Omnia Sana · Plant Monograph
Japanese Rose
Rosa rugosa
This monograph compiles 3 pharmacological actions, 6 traditional / indicated uses, supported by 13 cited sources, drawn directly from the Omnia Sana plant database.
Pharmacological Actions
Traditional & Indicated Uses
inferred from anti-inflammatory action
more plants for arthritis / joint pain →detailed sources →inferred from immunomodulator action
more plants for cold & flu →detailed sources →inferred from anti-inflammatory action
more plants for inflammation (general) →detailed sources →inferred from anti-inflammatory action
more plants for skin irritation →detailed sources →Safety, Cautions & Contraindications
Generally safe as a food plant. Rose hips should be used after removing the achenes (seeds and inner hairs), which can cause irritation. Allergic reactions are rare. No significant drug interactions documented.
References
REF-1005, REF-1006, REF-1007, REF-1008, REF-1009, REF-1010, REF-1011, REF-1012, REF-1013, REF-1014References & Sources
- Zhang, Z., Hu, W., Yu, A., Bai, M. and others (2024) 'Physicochemical properties, health benefits, and applications of the polysaccharides from Rosa rugosa Thunb.: A review', International Journal of Biological Macromolecules, 282(Pt 3), pp. 136975. doi:10.1016/j.ijbiomac.2024.136975 Traditional / reference
https://doi.org/10.1016/j.ijbiomac.2024.136975 - Dong, X., Li, Y., Yang, K., Zhang, L. and others (2024) 'Total flavonoids from Rosa rugosa Thunb.: A comprehensive review of its extraction and purification process, chemical composition, biological effect and applications', Naunyn-Schmiedeberg's Archives of Pharmacology, 398(3), pp. 2343-2363. doi:10.1007/s00210-024-03504-x Traditional / reference
https://doi.org/10.1007/s00210-024-03504-x - Kim, J., Lee, S., Park, H. and others (2024) 'Hair Growth Effect and the Mechanisms of Rosa rugosa Extract in DHT-Induced Alopecia Mice Model', International Journal of Molecular Sciences, 25(21), pp. 11362. doi:10.3390/ijms252111362 Preclinical
https://doi.org/10.3390/ijms252111362 - Baiyisaiti, A., Liu, Y., Zhang, J. and Yang, R (2019) 'Rosa rugosa flavonoids exhibited PPAR-alpha agonist-like effects on genetic severe hypertriglyceridemia of mice', Journal of Ethnopharmacology, 240, pp. 111952. doi:10.1016/j.jep.2019.111952 Preclinical
https://doi.org/10.1016/j.jep.2019.111952 - Lei, L., Zhu, Y., Gao, W., Du, X. and others (2023) 'Ethanol Extract of Rosa rugosa Ameliorates Acetaminophen-Induced Liver Injury via Upregulating Sirt1 and Subsequent Potentiation of LKB1/AMPK/Nrf2 Cascade in Hepatocytes', Molecules, 28(21), pp. 7307. doi:10.3390/molecules28217307 Preclinical
https://doi.org/10.3390/molecules28217307 - Dai, C., Zheng, X., Zhu, J., Zhang, H. and others (2025) 'Polysaccharides derived from Rosa rugosa cv. Plena ameliorate colorectal cancer by regulating intestinal microbiota composition and lipid metabolism pathway', NPJ Science of Food, 9(1), pp. 176. doi:10.1038/s41538-025-00544-2 Preclinical
https://doi.org/10.1038/s41538-025-00544-2 - Chen, M., Peng, Y., Zhu, R., Luo, X. and others (2025) 'Therapeutic potential of Rosa rugosa polysaccharide and its nanofiber membrane in psoriasis via PI3K-AKT/mTOR pathway inhibition', International Journal of Biological Macromolecules, 320(Pt 2), pp. 145724. doi:10.1016/j.ijbiomac.2025.145724 Preclinical
https://doi.org/10.1016/j.ijbiomac.2025.145724 - Park, C.K., Choi, S.J., Kim, C.R., Shin, H.R. and others (2025) 'Ethanolic Extract of Rosa rugosa Roots and Its Bioactive Compound, Oleamide, Prevented Amyloid beta-Induced Oxidative Stress and Improved Behavioral Tests in Mice', International Journal of Molecular Sciences, 26(9), pp. 4214. doi:10.3390/ijms26094214 Preclinical
https://doi.org/10.3390/ijms26094214 - Ashraf, S., Ashraf, M.Z., Miao, B. and Zhao, X (2025) 'Optimizing Extraction Methods for Bioactive Polysaccharides from Rosa rugosa and Rosa damascena', Foods, 14(18), pp. 3211. doi:10.3390/foods14183211 Traditional / reference
https://doi.org/10.3390/foods14183211 - Liu, X., Liu, H., Zhang, Y. and others (2022) 'Rosa rugosa polysaccharide induces autophagy-mediated apoptosis in human cervical cancer cells via the PI3K/AKT/mTOR pathway', International Journal of Biological Macromolecules, 212, pp. 257-274. doi:10.1016/j.ijbiomac.2022.05.023 Preclinical
https://doi.org/10.1016/j.ijbiomac.2022.05.023 - Chrubasik, C., Roufogalis, B.D., Müller-Ladner, U. and Chrubasik, S (2008) 'A systematic review on the Rosa canina effect and efficacy profiles', 22(6), pp. 725--733. Meta-analysis / review
Find this source - Grieve, M (1931) 'A Modern Herbal'. Traditional / reference
Find this source - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org
Generated June 22, 2026 from omniasana.bio