Plant Comparison

Field restharrow vs Scots Pine

A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.

First plant
Second plant
Show:
Plant AField restharrowOnonis arvensisFabaceaeFull monograph →
Plant BScots PinePinus sylvestrisPinaceaeFull monograph →

At a glance

Field restharrow and Scots Pine: they share 8 indicated uses (cancer (anticancer research), urinary support, urinary tract infection (uti), …); 5 pharmacological actions in common.

Field restharrowScots Pine
Constituents63
Pharmacological actions126
Indicated uses1112
Safety notes32
Cited sources4217
Indicated uses
Only Field restharrow
Kidney supportPain (general)Cardiovascular / heart health
Shared (8)
Cancer (anticancer research)Urinary supportUrinary tract infection (UTI)Swelling / fluid retentionInfection (general)WoundsSkin irritationInflammation (general)
Only Scots Pine
Arthritis / joint painBronchitisCoughRespiratory support
Pharmacological actions
Only Field restharrow
Urinary antisepticVulnerary (wound healing)Analgesic (pain relief)GastroprotectiveAntifungalLipid-loweringAntiplatelet / anticoagulant
Shared (5)
DiureticAnti-inflammatoryAntimicrobialAntioxidantAnticancer (preclinical)
Only Scots Pine
Expectorant

Evidence face-off — shared uses

ConditionField restharrowScots PineVerdict
Cancer (anticancer research)2/102/10Comparable evidence
Urinary support9/102/10Stronger for Field restharrow
Urinary tract infection (UTI)2/102/10Comparable evidence
Swelling / fluid retention7/102/10Stronger for Field restharrow
Infection (general)2/102/10Comparable evidence
Wounds2/102/10Comparable evidence
Skin irritation2/102/10Comparable evidence
Inflammation (general)2/102/10Comparable evidence

Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.

Key Constituents

Isoflavonoids (formononetin, ononin and derivatives)[1, 3, 5, 20]

Formononetin and its 7-O-glucoside ononin, plus related isoflavones - the signature restharrow constituents (also phytoestrogens).

FlavonoidsGlycosidesPhenolic compounds
Pterocarpans and isoflavanones (medicarpin, maackiain, onogenin, sativanone)[1, 4]

Pterocarpans and isoflavanones and their glucosides, contributing to antimicrobial and wound-healing activity.

FlavonoidsGlycosides
alpha-Onocerin[7]

alpha-Onocerin (onocerin), a characteristic triterpene of the genus Ononis.

Triterpene saponinsTerpenes / terpenoids
Coumarins (scopoletin, scopolin)[1]

Coumarins detected in the phytochemical profile.

Coumarins
Hydroxycinnamic / phenolic acids[6]

Caffeic, chlorogenic and p-coumaric acids (antioxidant).

Caffeic acidChlorogenic acidPhenolic acids
Essential (volatile) oil[10]

A volatile oil present in the root and aerial parts.

Essential (volatile) oil
Essential oil (alpha-pinene, beta-pinene, limonene)[3, 4]

The needle oil is dominated by monoterpene hydrocarbons, chiefly alpha-pinene, giving the characteristic resinous scent and much of its antimicrobial activity.

Essential (volatile) oilTerpenes / terpenoids
Resin acids (diterpene resin acids)[10]

The resinous sap/pitch, traditionally used topically for wounds and skin complaints.

Terpenes / terpenoids
Vitamin C and flavonoids (needles)

The needle is traditionally valued as a source of vitamin C, particularly in winter.

Flavonoids

Pharmacological Actions

Diuretic[8, 13, 28, 30, 42]

Aquaretic diuretic; the classic irrigation-therapy action of restharrow root (Ononidis radix), used interchangeably for O. arvensis and O. spinosa.

Urinary antiseptic[15]

Aqueous root extract reduced adhesion of uropathogenic E. coli to bladder cells (anti-adhesive).

