Plant Comparison
Goldenseal vs Speedwell
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Goldenseal and Speedwell: they share 5 indicated uses (arthritis / joint pain, bloating, indigestion, …); 2 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Goldenseal | Speedwell | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 5/10 | 1/10 | Stronger for Goldenseal |
| Bloating | 5/10 | 1/10 | Stronger for Goldenseal |
| Indigestion | 5/10 | 2/10 | Stronger for Goldenseal |
| Inflammation (general) | 5/10 | 2/10 | Stronger for Goldenseal |
| Skin irritation | 5/10 | 1/10 | Stronger for Goldenseal |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Berberine is the main antimicrobial, hypoglycaemic and hypolipidaemic constituent. Notably, whole-leaf extracts are more potent against MRSA than isolated berberine (owing to efflux-pump-inhibitory flavonoids) and show quorum-quenching, anti-virulence activity.
Pharmacological Actions
Anti-inflammatory and astringent for inflamed mucous membranes (sore-throat gargle, mouth)
Antimicrobial (berberine) - supports skin, mucosal and gastrointestinal infections and sore throat
Anti-inflammatory and astringent for inflamed mucous membranes (sore-throat gargle, mouth)
Anti-inflammatory and antioxidant
Traditional & Indicated Uses
inferred from anti-inflammatory action
Digestive / gastrointestinal support (traditional for dyspepsia and ulcers)
Antimicrobial (berberine) - supports skin, mucosal and gastrointestinal infections and sore throat; Topical for skin infections and irritation - whole-leaf extract is active in vitro against methicillin-resistant Staphylococcus aureus (MRSA)
inferred from anti-inflammatory action
inferred from anti-inflammatory action
Anti-inflammatory and astringent for inflamed mucous membranes (sore-throat gargle, mouth); Antimicrobial (berberine) - supports skin, mucosal and gastrointestinal infections and sore throat
inferred from anti-inflammatory action
Traditional expectorant for cough and respiratory complaints (iridoid glycosides inhibit lung inflammation) - a standardised extract suppressed COX-2 and eotaxin via the NF-kB pathway in human lung epithelial cells
Mild digestive / stomach tonic (indigestion)
Traditional expectorant for cough and respiratory complaints (iridoid glycosides inhibit lung inflammation) - a standardised extract suppressed COX-2 and eotaxin via the NF-kB pathway in human lung epithelial cells
inferred from expectorant action
Soothing for skin irritation (topical)
Safety, Cautions & Contraindications
Contraindicated in pregnancy and breastfeeding: berberine crosses the placenta and into milk and can cause or worsen newborn jaundice (risk of kernicterus); do not give to infants.
Berberine strongly inhibits drug-metabolising enzymes (especially CYP3A4 and CYP2D6), so it can raise the blood levels of many medicines - a significant herb-drug-interaction risk. In a screen of commercial herbal products, goldenseal was among the most potent CYP2D6 inhibitors and also inhibited CYP3A4. High doses have shown possible liver, nerve and photo-toxicity.
Traditional use only; clinical evidence is limited, so a persistent cough or digestive complaint needs medical assessment. Safety in pregnancy and breastfeeding is not established.
External Ids
Botanical Description
Low, woodland perennial herb rising from a knotted, bright yellow rhizome with wiry yellow roots. Each stem bears two ragged, palmately lobed, maple-like leaves and a single small, inconspicuous greenish-white flower, followed by a raspberry-like cluster of red berries.[1]
Low, creeping, mat-forming perennial herb with softly hairy, oval, finely toothed leaves along trailing stems that root as they spread. Small, pale lilac-blue flowers with darker veining are borne in slender upright spikes rising from the leaf axils.[8]
Habitat
Grows in rich, shaded deciduous woodland with humus-rich soil; native to eastern North America, now scarce in the wild due to overharvesting and largely supplied by cultivation.[1]
Grows on dry heath, moorland, open woodland, grassland and banks on acidic, well-drained soils; native to Europe and naturalised in North America.[8]
Harvesting
The rhizome and root are dug in autumn from plants at least three to four years old, when berberine content is highest, then cleaned and dried; because wild populations are depleted, cultivated or sustainably sourced material is strongly preferred, and careful identification against the toxic mayapple and bloodroot, which share its woodland habitat, is essential before any wild-harvesting.[1]
The flowering aerial parts are cut in summer while in flower and dried in a warm, shaded, airy place; the closely related Veronica chamaedrys is a frequent adulterant, so careful identification (or a reputable source) is important.[8]
Traditional Uses
Goldenseal root has a Native American and, after adoption by Eclectic physicians, wider North American tradition as a bitter tonic and antimicrobial remedy for mucous-membrane infections, sore throat, digestive upset and topical skin infections, directly reflecting its high berberine content.[1]
Speedwell has a long European folk history as a mild digestive tonic and traditional expectorant for cough and respiratory complaints, and has also been used topically as a soothing wash for irritated skin; modern research on its iridoid glycosides supports a molecular basis for the traditional respiratory use.
