Plant Comparison
Field scabious vs Valerian
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Field scabious and Valerian: both belong to the Caprifoliaceae family; they share 2 indicated uses (skin irritation, inflammation (general)); 2 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Field scabious | Valerian | Verdict |
|---|---|---|---|
| Skin irritation | 2/10 | 8/10 | Stronger for Valerian |
| Inflammation (general) | 7/10 | 8/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Chlorogenic, cryptochlorogenic and dicaffeoylquinic acids and caffeoylhydrocitric acid (antioxidant).
C-glycosidic flavones such as isovitexin and related flavonoids.
Saponin glycosides (knautiosides) characteristic of the plant and the Caprifoliaceae family.
Sesquiterpenes thought to be key contributors to the sedative, GABA-A-modulating action.
Unstable iridoid esters historically of pharmacological interest, though their contribution to the whole-root effect is debated.
Responsible for the root's characteristic strong aroma.
Pharmacological Actions
Traditional 'blood purifier' (depurative) for skin complaints; the classic use of field scabious.
Knautia and related Caprifoliaceae extracts inhibit inflammatory mediators (COX/LOX).
Traditional & Indicated Uses
Traditional remedy for eczema, itching and skin complaints; anti-acne activity of Knautia extracts.
Anti-acne activity of Knautia species extracts (antibacterial, anti-inflammatory).
inferred from traditional external use on cuts and sores
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from sedative action
Safety, Cautions & Contraindications
Very little is known about the safety of field scabious and there are no clinical data; avoid medicinal doses in pregnancy and breastfeeding and use only modest amounts.
Most pharmacological data come from closely related Caprifoliaceae (genus Knautia, Scabiosa, Dipsacus) rather than Knautia arvensis itself; apply to field scabious with caution.
Generally well tolerated for short-to-medium term use. May cause vivid dreams, morning grogginess, or headache in some individuals. Avoid combining with alcohol, sedatives, or anaesthetics. Do not drive immediately after taking high doses. Do not use in children under 3 years. Abrupt discontinuation after long-term use may cause withdrawal symptoms.
Duke (2002) does not appear to include a primary entry for Valeriana officinalis (European valerian) in the sections searched. The entry found was for Indian valerian (Valeriana jatamansi). Commission E approves European valerian for restlessness and sleep disorders. Dose: 400–900 mg standardized root extract before bedtime. Interactions include potentiation of CNS depressants and sedatives.
External Ids
Synonyms
Not documented
Botanical Description
A hairy perennial herb of the honeysuckle family (formerly Dipsacaceae), 25-100 cm tall, growing from a stout rootstock. The stems are roughly hairy and bear opposite leaves that are variable - the lower ones often lyre-shaped or pinnately lobed, the upper deeply cut. The flowers are massed into flat, domed pincushion heads about 3-4 cm across, lilac to bluish-violet, with the outer florets enlarged; the heads are carried on long stalks and, unlike true scabious (Scabiosa), the receptacle is hairy rather than scaly. It flowers through summer and is a favourite of bees and butterflies.[1]
Tall, upright perennial herb with hollow, grooved stems and opposite, pinnately divided leaves. Small, pale pink to white, sweetly scented flowers are borne in dense, domed clusters (cymes) at the top of the stem; the dried root has a distinctive strong, earthy, 'dirty sock' smell.[12]
Habitat
Dry grassland, meadows, pastures, dry hills, roadside banks, field margins and open woods, on well-drained and often calcareous soils across Europe and into western Asia and parts of Africa. A characteristic plant of unimproved dry meadows.[1]
Grows in damp meadows, ditches, riverbanks and marshy ground, tolerating both sun and partial shade; native to Europe and parts of Asia and naturalised in North America.[12]
Harvesting
The flowering aerial parts (leaves, stems, flower heads) are gathered in summer while in flower and dried; the root is also used. Best cut from established plants in dry grassland.[1]
The rhizome and roots are dug in autumn of the second year, once the strong characteristic aroma has developed, then cleaned and dried.[12]
Traditional Uses
Field scabious has a European folk-medicine reputation chiefly as a remedy for skin complaints - eczema, itching, scabies (the name 'scabious' comes from its use against 'the scab'), cuts and sores - taken internally as a 'blood purifier' (alterative/depurative) and applied externally as a wash or poultice. It has also been used for coughs and sore throats. The plant is rich in phenolic acids, flavonoids and saponins; the closely related genera Knautia, Scabiosa and Dipsacus in the honeysuckle family share this chemistry and a tradition of use in skin disease and inflammation.[3, 4]
Preparations
Standardized root extract taken shortly before bedtime, the form most used in clinical research.
