Plant Comparison
Agrimony vs Cardamom
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Agrimony and Cardamom: they share 6 indicated uses (arthritis / joint pain, bloating, indigestion, …); 3 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Agrimony | Cardamom | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 2/10 | 1/10 | Comparable evidence |
| Bloating | 2/10 | 1/10 | Comparable evidence |
| Indigestion | 2/10 | 1/10 | Comparable evidence |
| Inflammation (general) | 2/10 | 1/10 | Comparable evidence |
| Skin irritation | 1/10 | 1/10 | Comparable evidence |
| Wounds | 2/10 | 1/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Responsible for the characteristic astringency.
Antioxidant and anti-inflammatory constituents.
Seed essential oil dominated by 1,8-cineole and alpha-terpinyl acetate, giving the characteristic aroma and much of the carminative, antimicrobial and antioxidant activity.
Additional antioxidant constituents of the seed.
Pharmacological Actions
Anti-inflammatory gargle (mild inflammation of the mouth and throat / sore throat)
Agrimonia eupatoria ethanolic extract is cytotoxic to breast, colon, lung and cervical cancer cells and inhibits the PI3K/Akt/mTOR pathway (preclinical/in silico).
Traditional & Indicated Uses
inferred from bitter-tonic action
inferred from anti-inflammatory action
Agrimonia eupatoria ethanolic extract shows dose-dependent cytotoxicity against MCF-7 (breast), HT-29 (colon), A549 (lung) and HeLa (cervical) cancer cells and inhibits the PI3K/Akt/mTOR/COX-2/MMP-2 axis (preclinical).
Astringent (relief of mild diarrhoea)
Mild bitter digestive tonic (indigestion)
Anti-inflammatory gargle (mild inflammation of the mouth and throat / sore throat); Vulnerary (minor skin inflammation and small superficial wounds, topical)
inferred from astringent action
Anti-inflammatory gargle (mild inflammation of the mouth and throat / sore throat)
inferred from anti-inflammatory action
inferred from digestive action
inferred from digestive action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
Safety, Cautions & Contraindications
Traditional-use indication only: if diarrhoea persists longer than 3-4 days, or symptoms of mouth/throat inflammation persist beyond about a week, a doctor should be consulted.
Use during pregnancy and breastfeeding is not recommended, as safety has not been established.
Cardamom is generally considered safe for most people when used in culinary amounts. At medicinal doses (supplement form), rare side effects include mild gastrointestinal discomfort and allergic reactions. There are no well-documented serious drug interactions at culinary doses. Cardamom may mildly lower blood pressure — caution if combined with antihypertensive medications. Some sources suggest potential gallstone formation with very high doses, as cardamom may stimulate bile flow. Avoid therapeutic doses during pregnancy until more safety data are available; culinary use is considered safe. Allergy to other Zingiberaceae (ginger, turmeric) may indicate cross-reactivity risk (Korikanthimath and Hiremath, 2002).
Duke (2002) provides clinical support (score 2) for cardamom as a cholagogue, antiviral agent, and appetite stimulant. Commission E and the German PDR (PHR) approve it for loss of appetite and bronchitis (score 2). The essential oil shows antispasmodic and carminative activity. Dose: 1.5 g ground fruit or equivalent preparation three times daily. Duke rates cardamom as generally safe (++), with no significant contraindications at therapeutic doses (Duke, 2002).
External Ids
Botanical Description
Slender, downy perennial herb with a basal rosette of pinnately compound leaves and a single, unbranched, upright flowering stem. The leaflets are toothed, alternating large and small, and silvery-downy beneath. Small, five-petalled, bright yellow flowers are borne closely along a slender terminal spike (raceme), opening a few at a time from the base upwards, giving the old name 'church steeples'. After flowering, small bristly, hooked burrs form that cling to clothing and animal fur for dispersal.[13, 14]
Large, rhizomatous perennial herb with tall, reed-like leafy stems (pseudostems) formed by overlapping leaf sheaths, arising from a stout underground rhizome. Small, pale flowers with a violet-veined white lip are borne on separate trailing panicles that grow along the ground from the base of the plant. The fruit is a small, ridged, pale green three-sided capsule (the cardamom pod) containing numerous dark, aromatic seeds.[1]
Habitat
Native to the moist evergreen forests of the Western Ghats of southern India and Sri Lanka; cultivated in warm, humid, shaded tropical conditions, notably in India, Guatemala and Sri Lanka.[1]
Harvesting
The flowering aerial parts are cut in summer, at the start of flowering, and dried promptly in a warm, airy, shaded place.[13]
The unripe green pods are hand-picked just before full maturity, then carefully dried (traditionally in the shade or by gentle heat) to preserve the green colour and aromatic oil; the pods are typically used whole or the seeds removed and ground just before use.
