Symptom → Plant Sources
Pot marigold (Calendula officinalis) as a tool for helping with Skin irritation
inferred from anti-inflammatory action
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Full Pot marigold monograph →All plants for skin irritation →
The effects of oral and topical application of Calendula officinalis flower extract on excision wounds made in rats were checked. The parameters assessed were the days needed for re-epithelization and percentage of wound closure. The hydroxy proline and hexosamine content in the granuloma tissue of the wound was also measured. The percentage of wound closure was 90.0% in the extract-treated group, whereas the control group showed only 51.1% on the eighth day of wounding (p < .01). The days needed for re-epithelization were 17.7 for the control animals; extract treatment at a dose of 20 or 100 mg/kg b.wt reduced the period to 14 and 13 days, respectively. A significant increase was observed in the hydroxy proline and hexosamine content in the extract-treated group compared with the untreated animals. The data indicate potent wound healing activity ofC. officinalis extract.
3 sources supporting Pot marigold for Skin irritation. Includes scientific publications, books, monographs and traditional-use references.
Mechanistic basis
This use is associated with the plant's anti-inflammatory, antifungal, emollient / skin-soothing actions. Further evidence for that pharmacology:
Calendula officinalis contains flavonoids, triterpenoids, glycosides, saponins, carotenoids, volatile oil and sterols, conferring anti-inflammatory, anti-cancer, antihelminthic, antidiabetic, wound-healing, hepatoprotective and antioxidant activities, and it is used in burns and gastrointestinal, gynecological, ocular and skin conditions. The review summarizes recent research on its therapeutic applications, molecular mechanisms and clinical studies.
Bioassay-guided fractionation of Calendula officinalis roots isolated prenylated acetophenones with anti-inflammatory activity, supporting the anti-inflammatory use of pot marigold.
Ethanol extract of Calendula officinalis flowers ameliorated l-arginine-induced acute necrotizing pancreatitis in rats by reducing inflammation and oxidative stress, supporting the anti-inflammatory use of pot marigold.