Plant Comparison
Oregon Grape vs Tormentil
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Oregon Grape and Tormentil: they share 4 indicated uses (arthritis / joint pain, inflammation (general), skin irritation, …); 1 pharmacological action in common.
Evidence face-off — shared uses
| Condition | Oregon Grape | Tormentil | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 7/10 | 1/10 | Stronger for Oregon Grape |
| Inflammation (general) | 7/10 | 3/10 | Stronger for Oregon Grape |
| Skin irritation | 8/10 | 6/10 | Stronger for Oregon Grape |
| Wounds | 1/10 | 5/10 | Stronger for Tormentil |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Pharmacological Actions
Anti-inflammatory and antiproliferative (slows the skin-cell overgrowth of psoriasis)
Anti-inflammatory and antiproliferative (slows the skin-cell overgrowth of psoriasis)
Anti-inflammatory gargle / mouthwash for sore throat and inflammation of the mouth and throat
Astringent for mild diarrhoea (ellagitannins tighten the gut lining) - in a paediatric RCT, tormentil root extract shortened rotavirus diarrhoea (3 vs 5 days) and reduced rehydration needs
Traditional & Indicated Uses
inferred from anti-inflammatory action
inferred from anticancer action
Topical for atopic dermatitis (eczema) and skin irritation
Antimicrobial (berberine) - supports skin and mucosal infection
inferred from anti-inflammatory action
Anti-inflammatory and antiproliferative (slows the skin-cell overgrowth of psoriasis); Topical treatment of mild-to-moderate psoriasis (reduces plaque severity) - a double-blind, placebo-controlled RCT showed significant improvement in PASI and quality-of-life scores
Topical for atopic dermatitis (eczema) and skin irritation
inferred from anti-inflammatory action
Astringent for mild diarrhoea (ellagitannins tighten the gut lining) - in a paediatric RCT, tormentil root extract shortened rotavirus diarrhoea (3 vs 5 days) and reduced rehydration needs
Supportive in inflammatory bowel disease / ulcerative colitis (limited trial evidence)
Anti-inflammatory gargle / mouthwash for sore throat and inflammation of the mouth and throat
inferred from astringent action
Anti-inflammatory gargle / mouthwash for sore throat and inflammation of the mouth and throat
Safety, Cautions & Contraindications
Avoid internal use in pregnancy and breastfeeding: like goldenseal, the berberine it contains can cross the placenta and into milk and worsen newborn jaundice (kernicterus risk).
Tannin-rich: high or prolonged intake may cause stomach upset or constipation and can reduce the absorption of iron and some medicines taken at the same time.
Diarrhoea persisting more than 3-4 days, or with fever or blood in the stool, needs medical care. Use in pregnancy and breastfeeding is not recommended in the absence of data.
External Ids
Botanical Description
Evergreen shrub, 0.5-2 m tall, spreading by underground rhizomes to form thickets. The pinnate leaves resemble holly, with 5-9 glossy, dark green, spiny-toothed leaflets that often turn bronze-red in winter. Small, bright yellow, six-petalled flowers are borne in dense, upright terminal racemes in early spring, followed by clusters of blue-black, grape-like berries with a waxy bloom. The wood and inner bark of the stem and root are bright yellow when cut, owing to their high content of berberine-type alkaloids.
Low, sprawling to semi-erect perennial herb (Rosaceae) with wiry stems. Leaves are palmate, typically with 4-5 leaflets and large leaf-like stipules that give the impression of more leaflets. Flowers are small, yellow and four-petalled - unusual among Potentilla species, most of which have five petals. The thick, woody rhizome is reddish inside when cut, the origin of the old name 'bloodroot' for this European species.[14]
Habitat
Native to the Pacific Northwest of North America, growing in coniferous woodland understorey, forest margins and rocky slopes; widely introduced and naturalised as an ornamental and hedging shrub in temperate regions elsewhere.
