Plant Comparison

Selfheal vs Rosemary

A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.

First plant
Second plant
Show:
Plant ASelfhealPrunella vulgarisLamiaceaeFull monograph →
Plant BRosemarySalvia rosmarinusLamiaceaeFull monograph →

At a glance

Selfheal and Rosemary: both belong to the Lamiaceae family; they share 8 indicated uses (arthritis / joint pain, infection (general), inflammation (general), …); 5 pharmacological actions in common.

SelfhealRosemary
Constituents23
Pharmacological actions107
Indicated uses1213
Safety notes22
Cited sources3714
Indicated uses
Only Selfheal
BruisingCold & fluImmune supportBlood sugar / diabetes support
Shared (8)
Arthritis / joint painInfection (general)Inflammation (general)Skin irritationWoundsCancer (anticancer research)Cardiovascular / heart healthCognitive function
Only Rosemary
BloatingIndigestionMemoryMenstrual crampsMuscle spasm
Pharmacological actions
Only Selfheal
AntiviralImmunomodulator / immune supportVulnerary (wound healing)Hepatoprotective (liver support)Antidiabetic (blood-sugar lowering)
Shared (5)
Anti-inflammatoryAntimicrobialAntioxidantAnticancer (preclinical)Neuroprotective / cognition support
Only Rosemary
AntispasmodicDigestive aid

Evidence face-off — shared uses

ConditionSelfhealRosemaryVerdict
Arthritis / joint pain2/103/10Comparable evidence
Infection (general)2/103/10Comparable evidence
Inflammation (general)2/108/10Stronger for Rosemary
Skin irritation2/103/10Comparable evidence
Wounds2/103/10Comparable evidence
Cancer (anticancer research)7/107/10Comparable evidence
Cardiovascular / heart health2/103/10Comparable evidence
Cognitive function2/108/10Stronger for Rosemary

Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.

Key Constituents

Triterpenoids and phenolic acids[1, 3]

Pentacyclic triterpenoids (ursolic, oleanolic and betulinic acids), the phenolic acid rosmarinic acid, coumarins (umbelliferone, scopoletin, esculetin) and the flavonoid luteolin are the main bioactives behind self-heal's antioxidant, anti-inflammatory and antimicrobial activity.

Rosmarinic acidPhenolic acidsCoumarinsFlavonoidsLuteolin
Sulphated and polyphenol-conjugated polysaccharides[4, 29, 30, 31]

Water-extracted polysaccharides — including a partially sulphated arabinogalactomannan (PSP-2B) and polyphenolic-protein-polysaccharide conjugates (PVG/PVE30) — are the principal antiviral and immunomodulatory constituents, blocking herpes simplex virus attachment and modulating innate immune signalling.

PolysaccharidesPhenolic compounds
Essential oil (1,8-cineole, camphor, alpha-pinene)[1]

The volatile oil, dominated by 1,8-cineole and camphor, gives the characteristic aroma and much of the antimicrobial activity.

Essential (volatile) oil1,8-Cineole (eucalyptol)CamphorTerpenes / terpenoids
Diterpenes (carnosic acid, carnosol)[1]

Potent antioxidant diterpenes considered largely responsible for rosemary's strong preservative and antioxidant activity.

Rosmarinic acid and phenolic acids[1, 13]

Contribute to antioxidant, anti-inflammatory and cognitive-supportive activity.

Rosmarinic acidPhenolic acids

Pharmacological Actions

Anti-inflammatory[1, 2, 3, 4, 12, 15, 18, 20, 26, 27, 29, 32, 33, 34, 35]
Antimicrobial[1, 3, 32, 33, 34]
Antioxidant[1, 2, 5, 9, 12, 17, 32, 33, 34]
Antiviral[2, 29, 30, 31, 32, 33, 34, 36]
Immunomodulator / immune support[4, 5, 9, 10, 15, 23, 26, 29, 32, 33, 34, 35, 36]
Vulnerary (wound healing)[1, 27, 32, 33, 34]
Anticancer (preclinical)[6, 7, 10, 13, 14, 16, 21, 22, 28]
Neuroprotective / cognition support[11, 25]
Hepatoprotective (liver support)[12, 16, 17]
Antidiabetic (blood-sugar lowering)[19, 20, 24]
Anti-inflammatory[1, 3, 11, 12, 13]
Anticancer (preclinical)[7]
Antimicrobial[1, 4, 11, 12, 13]
Antioxidant[1, 11, 12, 13]
Antispasmodic[11, 12, 13]

