Plant Comparison
Selfheal vs Thyme
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Selfheal and Thyme: both belong to the Lamiaceae family; they share 4 indicated uses (cold & flu, infection (general), wounds, …); 2 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Selfheal | Thyme | Verdict |
|---|---|---|---|
| Cold & flu | 2/10 | 5/10 | Stronger for Thyme |
| Infection (general) | 2/10 | 2/10 | Comparable evidence |
| Wounds | 2/10 | 2/10 | Comparable evidence |
| Cancer (anticancer research) | 7/10 | 2/10 | Stronger for Selfheal |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Pentacyclic triterpenoids (ursolic, oleanolic and betulinic acids), the phenolic acid rosmarinic acid, coumarins (umbelliferone, scopoletin, esculetin) and the flavonoid luteolin are the main bioactives behind self-heal's antioxidant, anti-inflammatory and antimicrobial activity.
Water-extracted polysaccharides — including a partially sulphated arabinogalactomannan (PSP-2B) and polyphenolic-protein-polysaccharide conjugates (PVG/PVE30) — are the principal antiviral and immunomodulatory constituents, blocking herpes simplex virus attachment and modulating innate immune signalling.
Phenolic monoterpenes responsible for the antimicrobial and expectorant actions.
Antioxidant and anti-inflammatory constituents.
Pharmacological Actions
Traditional & Indicated Uses
inferred from anti-inflammatory action
inferred from antiviral action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from antimicrobial action
inferred from anticancer action
Expectorant for productive (chesty) cough associated with cold and bronchitis - a fixed thyme-ivy extract combination outperformed placebo in acute bronchitis (faster, greater reduction in coughing fits)
inferred from anticancer action
Expectorant for productive (chesty) cough associated with cold and bronchitis - a fixed thyme-ivy extract combination outperformed placebo in acute bronchitis (faster, greater reduction in coughing fits)
Expectorant for productive (chesty) cough associated with cold and bronchitis - a fixed thyme-ivy extract combination outperformed placebo in acute bronchitis (faster, greater reduction in coughing fits)
Antimicrobial (thymol and carvacrol) - supports respiratory infection
inferred from antispasmodic action
inferred from expectorant action
Sore throat relief (antiseptic gargle)
Safety, Cautions & Contraindications
Generally very safe and well tolerated. No significant known toxicity or drug interactions. Safe for topical and internal use in normal medicinal doses. Suitable for most adults including children in appropriate doses.
Duke (2002) rates self-heal as +++ and notes antioxidant (score 2), anti-inflammatory, antiviral, and COX-2 inhibitory activities. The plant contains luteolin, rosmarinic acid, and hyperoside — all with well-documented bioactivities. Hepatoprotective activity has been experimentally demonstrated. Duke notes that self-heal has a broad antimicrobial spectrum and an impressive antioxidant profile, supporting its traditional reputation as a versatile wound-healing herb. No significant safety concerns at normal herbal doses (Duke, 2002).
Culinary amounts are safe. Thyme essential oil is a strong irritant - dilute well before any topical use and do not take the undiluted oil internally.
A cough that persists beyond about a week, or with fever or breathlessness, needs medical assessment. Avoid medicinal/oil doses in pregnancy; allergy is possible in people sensitive to the mint family (Lamiaceae).
External Ids
Botanical Description
Low, creeping to semi-erect perennial herb (Lamiaceae), 5-30 cm tall, with square, often purplish stems. Leaves are opposite, ovate with slightly toothed margins. Small, two-lipped, violet-purple flowers are densely packed into a compact, club-shaped terminal spike subtended by purplish bracts.[1]
Low, woody-based aromatic perennial subshrub with small, narrow, grey-green leaves and small, pale pink to lilac, two-lipped flowers borne in whorled clusters along the upper stems.[11]
Habitat
Native throughout Europe, Asia and North America (circumboreal), extremely common in lawns, meadows, woodland clearings, roadsides and waste ground, tolerating mowing and a wide range of soils.[1]
Grows on dry, sunny, rocky, well-drained soils; native to the western Mediterranean and widely cultivated as a culinary and medicinal herb worldwide.[11]
Harvesting
Whole flowering aerial parts (flower, leaf and stem) are cut during flowering (summer) and dried.[1]
The flowering aerial parts are cut just as flowering begins, when essential oil content is highest, and dried in a warm, shaded, airy place; essential oil is obtained by steam distillation of the fresh or dried herb.[11]
Traditional Uses
Selfheal has an extremely broad folk-medicine reputation across European, North American and Traditional Chinese Medicine traditions - as its name suggests, used as an all-purpose wound herb, gargle for sore throat, and internal remedy for fevers and inflammation. Modern research on its triterpenoid, phenolic and polysaccharide constituents supports wide-ranging antioxidant, anti-inflammatory, antimicrobial and antiviral activity.[1]
Thyme has a long Mediterranean and European tradition as an antimicrobial and expectorant remedy for coughs, bronchitis and sore throat, formalised in EU herbal monograph recognition, with a fixed thyme-ivy extract combination shown superior to placebo for acute bronchitis with productive cough in clinical trial.[11, 13]
Preparations
Dried aerial parts steeped in hot water, taken internally or used as a gargle or wash.