References
Lookalikes Review
Dosage
Not documented
Commission E and clinical research commonly suggest around 400-900 mg standardized root extract taken 30-60 minutes before bedtime. Educational reference only, not a prescription.
Drug Class Interactions
Not documented
Pairings
Not documented
Valerian and hops are traditionally combined for sleep; a controlled trial found the valerian-hops combination shortened the time to fall asleep more than valerian alone. Both add to sedation, so expect stronger drowsiness.[18, 19]
Valerian and passionflower are both mild GABA-acting sedatives often blended in sleep and calming formulas; combined use may enhance relaxation but also additive drowsiness.[19, 20]
Valerian and lemon balm are a classic calming pair acting on the GABA system to improve sleep quality; combined use may increase sedation.[19]
Dangerous Lookalikes
Not documented
References & Sources
- Karalija, E. and Muratovic, E. and Tarkowski, P. and Zeljkovic, S.C (2017) 'Variation in Phenolic Composition of Knautia arvensis in Correlation with Geographic Area and Plant Organ', Natural Product Communications, 12(4), pp. 545-548. doi:10.1177/1934578x1701200421 Preclinical
https://doi.org/10.1177/1934578x1701200421 - Moldoch, J. and Szajwaj, B. and Masullo, M. and Pecio, L. and Oleszek, W. and Piacente, S. and Stochmal, A (2011) 'Phenolic constituents of Knautia arvensis aerial parts', Natural Product Communications, 6(11), pp. 1627-1630. doi:10.1177/1934578x1100601117 Preclinical
https://doi.org/10.1177/1934578x1100601117 - Plouvier, V (1971) 'Research on heterosides: knautioside and saponosides from Knautia arvensis and related glycosides', Comptes Rendus de l'Academie des Sciences, Serie D, 272(10), pp. 1443-1446. Preclinical
https://scholar.google.com/scholar?q=Research%20on%20heterosides%3A%20knautioside%20and%20saponosides%20from%20Knautia%20arvensis%20and%20related%20glycosides - Chrzaszcz, M. and Miazga-Karska, M. and Klimek, K. and Dybowski, M.P. and Typek, R. and Tchorzewska, D. and Dos Santos Szewczyk, K (2023) 'The Anti-Acne Potential and Chemical Composition of Knautia Species (Caprifoliaceae) Extracts', International Journal of Molecular Sciences, 24(11), pp. 9188. doi:10.3390/ijms24119188 Preclinical
https://doi.org/10.3390/ijms24119188 - Skala, E. and Szopa, A (2023) 'Dipsacus and Scabiosa Species - The Source of Specialized Metabolites with High Biological Relevance: A Review', Molecules, 28(9), pp. 3754. doi:10.3390/molecules28093754 Meta-analysis / review
https://doi.org/10.3390/molecules28093754 - Pinto, D.C.G.A. and Rahmouni, N. and Beghidja, N. and Silva, A.M.S (2018) 'Scabiosa Genus: A Rich Source of Bioactive Metabolites', Medicines (Basel), 5(4), pp. 110. doi:10.3390/medicines5040110 Meta-analysis / review
https://doi.org/10.3390/medicines5040110 - Albayrak, S. and Aksoy, A. and Yilmaz, M.A. and Beyzi, E (2024) 'Investigation of Phytochemical, Antioxidant and Antidiabetic Potentials of Scabiosa L. (Caprifoliaceae) Species with Chemometric Methods', Chemistry and Biodiversity, 21(2), pp. e202301652. doi:10.1002/cbdv.202301652 Preclinical