Antispasmodic (cramp easing)

Digestive aid[10, 11, 12, 13]
Neuroprotective / cognition support[5, 8, 9, 11, 12, 13]

Traditional & Indicated Uses

Arthritis / joint pain[1, 29, 32, 33, 34, 35]Traditional · 2/10

inferred from anti-inflammatory action

Evidence: 2
Label: Arthritis / joint pain
Bruising[1, 32, 33, 34]Traditional · 2/10

inferred from vulnerary action

Evidence: 2
Label: Bruising
Cold & flu[29, 30, 31, 32, 33, 34, 36]Traditional · 2/10

inferred from antiviral action

Evidence: 2
Label: Cold & flu
Immune support[10, 15, 29, 32, 33, 34, 35, 36]Traditional · 2/10
Evidence: 2
Label: Immune support
Infection (general)[1, 32, 33, 34]Traditional · 2/10

inferred from antimicrobial action

Evidence: 2
Label: Infection (general)
Inflammation (general)[1, 12, 15, 29, 32, 33, 34, 35]Traditional · 2/10

inferred from anti-inflammatory action

Evidence: 2
Label: Inflammation (general)
Skin irritation[1, 29, 32, 33, 34, 35]Traditional · 2/10

inferred from anti-inflammatory action

Evidence: 2
Label: Skin irritation
Wounds[1, 27, 32, 33, 34]Traditional · 2/10

inferred from antimicrobial action

Evidence: 2
Label: Wounds
Cancer (anticancer research)[6, 7, 10, 13, 14, 16, 21, 22, 28]Good · 7/10

inferred from anticancer action

Evidence: 7
Label: Cancer (anticancer research)
Blood sugar / diabetes support[19, 20, 24]Traditional · 2/10
Evidence: 2
Label: Blood sugar / diabetes support
Cardiovascular / heart health[18, 19]Traditional · 2/10
Evidence: 2
Label: Cardiovascular / heart health
Cognitive function[25]Traditional · 2/10
Evidence: 2
Label: Cognitive function
Arthritis / joint pain[11, 12, 13]Limited · 3/10

inferred from anti-inflammatory action

Evidence: 3
Label: Arthritis / joint pain
Bloating[11, 12, 13]Limited · 3/10

inferred from digestive action

Evidence: 3
Label: Bloating
Cancer (anticancer research)[7]Good · 7/10

inferred from anticancer action

Evidence: 7
Label: Cancer (anticancer research)
Cardiovascular / heart health[11, 12, 13]Limited · 3/10
Evidence: 3
Label: Cardiovascular / heart health
Cognitive function[8, 11, 12, 13]Good · 8/10

inferred from neuroprotective action

Evidence: 8
Label: Cognitive function
Indigestion[11, 12, 13]Limited · 3/10

inferred from digestive action

Evidence: 3
Label: Indigestion
Infection (general)[11, 12, 13]Limited · 3/10

inferred from antimicrobial action

Evidence: 3
Label: Infection (general)
Inflammation (general)[3, 11, 12, 13]Good · 8/10

inferred from anti-inflammatory action

Evidence: 8
Label: Inflammation (general)
Memory[8, 9, 11, 12, 13]Strong · 9/10

inferred from neuroprotective action

Evidence: 9
Label: Memory
Menstrual cramps[11, 12, 13]Limited · 3/10

inferred from antispasmodic action

Evidence: 3
Label: Menstrual cramps
Muscle spasm[11, 12, 13]Limited · 3/10

inferred from antispasmodic action

Evidence: 3
Label: Muscle spasm
Skin irritation[11, 12, 13]Limited · 3/10

inferred from anti-inflammatory action

Evidence: 3
Label: Skin irritation
Wounds[11, 12, 13]Limited · 3/10

inferred from antimicrobial action

Evidence: 3
Label: Wounds

Safety, Cautions & Contraindications

Safety note[32, 33, 34]Caution

Generally very safe and well tolerated. No significant known toxicity or drug interactions. Safe for topical and internal use in normal medicinal doses. Suitable for most adults including children in appropriate doses.

Safety note[32, 33, 34, 37]Info

Duke (2002) rates self-heal as +++ and notes antioxidant (score 2), anti-inflammatory, antiviral, and COX-2 inhibitory activities. The plant contains luteolin, rosmarinic acid, and hyperoside — all with well-documented bioactivities. Hepatoprotective activity has been experimentally demonstrated. Duke notes that self-heal has a broad antimicrobial spectrum and an impressive antioxidant profile, supporting its traditional reputation as a versatile wound-healing herb. No significant safety concerns at normal herbal doses (Duke, 2002).