Dried herb infused in hot water as a traditional cough, cold and digestive tea.
Infusion used as a gargle for sore throat, drawing on the antiseptic essential oil constituents.
Standardized fluid extract, often combined with ivy leaf, the form studied in clinical trials for acute bronchitis.
Dosage
Traditional guidance suggests roughly 2-4 g dried herb per cup as an infusion, up to three times daily, or an equivalent tincture; used topically as a wash or gargle at similar strength. Educational reference only, not a prescription.
The EU herbal monograph suggests around 1-2 g of dried herb per cup, up to three times daily. Educational reference only, not a prescription; do not take the essential oil undiluted internally.
References
Lookalikes Review
References & Sources
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https://doi.org/10.2174/1570163818666210203181542 - Pan, J. and Wang, H. and Chen, Y (2022) 'Prunella vulgaris L. - A Review of its Ethnopharmacology, Phytochemistry, Quality Control and Pharmacological Effects', Frontiers in Pharmacology, 13, pp. 903171. doi:10.3389/fphar.2022.903171 Meta-analysis / review
https://doi.org/10.3389/fphar.2022.903171 - Wang, S.J. and Wang, X.H. and Dai, Y.Y. and Ma, M.H. and Rahman, K. and Nian, H. and Zhang, H (2019) 'Prunella vulgaris: A Comprehensive Review of Chemical Constituents, Pharmacological Effects and Clinical Applications', Current Pharmaceutical Design, 25(3), pp. 359-369. doi:10.2174/1381612825666190313121608 Meta-analysis / review
https://doi.org/10.2174/1381612825666190313121608 - Zhu, M.J. and Song, Y.J. and Rao, P.L. and Gu, W.Y. and Xu, Y. and Xu, H.X (2025) 'Therapeutic role of Prunella vulgaris L. polysaccharides in non-alcoholic steatohepatitis and gut dysbiosis', Journal of Integrative Medicine, 23(3), pp. 297-308. doi:10.1016/j.joim.2025.03.002 Preclinical
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https://doi.org/10.1016/j.phymed.2024.155818 - Zhang, S. and Wang, Y. and Wang, M. and Jiang, L. and Ma, X. and Huang, Y. and Liu, T. and Zheng, L. and Li, Y (2024) 'Construction and anti-pancreatic cancer activity of selenium nanoparticles stabilized by Prunella vulgaris polysaccharide', Int J Biol Macromol, 278(Pt 3), pp. 134924. doi:10.1016/j.ijbiomac.2024.134924 Preclinical
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https://doi.org/10.3390/molecules29081843 - Han, Q. and Xu, N. and Chen, B. and Wu, W. and Sheng, L (2021) 'Safety and efficacy of Prunella vulgaris preparation in adjuvant treatment of thyroid nodules: A meta-analysis', Medicine (Baltimore), 100(41), pp. e27490. doi:10.1097/MD.0000000000027490 Meta-analysis / review
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https://doi.org/10.3389/fimmu.2023.1196434 - Ma, F. and Deng, Q. and Lou, H. and Li, J. and Xu, S. and Wu, W. and Wen, Q. and Tang, L. and Wang, X. and Pan, W (2022) 'Vulgarisin-type diterpenoids from self-heal (Prunella vulgaris) and their neuroprotective effects against ischemia/reperfusion (I/R) via a mitochondria-related pathway', Food Funct, 13(13), pp. 7062-7074. doi:10.1039/d2fo00150k Preclinical
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https://doi.org/10.1002/ptr.8024 - Jiao, X. and Liu, H. and Lu, Q. and Wang, Y. and Zhao, Y. and Liu, X. and Liu, F. and Zuo, Y. and Wang, W. and Li, Y (2021) 'Study on the Mechanism of Prunella Vulgaris L on Diabetes Mellitus Complicated with Hypertension Based on Network Pharmacology and Molecular Docking Analyses', Journal of Diabetes Research, 2021, pp. 1-14. doi:10.1155/2021/9949302 Preclinical