Anti-inflammatory[14, 16, 17, 39]

Inhibits IL-8 release via TLR4/LPS and cytosolic phospholipase A2alpha (restharrow root).

Antimicrobial[2, 13, 21, 41]
Vulnerary (wound healing)[16, 20]

Isoflavonoids from restharrow root promote wound healing in vivo.

Antioxidant[5, 6, 13, 21, 31, 34, 40]
Analgesic (pain relief)[18, 33]

Analgesic activity of Ononis extract in animals (congener O. spinosa).

Gastroprotective[19]

Protective against ethanol-induced gastric mucosal injury (congener O. spinosa).

Anticancer (preclinical)[5, 27]

Ononis isoflavones showed chemopreventive/antiproliferative activity against breast cancer cells (preclinical).

Antifungal[22]
Lipid-lowering[24, 35]
Antiplatelet / anticoagulant[26]
Anti-inflammatory[2, 10, 11, 12, 13]
Anticancer (preclinical)[7]
Antimicrobial[1, 8, 9, 11, 12, 13]
Antioxidant[5, 11, 12, 13]
Diuretic[11, 12, 13]
Expectorant[11, 12, 13]

Traditional & Indicated Uses

Cancer (anticancer research)[5, 27]Traditional · 2/10

inferred from anticancer action

Evidence: 2
Label: Cancer (anticancer research)
Urinary support[8, 13, 15, 28, 30]Strong · 9/10

Aquaretic diuretic for irrigation therapy of the urinary tract.

Evidence: 9
Label: Urinary support
Urinary tract infection (UTI)[15]Traditional · 2/10

Anti-adhesive activity against uropathogenic E. coli.

Evidence: 2
Label: Urinary tract infection (UTI)
Kidney support[8, 13]Good · 7/10

inferred from diuretic / urinary 'gravel' traditional use

Evidence: 7
Label: Kidney support
Swelling / fluid retention[13]Good · 7/10

inferred from diuretic (aquaretic) action

Evidence: 7
Label: Swelling / fluid retention
Infection (general)[2]Traditional · 2/10

inferred from antimicrobial action

Evidence: 2
Label: Infection (general)
Wounds[16]Traditional · 2/10

Isoflavonoid wound-healing agents from restharrow root.

Evidence: 2
Label: Wounds
Skin irritation[8, 17]Traditional · 2/10

inferred from anti-inflammatory and traditional skin/eczema use

Evidence: 2
Label: Skin irritation
Inflammation (general)[14, 17]Traditional · 2/10
Evidence: 2
Label: Inflammation (general)
Pain (general)[18]Traditional · 2/10

inferred from analgesic action

Evidence: 2
Label: Pain (general)
Cardiovascular / heart health[24, 26, 35]Traditional · 2/10

Ononis isoflavonoids (maackiain, ononin) showed anti-adipogenic activity via PPAR-gamma inhibition (preclinical).

Evidence: 2
Label: Cardiovascular / heart health
Arthritis / joint pain[11, 12, 13]Traditional · 2/10

inferred from anti-inflammatory action

Evidence: 2
Label: Arthritis / joint pain
Bronchitis[11, 12, 13]Traditional · 2/10

inferred from expectorant action

Evidence: 2
Label: Bronchitis
Cancer (anticancer research)[7]Traditional · 2/10

inferred from anticancer action

Evidence: 2
Label: Cancer (anticancer research)
Cough[11, 12, 13]Traditional · 2/10

inferred from expectorant action

Evidence: 2
Label: Cough
Infection (general)[11, 12, 13]Traditional · 2/10

inferred from antimicrobial action

Evidence: 2
Label: Infection (general)
Inflammation (general)[11, 12, 13]Traditional · 2/10

inferred from anti-inflammatory action

Evidence: 2
Label: Inflammation (general)
Respiratory support[2, 11, 12, 13]Traditional · 2/10
Evidence: 2
Label: Respiratory support
Skin irritation[10, 11, 12, 13]Traditional · 2/10