Preparations
Dried rhizome and root simmered in water as a traditional bitter antimicrobial tea, or used as a gargle for sore throat.
Tincture 1:10 in 60% ethanol of the dried rhizome and root, 2-4 ml three times daily per the WHO monograph Rhizoma Hydrastis. Educational reference only, not a prescription.
Extract standardised to berberine/hydrastine content, taken as capsules; whole-leaf extracts have shown stronger antimicrobial activity than isolated berberine in some studies.
Not documented
Dosage
The WHO monograph on Rhizoma Hydrastis gives a daily dose of 0.5-1.0 g of the dried rhizome and root three times, or taken as a decoction; a 1:1 liquid extract in 60% ethanol at 0.3-1.0 mL three times; or a 1:10 tincture in 60% ethanol at 2-4 mL three times. For short-term use only, given goldenseal's potent CYP-enzyme inhibition and its contraindication in pregnancy. Educational reference only, not a prescription.
Not documented
References
Drug Class Interactions
Not documented
Lookalikes Review
Dangerous Lookalikes
Not documented
References & Sources
- Mandal, S.K., Maji, A.K., Mishra, S.K., Ishfaq, P.M., Devkota, H.P., Silva, A.S. and Das, N (2020) 'Goldenseal (Hydrastis canadensis L.) and its active constituents: A critical review of their efficacy and toxicological issues', Pharmacological Research. doi:10.1016/j.phrs.2020.105085 Randomized trial
https://doi.org/10.1016/j.phrs.2020.105085 - Corn, J., Tibbitts, D., Ito, H., Schafer, M. and Vasilevsky, N (2021) 'Effects of Hydrastis Canadensis, Commiphora Habessinica, Phytolacca Americana, and Echinacea Purpurea on Bacterial Growth', Alternative Therapies in Health and Medicine, 27(4), pp. 24-27. Preclinical
https://scholar.google.com/scholar?q=Effects%20of%20Hydrastis%20Canadensis%2C%20Commiphora%20Habessinica%2C%20Phytolacca%20Americana%2C%20and%20Echinacea%20Purpurea%20on%20Bacterial%20Growth - Ettefagh, K.A., Burns, J.T., Junio, H.A., Kaatz, G.W. and Cech, N.B (2010) 'Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition', Planta Medica, 77(8), pp. 835-840. doi:10.1055/s-0030-1250606 Preclinical
https://doi.org/10.1055/s-0030-1250606 - Cech, N.B., Junio, H.A., Ackermann, L.W., Kavanaugh, J.S. and Horswill, A.R (2012) 'Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA)', Planta Medica, 78(14), pp. 1556--1561. doi:10.1055/s-0032-1315042 Traditional / reference
https://doi.org/10.1055/s-0032-1315042 - Mahady, G.B., Pendland, S.L., Stoia, A. and Chadwick, L.R (2003) 'In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis', Phytotherapy Research, 17(3), pp. 217-221. doi:10.1002/ptr.1108 Preclinical
https://doi.org/10.1002/ptr.1108 - Junio, H.A., Sy-Cordero, A.A., Ettefagh, K.A., Burns, J.T., Micko, K.T., Graf, T.N., Richter, S.J., Cannon, R.E., Oberlies, N.H. and Cech, N.B (2011) 'Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis)', Journal of Natural Products, 74(7), pp. 1621-1629. doi:10.1021/np200336g Preclinical
https://doi.org/10.1021/np200336g - Britton, E.R., Kellogg, J.J., Kvalheim, O.M. and Cech, N.B (2017) 'Biochemometrics to Identify Synergists and Additives from Botanical Medicines: A Case Study with Hydrastis canadensis (Goldenseal)', Journal of Natural Products, 81(3), pp. 484-493. doi:10.1021/acs.jnatprod.7b00654 Preclinical
https://doi.org/10.1021/acs.jnatprod.7b00654 - Leyte-Lugo, M., Britton, E.R., Foil, D.H., Brown, A.R., Todd, D.A., Rivera-Chavez, J., Oberlies, N.H. and Cech, N.B (2017) 'Secondary Metabolites from the Leaves of the Medicinal Plant Goldenseal (Hydrastis canadensis)', Phytochemistry Letters, 20, pp. 54-60. doi:10.1016/j.phytol.2017.03.012 Preclinical