Safety note[11, 12, 13]Caution

Culinary use is entirely safe. Essential oil should not be ingested in large amounts; avoid during pregnancy in medicinal doses. May trigger epileptic seizures in predisposed individuals at high doses. May interact with anticoagulants and antiplatelet drugs.

Safety note[11, 12, 13, 14]Info

Duke (2002) does not appear to include a dedicated entry for rosemary (Salvia rosmarinus / Rosmarinus officinalis) as a primary herb entry in the section searched; however, rosemary is referenced throughout the text in relation to antioxidant and antimicrobial properties of its key compounds (carnosol, rosmarinic acid). Commission E (KOM) approves rosemary for dyspeptic complaints and externally for rheumatic conditions and circulatory problems.

External Ids

Gbif: 5341297
Wikidata: Q158469
Gbif: 10902460
Wikidata: Q102240169

Botanical Description

Low, creeping to semi-erect perennial herb (Lamiaceae), 5-30 cm tall, with square, often purplish stems. Leaves are opposite, ovate with slightly toothed margins. Small, two-lipped, violet-purple flowers are densely packed into a compact, club-shaped terminal spike subtended by purplish bracts.[1]

Height: 5-30 cm
Habit: Low, creeping to semi-erect perennial herb
Leaves: Opposite, ovate, slightly toothed
Flowers: Small, two-lipped, violet-purple, in a compact club-shaped terminal spike
Stem: Square, often purplish
Root: Fibrous, spreading perennial rootstock
Fruit: Four small nutlets (typical Lamiaceae schizocarp)
Flowering Period: June-September

Evergreen, woody shrub (Lamiaceae), 1-2 m tall, with dense, needle-like, dark green, aromatic leaves, white-felted beneath. Small, pale blue to violet, two-lipped flowers are borne in the leaf axils.[1]

Height: 1-2 m
Habit: Evergreen, woody shrub
Leaves: Needle-like, dark green, aromatic, white-felted beneath
Flowers: Small, pale blue to violet, two-lipped, in the leaf axils
Stem: Woody, much-branched
Root: Woody perennial root system
Fruit: Four small nutlets (typical Lamiaceae schizocarp)
Flowering Period: Can flower over much of the year in mild climates, peaking in spring

Habitat

Native throughout Europe, Asia and North America (circumboreal), extremely common in lawns, meadows, woodland clearings, roadsides and waste ground, tolerating mowing and a wide range of soils.[1]

Native to the Mediterranean coast, growing on dry, rocky, sunny slopes and coastal scrub; widely cultivated as a culinary and medicinal herb worldwide, tolerating poor, well-drained soils and drought.[1]

Harvesting

Whole flowering aerial parts (flower, leaf and stem) are cut during flowering (summer) and dried.[1]

Parts: Flower, Leaf, Stem
Season: Summer, during flowering

Leafy sprigs are cut throughout the year (the plant is evergreen), though essential-oil content is often considered highest just before or during flowering; leaves are stripped from the stem and dried, or used fresh.[1]

Parts: Leaf, Flower
Season: Year-round; oil content peaks around flowering

Traditional Uses

Selfheal has an extremely broad folk-medicine reputation across European, North American and Traditional Chinese Medicine traditions - as its name suggests, used as an all-purpose wound herb, gargle for sore throat, and internal remedy for fevers and inflammation. Modern research on its triterpenoid, phenolic and polysaccharide constituents supports wide-ranging antioxidant, anti-inflammatory, antimicrobial and antiviral activity.[1]

Rosemary has an ancient Mediterranean reputation as a memory and circulation tonic ('rosemary for remembrance'), a digestive carminative, and an antiseptic for minor wounds. Commission E approves it for dyspeptic complaints internally and for rheumatic conditions and circulatory problems externally; modern research on rosmarinic acid and carnosic acid supports antioxidant, anti-inflammatory, antimicrobial and cognitive-supportive activity.[1]

Preparations

Infusion (tea)[1]

Dried aerial parts steeped in hot water, taken internally or used as a gargle or wash.

Infusion (tea)[11, 12, 13]

Dried leaf steeped in hot water, for digestive complaints.

Essential oil (aromatherapy/topical)[12]

Inhaled for cognitive/mood effects, or diluted and applied for muscular and rheumatic complaints.

