Plant Comparison

Rhodiola Rosea vs White clover

A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.

First plant
Second plant
Show:
Plant ARhodiola RoseaRhodiola roseaCrassulaceaeFull monograph →
Plant BWhite cloverTrifolium repensFabaceaeFull monograph →

At a glance

Rhodiola Rosea and White clover: they share 7 indicated uses (arthritis / joint pain, blood sugar / diabetes support, cognitive function, …); 5 pharmacological actions in common.

Rhodiola RoseaWhite clover
Constituents33
Pharmacological actions611
Indicated uses1115
Safety notes22
Cited sources1833
Indicated uses
Only Rhodiola Rosea
Fatigue / low energyMemoryMetabolic supportMuscle soreness
Shared (7)
Arthritis / joint painBlood sugar / diabetes supportCognitive functionCold & fluImmune supportInflammation (general)Skin irritation
Only White clover
BruisingCancer (anticancer research)Menstrual crampsMuscle spasmWoundsKidney supportLiver supportInfection (general)
Pharmacological actions
Only Rhodiola Rosea
Physical performance / ergogenic
Shared (5)
Anti-inflammatoryAntidiabetic (blood-sugar lowering)AntioxidantImmunomodulator / immune supportNeuroprotective / cognition support
Only White clover
AntispasmodicVulnerary (wound healing)Nephroprotective (kidney support)Anticancer (preclinical)Hepatoprotective (liver support)Antimicrobial

Evidence face-off — shared uses

ConditionRhodiola RoseaWhite cloverVerdict
Arthritis / joint pain6/101/10Stronger for Rhodiola Rosea
Blood sugar / diabetes support6/102/10Stronger for Rhodiola Rosea
Cognitive function9/102/10Stronger for Rhodiola Rosea
Cold & flu6/101/10Stronger for Rhodiola Rosea
Immune support6/101/10Stronger for Rhodiola Rosea
Inflammation (general)9/102/10Stronger for Rhodiola Rosea
Skin irritation6/101/10Stronger for Rhodiola Rosea

Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.

Key Constituents

Rosavins (rosavin, rosarin, rosin)[3]

Characteristic phenylpropanoid glycosides largely unique to Rhodiola rosea, used as a standardisation marker for commercial extracts.

Salidroside and tyrosol[3]

Phenylethanoid glycosides considered key adaptogenic and antioxidant constituents.

Phenylpropanoids and flavonoids[2]

Contribute to the anti-inflammatory and antioxidant activity of the root.

Flavonoids
Isoflavones[32]

Phytoestrogenic isoflavones, present at lower levels than in red clover.

Flavonoids
Cyanogenic glycosides (trace)[30]

Present in small amounts; not significant in normal food or tea use.

Glycosides
Phenolic acids and flavonoids[32]

Contribute to antioxidant activity.

Phenolic acidsFlavonoids

Pharmacological Actions

Anti-inflammatory[2, 9, 11, 12, 13]
Antidiabetic (blood-sugar lowering)[11, 12, 13]
Antioxidant[11, 12, 13]
Physical performance / ergogenic[4, 11, 12, 13]

Physical performance / strength improvement

Immunomodulator / immune support[11, 12, 13]
Neuroprotective / cognition support[10, 11, 12, 13]
Anti-inflammatory[1, 2, 5, 6, 22, 28, 30, 31, 32]
Antioxidant[1, 2, 4, 5, 7, 8, 9, 10, 14, 16, 17, 20, 21, 23, 24, 25, 28, 30, 31, 32]
Antispasmodic[30, 31, 32]

Antispasmodic (cramp easing)

Immunomodulator / immune support[2, 30, 31, 32]
Vulnerary (wound healing)[1, 7, 13, 30, 31, 32]
Nephroprotective (kidney support)[4]
Anticancer (preclinical)[3, 10]
Hepatoprotective (liver support)[9]
Antimicrobial[12, 18, 22, 26, 28]
Antidiabetic (blood-sugar lowering)[10, 20]
Neuroprotective / cognition support[22, 23]

Traditional & Indicated Uses

Arthritis / joint pain[11, 12, 13]Moderate · 6/10

inferred from anti-inflammatory action

Evidence: 6
Label: Arthritis / joint pain
Blood sugar / diabetes support[11, 12, 13]Moderate · 6/10

inferred from antidiabetic action

Evidence: 6
Label: Blood sugar / diabetes support
Cognitive function[3, 5, 10, 11, 12, 13]Strong · 9/10

inferred from neuroprotective action

Evidence: 9
Label: Cognitive function
Cold & flu[11, 12, 13]Moderate · 6/10

inferred from immunomodulator action

Evidence: 6
Label: Cold & flu
Fatigue / low energy[1, 3, 4, 7, 8, 11, 12, 13]Strong · 10/10

inferred from ergogenic action

Evidence: 10
Label: Fatigue / low energy
Immune support[11, 12, 13]Moderate · 6/10
Evidence: 6
Label: Immune support
Inflammation (general)[2, 9, 11, 12, 13]Strong · 9/10