inferred from anti-inflammatory action

Evidence: 2
Label: Skin irritation
Swelling / fluid retention[11, 12, 13]Traditional · 2/10

inferred from diuretic action

Evidence: 2
Label: Swelling / fluid retention
Urinary support[11, 12, 13]Traditional · 2/10

inferred from diuretic action

Evidence: 2
Label: Urinary support
Urinary tract infection (UTI)[11, 12, 13]Traditional · 2/10

inferred from diuretic action

Evidence: 2
Label: Urinary tract infection (UTI)
Wounds[10, 11, 12, 13]Traditional · 2/10

inferred from antimicrobial action

Evidence: 2
Label: Wounds

Safety, Cautions & Contraindications

Safety note[18]Warning

A safety signal exists in the genus: an Ononis spinosa root extract showed hepatotoxic effects at higher doses in animals (alongside analgesic activity). Avoid excessive or prolonged use, and use caution in liver disease.

Safety note[13]Caution

Used as an aquaretic for irrigation therapy of the urinary tract, restharrow should be taken with a generous fluid intake; it should NOT be used for 'flushing' when there is oedema due to impaired heart or kidney function (standard irrigation-therapy caution).

Safety note[1, 3]Caution

The root is rich in isoflavone phytoestrogens (formononetin); avoid medicinal doses in pregnancy and breastfeeding and use caution in hormone-sensitive conditions.

Safety note[11, 12, 13]Caution

Generally safe in normal amounts. Pine essential oil should not be ingested; topical use only in diluted form. May irritate airways in high concentrations. Allergic reactions to pine pollen and resin are common. Turpentine products are irritant and potentially toxic if ingested.

Safety note[11, 12, 13, 14]Caution

Duke (2002) rates Scotch pine as + and notes antiseptic, antibacterial (score 1), and bronchospasmolytic activities. Commission E (KOM) and PhEur (PIP) approve pine needle preparations for topical use in rheumatic and neuralgic conditions and for inhalations in upper respiratory catarrh. Duke cautions that pine needle oil should not be inhaled by patients with severe asthma, whooping cough, or laryngospasm. Pine bud preparations are traditionally used for bronchitis and sinus congestion. Dose: 100–200 mg essential oil in ointment or cream for topical use (Duke, 2002).

External Ids

Gbif: 2977171
Wikidata: Q164263
Gbif: 5285637
Wikidata: Q133128

Synonyms

Ononis hircina, Ononis arvensis subsp. arvensis

Not documented

Botanical Description

A tough, deep-rooted perennial herb or low subshrub of the pea family, 30-80 cm tall, sometimes bearing soft spines. It has a very long, woody, tenacious taproot - so strong it was said to stop (arrest) the harrow, giving 'rest-harrow' its name. The stems are hairy and sticky, often reddish, and clothed in small trifoliolate (clover-like) leaves with toothed leaflets. The flowers are typical pea flowers, pink to purplish-pink (occasionally white), borne singly or in pairs in the leaf axils. Field restharrow (O. arvensis) is generally less spiny than its close relative spiny restharrow (O. spinosa).[8, 10]

Height: 30-80 cm
Habit: Deep-rooted perennial herb or low subshrub, sometimes softly spiny
Leaves: Trifoliolate (clover-like), with finely toothed leaflets; stems hairy and glandular-sticky
Flowers: Pea-type, pink to purplish-pink (rarely white), solitary or paired in the leaf axils
Stem: Erect to ascending, hairy and sticky, often reddish; less spiny than O. spinosa
Root: Very long, woody, tenacious taproot (the medicinal Ononidis radix)
Fruit: A small, hairy, few-seeded pea pod
Flowering Period: June-September