Traditional Uses
Agrimony has a long folk history as an astringent remedy for mild diarrhoea, as a gargle for sore throats and mild mouth/throat inflammation, and as a mild bitter digestive tonic; it has also been applied topically to minor wounds and skin inflammation. It is officially recognised in the European Union herbal monograph for traditional use in mild diarrhoea and mild inflammation of the mouth or throat.[13, 14]
Cardamom has a long Ayurvedic, Middle Eastern and Asian tradition as a warming digestive carminative for indigestion and bloating, a remedy for respiratory complaints such as asthma and bronchitis, and a valued spice for tea, coffee and cooking.[1]
Preparations
Crushed pods or seeds infused in hot water, or added to tea/coffee, as a traditional carminative digestive preparation.
Dosage
The EU herbal monograph gives 1.5-4 g of the comminuted herb in 250 mL (or less) of boiling water as an infusion, 2-3 times daily, in adolescents, adults and elderly. As a gargle for mild oral or throat inflammation, 1.5 g in 150 mL of boiling water 2-4 times daily, or a decoction of 3-4.5 g in 250 mL 2-3 times daily. Educational reference only, not a prescription.
The EU herbal monograph gives 1-4 mL three times daily (orally, or as a gargle for oral and throat use). Educational reference only, not a prescription.
The WHO monograph on Semen Cardamomi gives an average DAILY dosage of 1.5 g of the drug, or equivalent preparations; for tincture, a daily dosage equivalent to 12 g. Note the 1.5 g is a daily total, not a per-dose amount. Educational reference only, not a prescription.
References
Lookalikes Review
References & Sources
- Malheiros, J., Simoes, D.M., Figueirinha, A., Cotrim, M.D. and Fonseca, D.A (2022) 'Agrimonia eupatoria L.: An integrative perspective on ethnomedicinal use, phenolic composition and pharmacological activity', Journal of Ethnopharmacology, pp. 2022. doi:10.1016/j.jep.2022.115498 Preclinical
https://doi.org/10.1016/j.jep.2022.115498 - Paluch, Z., Biriczova, L., Pallag, G., Carvalheiro Marques, E., Vargova, N. and Kmonickova, E (2020) 'The therapeutic effects of Agrimonia eupatoria L', Physiological Research, pp. S555--S571. doi:10.33549/physiolres.934641 Preclinical
https://doi.org/10.33549/physiolres.934641 - Kuczmannova, A., Balazova, A., Racanska, E., Kamenikova, M., Fialova, S., Majernik, J., Nagy, M., Gal, P. and Mucaji, P (2016) 'Agrimonia eupatoria L. and Cynara cardunculus L. water infusions: comparison of anti-diabetic activities', Molecules, 21(5), pp. 564. doi:10.3390/molecules21050564 Preclinical
https://doi.org/10.3390/molecules21050564 - Huzio, N., Grytsyk, A., Raal, A., Grytsyk, L. and Koshovyi, O (2022) 'Phytochemical and pharmacological research in Agrimonia eupatoria L. herb extract with anti-inflammatory and hepatoprotective properties', Plants, 11(18), pp. 2371. doi:10.3390/plants11182371 Preclinical
https://doi.org/10.3390/plants11182371 - Correia, H.S., Batista, M.T. and Dinis, T.C.P (2007) 'The activity of an extract and fraction of Agrimonia eupatoria L. against reactive species', BioFactors, 29(2-3), pp. 91-104. doi:10.1002/biof.552029209 Preclinical
