Polysaccharides derived from Rosa rugosa cv. Plena ameliorate colorectal cancer by regulating intestinal microbiota composition and lipid metabolism pathway
Abstract
A Rosa rugosa cv. Plena polysaccharide (RPP1) ameliorated AOM/DSS-induced colorectal cancer in mice, reducing colonic polyps, normalising serum IL-1beta and TNF-alpha and remodelling gut microbiota and lipid metabolism, with activation of immune (NLR, PPAR) signalling, indicating immunomodulatory and anti-tumour effects.
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How to cite
Dai, C., Zheng, X., Zhu, J., Zhang, H. and others (2025) 'Polysaccharides derived from Rosa rugosa cv. Plena ameliorate colorectal cancer by regulating intestinal microbiota composition and lipid metabolism pathway', NPJ Science of Food, 9(1), pp. 176. doi:10.1038/s41538-025-00544-2
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