inferred from anti-inflammatory action

Evidence: 9
Label: Inflammation (general)
Memory[11, 12, 13]Moderate · 6/10

inferred from neuroprotective action

Evidence: 6
Label: Memory
Metabolic support[11, 12, 13]Moderate · 6/10
Evidence: 6
Label: Metabolic support
Muscle soreness[4, 11, 12, 13]Strong · 9/10

inferred from ergogenic action

Evidence: 9
Label: Muscle soreness
Skin irritation[11, 12, 13]Moderate · 6/10

inferred from anti-inflammatory action

Evidence: 6
Label: Skin irritation
Arthritis / joint pain[30, 31, 32]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Arthritis / joint pain
Bruising[30, 31, 32]Traditional · 1/10

inferred from vulnerary action

Evidence: 1
Label: Bruising
Cancer (anticancer research)[3, 10]Traditional · 2/10

inferred from anticancer action

Evidence: 2
Label: Cancer (anticancer research)
Cold & flu[30, 31, 32]Traditional · 1/10

inferred from immunomodulator action

Evidence: 1
Label: Cold & flu
Immune support[30, 31, 32]Traditional · 1/10
Evidence: 1
Label: Immune support
Inflammation (general)[6, 30, 31, 32]Traditional · 2/10

inferred from anti-inflammatory action

Evidence: 2
Label: Inflammation (general)
Menstrual cramps[30, 31, 32]Traditional · 1/10

inferred from antispasmodic action

Evidence: 1
Label: Menstrual cramps
Muscle spasm[30, 31, 32]Traditional · 1/10

inferred from antispasmodic action

Evidence: 1
Label: Muscle spasm
Skin irritation[30, 31, 32]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Skin irritation
Wounds[1, 7, 13, 30, 31, 32]Good · 7/10

inferred from vulnerary action

Evidence: 7
Label: Wounds
Kidney support[4]Traditional · 2/10
Evidence: 2
Label: Kidney support
Liver support[9]Traditional · 2/10
Evidence: 2
Label: Liver support
Blood sugar / diabetes support[10, 20]Traditional · 2/10
Evidence: 2
Label: Blood sugar / diabetes support
Infection (general)[12, 18, 22, 26]Traditional · 2/10

inferred from antimicrobial action

Evidence: 2
Label: Infection (general)
Cognitive function[22, 23]Traditional · 2/10
Evidence: 2
Label: Cognitive function

Safety, Cautions & Contraindications

Safety note[11, 12, 13]Caution

Generally well tolerated. May cause agitation, insomnia, or vivid dreams in sensitive individuals — take in the morning. Avoid in manic episodes or severe anxiety. Theoretical interactions with MAOIs, SSRIs, and CNS stimulants. Avoid during pregnancy and breastfeeding.

Safety note[11, 12, 13, 14]Info

Duke (2002) does not include a dedicated entry for Rhodiola rosea in the Handbook of Medicinal Herbs, Second Edition.

Safety note[30, 31, 32]Caution

Generally very safe as a food and in moderate herbal use. Cyanogenic glucosides present in very small amounts — not significant in normal food or tea use. Isoflavones are phytoestrogens (as in red clover) — same precautions apply in hormone-sensitive conditions. Well tolerated by most people.

Safety note[30, 31, 32, 33]Info

Duke (2002) does not include a dedicated entry for white clover (Trifolium repens) in the Handbook of Medicinal Herbs, Second Edition.

External Ids

Gbif: 2985688
Wikidata: Q161665
Gbif: 5358748
Wikidata: Q148675

Botanical Description

Succulent perennial herb (Crassulaceae), 15-40 cm tall, with a thick, fleshy, branching rhizome that has a rose-like fragrance when cut - the origin of the name 'rosea'. Leaves are fleshy, greyish-green, oval to oblong. Small yellow (occasionally reddish) flowers are clustered in dense terminal heads; the species is dioecious, with separate male and female plants. Fruit follicles turn red as they ripen.[3]

Height: 15-40 cm
Habit: Succulent perennial herb, dioecious
Leaves: Fleshy, greyish-green, oval to oblong
Flowers: Small, yellow (occasionally reddish), in dense terminal clusters
Stem: Erect, succulent
Root: Thick, fleshy, branching rhizome, rose-scented when cut
Fruit: Follicles, turning red as they ripen
Flowering Period: June-July

Low, creeping perennial herb rooting at the nodes, with trifoliate leaves, each leaflet oval and often marked with a pale chevron. Rounded white (sometimes pink-tinged) flower heads are borne on long stalks above the foliage.[30]

Height: 5-15 cm (creeping, flower stalks slightly taller)
Habit: Low, creeping, mat-forming perennial herb
Leaves: Trifoliate, each leaflet oval, often marked with a pale chevron
Flowers: Rounded white (sometimes pink-tinged) heads of small pea-like flowers on long stalks
Stem: Creeping, rooting at the nodes
Root: Fibrous roots with nitrogen-fixing nodules
Fruit: Small pod containing 3-4 seeds
Flowering Period: May-October