https://doi.org/10.1002/cbdv.202301652 - Saar-Reismaa, P. and Koel, M. and Tarto, R. and Vaher, M (2022) 'Extraction of bioactive compounds from Dipsacus fullonum leaves using deep eutectic solvents', Journal of Chromatography A, 1677, pp. 463330. doi:10.1016/j.chroma.2022.463330 Preclinical
https://doi.org/10.1016/j.chroma.2022.463330
- Chandra Shekhar, H., Joshua, L. and Thomas, J.V (2024) 'Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study', Advances in Therapy, 41(1), pp. 246-261. doi:10.1007/s12325-023-02708-6 Randomized trial
https://doi.org/10.1007/s12325-023-02708-6 - Shinjyo, N., Waddell, G. and Green, J (2020) 'Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis', Journal of Evidence-Based Integrative Medicine, 25, pp. 2515690X20967323. doi:10.1177/2515690X20967323 Meta-analysis / review
https://doi.org/10.1177/2515690X20967323 - Borras, S., Martinez-Solis, I. and Rios, J.L (2021) 'Medicinal Plants for Insomnia Related to Anxiety: An Updated Review', Planta Medica, 87(10-11), pp. 738-753. doi:10.1055/a-1510-9826 Meta-analysis / review
https://doi.org/10.1055/a-1510-9826 - Nunes, A. and Sousa, M (2011) 'Use of valerian in anxiety and sleep disorders: what is the best evidence?', Acta Medica Portuguesa, 24(Suppl 4), pp. 961-966. Meta-analysis / review
https://scholar.google.com/scholar?q=Use%20of%20valerian%20in%20anxiety%20and%20sleep%20disorders%3A%20what%20is%20the%20best%20evidence%3F - Tammadon, M.R., Nobahar, M., Hydarinia-Naieni, Z., Ebrahimian, A. and others (2021) 'The Effects of Valerian on Sleep Quality, Depression, and State Anxiety in Hemodialysis Patients: A Randomized, Double-blind, Crossover Clinical Trial', Oman Medical Journal, 36(2), pp. e255. doi:10.5001/omj.2021.56 Randomized trial
https://doi.org/10.5001/omj.2021.56 - Alternative Medicine Review (2004) 'Monograph: Valeriana officinalis', Alternative Medicine Review, 9(4), pp. 438-441. Meta-analysis / review
https://scholar.google.com/scholar?q=Monograph%3A%20Valeriana%20officinalis - Soltani, A., Bahrami, F., Bahari, Z., Shankayi, Z. and others (2021) 'The effects of Valerian on sleep spindles in a model of neuropathic pain', Sleep Science, 14(Spec 2), pp. 133-139. doi:10.5935/1984-0063.20200110 Preclinical
https://doi.org/10.5935/1984-0063.20200110 - Mineo, L., Concerto, C., Patel, D., Mayorga, T. and others (2017) 'Valeriana officinalis Root Extract Modulates Cortical Excitatory Circuits in Humans', Neuropsychobiology, 75(1), pp. 46-51. doi:10.1159/000480053 Randomized trial
https://doi.org/10.1159/000480053 - Jacobs, B.P., Bent, S., Tice, J.A., Blackwell, T. and Cummings, S.R (2005) 'An internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomnia', Medicine (Baltimore), 84(4), pp. 197-207. doi:10.1097/01.md.0000172299.72364.95 Randomized trial
https://doi.org/10.1097/01.md.0000172299.72364.95 - Alkharfy, K.M. and Frye, R.F (2007) 'Effect of valerian, valerian/hops extracts, and valerenic acid on glucuronidation in vitro', Xenobiotica, 37(2), pp. 113-123. doi:10.1080/00498250601050420 Preclinical
https://doi.org/10.1080/00498250601050420 - Garges, H.P., Varia, I. and Doraiswamy, P.M (1998) 'Cardiac complications and delirium associated with valerian root withdrawal', 280(18), pp. 1566--1567. Traditional / reference
