Symptom → Plant Sources
Schisandra (Schisandra chinensis) as a tool for helping with Arthritis / joint pain
inferred from anti-inflammatory action
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Full Schisandra monograph →All plants for arthritis / joint pain →
Schisandra chinensis Turcz. (Baill.) fruits, their extracts, and bioactive compounds are used in alternative medicine as adaptogens and ergogens protecting against numerous neurological, cardiovascular, gastrointestinal, liver, and skin disorders. S. chinensis fruit extracts and their active compounds are potent antioxidants and mitoprotectors exerting anti-inflammatory, antiviral, anticancer, and anti-aging effects. S. chinensis polyphenolic compounds-flavonoids, phenolic acids and the major constituents dibenzocyclooctadiene lignans are responsible for the S. chinensis antioxidant activities. This review will focus on the direct and indirect antioxidant effects of S. chinensis fruit extract and its bioactive compounds in the cells during normal and pathological conditions.
1 source supporting Schisandra for Arthritis / joint pain. Includes scientific publications, books, monographs and traditional-use references.
Mechanistic basis
This use is associated with the plant's anti-inflammatory action. Further evidence for that pharmacology:
Schisandra chinensis extract reduced osteoarthritis symptoms and modulated inflammatory mechanisms in monosodium-iodoacetate-induced osteoarthritis rats, demonstrating the anti-inflammatory activity of schisandra.
Schisandra chinensis lignans ameliorated hepatic inflammation and steatosis in methionine-choline-deficient-diet mice by modulating the gut-liver axis, supporting the hepatoprotective and anti-inflammatory use of schisandra.
A lignan-enriched extract of Schisandra chinensis inhibited Parkinson's disease progression by reducing neuroinflammation via TRPV1 expression in microglia, supporting the anti-inflammatory neuroprotective use of schisandra.