Plant Comparison

Chaga vs Noni

A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.

First plant
Second plant
Show:
Plant AChagaInonotus obliquusHymenochaetaceaeFull monograph →
Plant BNoniMorinda citrifoliaRubiaceaeFull monograph →

At a glance

Chaga and Noni: they share 9 indicated uses (arthritis / joint pain, cancer (anticancer research), cold & flu, …); 6 pharmacological actions in common.

ChagaNoni
Constituents34
Pharmacological actions108
Indicated uses1113
Safety notes22
Cited sources4114
Indicated uses
Only Chaga
Cognitive functionCardiovascular / heart health
Shared (9)
Arthritis / joint painCancer (anticancer research)Cold & fluImmune supportInfection (general)Inflammation (general)Metabolic supportSkin irritationWounds
Only Noni
Back painBlood sugar / diabetes supportHeadachePain (general)
Pharmacological actions
Only Chaga
Nephroprotective (kidney support)Neuroprotective / cognition supportHepatoprotective (liver support)Lipid-lowering
Shared (6)
Anti-inflammatoryAnticancer (preclinical)AntimicrobialAntioxidantImmunomodulator / immune supportAntidiabetic (blood-sugar lowering)
Only Noni
Analgesic (pain relief)Antiviral

Evidence face-off — shared uses

ConditionChagaNoniVerdict
Arthritis / joint pain1/102/10Comparable evidence
Cancer (anticancer research)2/107/10Stronger for Noni
Cold & flu1/102/10Comparable evidence
Immune support2/102/10Comparable evidence
Infection (general)1/102/10Comparable evidence
Inflammation (general)1/102/10Comparable evidence
Metabolic support1/102/10Comparable evidence
Skin irritation1/102/10Comparable evidence
Wounds1/102/10Comparable evidence

Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.

Key Constituents

Melanin-rich pigments and betulinic acid derivatives[1]

Chaga's dark colour comes from melanin-like pigments; it also concentrates betulinic-acid-type triterpenes absorbed from its birch host, associated with antioxidant and anticancer research interest.

Polysaccharides (beta-glucans)[4]

Immunomodulatory polysaccharides contributing to the traditional tonic and immune-support use.

Polysaccharides
Phenolic compounds[4]

Antioxidant phenolics contributing to chaga's free-radical-scavenging activity.

Phenolic compounds
Iridoids (asperulosidic acid and related iridoid glycosides)[1, 6]

A major phytochemical class of noni fruit and leaf, studied for antioxidant and anti-inflammatory activity.

Iridoid glycosides
Anthraquinones (damnacanthal and related compounds)[1, 2]

Found mainly in the root and, at lower levels, the fruit; studied for anticancer and antimicrobial activity.

Anthraquinones
Polysaccharides[8]

Fruit polysaccharides studied for gut-microbiota-modulating and anti-inflammatory effects in animal models of inflammatory bowel disease.

Polysaccharides
Scopoletin (coumarin)[1]

A phenolic coumarin found in the fruit, studied for anti-inflammatory and vascular effects.

Coumarins

Pharmacological Actions

Anti-inflammatory[4, 5, 9, 13, 15, 19, 27, 30, 38, 39, 40]
Anticancer (preclinical)[15, 17, 21, 22, 26, 28, 31, 38]
Antimicrobial[38, 39, 40]
Antioxidant[8, 10, 12, 29, 35, 38, 39, 40]
Immunomodulator / immune support[2, 4, 7, 14, 16, 19, 26, 32, 37, 38, 39, 40]
Nephroprotective (kidney support)[20]
Neuroprotective / cognition support[24, 35]
Antidiabetic (blood-sugar lowering)[25, 31, 34, 36]
Hepatoprotective (liver support)[28]
Lipid-lowering[33, 36]
Analgesic (pain relief)[11, 12, 13]
Anti-inflammatory[1, 6, 7, 8, 9, 11, 12, 13]
Anticancer (preclinical)[2, 10]
Antidiabetic (blood-sugar lowering)[11, 12, 13]
Antimicrobial[3, 6, 11, 12, 13]
Antioxidant[1, 6, 11, 12, 13]
Antiviral[11, 12, 13]
Immunomodulator / immune support[1, 11, 12, 13]