https://scholar.google.com/scholar?q=Cardiac%20complications%20and%20delirium%20associated%20with%20valerian%20root%20withdrawal - Hoffmann, D (2003) 'Medical Herbalism'. Traditional / reference
https://scholar.google.com/scholar?q=Medical%20Herbalism - Bent, S., Padula, A., Moore, D., Patterson, M. and Mehling, W (2006) 'Valerian for sleep: a systematic review and meta-analysis', 119(12), pp. 1005--1012. doi:10.1016/j.amjmed.2006.02.026 Meta-analysis / review
https://doi.org/10.1016/j.amjmed.2006.02.026 - Francis, A.J. and Dempster, R.J (2002) 'Effect of valerian, Valeriana edulis, on sleep difficulties in children with intellectual deficits: randomised trial', 9(4), pp. 273--279. doi:10.1078/0944-7113-00110 Randomized trial
https://doi.org/10.1078/0944-7113-00110 - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Ortiz, J.G., Rassi, N., Maldonado, P.M., Gonzalez-Cabrera, S. and Ramos, I (2006) 'Commercial valerian interactions with [3H]Flunitrazepam and [3H]MK-801 binding to rat synaptic membranes', Phytotherapy Research, 20(9), pp. 794-798. doi:10.1002/ptr.1960 Preclinical
https://doi.org/10.1002/ptr.1960 - Bent, S., Padula, A., Moore, D., Patterson, M. and Mehling, W (2006) 'Valerian for sleep: a systematic review and meta-analysis', The American Journal of Medicine, 119(12), pp. 1005-1012. doi:10.1016/j.amjmed.2006.02.026 Meta-analysis / review
https://doi.org/10.1016/j.amjmed.2006.02.026 - Koetter, U., Schrader, E., Kaeufeler, R. and Brattstroem, A (2007) 'A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder', Phytotherapy Research, 21(9), pp. 847-851. doi:10.1002/ptr.2167 Randomized trial
https://doi.org/10.1002/ptr.2167 - Ghasemzadeh Rahbardar, M. and Hosseinzadeh, H (2024) 'Therapeutic potential of hypnotic herbal medicines: A comprehensive review', Phytotherapy Research, 38(6), pp. 3037-3059. doi:10.1002/ptr.8201 Meta-analysis / review
https://doi.org/10.1002/ptr.8201 - Ngan, A. and Conduit, R (2011) 'A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality', Phytotherapy Research, 25(8), pp. 1153-1159. doi:10.1002/ptr.3400 Randomized trial
https://doi.org/10.1002/ptr.3400 - Practical Self Reliance 'Foraging Wild Valerian For Better Sleep'. Available at: https://practicalselfreliance.com/foraging-valerian/ Traditional / reference
https://practicalselfreliance.com/foraging-valerian/ - Dayan, A.D (2024) 'Death of Socrates: a likely case of poison hemlock (Conium maculatum) poisoning', Clinical Toxicology (Philadelphia, Pa.), 62(1), pp. 56-60. doi:10.1080/15563650.2024.2309328 Clinical study
https://doi.org/10.1080/15563650.2024.2309328 - King County Noxious Weeds (2024) 'Poison hemlock (Conium maculatum) identification and control'. Available at: https://kingcounty.gov/en/dept/dnrp/nature-recreation/environment-ecology-conservation/noxious-weeds/identification-control/poison-hemlock Traditional / reference
https://kingcounty.gov/en/dept/dnrp/nature-recreation/environment-ecology-conservation/noxious-weeds/identification-control/poison-hemlock
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.