https://doi.org/10.1002/biof.552029209 - Granica, S., Kluge, H., Horn, G., Matkowski, A. and Kiss, A.K (2015) 'The phytochemical investigation of Agrimonia eupatoria L. and Agrimonia procera Wallr. as valid sources of Agrimoniae herba - the pharmacopoeial plant material', Journal of Pharmaceutical and Biomedical Analysis, 114, pp. 272-279. doi:10.1016/j.jpba.2015.05.027 Preclinical
https://doi.org/10.1016/j.jpba.2015.05.027 - Tsirigotis-Maniecka, M., Zaczynska, E., Czarny, A., Jadczyk, P., Uminska-Wasiluk, B., Gancarz, R. and Pawlaczyk-Graja, I (2023) 'Antioxidant and protective effects of the polyphenolic glycoconjugate from Agrimonia eupatoria L. herb in the prevention of inflammation in human cells', Journal of Functional Biomaterials, 14(4), pp. 182. doi:10.3390/jfb14040182 Preclinical
https://doi.org/10.3390/jfb14040182 - Kwon, D.H., Kwon, H.Y., Kim, H.J., Chang, E.J., Kim, M.B., Yoon, S.K., Song, E.Y., Yoon, D.Y., Lee, Y.H., Choi, I.S. and Choi, Y.K (2005) 'Inhibition of hepatitis B virus by an aqueous extract of Agrimonia eupatoria L', Phytotherapy Research, 19(4), pp. 355-358. doi:10.1002/ptr.1689 Preclinical
https://doi.org/10.1002/ptr.1689 - Karlinska, E., Romanowska, B. and Kosmala, M (2021) 'The aerial parts of Agrimonia procera Wallr. and Agrimonia eupatoria L. as a source of polyphenols, and especially agrimoniin and flavonoids', Molecules, 26(24), pp. 7706. doi:10.3390/molecules26247706 Preclinical
https://doi.org/10.3390/molecules26247706 - Kuczmannova, A., Gal, P., Varinska, L., Treml, J., Kovac, I., Novotny, M., Vasilenko, T., Dall'Acqua, S., Nagy, M. and Mucaji, P (2015) 'Agrimonia eupatoria L. and Cynara cardunculus L. water infusions: phenolic profile and comparison of antioxidant activities', Molecules, 20(11), pp. 20538-20550. doi:10.3390/molecules201119715 Preclinical
https://doi.org/10.3390/molecules201119715 - Ivanova, D., Vankova, D. and Nashar, M (2013) 'Agrimonia eupatoria tea consumption in relation to markers of inflammation, oxidative status and lipid metabolism in healthy subjects', Archives of Physiology and Biochemistry, 119(1), pp. 32-37. doi:10.3109/13813455.2012.729844 Clinical study
https://doi.org/10.3109/13813455.2012.729844 - Venskutonis, P.R., Skemaite, M. and Ragazinskiene, O (2007) 'Radical scavenging capacity of Agrimonia eupatoria and Agrimonia procera', Fitoterapia, 78(2), pp. 166-168. doi:10.1016/j.fitote.2006.10.002 Preclinical
https://doi.org/10.1016/j.fitote.2006.10.002 - European Medicines Agency (HMPC) (2015) 'European Union herbal monograph on Agrimonia eupatoria L., herba (Agrimoniae herba)'. Available at: https://www.ema.europa.eu/en/medicines/herbal/agrimoniae-herba Traditional / reference
https://www.ema.europa.eu/en/medicines/herbal/agrimoniae-herba - (2022) 'Agrimonia eupatoria L.: An integrative perspective on ethnomedicinal use, phenolic composition and pharmacological activity', Journal of Ethnopharmacology. doi:10.1016/j.jep.2022.115498 Traditional / reference
https://doi.org/10.1016/j.jep.2022.115498 - Herbal Reality (n.d.) 'Agrimony (Agrimonia eupatoria): Benefits, Uses, Safety'. Available at: https://www.herbalreality.com/herb/agrimony/ Traditional / reference
https://www.herbalreality.com/herb/agrimony/ - Lee, K.H. and Rhee, K.H (2016) 'Anti-nociceptive effect of Agrimonia eupatoria extract on a cisplatin-induced neuropathic model', African Journal of Traditional, Complementary and Alternative Medicines, 13(5), pp. 139--144. doi:10.21010/ajtcam.v13i5.18 Preclinical