Traditional & Indicated Uses

Arthritis / joint pain[38, 39, 40]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Arthritis / joint pain
Cancer (anticancer research)[15, 21, 38]Traditional · 2/10

inferred from anticancer action

Evidence: 2
Label: Cancer (anticancer research)
Cold & flu[38, 39, 40]Traditional · 1/10

inferred from immunomodulator action

Evidence: 1
Label: Cold & flu
Immune support[14, 38, 39, 40]Traditional · 2/10
Evidence: 2
Label: Immune support
Infection (general)[38, 39, 40]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1
Label: Infection (general)
Inflammation (general)[38, 39, 40]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Inflammation (general)
Metabolic support[38, 39, 40]Traditional · 1/10
Evidence: 1
Label: Metabolic support
Skin irritation[38, 39, 40]Traditional · 1/10

inferred from anti-inflammatory action

Evidence: 1
Label: Skin irritation
Wounds[38, 39, 40]Traditional · 1/10

inferred from antimicrobial action

Evidence: 1
Label: Wounds
Cognitive function[24, 35]Traditional · 2/10

Chaga-derived 3,4-DHBA protected against Parkinson's-related neurotoxicity (preclinical).

Evidence: 2
Label: Cognitive function
Cardiovascular / heart health[33]Traditional · 2/10

Chaga polysaccharide lowered lipids in vivo and in vitro.

Evidence: 2
Label: Cardiovascular / heart health
Arthritis / joint pain[11, 12, 13]Traditional · 2/10

inferred from anti-inflammatory action

Evidence: 2
Label: Arthritis / joint pain
Back pain[11, 12, 13]Traditional · 2/10

inferred from analgesic action

Evidence: 2
Label: Back pain
Blood sugar / diabetes support[11, 12, 13]Traditional · 2/10

inferred from antidiabetic action

Evidence: 2
Label: Blood sugar / diabetes support
Cancer (anticancer research)[2, 10]Good · 7/10

inferred from anticancer action

Evidence: 7
Label: Cancer (anticancer research)
Cold & flu[11, 12, 13]Traditional · 2/10

inferred from antiviral action

Evidence: 2
Label: Cold & flu
Headache[11, 12, 13]Traditional · 2/10

inferred from analgesic action

Evidence: 2
Label: Headache
Immune support[11, 12, 13]Traditional · 2/10
Evidence: 2
Label: Immune support
Infection (general)[11, 12, 13]Traditional · 2/10

inferred from antimicrobial action

Evidence: 2
Label: Infection (general)
Inflammation (general)[8, 11, 12, 13]Traditional · 2/10

inferred from anti-inflammatory action

Evidence: 2
Label: Inflammation (general)
Metabolic support[11, 12, 13]Traditional · 2/10

inferred from antidiabetic action

Evidence: 2
Label: Metabolic support
Pain (general)[11, 12, 13]Traditional · 2/10
Evidence: 2
Label: Pain (general)
Skin irritation[7, 11, 12, 13]Traditional · 2/10

inferred from anti-inflammatory action

Evidence: 2
Label: Skin irritation
Wounds[11, 12, 13]Traditional · 2/10

inferred from antimicrobial action

Evidence: 2
Label: Wounds

Safety, Cautions & Contraindications

Safety note[38, 39, 40]Caution

Autoimmune conditions: Chaga can stimulate parts of the immune system—people with autoimmune diseases should be cautious.Blood thinners: Chaga contains compounds that may affect clotting—avoid large doses if on anticoagulants.Blood sugar meds: May slightly lower glucose—monitor if taking diabetes medication.Pregnancy & breastfeeding: Limited safety data—best avoided unless guided by a professional.Quality matters: Wild-harvested Chaga can accumulate heavy metals from trees and soil—source from reputable suppliers.

Safety note[38, 39, 40, 41]Info

Duke (2002) does not include a dedicated entry for chaga (Inonotus obliquus) in the Handbook of Medicinal Herbs, Second Edition, as this medicinal fungus was not widely documented in Western herbal literature at that time (Duke, 2002).

Safety note[11, 12, 13]Serious

Generally safe in moderate amounts. High potassium content — use caution in renal disease. Rare cases of hepatotoxicity reported with excessive consumption. May interact with warfarin (due to vitamin K content). Avoid during pregnancy.

Safety note[11, 12, 13, 14]Info

Duke (2002) rates noni as +++ and notes analgesic, antirheumatic, antiarthritic, antitumor, antispasmodic, and hypotensive activities at the experimental level (score 1). Traditional Polynesian and South Asian medicine values it as a broad-spectrum tonic. The plant contains morindine, proxeronine, and damnacanthal, which are under investigation for immunomodulatory and anti-tumor effects. Duke notes that noni fruit can be consumed as food and is generally safe, though the juice has a strong unpleasant odor and taste. No significant toxicity has been reported with regular food consumption (Duke, 2002).