Native to Europe and western Asia, common in acidic grassland, heath, moorland, open woodland and pastures on poor, well-drained soils.[14]
Harvesting
The root and root bark, the medicinal parts, are dug from established plants - traditionally in autumn - and dried. Because wild populations are slow-growing, cultivated or nursery-sourced material is preferred over wild-harvesting.
The rhizome is dug in autumn or early spring, when tannin content is highest, then cleaned and dried.[14]
Traditional Uses
Oregon grape root has a traditional Native American and Eclectic-medicine history as a bitter tonic and alterative (blood-purifying) remedy and for skin conditions. Its main modern use, supported by clinical trials, is topical application of a standardised bark extract for mild-to-moderate psoriasis and atopic dermatitis (eczema), where its berberine-type alkaloids give anti-inflammatory and antiproliferative effects on skin cells.[1, 11, 12]
Tormentil rhizome has an official European herbal-monograph tradition for mild diarrhoea and inflammation of the mouth and throat, reflecting its long folk use as a powerful astringent for gut and mucous-membrane complaints. Modern trials confirm its ellagitannin-rich rhizome shortens the duration of infectious (rotavirus) diarrhoea.[8, 14, 15]
Preparations
Dosage
References
Lookalikes Review
References & Sources
- Gulliver, W.P. and Donsky, H.J (2005) 'A report on three recent clinical trials using Mahonia aquifolium 10% topical cream and a review of the worldwide clinical experience with Mahonia aquifolium for the treatment of plaque psoriasis', American Journal of Therapeutics, 12(5), pp. 398-406. doi:10.1097/01.mjt.0000174350.82270.da Clinical study
https://doi.org/10.1097/01.mjt.0000174350.82270.da - Cernakova, M. and Kostalova, D (2002) 'Antimicrobial activity of berberine--a constituent of Mahonia aquifolium', Folia Microbiologica, 47(4), pp. 375-378. doi:10.1007/BF02818693 Preclinical
https://doi.org/10.1007/BF02818693 - Damjanovic, A., Kolundzija, B., Matic, I.Z., Krivokuca, A. and others (2020) 'Mahonia aquifolium Extracts Promote Doxorubicin Effects against Lung Adenocarcinoma Cells In Vitro', Molecules, 25(22), pp. 5233. doi:10.3390/molecules25225233 Preclinical
https://doi.org/10.3390/molecules25225233 - Cernakova, M., Kostalova, D., Kettmann, V., Plodova, M. and others (2002) 'Potential antimutagenic activity of berberine, a constituent of Mahonia aquifolium', BMC Complementary and Alternative Medicine, 2, pp. 2. doi:10.1186/1472-6882-2-2 Preclinical
https://doi.org/10.1186/1472-6882-2-2 - Slobodnikova, L., Kostalova, D., Labudova, D., Kotulova, D. and Kettmann, V (2004) 'Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids', Phytotherapy Research, 18(8), pp. 674-676. doi:10.1002/ptr.1517 Preclinical
https://doi.org/10.1002/ptr.1517 - Godjevac, D., Damjanovic, A., Stanojkovic, T.P., Andjelkovic, B. and Zdunic, G (2018) 'Identification of cytotoxic metabolites from Mahonia aquifolium using 1H NMR-based metabolomics approach', Journal of Pharmaceutical and Biomedical Analysis, 150, pp. 9-14. doi:10.1016/j.jpba.2017.11.075 Preclinical
https://doi.org/10.1016/j.jpba.2017.11.075 - Muller, K. and Ziereis, K (1994) 'The antipsoriatic Mahonia aquifolium and its active constituents; I. Pro- and antioxidant properties and inhibition of 5-lipoxygenase', Planta Medica, 60(5), pp. 421-424. doi:10.1055/s-2006-959523 Preclinical