https://doi.org/10.1016/j.phytol.2017.03.012 - Gurley, B.J., Swain, A., Hubbard, M.A., Hartsfield, F., Thaden, J., Williams, D.K., Gentry, W.B. and Tong, Y (2007) 'Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo', Clinical Pharmacology and Therapeutics, 83(1), pp. 61-69. doi:10.1038/sj.clpt.6100222 Randomized trial
https://doi.org/10.1038/sj.clpt.6100222 - Wallace, E.D., Oberlies, N.H., Cech, N.B. and Kellogg, J.J (2018) 'Detection of adulteration in Hydrastis canadensis (goldenseal) dietary supplements via untargeted mass spectrometry-based metabolomics', Food and Chemical Toxicology, 120, pp. 439-447. doi:10.1016/j.fct.2018.07.033 Preclinical
https://doi.org/10.1016/j.fct.2018.07.033 - Douglas, J.A., Follett, J.M., Parmenter, G.A., Sansom, C.E., Perry, N.B. and Littler, R.A (2010) 'Seasonal variation of biomass and bioactive alkaloid content of goldenseal, Hydrastis canadensis', Fitoterapia, 81(7), pp. 925-928. doi:10.1016/j.fitote.2010.06.006 Preclinical
https://doi.org/10.1016/j.fitote.2010.06.006 - Singh, S., Pathak, N., Fatima, E. and Negi, A.S (2021) 'Plant isoquinoline alkaloids: Advances in the chemistry and biology of berberine', European Journal of Medicinal Chemistry. doi:10.1016/j.ejmech.2021.113839 Preclinical
https://doi.org/10.1016/j.ejmech.2021.113839 - World Health Organization (2007) 'Rhizoma Hydrastis'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 - Sevior, D.K., Hokkanen, J., Tolonen, A., Abass, K., Tursas, L., Pelkonen, O. and Ahokas, J.T (2010) 'Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail', Xenobiotica, 40(4), pp. 245--254. doi:10.3109/00498251003592683 Preclinical
https://doi.org/10.3109/00498251003592683 - Gurley, B.J., Gardner, S.F., Hubbard, M.A., Williams, D.K., Gentry, W.B., Khan, I.A. and Shah, A (2005) 'In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes', Clinical Pharmacology and Therapeutics, 77(5), pp. 415-426. doi:10.1016/j.clpt.2005.01.009 Randomized trial
https://doi.org/10.1016/j.clpt.2005.01.009 - McDonald, M.G., Tian, D.D., Thummel, K.E., Paine, M.F. and Rettie, A.E (2020) 'Modulation of major human liver microsomal cytochromes P450 by component alkaloids of goldenseal: time-dependent inhibition and allosteric effects', Drug Metabolism and Disposition, 48(10), pp. 1018-1027. doi:10.1124/dmd.120.091041 Preclinical
https://doi.org/10.1124/dmd.120.091041 - Guo, J., Chen, H., Zhang, X., Lou, W., Zhang, P., Qiu, Y., Zhang, C., Wang, Y. and Liu, W.J (2021) 'The effect of berberine on metabolic profiles in type 2 diabetic patients: a systematic review and meta-analysis of randomized controlled trials', Oxidative Medicine and Cellular Longevity, 2021, pp. 2074610. doi:10.1155/2021/2074610 Meta-analysis / review
https://doi.org/10.1155/2021/2074610 - Forest Farming (Cooperative Extension) 'Goldenseal (Hydrastis canadensis L.)'. Available at: https://forest-farming.extension.org/goldenseal-hydrastis-canadensis-l/ Traditional / reference
https://forest-farming.extension.org/goldenseal-hydrastis-canadensis-l/ - Frasca, T. and Brett, A.S. and Yoo, S.D (1997) 'Mandrake toxicity. A case of mistaken identity', Archives of Internal Medicine, 157(17), pp. 2007-9. doi:10.1001/archinte.157.17.2007 Clinical study
https://doi.org/10.1001/archinte.157.17.2007 - North Carolina Extension Gardener Plant Toolbox 'Sanguinaria canadensis (Bloodroot)'. Available at: https://plants.ces.ncsu.edu/plants/sanguinaria-canadensis/ Traditional / reference