External Ids

Gbif: 2521089
Wikidata: Q1956937
Gbif: 5339879
Wikidata: Q234238

Botanical Description

Parasitic wood-decay fungus (not a true plant) that grows almost entirely inside the trunk of living birch trees, visible externally only as a hard, black, cracked, charcoal-like mass (a sclerotium, sometimes called a 'conk') erupting through the bark. Unlike typical mushrooms, chaga has no true cap, gills or stem; its fertile spore-producing surface develops later, hidden beneath the bark after the tree dies.[1]

Height: External mass 10-40 cm
Habit: Parasitic wood-decay fungus, growing mostly inside the host tree
Leaves: Not applicable (fungus)
Flowers: Not applicable (fungus); reproduces by spores
Stem: No true cap-and-stem structure; visible only as a hard black external mass (sclerotium)
Root: Fungal mycelium spreading through the living wood of the host tree
Fruit: Fertile spore-producing layer develops hidden beneath the bark, typically after the host tree dies
Flowering Period: The visible black mass persists and grows for years; not a seasonal fruiting body

Small evergreen tree or shrub (Rubiaceae), 3-10 m tall, with large, glossy, dark green, elliptical leaves marked by prominent parallel veins. Small, white, tubular, fragrant flowers are borne in dense rounded heads, developing into a compound fleshy fruit (syncarp) that is warty, semi-translucent and yellow-white when ripe, with a strong, pungent, cheese-like odour.[1]

Height: 3-10 m
Habit: Small evergreen tree or shrub
Leaves: Large, glossy, dark green, elliptical, prominently veined
Flowers: Small, white, tubular, fragrant, in dense rounded heads
Stem: Woody, branching
Root: Woody taproot with lateral roots
Fruit: Compound fleshy syncarp, warty and semi-translucent, yellow-white when ripe, pungent cheese-like odour
Flowering Period: Year-round in tropical climates, with peak flushes seasonally

Habitat

Grows almost exclusively as a parasite on living birch trees in cold, northern temperate and boreal forests of Europe, Russia, North America and Asia.[1]

Native to Southeast Asia and Australasia, and dispersed across the Pacific islands and into India and the Caribbean by early Polynesian voyagers and subsequent cultivation; grows in coastal areas, open and disturbed forest, and even on bare lava flows, tolerating poor, saline and drought-prone soils.[1, 6]

Harvesting

The hard black external mass (conk) is chopped or broken away from the living birch trunk, ideally without killing the tree, then dried and broken into pieces or ground for use; sustainable harvesting (leaving part of the conk to regrow) is recommended given the fungus's slow growth.

Parts: Mycelium, Whole Plant

Ripe fruit is hand-picked as it softens and turns yellow-white, then traditionally left to further ripen or ferment for juice production; leaves and root are also traditionally gathered.[6]

Parts: Fruit, Leaf, Root
Season: Fruit harvested as it ripens, largely year-round in the tropics

Traditional Uses

Chaga has a long traditional use in Russian, Siberian, Baltic and Scandinavian folk medicine as a tonic remedy for digestive complaints, immune support and general vitality, traditionally taken as a dark, tea-like decoction; this traditional tonic reputation is now studied for its antioxidant, immunomodulatory and anti-inflammatory properties.[1, 4]

Noni has an extensive Polynesian, South Asian and Southeast Asian traditional-medicine history, used as a broad-spectrum tonic for pain, inflammation, infection and immune support, and traditionally for diabetes and skin complaints. The fermented fruit juice is the most widely used modern preparation, now studied for antioxidant, anti-inflammatory, immunomodulatory and metabolic effects supporting several of these traditional uses.[1, 6]

Preparations

Decoction[1]

Chunks of the dried black conk simmered gently in water for an extended period, producing a dark, tea-like traditional tonic.

Standardised extract[4]

Extract standardised to polysaccharide or polyphenol content, taken as capsules or powder.

Fermented fruit juice[5, 6]

The classic Polynesian preparation: ripe fruit fermented in sealed containers for several weeks, then strained; the most-studied modern form.