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https://doi.org/10.1016/j.biopha.2016.09.095 - Qu, Z. and Zhang, J. and Yang, H. and Gao, J. and Chen, H. and Liu, C. and Gao, W (2016) 'Prunella vulgaris L., an Edible and Medicinal Plant, Attenuates Scopolamine-Induced Memory Impairment in Rats', Journal of Agricultural and Food Chemistry, 65(2), pp. 291-300. doi:10.1021/acs.jafc.6b04597 Preclinical
https://doi.org/10.1021/acs.jafc.6b04597 - Guo, Q. and Qu, H. and Zhang, H. and Zhong, X (2021) 'Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling', Drug Design Development and Therapy, Volume 15, pp. 4559-4574. doi:10.2147/dddt.s325814 Preclinical
https://doi.org/10.2147/dddt.s325814 - Akkol, E.K. and Renda, G. and İlhan, M. and Bektaş, N.Y (2022) 'Wound healing acceleration and anti-inflammatory potential of Prunella vulgaris L.: From conventional use to preclinical scientific verification', Journal of Ethnopharmacology, 295, pp. 115411-115411. doi:10.1016/j.jep.2022.115411 Preclinical
https://doi.org/10.1016/j.jep.2022.115411 - Yu, F. and Zhang, L. and Ma, R. and Liu, C. and Wang, Q. and Yin, D (2021) 'The Antitumour Effect of Prunella vulgaris Extract on Thyroid Cancer Cells In Vitro and In Vivo', Evidence-based Complementary and Alternative Medicine, 2021, pp. 1-12. doi:10.1155/2021/8869323 Preclinical
https://doi.org/10.1155/2021/8869323 - Zhong, X., Zhang, Y., Yuan, M., Xu, L., Luo, X., Wu, R., Xi, Z., Li, Y. and Xu, H (2024) 'Prunella vulgaris polysaccharide inhibits herpes simplex virus infection by blocking TLR-mediated NF-kB activation', Chinese Medicine, 19(1). doi:10.1186/s13020-023-00865-y Preclinical
https://doi.org/10.1186/s13020-023-00865-y - Zhang, Q., Li, Y., Zhong, X., Fu, W., Luo, X., Feng, J., Yuan, M., Xiao, L. and Xu, H (2021) 'Polyphenolic-protein-polysaccharide conjugates from Spica of Prunella vulgaris: Chemical profile and anti-herpes simplex virus activities', International Journal of Biological Macromolecules. doi:10.1016/j.ijbiomac.2021.11.200 Preclinical
https://doi.org/10.1016/j.ijbiomac.2021.11.200 - Ma, F.W., Kong, S.Y., Tan, H.S., Wu, R., Xia, B., Zhou, Y. and Xu, H.X (2016) 'Structural characterization and antiviral effect of a novel polysaccharide PSP-2B from Prunellae Spica', Carbohydrate Polymers, pp. 699--709. doi:10.1016/j.carbpol.2016.07.062 Preclinical
https://doi.org/10.1016/j.carbpol.2016.07.062 - Grieve, M (1931) 'A Modern Herbal'. Traditional / reference
https://scholar.google.com/scholar?q=A%20Modern%20Herbal - Psotova, J. et al (2003) 'Biological activities of Prunella vulgaris extract', 17(9), pp. 1082--1087. doi:10.1002/ptr.1324 Preclinical
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https://scholar.google.com/scholar?q=Antiviral%20activity%20of%20aqueous%20extract%20of%20Prunella%20vulgaris%20L - Haarberg, K.M.K., Wymore Brand, M.J., Overstreet, A.M.C., Hauck, C.C., Murphy, P.A., Hostetter, J.M., Ramer-Tait, A.E. and Wannemuehler, M.J (2015) 'Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a(-/-) mice', World Journal of Gastrointestinal Pharmacology and Therapeutics, 6(4), pp. 223--237. doi:10.4292/wjgpt.v6.i4.223 Preclinical
https://doi.org/10.4292/wjgpt.v6.i4.223 - Zhang, Y.B., Xu, L., Yuan, M., Liu, M.F., Li, Y., Zhong, X.L., Lin, Z.X., Xian, Y.F., Lu, P., Xi, Z.C. and Xu, H.X (2025) 'Protective effects of Prunella vulgaris polysaccharides against herpes simplex virus type 1 infection through the STING-TBK1-IRF3 pathway', Journal of Integrative Medicine, 24(3), pp. 454--465. doi:10.1016/j.joim.2025.12.008 Preclinical