https://plants.ces.ncsu.edu/plants/sanguinaria-canadensis/
- Mocan, A., Vodnar, D.C., Vlase, L., Crisan, O. and others (2015) 'Phytochemical Characterization of Veronica officinalis L., V. teucrium L. and V. orchidea Crantz from Romania and Their Antioxidant and Antimicrobial Properties', International Journal of Molecular Sciences, 16(9), pp. 21109-21127. doi:10.3390/ijms160921109 Preclinical
https://doi.org/10.3390/ijms160921109 - Crisan, G., Tamas, M., Miclaus, V., Krausz, T. and others (2007) 'A comparative study of some Veronica species', Revista Medico-Chirurgicala a Societatii de Medici si Naturalisti din Iasi, 111(1), pp. 280-284. Preclinical
https://scholar.google.com/scholar?q=A%20comparative%20study%20of%20some%20Veronica%20species - Korzhikova, E.B (1991) 'Speedwell (Veronica officinalis)', Feldsher i Akusherka, 56(2), pp. 37-39. Traditional / reference
https://scholar.google.com/scholar?q=Speedwell%20%28Veronica%20officinalis%29 - Scarlat, M., Sandor, V., Tamas, M. and Cuparencu, B (1985) 'Experimental anti-ulcer activity of Veronica officinalis L. extracts', Journal of Ethnopharmacology, 13(2), pp. 157-163. doi:10.1016/0378-8741(85)90003-0 Preclinical
https://doi.org/10.1016/0378-8741(85)90003-0 - Wojcik, E (1973) 'Phytochemical studies of the Veronica officinalis L', Acta Poloniae Pharmaceutica, 30(2), pp. 195-201. Available at: https://pubmed.ncbi.nlm.nih.gov/4703978/ Preclinical
https://pubmed.ncbi.nlm.nih.gov/4703978/ - Wojcik, E (1977) 'Occurrence of 6-hydroxyluteolin 7-glucoside in the herb of Veronica officinalis L', Acta Poloniae Pharmaceutica, 34(3), pp. 295-298. Available at: https://pubmed.ncbi.nlm.nih.gov/906876/ Preclinical
https://pubmed.ncbi.nlm.nih.gov/906876/ - Bellia, G. and Pieroni, A (2015) 'Isolated, but transnational: the glocal nature of Waldensian ethnobotany, Western Alps, NW Italy', Journal of Ethnobiology and Ethnomedicine, 11, pp. 37. doi:10.1186/s13002-015-0027-1 Traditional / reference
https://doi.org/10.1186/s13002-015-0027-1 - (2017) 'Veronica officinalis Product Authentication Using DNA Metabarcoding and HPLC-MS Reveals Widespread Adulteration with Veronica chamaedrys', Frontiers in Pharmacology. doi:10.3389/fphar.2017.00378 Traditional / reference
https://doi.org/10.3389/fphar.2017.00378 - Wojcik, E (1973) 'Flavonoids of the Veronica officinalis L. herb', Acta Poloniae Pharmaceutica, 30(4), pp. 447-451. Available at: https://pubmed.ncbi.nlm.nih.gov/4762340/ Preclinical
https://pubmed.ncbi.nlm.nih.gov/4762340/ - Salehi, B., Shivaprasad Shetty, M., V. Anil Kumar, N., Zivkovic, J., Calina, D., Oana Docea, A. and others (2019) 'Veronica Plants - Drifting from Farm to Traditional Healing, Food Application, and Phytopharmacology', Molecules, 24(13), pp. 2454. doi:10.3390/molecules24132454 Preclinical
https://doi.org/10.3390/molecules24132454 - HerbaZest (n.d.) 'Veronica (Speedwell)'. Available at: https://www.herbazest.com/herbs/veronica Traditional / reference
https://www.herbazest.com/herbs/veronica - Grundemann, C., Garcia-Kaufer, M., Sauer, B., Stangenberg, E., Konczol, M., Merfort, I., Zehl, M. and Huber, R (2012) 'Traditionally used Veronica officinalis inhibits proinflammatory mediators via the NF-kB signalling pathway in a human lung cell line', Journal of Ethnopharmacology, 145(1), pp. 118--126. doi:10.1016/j.jep.2012.10.039 Preclinical
https://doi.org/10.1016/j.jep.2012.10.039
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.