References

REF-0848, REF-0849, REF-0850, REF-2195, REF-2196, REF-2197, REF-2198, REF-2199, REF-2200, REF-2201, REF-2202, REF-2203, REF-2204, REF-2969, REF-2970, REF-2971, REF-2972, REF-2973, REF-2974, REF-2975, REF-2976, REF-2977, REF-2978, REF-2979, REF-2980, REF-2981, REF-2982, REF-2983, REF-2984, REF-2985, REF-2986, REF-2987, REF-2988, REF-2989, REF-2990, REF-2991, REF-2992
REF-1417, REF-1418, REF-1419, REF-1420, REF-1421, REF-1422, REF-1423, REF-1424, REF-1425, REF-1426

Lookalikes Review

Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07
Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

Dosage

Not documented

Fermented fruit juice[11, 12, 13]

Commercial noni juice is typically taken in modest daily amounts (a few tablespoons); given rare reports of hepatotoxicity with excessive or prolonged intake, avoid high doses, especially with pre-existing liver disease. Educational reference only, not a prescription.

References & Sources

  1. Camilleri, E., Blundell, R., Baral, B., Karpinski, T.M. et al (2024) 'A brief overview of the medicinal and nutraceutical importance of Inonotus obliquus (chaga) mushrooms', Heliyon, 10(15), pp. e35638. doi:10.1016/j.heliyon.2024.e35638 Traditional / reference
    https://doi.org/10.1016/j.heliyon.2024.e35638
  2. Lu, Y., Jia, Y., Xue, Z., Li, N. et al (2021) 'Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application', Polymers (Basel), 13(9), pp. 1441. doi:10.3390/polym13091441 Traditional / reference
    https://doi.org/10.3390/polym13091441
  3. Kobus, Z., Krzywicka, M., Blicharz-Kania, A., Bosacka, A. et al (2024) 'Impact of Incorporating Dried Chaga Mushroom (Inonotus obliquus) into Gluten-Free Bread on Its Antioxidant and Sensory Characteristics', Molecules, 29(16), pp. 3801. doi:10.3390/molecules29163801 Preclinical
    https://doi.org/10.3390/molecules29163801
  4. Szychowski, K.A., Skora, B., Pomianek, T. and Gminski, J (2020) 'Inonotus obliquus - from folk medicine to clinical use', Journal of Traditional and Complementary Medicine, 11(4), pp. 293-302. doi:10.1016/j.jtcme.2020.08.003 Meta-analysis / review
    https://doi.org/10.1016/j.jtcme.2020.08.003
  5. Javed, S., Mitchell, K., Sidsworth, D., Sellers, S.L., Reutens-Hernandez, J., Massicotte, H.B., Egger, K.N., Lee, C.H. and Payne, G.W (2019) 'Inonotus obliquus attenuates histamine-induced microvascular inflammation', PLoS One, 14(8), pp. e0220776. doi:10.1371/journal.pone.0220776 Preclinical
    https://doi.org/10.1371/journal.pone.0220776
  6. Zou, C., Hou, Z., Bai, M., Guo, R., Lin, B., Wang, X., Huang, X. and Song, S (2020) 'Highly modified steroids from Inonotus obliquus', Organic & Biomolecular Chemistry, 18(20), pp. 3908-3916. doi:10.1039/d0ob00474j Preclinical
    https://doi.org/10.1039/d0ob00474j
  7. Zhong, X.H., Ren, K., Lu, S.J., Yang, S.Y. and Sun, D.Z (2009) 'Progress of research on Inonotus obliquus', Chinese Journal of Integrative Medicine, 15(2), pp. 156-160. doi:10.1007/s11655-009-0156-2 Meta-analysis / review
    https://doi.org/10.1007/s11655-009-0156-2
  8. Burmasova, M.A., Utebaeva, A.A., Sysoeva, E.V. and Sysoeva, M.A (2019) 'Melanins of Inonotus obliquus: bifidogenic and antioxidant properties', Biomolecules, 9(6), pp. 248. doi:10.3390/biom9060248 Preclinical
    https://doi.org/10.3390/biom9060248
  9. Sun, Y., Deng, X., Li, Z., Dong, Y., Jiang, W., Ma, Y., Zhou, W., Zhu, T., Wang, G., Liu, S. and Hu, B (2022) 'Polysaccharide derived from Inonotus obliquus inhibits lipopolysaccharide-induced acute endometritis in mice', American Journal of Translational Research, 14(11), pp. 8332-8342. Preclinical