Evergreen coniferous tree (Pinaceae), 15-35 m tall, with a long, straight trunk at maturity, distinctive orange-red flaking bark in the upper crown and grey-brown fissured bark at the base. Needles are blue-green, borne in pairs (fascicles of two) with a papery basal sheath. Small yellow male cones release pollen in spring; female cones are woody and mature over two years.[11]

Height: 15-35 m
Habit: Evergreen coniferous tree
Leaves: Needles blue-green, in pairs, with a papery basal sheath
Flowers: Small yellow male cones (pollen); separate woody female cones
Stem: Long, straight trunk; orange-red flaking bark in the upper crown, grey-brown fissured bark at the base
Root: Deep, wide-spreading root system
Fruit: Woody cone, maturing over two years
Flowering Period: May (pollen release)

Habitat

Rough grassland, field margins, roadsides, dunes and dry, sandy or calcareous waste ground across Europe, western Asia and parts of North Africa. As a deep-rooted, nitrogen-fixing legume it colonises poor, disturbed soils and was historically a troublesome weed of arable fields (hence 'restharrow').[8]

Native across northern and central Europe and Siberia - the most widely distributed pine species in the world - forming extensive boreal and montane forests on poor, sandy or peaty, acidic soils; a pioneer species tolerant of dry, nutrient-poor ground.[11]

Harvesting

The root (Ononidis radix) is the principal medicinal part, dug in autumn from the second year onward and dried; the aerial flowering parts are also gathered in summer. The long woody taproot is cleaned and cut before drying for decoctions and infusions.[8]

Parts: Root, Aerial parts
Season: Root in autumn; aerial parts in flower (summer)

Young shoots ('candles') and needles are gathered in spring; bark is stripped from felled or cultivated trees; resin/sap is tapped from the trunk. Needle-bearing twigs can be cut for tea and for steam distillation of the essential oil year-round.[11]

Parts: Bark, Leaf (needles), Sap, Young sprouts
Season: Young shoots/needles in spring; bark and sap variable

Traditional Uses

Restharrow root has a long place in European herbal medicine as a gentle aquaretic diuretic used for 'irrigation therapy' of the urinary tract - to increase urine flow in cystitis, urinary gravel and stones, and to flush the bladder. Field restharrow (Ononis arvensis) is used interchangeably with the officinal spiny restharrow (O. spinosa, Ononidis radix). The root and flowering herb have also been used as a mild anti-inflammatory, for skin complaints and eczema, for rheumatic conditions, and (as a decoction or gargle) for the mouth and throat. The isoflavone-rich root is a folk remedy in central and eastern European traditions.[8, 13]

Scots pine has a long northern European tradition as a source of resinous, aromatic preparations for respiratory complaints (coughs, bronchitis, catarrh) and topical rheumatic/muscular remedies, and pine-needle tea has traditionally been valued as a vitamin-C-rich winter tonic. Modern research on the needle essential oil supports antimicrobial, anti-inflammatory and expectorant activity.[11, 12]

Preparations

Decoction[8, 13]

The dried root simmered in water and taken as an aquaretic diuretic for irrigation of the urinary tract; the classic restharrow preparation.

Infusion[8]

The flowering aerial parts infused as a milder diuretic and anti-inflammatory tea.

Gargle / wash[8]

A root decoction used traditionally as a mouth/throat gargle and as a wash for skin complaints.

Needle infusion (tea)[11]

Fresh or dried young needles steeped in hot water - the traditional vitamin-C-rich tonic tea. Only use needles from a certainly identified pine, never yew (see dangerous look-alikes).

Essential oil (inhalation/topical)[12]

Steam-distilled from the needles; used diluted in ointments, chest rubs or steam inhalation for respiratory complaints.