Dosage

Infusion (tea)[1]

Traditional guidance suggests roughly 2-4 g dried herb per cup as an infusion, up to three times daily, or an equivalent tincture; used topically as a wash or gargle at similar strength. Educational reference only, not a prescription.

Infusion (tea)[11, 12, 13]

Commission E approves rosemary for dyspeptic complaints (internal use) and, externally, for rheumatic conditions and circulatory problems; typical internal use is roughly 2-4 g dried leaf as tea, up to three times daily. Educational reference only, not a prescription; avoid concentrated essential oil internally and in pregnancy/epilepsy.

References

REF-0659, REF-2422, REF-2423, REF-2424, REF-2425, REF-2878, REF-2879, REF-2880, REF-2881, REF-2882, REF-2883, REF-2884, REF-2885, REF-2886, REF-2887, REF-2888, REF-2911, REF-2912, REF-2913, REF-2914, REF-2915, REF-2916, REF-2917, REF-2918, REF-2919, REF-2920, REF-2921, REF-2922
REF-1283, REF-1284, REF-1285, REF-1286, REF-1287, REF-1288, REF-1289, REF-1290, REF-1291, REF-1292

Lookalikes Review

Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07
Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

References & Sources

  1. Mir, R.H., Bhat, M.F., Sawhney, G., Kumar, P., Andrabi, N.I., Shaikh, M., Mohi-Ud-Din, R. and Masoodi, M.H (2022) 'Prunella vulgaris L.: Critical Pharmacological, Expository Traditional Uses and Extensive Phytochemistry: A Review', Current Drug Discovery Technologies, 19(1). doi:10.2174/1570163818666210203181542 Traditional / reference
    https://doi.org/10.2174/1570163818666210203181542
  2. Pan, J. and Wang, H. and Chen, Y (2022) 'Prunella vulgaris L. - A Review of its Ethnopharmacology, Phytochemistry, Quality Control and Pharmacological Effects', Frontiers in Pharmacology, 13, pp. 903171. doi:10.3389/fphar.2022.903171 Meta-analysis / review
    https://doi.org/10.3389/fphar.2022.903171
  3. Wang, S.J. and Wang, X.H. and Dai, Y.Y. and Ma, M.H. and Rahman, K. and Nian, H. and Zhang, H (2019) 'Prunella vulgaris: A Comprehensive Review of Chemical Constituents, Pharmacological Effects and Clinical Applications', Current Pharmaceutical Design, 25(3), pp. 359-369. doi:10.2174/1381612825666190313121608 Meta-analysis / review
    https://doi.org/10.2174/1381612825666190313121608
  4. Zhu, M.J. and Song, Y.J. and Rao, P.L. and Gu, W.Y. and Xu, Y. and Xu, H.X (2025) 'Therapeutic role of Prunella vulgaris L. polysaccharides in non-alcoholic steatohepatitis and gut dysbiosis', Journal of Integrative Medicine, 23(3), pp. 297-308. doi:10.1016/j.joim.2025.03.002 Preclinical
    https://doi.org/10.1016/j.joim.2025.03.002
  5. Zhang, Y. and Qu, X. and Xu, N. and He, H. and Li, Q. and Wei, X. and Chen, Y. and Xu, Y. and Li, X. and Zhang, R. and Zhong, R. and Liu, C. and Xiang, P. and Zhu, F (2024) 'Mechanism of Prunella vulgaris L. and luteolin in restoring Tfh/Tfr balance and alleviating oxidative stress in Graves' disease', Phytomedicine, 132, pp. 155818. doi:10.1016/j.phymed.2024.155818 Preclinical
    https://doi.org/10.1016/j.phymed.2024.155818
  6. Zhang, S. and Wang, Y. and Wang, M. and Jiang, L. and Ma, X. and Huang, Y. and Liu, T. and Zheng, L. and Li, Y (2024) 'Construction and anti-pancreatic cancer activity of selenium nanoparticles stabilized by Prunella vulgaris polysaccharide', Int J Biol Macromol, 278(Pt 3), pp. 134924. doi:10.1016/j.ijbiomac.2024.134924 Preclinical
    https://doi.org/10.1016/j.ijbiomac.2024.134924