    https://scholar.google.com/scholar?q=Polysaccharide%20derived%20from%20Inonotus%20obliquus%20inhibits%20lipopolysaccharide-induced%20acute%20endometritis%20in%20mice
  10. Ishfaq, P.M., Mishra, S., Mishra, A., Ahmad, Z., Gayen, S., Jain, S.K., Tripathi, S. and Mishra, S.K (2022) 'Inonotus obliquus aqueous extract prevents histopathological alterations in liver induced by environmental toxicant Microcystin', Current Research in Pharmacology and Drug Discovery, 3, pp. 100118. doi:10.1016/j.crphar.2022.100118 Preclinical
    https://doi.org/10.1016/j.crphar.2022.100118
  11. Peng, A., Liu, S., Fang, L., Zhu, Z., Zhou, Y., Yue, S., Ma, Z., Liu, X., Xue, S., Qiu, Y. and Qi, R (2022) 'Inonotus obliquus and its bioactive compounds alleviate non-alcoholic fatty liver disease via regulating FXR/SHP/SREBP-1c axis', European Journal of Pharmacology, 921, pp. 174841. doi:10.1016/j.ejphar.2022.174841 Preclinical
    https://doi.org/10.1016/j.ejphar.2022.174841
  12. Zhang, Y., Liu, Q., Sun, Y. and Jiang, J (2023) 'Inonotus obliquus sclerotia epidermis were different from internal tissues in compound composition, antioxidant activity, and associated fungi', FEMS Microbiology Letters, 370, pp. fnad126. doi:10.1093/femsle/fnad126 Preclinical
    https://doi.org/10.1093/femsle/fnad126
  13. Yu, S., Lai, Z., Xue, H., Zhu, J., Yue, G., Wang, J. and Jin, L.H (2024) 'Inonotus obliquus aqueous extract inhibits intestinal inflammation and insulin metabolism defects in Drosophila', Toxicology Mechanisms and Methods, 34(9), pp. 970-984. doi:10.1080/15376516.2024.2368795 Preclinical
    https://doi.org/10.1080/15376516.2024.2368795
  14. Wold, C.W. and Christopoulos, P. and Arias, M. and Dzovor, D.E. and Øynebråten, I. and Corthay, A. and Inngjerdingen, K.T (2024) 'Fungal polysaccharides from Inonotus obliquus are agonists for Toll-like receptors and induce macrophage anti-cancer activity', Communications Biology. doi:10.1038/s42003-024-05853-y Preclinical
    https://doi.org/10.1038/s42003-024-05853-y
  15. Li, J. and Qu, C. and Li, F. and Chen, Y. and Zheng, J. and Xiao, Y. and Jin, Q. and Jin, G. and Huang, X. and Jin, D (2021) 'Inonotus obliquus Polysaccharide Ameliorates Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Cancer in Mice via Activation of the NLRP3 Inflammasome', Frontiers in Pharmacology. doi:10.3389/fphar.2020.621835 Preclinical
    https://doi.org/10.3389/fphar.2020.621835
  16. Wold, C.W. and Gerwick, W.H. and Wangensteen, H. and Inngjerdingen, K.T (2020) 'Bioactive triterpenoids and water-soluble melanin from Inonotus obliquus (Chaga) with immunomodulatory activity', Journal of Functional Foods. doi:10.1016/j.jff.2020.104025 Preclinical
    https://doi.org/10.1016/j.jff.2020.104025
  17. Kim, J. and Yang, S. and Hwang, A.Y. and Cho, H. and Hwang, K.T (2020) 'Composition of Triterpenoids in Inonotus obliquus and Their Anti-Proliferative Activity on Cancer Cell Lines', Molecules. doi:10.3390/molecules25184066 Preclinical
    https://doi.org/10.3390/molecules25184066
  18. Duru, K.C. and Kovaleva, E.G. and Данилова, И.Г. and Bijl, P.V.D (2019) 'The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies', Phytotherapy Research. doi:10.1002/ptr.6384 Preclinical
    https://doi.org/10.1002/ptr.6384
  19. Hu, Y. and Teng, C. and Yu, S. and Wang, X. and Liang, J. and Bai, X. and Dong, L. and Song, T. and Yu, M. and Qu, J (2017) 'Inonotus obliquus polysaccharide regulates gut microbiota of chronic pancreatitis in mice', AMB Express. doi:10.1186/s13568-017-0341-1 Preclinical
    https://doi.org/10.1186/s13568-017-0341-1