https://doi.org/10.1055/s-2006-959523 - Rohrer, U., Kunz, E.M.K., Lenkeit, K., Schaffner, W. and Meyer, J (2007) 'Antimicrobial activity of Mahonia aquifolium and two of its alkaloids against oral bacteria', Schweizer Monatsschrift fur Zahnmedizin, 117(11), pp. 1126-1131. Preclinical
https://scholar.google.com/scholar?q=Antimicrobial%20activity%20of%20Mahonia%20aquifolium%20and%20two%20of%20its%20alkaloids%20against%20oral%20bacteria - Vollekova, A., Kostalova, D., Kettmann, V. and Toth, J (2003) 'Antifungal activity of Mahonia aquifolium extract and its major protoberberine alkaloids', Phytotherapy Research, 17(7), pp. 834-837. doi:10.1002/ptr.1256 Preclinical
https://doi.org/10.1002/ptr.1256 - Hajnicka, V., Kostalova, D., Svecova, D., Sochorova, R. and others (2002) 'Effect of Mahonia aquifolium active compounds on interleukin-8 production in the human monocytic cell line THP-1', Planta Medica, 68(3), pp. 266-268. doi:10.1055/s-2002-23126 Preclinical
https://doi.org/10.1055/s-2002-23126 - Gulliver, W.P. and colleagues (2018) 'Review of the Efficacy and Safety of Topical Mahonia aquifolium for the Treatment of Psoriasis and Atopic Dermatitis', Journal of Clinical and Aesthetic Dermatology. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334833/ Meta-analysis / review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334833/ - Herbal Reality (n.d.) 'Oregon Grape Root (Berberis aquifolium): Benefits, Uses, Safety'. Available at: https://www.herbalreality.com/herb/oregon-grape/ Traditional / reference
https://www.herbalreality.com/herb/oregon-grape/ - Bernstein, S., Donsky, H., Gulliver, W., Hamilton, D., Nobel, S. and Norman, R (2006) 'Treatment of mild to moderate psoriasis with Relieva, a Mahonia aquifolium extract - a double-blind, placebo-controlled study', American Journal of Therapeutics, 13(2), pp. 121--126. doi:10.1097/00045391-200603000-00007 Randomized trial
https://doi.org/10.1097/00045391-200603000-00007
- Bandick, R., Busmann, L.V., Mousavi, S., Shayya, N.W. and others (2023) 'Therapeutic Effects of Oral Application of Menthol and Extracts from Tormentil (Potentilla erecta), Raspberry Leaves and Loosestrife during Acute Murine Campylobacteriosis', Pharmaceutics, 15(10), pp. 2410. doi:10.3390/pharmaceutics15102410 Preclinical
https://doi.org/10.3390/pharmaceutics15102410 - Fecka, I., Kucharska, A.Z. and Kowalczyk, A (2015) 'Quantification of tannins and related polyphenols in commercial products of tormentil (Potentilla tormentilla)', Phytochemical Analysis, 26(5), pp. 353-366. doi:10.1002/pca.2570 Preclinical
https://doi.org/10.1002/pca.2570 - Marcinczyk, N., Jarmoc, D., Leszczynska, A., Zakrzeska, A. and others (2017) 'Antithrombotic Potential of Tormentil Extract in Animal Models', Frontiers in Pharmacology, 8, pp. 534. doi:10.3389/fphar.2017.00534 Preclinical
https://doi.org/10.3389/fphar.2017.00534 - Melzig, M.F. and Bottger, S (2020) 'Tormentillae rhizoma - Review for an Underestimated European Herbal Drug', Planta Medica, 86(15), pp. 1050-1057. doi:10.1055/a-1129-7214 Traditional / reference
https://doi.org/10.1055/a-1129-7214 - Marcinczyk, N., Golaszewska, A., Gromotowicz-Poplawska, A., Misztal, T. and others (2021) 'Multidirectional Effects of Tormentil Extract on Hemostasis in Experimental Diabetes', Frontiers in Pharmacology, 12, pp. 682987. doi:10.3389/fphar.2021.682987 Preclinical