https://doi.org/10.21010/ajtcam.v13i5.18 - Ginovyan, M. and Gevorgyan, S. and Javrushyan, H. and Kusznierewicz, B. and Koss-Mikolajczyk, I. and Sahakyan, N. and Bartoszek, A. and Avtandilyan, N (2026) 'Inhibition of the PI3K signaling pathway in cancer cells by Agrimonia eupatoria L. ethanolic extract: identification of tricoumaroyl spermidine as a potential PI3K inhibitor', BMC Complementary Medicine and Therapies, 26(1), pp. 41. doi:10.1186/s12906-025-05231-z Preclinical
https://doi.org/10.1186/s12906-025-05231-z - Shareef, S.H., Asaad, N.K., Gheni, N.A., Fisal, D.N., Shakir Agha, N.F., Ali, R.T. and Abdulla, M.A (2025) 'Agrimonia eupatoria leaf extract attenuates alcohol-induced oxidative stress, ulcer and alleviates stomach damage in rats', Food Science and Nutrition, 13(11). doi:10.1002/fsn3.71203 Preclinical
https://doi.org/10.1002/fsn3.71203 - Vasilenko, T., Kovac, I., Slezak, M., Durkac, J., Perzelova, V., Coma, M. and others (2022) 'Agrimonia eupatoria L. aqueous extract improves skin wound healing: an in vitro study in fibroblasts and keratinocytes and in vivo study in rats', In Vivo, 36(3), pp. 1236--1244. doi:10.21873/invivo.12822 Preclinical
https://doi.org/10.21873/invivo.12822
- Ashokkumar, K., Murugan, M., Dhanya, M.K. and Warkentin, T.D (2019) 'Botany, traditional uses, phytochemistry and biological activities of cardamom [Elettaria cardamomum (L.) Maton] - A critical review', Journal of Ethnopharmacology, 246, pp. 112244. doi:10.1016/j.jep.2019.112244 Meta-analysis / review
https://doi.org/10.1016/j.jep.2019.112244 - Jamal, A., Javed, K., Aslam, M. and Jafri, M.A (2006) 'Gastroprotective effect of cardamom, Elettaria cardamomum Maton. fruits in rats', Journal of Ethnopharmacology, 103(2), pp. 149-153. doi:10.1016/j.jep.2005.07.016 Preclinical
https://doi.org/10.1016/j.jep.2005.07.016 - Yahyazadeh, R., Ghasemzadeh Rahbardar, M., Razavi, B.M., Karimi, G. and Hosseinzadeh, H (2021) 'The effect of Elettaria cardamomum (cardamom) on the metabolic syndrome: Narrative review', Iranian Journal of Basic Medical Sciences, 24(11), pp. 1462-1469. doi:10.22038/IJBMS.2021.54417.12228 Meta-analysis / review
https://doi.org/10.22038/IJBMS.2021.54417.12228 - Cardenas Garza, G.R., Elizondo Luevano, J.H., Bazaldua Rodriguez, A.F., Chavez Montes, A., Perez Hernandez, R.A. and Martinez Delgado, A.J (2021) 'Benefits of Cardamom (Elettaria cardamomum (L.) Maton) and Turmeric (Curcuma longa L.) Extracts for Their Applications as Natural Anti-Inflammatory Adjuvants', Plants, 10(9), pp. 1908. doi:10.3390/plants10091908 Preclinical
https://doi.org/10.3390/plants10091908 - Sreedharan, S., Nair, V. and Cisneros-Zevallos, L (2023) 'Protective Role of Phenolic Compounds from Whole Cardamom (Elettaria cardamomum (L.) Maton) against LPS-Induced Inflammation in Colon and Macrophage Cells', Nutrients, 15(13), pp. 2965. doi:10.3390/nu15132965 Preclinical
https://doi.org/10.3390/nu15132965 - Almeer, R.S., Alnasser, M., Aljarba, N. and AlBasher, G.I (2021) 'Effects of Green cardamom (Elettaria cardamomum Maton) and its combination with cyclophosphamide on Ehrlich solid tumors', BMC Complementary Medicine and Therapies, 21(1), pp. 133. doi:10.1186/s12906-021-03305-2 Preclinical
