Omnia Sana · Plant Monograph
Lungwort
Pulmonaria officinalis
This monograph compiles 2 documented constituents, 4 pharmacological actions, 7 traditional / indicated uses, supported by 12 cited sources, drawn directly from the Omnia Sana plant database.
Key Constituents
The main antioxidant and COX-2-inhibiting constituents; LC-MS/MS profiling of the aerial parts identified dozens of phenolic compounds (caffeic acid esters and danshensu/dicaffeic-acid conjugates), nine of them previously undescribed, with marked seasonal variation.
Pharmacological Actions
Traditional & Indicated Uses
inferred from anti-inflammatory action
more plants for arthritis / joint pain →detailed sources →Traditional demulcent / expectorant for cough, bronchitis, sore throat and respiratory catarrh (mucilage and saponins)
more plants for bronchitis →detailed sources →Traditional demulcent / expectorant for cough, bronchitis, sore throat and respiratory catarrh (mucilage and saponins)
more plants for cough →detailed sources →inferred from anti-inflammatory action
more plants for inflammation (general) →detailed sources →Traditional demulcent / expectorant for cough, bronchitis, sore throat and respiratory catarrh (mucilage and saponins)
more plants for respiratory support →detailed sources →inferred from demulcent action
more plants for skin irritation →detailed sources →Traditional demulcent / expectorant for cough, bronchitis, sore throat and respiratory catarrh (mucilage and saponins)
more plants for sore throat →detailed sources →Safety, Cautions & Contraindications
As a member of the borage family (Boraginaceae), which can contain hepatotoxic pyrrolizidine alkaloids, prolonged or high-dose internal use is best avoided; use in pregnancy and breastfeeding is not recommended.
Traditional use only; clinical evidence in humans is limited, so a cough or respiratory complaint that persists needs medical assessment.
References
REF-1544, REF-1545, REF-1546, REF-1547, REF-1548, REF-1549, REF-1550, REF-1551, REF-1552References & Sources
- Ignjatijevic, A., Andjic, T., Ljesevic, M., Nikolic, B. and others (2025) 'Assessment of Antioxidant Activity and Dose-Dependent Effect on Genotoxicity/Antigenotoxicity of Pulmonaria officinalis Ethanolic Extract', Pharmaceutics, 17(9), pp. 1134. doi:10.3390/pharmaceutics17091134 Preclinical
https://doi.org/10.3390/pharmaceutics17091134 - Krzaczek, T. and others (1995) 'Flavonoid glycosides from aerial parts of Pulmonaria officinalis', Planta Medica, 61(5), pp. 488. doi:10.1055/s-2006-959385 Preclinical
https://doi.org/10.1055/s-2006-959385 - Krzyzanowska-Kowalczyk, J. and others (2019) 'Pulmonaria officinalis L. Extract in Cystic Fibrosis: In Vitro Evidence on Staphylococcus aureus Clinical Isolates', Molecules, 24(6), pp. 1151. doi:10.3390/molecules24061151 Preclinical
https://doi.org/10.3390/molecules24061151 - Neagu, E., Radu, G.L., Albu, C. and Paun, G (2016) 'Antioxidant activity, acetylcholinesterase and tyrosinase inhibitory potential of Pulmonaria officinalis and Centaurium umbellatum extracts', Saudi Journal of Biological Sciences, 25(3), pp. 578-585. doi:10.1016/j.sjbs.2016.02.016 Preclinical
https://doi.org/10.1016/j.sjbs.2016.02.016 - Akram, M. and Rashid, A (2017) 'Anti-coagulant activity of plants: mini review', Journal of Thrombosis and Thrombolysis, 44(3), pp. 406-411. doi:10.1007/s11239-017-1546-5 Meta-analysis / review
https://doi.org/10.1007/s11239-017-1546-5 - Byshevskii, A.Sh., Gerbert, I.Ia., Dement'eva, I.A., Leven, P.I. and Chiriat'ev, E.A (1990) 'Nature, properties and the mechanism of the effect on blood coagulation of the preparation obtained from Pulmonaria officinalis', Gematologiia i Transfuziologiia, 35(10), pp. 6-9. Preclinical
Find this source - Ivanova, D., Gerova, D., Chervenkov, T. and Yankova, T (2005) 'Polyphenols and antioxidant capacity of Bulgarian medicinal plants', Journal of Ethnopharmacology, 96(1-2), pp. 145-150. doi:10.1016/j.jep.2004.08.033 Preclinical
https://doi.org/10.1016/j.jep.2004.08.033 - Neuhauser, C., Schwarzinger, B., Schwarzinger, C., Feichtinger, M. and others (2024) 'Insulin-Mimetic Activity of Herbal Extracts Identified with Large-Scale Total Internal Reflection Fluorescence Microscopy', Nutrients, 16(14), pp. 2182. doi:10.3390/nu16142182 Preclinical
https://doi.org/10.3390/nu16142182 - Luthy, J., Brauchli, J., Zweifel, U., Schmid, P. and Schlatter, C (1984) 'Pyrrolizidine alkaloids in medicinal plants of Boraginaceae: Borago officinalis L. and Pulmonaria officinalis L', Pharmaceutica Acta Helvetiae, 59(9-10), pp. 242-246. Preclinical
Find this source - Krzyzanowska-Kowalczyk, J., Kowalczyk, M., Ponczek, M.B., Pecio, L., Nowak, P. and Kolodziejczyk-Czepas, J (2021) 'Pulmonaria officinalis and Pulmonaria obscura Extracts as Mitigators of Peroxynitrite-Induced Oxidative Stress and Cyclooxygenase-2 Inhibitors - In Vitro and In Silico Studies', Molecules. doi:10.3390/molecules26030631 Traditional / reference
https://doi.org/10.3390/molecules26030631 - Krzyzanowska-Kowalczyk, J. and Pecio, L. and Moldoch, J. and Ludwiczuk, A. and Kowalczyk, M (2018) 'Novel Phenolic Constituents of Pulmonaria officinalis L. LC-MS/MS Comparison of Spring and Autumn Metabolite Profiles', Molecules, 23(9). doi:10.3390/molecules23092277 Traditional / reference
https://doi.org/10.3390/molecules23092277 - Krzyzanowska-Kowalczyk, J., Kolodziejczyk-Czepas, J., Kowalczyk, M., Pecio, L., Nowak, P. and Stochmal, A (2017) 'Yunnaneic Acid B, a Component of Pulmonaria officinalis Extract, Prevents Peroxynitrite-Induced Oxidative Stress in Vitro', Journal of Agricultural and Food Chemistry, 65(19), pp. 3827--3834. doi:10.1021/acs.jafc.7b00718 Preclinical
https://doi.org/10.1021/acs.jafc.7b00718
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