  20. Chou, Y. and Kan, W. and Chang, C. and Peng, Y. and Wang, H. and Yu, W. and Cheng, Y. and Jhang, Y. and Liu, H. and Chuu, J (2016) 'Renal Protective Effects of Low Molecular Weight of Inonotus obliquus Polysaccharide (LIOP) on HFD/STZ-Induced Nephropathy in Mice', International Journal of Molecular Sciences. doi:10.3390/ijms17091535 Preclinical
    https://doi.org/10.3390/ijms17091535
  21. Arata, S. and Watanabe, J. and Maeda, M. and Yamamoto, M. and Matsuhashi, H. and Mochizuki, M. and Kagami, N. and Honda, K. and Inagaki, M (2016) 'Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice', Heliyon. doi:10.1016/j.heliyon.2016.e00111 Preclinical
    https://doi.org/10.1016/j.heliyon.2016.e00111
  22. Lee, K.R. and Lee, J.S. and Kim, Y.R. and Song, I.G. and Hong, E.K (2014) 'Polysaccharide from Inonotus obliquus inhibits migration and invasion in B16-F10 cells by suppressing MMP-2 and MMP-9 via downregulation of NF-κB signaling pathway', Oncology Reports. doi:10.3892/or.2014.3103 Preclinical
    https://doi.org/10.3892/or.2014.3103
  23. Song, F. and Liu, Y. and Kong, X. and Chang, W. and Song, G (2013) 'Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom: Inonotus Obliquus', Asian Pacific Journal of Cancer Prevention. doi:10.7314/apjcp.2013.14.3.1571 Preclinical
    https://doi.org/10.7314/apjcp.2013.14.3.1571
  24. Gunjima, K. and Tomiyama, R. and Takakura, K. and Yamada, T. and Hashida, K. and Nakamura, Y. and Konishi, T. and Matsugo, S. and Hori, O (2013) '3,4‐Dihydroxybenzalacetone Protects Against Parkinson's Disease‐Related Neurotoxin 6‐OHDA Through Akt/Nrf2/Glutathione Pathway', Journal of Cellular Biochemistry. doi:10.1002/jcb.24643 Preclinical
    https://doi.org/10.1002/jcb.24643
  25. Geng, Y. and Lu, Z. and Huang, W. and Xu, H. and Shi, J. and Xu, Z (2013) 'Bioassay-Guided Isolation of DPP-4 Inhibitory Fractions from Extracts of Submerged Cultured of Inonotus obliquus', Molecules. doi:10.3390/molecules18011150 Preclinical
    https://doi.org/10.3390/molecules18011150
  26. Zhang, L. and Fan, C. and Liu, S. and Zang, Z. and Jiao, L. and Zhang, L (2011) 'Chemical composition and antitumor activity of polysaccharide from Inonotus obliquus', Journal of Medicinal Plants Research. doi:10.5897/jmpr.9000346 Preclinical
    https://doi.org/10.5897/jmpr.9000346
  27. Choi, S. and Hur, S.J. and An, C.S. and Jeon, Y.H. and Jeoung, Y.J. and Bak, J.P. and Lim, B.O (2010) 'Anti-Inflammatory Effects ofInonotus obliquusin Colitis Induced by Dextran Sodium Sulfate', Journal of Biomedicine and Biotechnology. doi:10.1155/2010/943516 Preclinical
    https://doi.org/10.1155/2010/943516
  28. Youn, M. and Kim, J. and Park, S. and Kim, Y. and Kim, S. and Lee, J.S. and Chai, K.Y. and Kim, H. and Cui, M. and So, H.S. and Kim, K. and Park, R (2008) 'Chaga mushroom (Inonotus obliquus ) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells', World Journal of Gastroenterology. doi:10.3748/wjg.14.511 Preclinical
    https://doi.org/10.3748/wjg.14.511
  29. Nakajima, Y. and Sato, Y. and Konishi, T (2007) 'Antioxidant Small Phenolic Ingredients in Inonotus obliquus (persoon) Pilat (Chaga)', Chemical and Pharmaceutical Bulletin. doi:10.1248/cpb.55.1222 Preclinical
    https://doi.org/10.1248/cpb.55.1222
  30. Kim, H. and Yoon, D. and Kim, C. and Shrestha, B. and Chang, W. and Lim, S. and Lee, W. and Han, S. and Lee, J. and Lim, M. and Kim, G. and Choi, S. and Song, W.O. and Sung, J. and Hwang, K (2007) 'Ethanol Extract of Inonotus obliquus Inhibits Lipopolysaccharide-Induced Inflammation in RAW 264.7 Macrophage Cells', Journal of Medicinal Food. doi:10.1089/jmf.2006.156 Preclinical