  7. Ning, N. and Nan, Y. and Chen, G. and Huang, S. and Lu, D. and Yang, Y. and Meng, F. and Yuan, L (2024) 'Anti-Tumor Effects and Toxicity Reduction Mechanisms of Prunella vulgaris: A Comprehensive Review', Molecules, 29(8). doi:10.3390/molecules29081843 Meta-analysis / review
    https://doi.org/10.3390/molecules29081843
  8. Han, Q. and Xu, N. and Chen, B. and Wu, W. and Sheng, L (2021) 'Safety and efficacy of Prunella vulgaris preparation in adjuvant treatment of thyroid nodules: A meta-analysis', Medicine (Baltimore), 100(41), pp. e27490. doi:10.1097/MD.0000000000027490 Meta-analysis / review
    https://doi.org/10.1097/MD.0000000000027490
  9. Li, P. and Lv, X. and Wang, J. and Zhang, C. and Zhao, J. and Yang, Y (2023) 'Research on the anti-ageing mechanism of Prunella vulgaris L', Sci Rep, 13(1), pp. 12398. doi:10.1038/s41598-023-39609-1 Preclinical
    https://doi.org/10.1038/s41598-023-39609-1
  10. Zhang, Q. and Chen, X. and Palen, K. and Johnson, B. and Bui, D. and Xiong, D. and Pan, J. and Hu, M. and Wang, Y. and You, M (2023) 'Cancer chemoprevention with PV-1, a novel Prunella vulgaris-containing herbal mixture that remodels the tumor immune microenvironment in mice', Front Immunol, 14, pp. 1196434. doi:10.3389/fimmu.2023.1196434 Preclinical
    https://doi.org/10.3389/fimmu.2023.1196434
  11. Ma, F. and Deng, Q. and Lou, H. and Li, J. and Xu, S. and Wu, W. and Wen, Q. and Tang, L. and Wang, X. and Pan, W (2022) 'Vulgarisin-type diterpenoids from self-heal (Prunella vulgaris) and their neuroprotective effects against ischemia/reperfusion (I/R) via a mitochondria-related pathway', Food Funct, 13(13), pp. 7062-7074. doi:10.1039/d2fo00150k Preclinical
    https://doi.org/10.1039/d2fo00150k
  12. Xie, J. and Xiong, S. and Yu, J. and Ma, X. and Xiang, F. and Chen, Y. and Xia, B. and Li, Y. and Zhang, Z. and Liao, D. and Lin, L (2025) 'Prunella vulgaris polyphenols alleviate liver injury-uveitis comorbidity by regulating acylcarnitine via the S100A9-PP2A-AMPK pathway', Phytomedicine, 141, pp. 156675. doi:10.1016/j.phymed.2025.156675 Preclinical
    https://doi.org/10.1016/j.phymed.2025.156675
  13. Li, Y. and Luo, H. and Lin, X. and Hua, L. and Wang, J. and Xie, J. and Zhang, Z. and Shi, Z. and Li, M. and Peng, Q. and Lin, L. and Liao, D. and Xia, B (2025) 'Triterpenes of Prunella vulgaris Inhibit Triple-Negative Breast Cancer by Regulating PTP1B/PI3K/AKT/mTOR and IL-24/CXCL12/CXCR4 Pathways', Int J Mol Sci, 26(5). doi:10.3390/ijms26051959 Preclinical
    https://doi.org/10.3390/ijms26051959
  14. Zeng, S. and Liu, B. and Ge, R. and Yuan, Z. and Yang, Y. and Zhu, W. and Wang, Z (2025) 'An integrative analysis reveals mechanisms of Prunella vulgaris in thyroid cancer metastasis', Phytomedicine, 145, pp. 157051. doi:10.1016/j.phymed.2025.157051 Preclinical
    https://doi.org/10.1016/j.phymed.2025.157051
  15. Zhu, Q. and Muyayalo, K.P. and Xu, Q.H. and Wang, J. and Wang, H. and Liao, A.H (2021) 'Prunella vulgaris can improve the pregnancy outcomes of experimental autoimmune thyroiditis rats by inhibiting Th1/Th17 immune responses', J Reprod Immunol, 149, pp. 103469. doi:10.1016/j.jri.2021.103469 Preclinical
    https://doi.org/10.1016/j.jri.2021.103469
  16. Lin, J. and Zhou, J. and Ye, K. and Xie, F (2025) 'Prunella vulgaris: A potential molecule for the treatment of hepatocellular carcinoma', Medicine (Baltimore), 104(17), pp. e42267. doi:10.1097/MD.0000000000042267 Preclinical
    https://doi.org/10.1097/MD.0000000000042267
  17. Li, L. and Lin, L. and Deng, J. and Lin, X. and Li, Y. and Xia, B (2021) 'The therapeutic effects of Prunella vulgaris against fluoride‐induced oxidative damage by using the metabolomics method', Environmental Toxicology, 36(9), pp. 1802-1816. doi:10.1002/tox.23301 Preclinical