References

REF-2741, REF-2742, REF-2743, REF-2744, REF-2745, REF-2746, REF-2747, REF-2748, REF-2749, REF-2750, REF-2751, REF-2752, REF-2753, REF-2754, REF-2755, REF-2756, REF-2757, REF-2758, REF-2759, REF-2760, REF-3015, REF-3016, REF-3017, REF-3018, REF-3019, REF-3020, REF-3021, REF-3022, REF-3023, REF-3024, REF-3025, REF-3026, REF-3027, REF-3028, REF-3029, REF-3030, REF-3031, REF-3032, REF-3033, REF-3034, REF-3035, REF-3036
REF-1233, REF-1234, REF-1235, REF-1236, REF-1237, REF-1238, REF-1239, REF-1240, REF-1241, REF-1242

Drug Class Interactions

Safety note[8, 13]Caution
Drug Class: diuretics
Mechanism: Restharrow is an aquaretic diuretic; taken with pharmaceutical diuretics it may add to fluid and electrolyte loss.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-10
Safety note[1, 3]Caution
Drug Class: hormonal-therapies
Mechanism: The root is rich in the isoflavone phytoestrogen formononetin; it could theoretically interact with hormonal contraceptives, hormone replacement or hormone-sensitive conditions.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-10

Not documented

Pairings

Classic urinary irrigation-therapy pairing: both are aquaretic diuretics used to increase urine flow in cystitis and urinary gravel.[13]

Partner Id: solidago-virgaurea
Type: synergy
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-10

Both are traditional diuretic 'flushing' herbs for irrigation therapy of the urinary tract.[13]

Partner Id: betula-pendula
Type: synergy
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-10

Both are Fabaceae rich in the isoflavone phytoestrogen formononetin; combined use adds to phytoestrogen exposure - use caution in hormone-sensitive conditions.[1]

Partner Id: trifolium-pratense
Type: caution
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-10

Not documented

Lookalikes Review

[8]

Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-10
Outcome: has-lookalikes
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

Dosage

Not documented

Essential oil (topical)[11, 12, 13]

Duke (2002): about 100-200 mg essential oil in an ointment or cream for topical use. Do not ingest the essential oil; avoid inhalation in severe asthma, whooping cough or laryngospasm. Educational reference only, not a prescription.

Dangerous Lookalikes

Not documented

Safety note[15, 16, 17]Fatal
Dangerous Plant: taxus-baccata
Confused Part: Evergreen needles and twigs gathered to brew pine-needle tea; yew's flat evergreen needles and red berry-like arils are mistaken for edible conifer.
Confusion Context: Pine needles (from Scots pine, Pinus sylvestris) are foraged to brew a vitamin-C-rich tea. Yew (Taxus baccata), one of the most poisonous trees in Europe, is a common evergreen in gardens, churchyards and hedges, and its flat evergreen needles are mistaken for edible conifer needles. The Missouri Poison Center explicitly warns to beware of a toxic pine look-alike, the yew tree or English yew (Taxus species), which holds cardiotoxic taxine alkaloids in all parts except the red flesh of the aril. Eating even a few yew leaves - or brewing them as 'pine' tea - can cause fatal heart-rhythm disturbances, seizures and cardiac arrest, with no antidote. Because pine-needle tea is popular and yew is widespread, this is a potentially fatal confusion.
Distinguishing Features: Needle attachment (decisive): pine needles grow in bundles (Scots pine in pairs of two) wrapped at the base by a papery sheath. Yew needles grow SINGLY, attached directly to the twig in two flat rows. Bundled needles = pine; single flat needles in two rows = yew., Fruit: pines bear woody cones. Yew bears no cones - instead soft red, berry-like arils each holding a single seed. A red berry-like fruit means yew, not pine., Smell: crushed pine needles smell strongly resinous and piney. Yew needles have little or no pine scent.
Key Test: Look at how the needles attach. Pine needles come in bundles (Scots pine in pairs) with a papery sheath at the base, and the tree bears woody cones and a strong piney scent. Yew needles are single, soft and flat in two rows, the tree bears red berry-like arils instead of cones and has little scent - yew is deadly, so never brew it. If the needles are single rather than bundled, or you see red berries, do not use it.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

