Therapeutic potential of Rosa rugosa polysaccharide and its nanofiber membrane in psoriasis via PI3K-AKT/mTOR pathway inhibition
Abstract
Rosa rugosa polysaccharide (RRPS) reduced nitric oxide production in macrophages (anti-inflammatory) and, in an imiquimod-induced psoriasis mouse model, improved symptoms, reduced transepidermal water loss and inhibited pro-inflammatory cytokines (TNF-alpha, IL-6, IL-17A) by suppressing the PI3K-AKT/mTOR pathway, supporting use in inflammatory skin disease.
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How to cite
Chen, M., Peng, Y., Zhu, R., Luo, X. and others (2025) 'Therapeutic potential of Rosa rugosa polysaccharide and its nanofiber membrane in psoriasis via PI3K-AKT/mTOR pathway inhibition', International Journal of Biological Macromolecules, 320(Pt 2), pp. 145724. doi:10.1016/j.ijbiomac.2025.145724
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