    https://doi.org/10.1002/tox.23301
  18. Wei, J. and Leng, L. and Sui, Y. and Song, S. and Owusu, F.B. and Li, X. and Cao, Y. and Li, P. and Wang, H. and Li, R. and Yang, W. and Gao, X. and Wang, Q (2023) 'Phenolic acids from Prunella vulgaris alleviate cardiac remodeling following myocardial infarction partially by suppressing NLRP3 activation', Phytotherapy Research, 38(1), pp. 384-399. doi:10.1002/ptr.8024 Preclinical
    https://doi.org/10.1002/ptr.8024
  19. Jiao, X. and Liu, H. and Lu, Q. and Wang, Y. and Zhao, Y. and Liu, X. and Liu, F. and Zuo, Y. and Wang, W. and Li, Y (2021) 'Study on the Mechanism of Prunella Vulgaris L on Diabetes Mellitus Complicated with Hypertension Based on Network Pharmacology and Molecular Docking Analyses', Journal of Diabetes Research, 2021, pp. 1-14. doi:10.1155/2021/9949302 Preclinical
    https://doi.org/10.1155/2021/9949302
  20. Namgung, S. and Yoon, J.J. and Yoon, C. and Han, B.H. and Choi, E.S. and Oh, H. and Kim, Y. and Lee, Y.J. and Kang, D.G. and Lee, H.S (2017) 'Prunella vulgarisAttenuates Diabetic Renal Injury by Suppressing Glomerular Fibrosis and Inflammation', The American Journal of Chinese Medicine, 45(03), pp. 475-495. doi:10.1142/s0192415x1750029x Preclinical
    https://doi.org/10.1142/s0192415x1750029x
  21. Lim, G. and Sung, J.Y. and Yu, S. and Kim, Y. and Kim, Y. and Shim, J. and Kim, H.J. and Cho, M.L. and Lee, J. and Kim, Y. and Kim, Y (2020) 'Pygenic Acid A (PA) Sensitizes Metastatic Breast Cancer Cells to Anoikis and Inhibits Metastasis In Vivo', International Journal of Molecular Sciences, 21(22), pp. 8444-8444. doi:10.3390/ijms21228444 Preclinical
    https://doi.org/10.3390/ijms21228444
  22. Lin, Y. and Yang, C. and Tang, J. and Li, Q. and Zhang, Z. and Xia, B. and Li, Y. and He, Q. and Lin, L. and Liao, D (2020) 'Characterization and anti-uterine tumor effect of extract from Prunella vulgaris L', BMC Complementary Medicine and Therapies, 20(1), pp. 189-189. doi:10.1186/s12906-020-02986-5 Preclinical
    https://doi.org/10.1186/s12906-020-02986-5
  23. Chen, Y. and Jiang, B. and Qu, C. and Jiang, C. and Zhang, C. and Wang, Y. and Chen, F. and Sun, X. and Su, L. and Luo, Y (2024) 'Bioactive components in prunella vulgaris for treating Hashimoto's disease via regulation of innate immune response in human thyrocytes', Heliyon, 10(16), pp. e36103-e36103. doi:10.1016/j.heliyon.2024.e36103 Preclinical
    https://doi.org/10.1016/j.heliyon.2024.e36103
  24. Raafat, K. and Wurglics, M. and Schubert‐Zsilavecz, M (2016) 'Prunella vulgaris L. active components and their hypoglycemic and antinociceptive effects in alloxan-induced diabetic mice', Biomedicine & Pharmacotherapy, 84, pp. 1008-1018. doi:10.1016/j.biopha.2016.09.095 Preclinical
    https://doi.org/10.1016/j.biopha.2016.09.095
  25. Qu, Z. and Zhang, J. and Yang, H. and Gao, J. and Chen, H. and Liu, C. and Gao, W (2016) 'Prunella vulgaris L., an Edible and Medicinal Plant, Attenuates Scopolamine-Induced Memory Impairment in Rats', Journal of Agricultural and Food Chemistry, 65(2), pp. 291-300. doi:10.1021/acs.jafc.6b04597 Preclinical
    https://doi.org/10.1021/acs.jafc.6b04597
  26. Guo, Q. and Qu, H. and Zhang, H. and Zhong, X (2021) 'Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling', Drug Design Development and Therapy, Volume 15, pp. 4559-4574. doi:10.2147/dddt.s325814 Preclinical
    https://doi.org/10.2147/dddt.s325814