    https://doi.org/10.1089/jmf.2006.156
  31. Mizuno, T. and Zhuang, C. and Abe, K. and Okamoto, H. and Kiho, T. and Ukai, S. and Leclerc, S. and Meijer, L (1999) 'Antitumor and Hypoglycemic Activities of Polysaccharides from the Sclerotia and Mycelia of Inonotus obliquus (Pers.: Fr.) Pil. (Aphyllophoromycetideae)', International journal of medicinal mushrooms. doi:10.1615/intjmedmushr.v1.i4.20 Preclinical
    https://doi.org/10.1615/intjmedmushr.v1.i4.20
  32. Su, L. and Xin, C. and Yang, J. and Dong, L. and Mei, H. and Dai, X. and Wang, Q (2022) 'A polysaccharide from Inonotus obliquus ameliorates intestinal barrier dysfunction in mice with type 2 diabetes mellitus', International Journal of Biological Macromolecules. doi:10.1016/j.ijbiomac.2022.06.071 Preclinical
    https://doi.org/10.1016/j.ijbiomac.2022.06.071
  33. Yang, M. and Hu, D. and Cui, Z. and Li, H. and Man, C. and Jiang, Y (2021) 'Lipid-Lowering Effects of Inonotus obliquus Polysaccharide In Vivo and In Vitro', Foods. doi:10.3390/foods10123085 Preclinical
    https://doi.org/10.3390/foods10123085
  34. Wang, J. and Hu, W. and Li, L. and Huang, X. and Liu, Y. and Wang, D. and Teng, L (2017) 'Antidiabetic activities of polysaccharides separated from Inonotus obliquus via the modulation of oxidative stress in mice with streptozotocin-induced diabetes', PLoS ONE. doi:10.1371/journal.pone.0180476 Preclinical
    https://doi.org/10.1371/journal.pone.0180476
  35. Giridharan, V.V. and Thandavarayan, R.A. and Konishi, T (2011) 'Amelioration of scopolamine induced cognitive dysfunction and oxidative stress by Inonotus obliquus– a medicinal mushroom', Food & Function. doi:10.1039/c1fo10037h Preclinical
    https://doi.org/10.1039/c1fo10037h
  36. Lee, J. and Hyun, C (2014) 'Insulin‐Sensitizing and Beneficial Lipid‐Metabolic Effects of the Water‐Soluble Melanin Complex Extracted from Inonotus obliquus', Phytotherapy Research. doi:10.1002/ptr.5131 Preclinical
    https://doi.org/10.1002/ptr.5131
  37. Kim, Y (2005) 'Immunomodulatory Activity of the Water Extract from Medicinal MushroomInonotus obliquus', Mycobiology. doi:10.4489/myco.2005.33.3.158 Preclinical
    https://doi.org/10.4489/myco.2005.33.3.158
  38. Géry, A., Dubreule, C., André, V., Rioult, J.P., Bouchart, V., Heutte, N., Eldin de Pécoulas, P., Krivomaz, T. and Garon, D (2018) 'Chaga (Inonotus obliquus), a future potential medicinal fungus in oncology? A chemical study and a comparison of the cytotoxicity against human lung adenocarcinoma cells (A549) and human bronchial epithelial cells (BEAS-2B)', 17(3), pp. 832--843. doi:10.1177/1534735418757912 Traditional / reference
    https://doi.org/10.1177/1534735418757912
  39. Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
    https://powo.science.kew.org
  40. Shashkina, M.Ya., Shashkin, P.N. and Sergeev, A.V (2006) 'Chemical and medicobiological properties of chaga', 40(10), pp. 560--568. Traditional / reference
    https://scholar.google.com/scholar?q=Chemical%20and%20medicobiological%20properties%20of%20chaga
  41. Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
    https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
  1. Potterat, O. and Hamburger, M (2007) 'Morinda citrifolia (Noni) fruit--phytochemistry, pharmacology, safety', Planta Medica, 73(3), pp. 191-199. doi:10.1055/s-2007-967115 Meta-analysis / review
    https://doi.org/10.1055/s-2007-967115
  2. Brown, A.C (2012) 'Anticancer activity of Morinda citrifolia (Noni) fruit: a review', Phytotherapy Research, 26(10), pp. 1427-1440. doi:10.1002/ptr.4595 Meta-analysis / review