https://doi.org/10.1186/s12906-021-03305-2 - Almohammed, H.I., Alkhaibari, A.M. and Alanazi, A.D (2022) 'Antiparasitic effects of Elettaria cardamomum L. essential oil and its main compounds, 1,8-Cineole alone and in combination with albendazole against Echinococcus granulosus protoscoleces', Saudi Journal of Biological Sciences, 29(4), pp. 2811-2818. doi:10.1016/j.sjbs.2022.01.005 Preclinical
https://doi.org/10.1016/j.sjbs.2022.01.005 - Pavarino, M., Marengo, A., Cagliero, C., Bicchi, C., Rubiolo, P. and Sgorbini, B (2023) 'Elettaria cardamomum (L.) Maton Essential Oil: An Interesting Source of Bioactive Specialized Metabolites as Inhibitors of Acetylcholinesterase and Butyrylcholinesterase', Plants, 12(19), pp. 3463. doi:10.3390/plants12193463 Preclinical
https://doi.org/10.3390/plants12193463 - Masoumi-Ardakani, Y., Mahmoudvand, H., Mirzaei, A., Esmaeilpour, K., Ghazvini, H. and Khalifeh, S (2017) 'The effect of Elettaria cardamomum extract on anxiety-like behavior in a rat model of post-traumatic stress disorder', Biomedicine & Pharmacotherapy, 87, pp. 489-495. doi:10.1016/j.biopha.2016.12.116 Preclinical
https://doi.org/10.1016/j.biopha.2016.12.116 - Delgadillo-Puga, C., Torre-Villalvazo, I., Carino-Cervantes, Y.Y., Garcia-Luna, C., Soberanes-Chavez, P. and de Gortari, P (2023) 'Cardamom (Elettaria cardamomum (L.) Maton) Seeds Intake Increases Energy Expenditure and Reduces Fat Mass in Mice by Modulating Neural Circuits That Regulate Adipose Tissue Lipolysis and Mitochondrial Oxidative Metabolism in Liver and Skeletal Muscle', International Journal of Molecular Sciences, 24(4), pp. 3909. doi:10.3390/ijms24043909 Preclinical
https://doi.org/10.3390/ijms24043909 - World Health Organization (2009) 'Semen Cardamomi'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 - Bhilave, M.P., Bhosale, S.V. and Nadaf, S.B (2013) 'Evaluation of antibacterial activity of cardamom seeds of Elettaria cardamomum', 4(1), pp. 66--69. Traditional / reference
https://scholar.google.com/scholar?q=Evaluation%20of%20antibacterial%20activity%20of%20cardamom%20seeds%20of%20Elettaria%20cardamomum - Jamal, A., Javed, K., Aslam, M. and Jafri, M.A (2006) 'Gastroprotective effect of cardamom, Elettaria cardamomum (Maton) Fruits in Rats', 103(2), pp. 149--153. doi:10.1016/j.jep.2005.09.040 Traditional / reference
https://doi.org/10.1016/j.jep.2005.09.040 - Korikanthimath, V.S. and Hiremath, G.M (2002) 'Cardamom (Elettaria cardamomum Maton)', pp. 144--157. Traditional / reference
https://scholar.google.com/scholar?q=Cardamom%20%28Elettaria%20cardamomum%20Maton%29 - Royal Botanic Gardens, Kew (n.d.) 'Elettaria cardamomum (L.) Maton'. Available at: https://powo.science.kew.org/taxon/urn:lsid:http://ipni.org:names:796793-1 Traditional / reference
https://powo.science.kew.org/taxon/urn:lsid:http://ipni.org:names:796793-1 - Verma, S.K., Jain, V. and Katewa, S.S (2009) 'Blood pressure lowering, fibrinolysis enhancing and antioxidant activities of cardamom (Elettaria cardamomum)', 46(6), pp. 503--506. Traditional / reference
https://scholar.google.com/scholar?q=Blood%20pressure%20lowering%2C%20fibrinolysis%20enhancing%20and%20antioxidant%20activities%20of%20cardamom%20%28Elettaria%20cardamomum%29 - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.