  27. Akkol, E.K. and Renda, G. and İlhan, M. and Bektaş, N.Y (2022) 'Wound healing acceleration and anti-inflammatory potential of Prunella vulgaris L.: From conventional use to preclinical scientific verification', Journal of Ethnopharmacology, 295, pp. 115411-115411. doi:10.1016/j.jep.2022.115411 Preclinical
    https://doi.org/10.1016/j.jep.2022.115411
  28. Yu, F. and Zhang, L. and Ma, R. and Liu, C. and Wang, Q. and Yin, D (2021) 'The Antitumour Effect of Prunella vulgaris Extract on Thyroid Cancer Cells In Vitro and In Vivo', Evidence-based Complementary and Alternative Medicine, 2021, pp. 1-12. doi:10.1155/2021/8869323 Preclinical
    https://doi.org/10.1155/2021/8869323
  29. Zhong, X., Zhang, Y., Yuan, M., Xu, L., Luo, X., Wu, R., Xi, Z., Li, Y. and Xu, H (2024) 'Prunella vulgaris polysaccharide inhibits herpes simplex virus infection by blocking TLR-mediated NF-kB activation', Chinese Medicine, 19(1). doi:10.1186/s13020-023-00865-y Preclinical
    https://doi.org/10.1186/s13020-023-00865-y
  30. Zhang, Q., Li, Y., Zhong, X., Fu, W., Luo, X., Feng, J., Yuan, M., Xiao, L. and Xu, H (2021) 'Polyphenolic-protein-polysaccharide conjugates from Spica of Prunella vulgaris: Chemical profile and anti-herpes simplex virus activities', International Journal of Biological Macromolecules. doi:10.1016/j.ijbiomac.2021.11.200 Preclinical
    https://doi.org/10.1016/j.ijbiomac.2021.11.200
  31. Ma, F.W., Kong, S.Y., Tan, H.S., Wu, R., Xia, B., Zhou, Y. and Xu, H.X (2016) 'Structural characterization and antiviral effect of a novel polysaccharide PSP-2B from Prunellae Spica', Carbohydrate Polymers, pp. 699--709. doi:10.1016/j.carbpol.2016.07.062 Preclinical
    https://doi.org/10.1016/j.carbpol.2016.07.062
  32. Grieve, M (1931) 'A Modern Herbal'. Traditional / reference
    https://scholar.google.com/scholar?q=A%20Modern%20Herbal
  33. Psotova, J. et al (2003) 'Biological activities of Prunella vulgaris extract', 17(9), pp. 1082--1087. doi:10.1002/ptr.1324 Preclinical
    https://doi.org/10.1002/ptr.1324
  34. Yang, Y.Q. et al (2007) 'Antiviral activity of aqueous extract of Prunella vulgaris L', 73(3), pp. 157--162. Traditional / reference
    https://scholar.google.com/scholar?q=Antiviral%20activity%20of%20aqueous%20extract%20of%20Prunella%20vulgaris%20L
  35. Haarberg, K.M.K., Wymore Brand, M.J., Overstreet, A.M.C., Hauck, C.C., Murphy, P.A., Hostetter, J.M., Ramer-Tait, A.E. and Wannemuehler, M.J (2015) 'Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a(-/-) mice', World Journal of Gastrointestinal Pharmacology and Therapeutics, 6(4), pp. 223--237. doi:10.4292/wjgpt.v6.i4.223 Preclinical
    https://doi.org/10.4292/wjgpt.v6.i4.223
  36. Zhang, Y.B., Xu, L., Yuan, M., Liu, M.F., Li, Y., Zhong, X.L., Lin, Z.X., Xian, Y.F., Lu, P., Xi, Z.C. and Xu, H.X (2025) 'Protective effects of Prunella vulgaris polysaccharides against herpes simplex virus type 1 infection through the STING-TBK1-IRF3 pathway', Journal of Integrative Medicine, 24(3), pp. 454--465. doi:10.1016/j.joim.2025.12.008 Preclinical
    https://doi.org/10.1016/j.joim.2025.12.008
  37. Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
    https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
  1. de Oliveira, J.R., Camargo, S.E.A. and de Oliveira, L.D (2019) 'Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent', Journal of Biomedical Science, 26(1), pp. 5. doi:10.1186/s12929-019-0499-8 Meta-analysis / review
    https://doi.org/10.1186/s12929-019-0499-8