References & Sources

  1. Gampe, N. and Darcsi, A. and Nagyne Nedves, A. and Boldizsar, I. and Kursinszki, L. and Beni, S (2019) 'Phytochemical analysis of Ononis arvensis L. by liquid chromatography coupled with mass spectrometry', Journal of Mass Spectrometry, 54(2), pp. 121-133. doi:10.1002/jms.4308 Preclinical
    https://doi.org/10.1002/jms.4308
  2. Denes, T. and Bartha, S.G. and Kerenyi, M. and Varga, E. and Balazs, V.L. and Csepregi, R. and Papp, N (2017) 'Histological and antimicrobial study of Ononis arvensis L', Acta Biologica Hungarica, 68(3), pp. 321-333. doi:10.1556/018.68.2017.3.9 Preclinical
    https://doi.org/10.1556/018.68.2017.3.9
  3. Gampe, N. and Nagy, E. and Kursinszki, L. and Beni, S (2021) 'Quantitative determination of isoflavonoids in Ononis species by UPLC-UV-DAD', Phytochemical Analysis, 32(4), pp. 474-481. doi:10.1002/pca.2995 Preclinical
    https://doi.org/10.1002/pca.2995
  4. Gampe, N. and Szakacs, Z. and Darcsi, A. and Boldizsar, I. and Szoke, E. and Kuzovkina, I. and Kursinszki, L. and Beni, S (2021) 'Qualitative and Quantitative Phytochemical Analysis of Ononis arvensis Hairy Root Cultures', Frontiers in Plant Science, 11, pp. 622585. doi:10.3389/fpls.2020.622585 Preclinical
    https://doi.org/10.3389/fpls.2020.622585
  5. Pazdziora, W. and Grabowska, K. and Zagrodzki, P. and Pasko, P. and Prochownik, E. and Podolak, I. and Galanty, A (2025) 'Quantitative Analysis of Isoflavones from Ononis Species and Their Chemopreventive Potential on Breast Cancer Cells', Molecules, 30(11), pp. 2379. doi:10.3390/molecules30112379 Preclinical
    https://doi.org/10.3390/molecules30112379
  6. Spilkova, J. and Bednar, P. and Stroblikova, R (2001) 'Capillary electrophoretic analysis of hydroxycinnamic acids from Ononis arvensis L', Die Pharmazie, 56(5), pp. 424-425. Preclinical
    https://scholar.google.com/scholar?q=Capillary%20electrophoretic%20analysis%20of%20hydroxycinnamic%20acids%20from%20Ononis%20arvensis%20L.
  7. Spilkova, J. and Hubik, J (1982) 'Pharmacognosy study of Ononis arvensis L. II. Flavonoids and onocerin in the drug', Ceskoslovenska Farmacie, 31(1), pp. 24-26. Preclinical
    https://scholar.google.com/scholar?q=Pharmacognosy%20study%20of%20Ononis%20arvensis%20L.%20II.%20Flavonoids%20and%20onocerin%20in%20the%20drug
  8. Rezacova, A. and Spilkova, J. and Hubik, J (1978) 'A pharmacognostic study of the species Ononis arvensis L', Ceskoslovenska Farmacie, 27(10), pp. 452-455. Traditional / reference
    https://scholar.google.com/scholar?q=A%20pharmacognostic%20study%20of%20the%20species%20Ononis%20arvensis%20L.
  9. Felsberg, A.A. and Rosentsveig, P.E (1965) 'A comparative phytochemical study of the roots of Ononis arvensis L. and Ononis spinosa L', Aptechnoe Delo, 14(6), pp. 26-32. Preclinical
    https://scholar.google.com/scholar?q=A%20comparative%20phytochemical%20study%20of%20the%20roots%20of%20Ononis%20arvensis%20L.%20and%20Ononis%20spinosa%20L.
  10. Sichinava, M.B. and Mchelidze, K.Z. and Churadze, M.V. and Alaniia, M.D. and Aneli, D.N (2014) 'Chemical composition and microstructural peculiarities of overground and underground vegetative organs of field restharrow (Ononis arvensis L.)', Georgian Medical News, (231), pp. 88-94. Preclinical