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https://doi.org/10.1002/ptr.6109 - Kowalczyk, A., Przychodna, M., Sopata, S., Bodalska, A. and others (2020) 'Thymol and Thyme Essential Oil-New Insights into Selected Therapeutic Applications', Molecules, 25(18), pp. 4125. doi:10.3390/molecules25184125 Meta-analysis / review
https://doi.org/10.3390/molecules25184125 - Wirtu, S.F., Ramaswamy, K., Maitra, R., Chopra, S. and others (2024) 'Isolation, characterization and antimicrobial activity study of Thymus vulgaris', Scientific Reports, 14(1), pp. 21573. doi:10.1038/s41598-024-71012-2 Preclinical
https://doi.org/10.1038/s41598-024-71012-2 - Diniz, A.F., Santos, B., Nobrega, L.M.M.O., Santos, V.R.L. and others (2023) 'Antibacterial activity of Thymus vulgaris (thyme) essential oil against strains of Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus saprophyticus isolated from meat product', Brazilian Journal of Biology, 83, pp. e275306. doi:10.1590/1519-6984.275306 Preclinical
https://doi.org/10.1590/1519-6984.275306 - Tardugno, R., Serio, A., Purgatorio, C., Savini, V. and others (2022) 'Thymus vulgaris L. essential oils from Emilia Romagna Apennines (Italy): phytochemical composition and antimicrobial activity on food-borne pathogens', Natural Product Research, 36(3), pp. 837-842. doi:10.1080/14786419.2020.1798666 Preclinical
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https://doi.org/10.3390/molecules28196910 - Oliva, M.L., Carezzano, M.E., Giuliano, M., Daghero, J. and others (2015) 'Antimicrobial activity of essential oils of Thymus vulgaris and Origanum vulgare on phytopathogenic strains isolated from soybean', Plant Biology, 17(3), pp. 758-765. doi:10.1111/plb.12282 Preclinical
https://doi.org/10.1111/plb.12282 - Vetvicka, V. and Vetvickova, J (2016) 'Essential Oils from Thyme (Thymus vulgaris): Chemical Composition and Biological Effects in Mouse Model', Journal of Medicinal Food, 19(12), pp. 1180-1187. doi:10.1089/jmf.2016.0029 Preclinical
https://doi.org/10.1089/jmf.2016.0029 - Sikic Pogacar, M., Klancnik, A., Bucar, F., Langerholc, T. and others (2016) 'Anti-adhesion activity of thyme (Thymus vulgaris L.) extract, thyme post-distillation waste, and olive leaf extract against Campylobacter jejuni on polystyrene and intestine epithelial cells', Journal of the Science of Food and Agriculture, 96(8), pp. 2723-2730. doi:10.1002/jsfa.7391 Preclinical
https://doi.org/10.1002/jsfa.7391 - European Medicines Agency (HMPC) (n.d.) 'European Union herbal monograph on Thymus vulgaris L. and Thymus zygis L., herba (Thymi herba)'. Available at: https://www.ema.europa.eu/en/medicines/herbal/thymi-herba Traditional / reference
https://www.ema.europa.eu/en/medicines/herbal/thymi-herba - Sharifi-Rad, M., Varoni, E.M., Iriti, M., Martorell, M., Setzer, W.N., del Mar Contreras, M., Salehi, B., Soltani-Nejad, A., Rajabi, S., Tajbakhsh, M. and Sharifi-Rad, J (2018) 'Carvacrol and human health: A comprehensive review', Phytotherapy Research. doi:10.1002/ptr.6103 Preclinical
https://doi.org/10.1002/ptr.6103 - Kemmerich, B., Eberhardt, R. and Stammer, H (2006) 'Efficacy and tolerability of a fluid extract combination of thyme herb and ivy leaves and matched placebo in adults suffering from acute bronchitis with productive cough', Arzneimittel-Forschung, 56(9), pp. 652--660. doi:10.1055/s-0031-1296767 Randomized trial
https://doi.org/10.1055/s-0031-1296767
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.