  2. Ghasemzadeh Rahbardar, M. and Hosseinzadeh, H (2025) 'Toxicity and safety of rosemary (Rosmarinus officinalis): a comprehensive review', Naunyn-Schmiedeberg's Archives of Pharmacology, 398(1), pp. 9-23. doi:10.1007/s00210-024-03336-9 Meta-analysis / review
    https://doi.org/10.1007/s00210-024-03336-9
  3. Zhang, L. and Lu, J (2024) 'Rosemary (Rosmarinus officinalis L.) polyphenols and inflammatory bowel diseases: Major phytochemicals, functional properties, and health effects', Fitoterapia, 177, pp. 106074. doi:10.1016/j.fitote.2024.106074 Meta-analysis / review
    https://doi.org/10.1016/j.fitote.2024.106074
  4. Ahmed, H.M. and Babakir-Mina, M (2020) 'Investigation of rosemary herbal extracts (Rosmarinus officinalis) and their potential effects on immunity', Phytotherapy Research, 34(8), pp. 1829-1837. doi:10.1002/ptr.6648 Preclinical
    https://doi.org/10.1002/ptr.6648
  5. Li, T., Wang, W., Guo, Q., Li, J. and others (2023) 'Rosemary (Rosmarinus officinalis L.) hydrosol based on serotonergic synapse for insomnia', Journal of Ethnopharmacology, 318(Pt B), pp. 116984. doi:10.1016/j.jep.2023.116984 Preclinical
    https://doi.org/10.1016/j.jep.2023.116984
  6. Hassani, F.V., Shirani, K. and Hosseinzadeh, H (2016) 'Rosemary (Rosmarinus officinalis) as a potential therapeutic plant in metabolic syndrome: a review', Naunyn-Schmiedeberg's Archives of Pharmacology, 389(9), pp. 931-949. doi:10.1007/s00210-016-1256-0 Meta-analysis / review
    https://doi.org/10.1007/s00210-016-1256-0
  7. Gonzalez-Vallinas, M., Reglero, G. and Ramirez de Molina, A (2015) 'Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy', Nutrition and Cancer, 67(8), pp. 1221-1229. doi:10.1080/01635581.2015.1082110 Meta-analysis / review
    https://doi.org/10.1080/01635581.2015.1082110
  8. Hussain, S.M., Syeda, A.F., Alshammari, M., Alnasser, S. and others (2022) 'Cognition enhancing effect of rosemary (Rosmarinus officinalis L.) in lab animal studies: a systematic review and meta-analysis', Brazilian Journal of Medical and Biological Research, 55, pp. e11593. doi:10.1590/1414-431X2021e11593 Meta-analysis / review
    https://doi.org/10.1590/1414-431X2021e11593
  9. Nematolahi, P., Mehrabani, M., Karami-Mohajeri, S. and Dabaghzadeh, F (2018) 'Effects of Rosmarinus officinalis L. on memory performance, anxiety, depression, and sleep quality in university students: A randomized clinical trial', Complementary Therapies in Clinical Practice, 30, pp. 24-28. doi:10.1016/j.ctcp.2017.11.004 Randomized trial
    https://doi.org/10.1016/j.ctcp.2017.11.004
  10. Ulbricht, C., Abrams, T.R., Brigham, A., Ceurvels, J. and others (2010) 'An evidence-based systematic review of rosemary (Rosmarinus officinalis) by the Natural Standard Research Collaboration', Journal of Dietary Supplements, 7(4), pp. 351-413. doi:10.3109/19390211.2010.525049 Meta-analysis / review
    https://doi.org/10.3109/19390211.2010.525049
  11. Hoffmann, D (2003) 'Medical Herbalism'. Traditional / reference
    https://scholar.google.com/scholar?q=Medical%20Herbalism
  12. Moss, M., Cook, J., Wesnes, K. and Duckett, P (2003) 'Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults', 113(1), pp. 15--38. doi:10.1080/00207450390161903 Clinical study
    https://doi.org/10.1080/00207450390161903
  13. Petersen, M. and Simmonds, M.S.J (2003) 'Rosmarinic acid', 62(2), pp. 121--125. Traditional / reference
    https://scholar.google.com/scholar?q=Rosmarinic%20acid
  14. Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
    https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition

Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.