Habitat

Native to arctic and mountainous regions of Europe, Asia and North America (circumpolar), growing in cold, rocky, high-altitude or high-latitude terrain - cliffs, rocky slopes and tundra - tolerating harsh, exposed conditions.[3]

Grows in lawns, pastures, meadows and grassy waste ground; native to Europe and western Asia and now naturalised worldwide, including as a common lawn and forage plant.[30]

Harvesting

Rhizome and root are dug from plants at least a few years old (traditionally 4-5 years), typically in autumn, then cleaned and dried. Wild populations grow slowly, so cultivated sources are increasingly preferred for sustainability.[3]

Parts: Rhizome, Root
Season: Autumn, from plants at least 4-5 years old

Flowering heads and leaves are picked through the flowering season and dried in a warm, shaded, airy place.[30]

Parts: Flower, Leaf
Season: May-October

Traditional Uses

Rhodiola has a long tradition of use across Scandinavian, Russian and Central Asian folk medicine as a tonic for cold-climate hardiness, physical endurance and mental stamina. It is classified as a modern 'adaptogen', and clinical trials support benefits for stress-related fatigue, mood and cognitive performance.[1, 3]

White clover has a folk tradition, similar to but lighter than its relative red clover, as an anti-inflammatory and wound-healing remedy and mild expectorant, and modern research on its isoflavones and phenolics has additionally investigated antioxidant, kidney-protective and liver-protective activity.[30, 31, 32]

Preparations

Standardised root extract (capsule)[7, 8]

Standardised to rosavins and salidroside (commonly the SHR-5 extract), the form used in most clinical trials.

Infusion (flower/leaf)[30]

Dried flower and leaf infused in hot water as a traditional mild tonic and expectorant tea.

Dosage

Standardised extract[7, 8]

Clinical trials have most often used 340-680 mg/day of standardised root extract (e.g. SHR-5, standardised to rosavins/salidroside), typically taken in the morning to avoid overstimulation. Educational reference only, not a prescription.

Not documented

References

REF-1526, REF-1527, REF-1528, REF-1529, REF-1530, REF-1531, REF-1532, REF-1533, REF-1534, REF-1535
REF-1323, REF-1324, REF-1325, REF-1326, REF-1327, REF-2366, REF-2367, REF-2368, REF-2369, REF-2901, REF-2902, REF-2903, REF-2904, REF-2905, REF-2906, REF-2907, REF-2908, REF-2909, REF-2910, REF-2935, REF-2936, REF-2937, REF-2938, REF-2939, REF-2940, REF-2941, REF-2942, REF-2943, REF-2944

Drug Class Interactions

Safety note[15, 16]Caution
Drug Class: antidepressants-serotonergic
Mechanism: Rhodiola inhibits monoamine oxidase (MAO-A/B) and raises serotonin and dopamine activity; a case report described serotonergic-syndrome-type symptoms (restlessness, trembling) when rhodiola was added to the antidepressant paroxetine. Combined with antidepressants it may add to serotonergic effects.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

Not documented

Pairings

Rhodiola and eleuthero (Siberian ginseng) are classic adaptogens combined in traditional and studied fixed formulas to build resistance to stress and fatigue; used together their stress-protective effects are complementary.[17, 18]

Partner Id: eleutherococcus-senticosus
Type: synergy
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

Rhodiola and schisandra are adaptogens co-formulated in clinically studied combinations for stress, fatigue and mental performance; combined use is intended to be synergistic rather than harmful.[17, 18]

Partner Id: schisandra-chinensis
Type: synergy
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

Not documented

Lookalikes Review

Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07
Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

References & Sources

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  10. Coors, A., Brosch, M., Kahl, E., Khalil, R. and others (2019) 'Rhodiola rosea root extract has antipsychotic-like effects in rodent models of sensorimotor gating', Journal of Ethnopharmacology, 235, pp. 320-328. doi:10.1016/j.jep.2019.02.031 Preclinical
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  11. Darbinyan, V. et al (2000) 'Rhodiola rosea in stress induced fatigue — a double blind cross-over study of a standardized extract SHR-5', 7(5), pp. 365--371. Randomized trial
    https://scholar.google.com/scholar?q=Rhodiola%20rosea%20in%20stress%20induced%20fatigue%20%E2%80%94%20a%20double%20blind%20cross-over%20study%20of%20a%20standardized%20extract%20SHR-5
  12. Kelly, G.S (2001) 'Rhodiola rosea: a possible plant adaptogen', 6(3), pp. 293--302. Traditional / reference
    https://scholar.google.com/scholar?q=Rhodiola%20rosea%3A%20a%20possible%20plant%20adaptogen
  13. Panossian, A., Wikman, G. and Sarris, J (2010) 'Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy', 17(7), pp. 481--493. doi:10.1016/j.phymed.2010.02.002 Randomized trial
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    https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
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Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.