    https://doi.org/10.1002/ptr.4595
  3. Almeida-Souza, F., de Souza, C.S., Taniwaki, N.N., Silva, J.J. and others (2016) 'Morinda citrifolia Linn. fruit (Noni) juice induces an increase in NO production and death of Leishmania amazonensis amastigotes in peritoneal macrophages from BALB/c', Nitric Oxide, 58, pp. 51-58. doi:10.1016/j.niox.2016.06.004 Preclinical
    https://doi.org/10.1016/j.niox.2016.06.004
  4. Wang, R., Wang, L., Wang, S., Wang, J. and others (2022) 'Phenolics from noni (Morinda citrifolia L.) fruit alleviate obesity in high fat diet-fed mice via modulating the gut microbiota and mitigating intestinal damage', Food Chemistry, 402, pp. 134232. doi:10.1016/j.foodchem.2022.134232 Preclinical
    https://doi.org/10.1016/j.foodchem.2022.134232
  5. Yoshitomi, H., Zhou, J., Nishigaki, T., Li, W. and others (2020) 'Morinda citrifolia (Noni) fruit juice promotes vascular endothelium function in hypertension via glucagon-like peptide-1 receptor-CaMKKbeta-AMPK-eNOS pathway', Phytotherapy Research, 34(9), pp. 2341-2350. doi:10.1002/ptr.6685 Preclinical
    https://doi.org/10.1002/ptr.6685
  6. Almeida, E.S., de Oliveira, D. and Hotza, D (2019) 'Properties and Applications of Morinda citrifolia (Noni): A Review', Comprehensive Reviews in Food Science and Food Safety, 18(4), pp. 883-909. doi:10.1111/1541-4337.12456 Meta-analysis / review
    https://doi.org/10.1111/1541-4337.12456
  7. Kim, S.H., Seong, G.S. and Choung, S.Y (2020) 'Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice through Modulating Immune Balance and Skin Barrier Function', Nutrients, 12(1), pp. 249. doi:10.3390/nu12010249 Preclinical
    https://doi.org/10.3390/nu12010249
  8. Jin, M.Y., Wu, X.Y., Li, M.Y., Li, X.T. and others (2021) 'Noni (Morinda citrifolia L.) Fruit Polysaccharides Regulated IBD Mice Via Targeting Gut Microbiota: Association of JNK/ERK/NF-kappaB Signaling Pathways', Journal of Agricultural and Food Chemistry, 69(35), pp. 10151-10162. doi:10.1021/acs.jafc.1c03833 Preclinical
    https://doi.org/10.1021/acs.jafc.1c03833
  9. Lee, D., Yu, J.S., Huang, P., Qader, M. and others (2020) 'Identification of Anti-Inflammatory Compounds from Hawaiian Noni (Morinda citrifolia L.) Fruit Juice', Molecules, 25(21), pp. 4968. doi:10.3390/molecules25214968 Preclinical
    https://doi.org/10.3390/molecules25214968
  10. Ma, L.D., Lin, G.B., Yang, L.B., Cao, J.L. and others (2021) 'Morinda citrifolia (Noni) Juice Suppresses A549 Human Lung Cancer Cells via Inhibiting AKT/Nuclear Factor-kappaB Signaling Pathway', Chinese Journal of Integrative Medicine, 27(9), pp. 688-695. doi:10.1007/s11655-020-3421-y Preclinical
    https://doi.org/10.1007/s11655-020-3421-y
  11. Hirazumi, A. and Furusawa, E (1999) 'An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia', 13(5), pp. 380--387. Preclinical
    https://scholar.google.com/scholar?q=An%20immunomodulatory%20polysaccharide-rich%20substance%20from%20the%20fruit%20juice%20of%20Morinda%20citrifolia
  12. Potterat, O. and Hamburger, M (2007) 'Morinda citrifolia (Noni) fruit — phytochemistry, pharmacology, safety', 73(3), pp. 191--199. doi:10.1055/s-2007-967115 Preclinical
    https://doi.org/10.1055/s-2007-967115
  13. West, B.J., Jensen, C.J., Westendorf, J. and White, L.D (2006) 'A safety review of noni fruit juice', 71(8). doi:10.1111/j.1750-3841.2006.00164.x Traditional / reference
    https://doi.org/10.1111/j.1750-3841.2006.00164.x
  14. Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
    https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition

Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.