantain Traditional / reference
https://holisticfarming.substack.com/p/living-plant-wisdom-profile-plantain - Nine Herbs Charm (n.d.). Available at: https://en.wikipedia.org/wiki/Nine_Herbs_Charm Traditional / reference
https://en.wikipedia.org/wiki/Nine_Herbs_Charm - North Carolina Extension (n.d.) 'Plantago major'. Available at: https://plants.ces.ncsu.edu/plants/plantago-major/ Traditional / reference
https://plants.ces.ncsu.edu/plants/plantago-major/ - Royal Botanic Gardens, Kew (n.d.) 'Plantago major L'. Available at: https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:677229-1 Traditional / reference
https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:677229-1 - Royal Horticultural Society (n.d.) 'Plantago major (common plantain)'. Available at: https://www.rhs.org.uk/plants/42126/plantago-major/details Traditional / reference
https://www.rhs.org.uk/plants/42126/plantago-major/details - The Wildlife Trusts (n.d.) 'Greater plantain'. Available at: https://www.wildlifetrusts.org/wildlife-explorer/wildflowers/greater-plantain Traditional / reference
https://www.wildlifetrusts.org/wildlife-explorer/wildflowers/greater-plantain - Zubair, M (2012). Available at: https://research.slu.se/en/publications/genetic-variation-biochemical-contents-and-wound-healing-activity/ Traditional / reference
https://research.slu.se/en/publications/genetic-variation-biochemical-contents-and-wound-healing-activity/
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.