https://doi.org/10.3389/fphar.2021.682987 - Hoffmann, J., Gendrisch, F., Schempp, C.M. and Wolfle, U (2020) 'New Herbal Biomedicines for the Topical Treatment of Dermatological Disorders', Biomedicines, 8(2), pp. 27. doi:10.3390/biomedicines8020027 Traditional / reference
https://doi.org/10.3390/biomedicines8020027 - Tomczyk, M., Sosnowska, K., Pleszczynska, M., Strawa, J. and others (2017) 'Hydrogel Containing an Extract of Tormentillae rhizoma for the Treatment of Biofilm-Related Oral Diseases', Natural Product Communications, 12(3), pp. 417-421. doi:10.1177/1934578x1701200328 Preclinical
https://doi.org/10.1177/1934578x1701200328 - Subbotina, M.D., Timchenko, V.N., Vorobyov, M.M., Konunova, Y.S., Aleksandrovih, Y.S. and Shushunov, S (2003) 'Effect of oral administration of tormentil root extract (Potentilla tormentilla) on rotavirus diarrhea in children: a randomized, double blind, controlled trial', The Pediatric Infectious Disease Journal, 22(8), pp. 706--711. doi:10.1097/01.inf.0000078355.29647.d0 Randomized trial
https://doi.org/10.1097/01.inf.0000078355.29647.d0 - Wan, P., Chen, H., Guo, Y. and Bai, A.P (2014) 'Advances in treatment of ulcerative colitis with herbs: from bench to bedside', World Journal of Gastroenterology, 20(39), pp. 14099-14104. doi:10.3748/wjg.v20.i39.14099 Traditional / reference
https://doi.org/10.3748/wjg.v20.i39.14099 - Wolfle, U., Hoffmann, J., Haarhaus, B., Rao Mittapalli, V. and Schempp, C.M (2017) 'Anti-inflammatory and vasoconstrictive properties of Potentilla erecta - A traditional medicinal plant from the northern hemisphere', Journal of Ethnopharmacology, 204, pp. 86-94. doi:10.1016/j.jep.2017.03.058 Clinical study
https://doi.org/10.1016/j.jep.2017.03.058 - Moss, A.C. and Cheifetz, A.S (2007) 'Reducing the torment of diarrhea: tormentil for active ulcerative colitis', Journal of Clinical Gastroenterology, 41(9), pp. 797-798. doi:10.1097/MCG.0b013e3180684255 Clinical study
https://doi.org/10.1097/MCG.0b013e3180684255 - Shushunov, S., Balashov, L., Kravtsova, A., Krasnogorsky, I., Latte, K.P. and Vasiliev, A (2009) 'Determination of acute toxicity of the aqueous extract of Potentilla erecta (Tormentil) rhizomes in rats and mice', Journal of Medicinal Food, 12(5), pp. 1173-1176. doi:10.1089/jmf.2008.0281 Preclinical
https://doi.org/10.1089/jmf.2008.0281 - Kirsch, J., Jung, A., Hille, K., Konig, B., Hannig, C., Kolling-Speer, I., Speer, K. and Hannig, M (2020) 'Effect of fragaria vesca, hamamelis and tormentil on the initial bacterial colonization in situ', Archives of Oral Biology, 118, pp. 104853. doi:10.1016/j.archoralbio.2020.104853 Preclinical
https://doi.org/10.1016/j.archoralbio.2020.104853 - European Medicines Agency (HMPC) (n.d.) 'European Union herbal monograph on Potentilla erecta (L.) Raeusch., rhizoma (Tormentillae rhizoma)'. Available at: https://www.ema.europa.eu/en/medicines/herbal/tormentillae-rhizoma Traditional / reference
https://www.ema.europa.eu/en/medicines/herbal/tormentillae-rhizoma - ESCOP (European Scientific Cooperative on Phytotherapy) (n.d.) 'Tormentillae rhizoma (Tormentil) monograph', pp. com. Available at: https://www.escop.com/downloads/tormentil/ Traditional / reference
https://www.escop.com/downloads/tormentil/
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.