    https://scholar.google.com/scholar?q=Chemical%20composition%20and%20microstructural%20peculiarities%20of%20overground%20and%20underground%20vegetative%20organs%20of%20field%20restharrow%20%28Ononis%20arvensis%20L.%29
  11. Dedio, I. and Kozlowski, J (1977) 'Comparative morphological and phytochemical studies of Ononis spinosa L. and Ononis arvensis L. I. Biometric and chromatographic studies of methanolic extracts', Acta Poloniae Pharmaceutica, 34(1), pp. 97-102. Preclinical
    https://scholar.google.com/scholar?q=Comparative%20morphological%20and%20phytochemical%20studies%20of%20Ononis%20spinosa%20L.%20and%20Ononis%20arvensis%20L.%20I.%20Biometric%20and%20chromatographic%20studies%20of%20methanolic%20extracts
  12. Felsberg, A.A. and Rozentsveig, P.E (1965) 'Photochemical examination of Ononis arvensis. I', Aptechnoe Delo, 14(3), pp. 25-27. Preclinical
    https://scholar.google.com/scholar?q=Photochemical%20examination%20of%20Ononis%20arvensis.%20I
  13. Nechita, V. and Tarau, A. and Suster, A. and Nechita, M. and Toiu, A. and Benedec, D. and Hanganu, D. and Siserman, C. and Drugan, C. and Oniga, I (2026) 'Phytochemical Constituents and Biological Activities of Ononis spinosa: A Comprehensive Review', Plants (Basel), 15(9), pp. 1409. doi:10.3390/plants15091409 Meta-analysis / review
    https://doi.org/10.3390/plants15091409
  14. Spiegler, V. and Gierlikowska, B. and Saenger, T. and Addotey, J.N. and Sendker, J. and Jose, J. and Kiss, A.K. and Hensel, A (2020) 'Root Extracts From Ononis spinosa Inhibit IL-8 Release Via Interactions With Toll-Like Receptor 4 and Lipopolysaccharide', Frontiers in Pharmacology, 11, pp. 889. doi:10.3389/fphar.2020.00889 Preclinical
    https://doi.org/10.3389/fphar.2020.00889
  15. Deipenbrock, M. and Sendker, J. and Hensel, A (2020) 'Aqueous Root Extract from Ononis spinosa Exerts Anti-adhesive Activity against Uropathogenic Escherichia coli', Planta Medica, 86(4), pp. 247-254. doi:10.1055/a-1089-8645 Preclinical
    https://doi.org/10.1055/a-1089-8645
  16. Ergene Oz, B. and Saltan Iscan, G. and Kupeli Akkol, E. and Suntar, I. and Bahadir Acikara, O (2017) 'Isoflavonoids as wound healing agents from Ononidis Radix', Journal of Ethnopharmacology, 211, pp. 384-393. doi:10.1016/j.jep.2017.09.029 Preclinical
    https://doi.org/10.1016/j.jep.2017.09.029
  17. Arnold, E. and Benz, T. and Zapp, C. and Wink, M (2015) 'Inhibition of Cytosolic Phospholipase A2alpha (cPLA2alpha) by Medicinal Plants in Relation to Their Phenolic Content', Molecules, 20(8), pp. 15033-15048. doi:10.3390/molecules200815033 Preclinical
    https://doi.org/10.3390/molecules200815033
  18. Yilmaz, B.S. and Ozbek, H. and Citoglu, G.S. and Ugras, S. and Bayram, I. and Erdogan, E (2006) 'Analgesic and hepatotoxic effects of Ononis spinosa L', Phytotherapy Research, 20(6), pp. 500-503. doi:10.1002/ptr.1891 Preclinical
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Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.