Plant Comparison

Goldenseal vs Turkey tail

A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.

First plant

Second plant

Plant AGoldensealHydrastis canadensisRanunculaceaeFull monograph →

Plant BTurkey tailTrametes versicolorPolyporaceaeFull monograph →

At a glance

Goldenseal and Turkey tail: they share 5 indicated uses (arthritis / joint pain, infection (general), inflammation (general), …); 2 pharmacological actions in common.

GoldensealTurkey tail

Constituents13

Pharmacological actions46

Indicated uses98

Safety notes22

Cited sources2017

Indicated uses

Only Goldenseal

BloatingDiarrhoeaIndigestionSore throat

Shared (5)

Arthritis / joint painInfection (general)Inflammation (general)Skin irritationWounds

Only Turkey tail

Cancer (anticancer research)Cold & fluImmune support

Pharmacological actions

Only Goldenseal

AstringentDigestive aid

Shared (2)

Anti-inflammatoryAntimicrobial

Only Turkey tail

Anticancer (preclinical)AntioxidantAntiviralImmunomodulator / immune support

Evidence face-off — shared uses

Condition	Goldenseal	Turkey tail	Verdict
Arthritis / joint pain	5/10	5/10	Comparable evidence
Infection (general)	5/10	5/10	Comparable evidence
Inflammation (general)	5/10	5/10	Comparable evidence
Skin irritation	5/10	5/10	Comparable evidence
Wounds	5/10	5/10	Comparable evidence

Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.

Key Constituents

Isoquinoline alkaloids - berberine (principal), hydrastine and canadine^{[1, 4, 12]}

Berberine is the main antimicrobial, hypoglycaemic and hypolipidaemic constituent. Notably, whole-leaf extracts are more potent against MRSA than isolated berberine (owing to efflux-pump-inhibitory flavonoids) and show quorum-quenching, anti-virulence activity.

FlavonoidsAlkaloidsBerberine

Beta-glucan polysaccharides^{[11, 12]}

The principal immunomodulating constituents, forming the basis of PSK/PSP extracts.

Polysaccharides

Polysaccharopeptide (PSK/PSP, protein-bound polysaccharide)^[12]

Protein-bound polysaccharide complex studied extensively as an adjunct immunotherapy.

Polysaccharides

Phenolic compounds and triterpenes^[13]

Minor antioxidant constituents.

Phenolic compoundsTerpenes / terpenoids

Pharmacological Actions

Anti-inflammatory^[1]

Anti-inflammatory and astringent for inflamed mucous membranes (sore-throat gargle, mouth)

Antimicrobial^{[1, 2, 3, 4, 5, 6, 12]}

Antimicrobial (berberine) - supports skin, mucosal and gastrointestinal infections and sore throat

Astringent^[1]

Anti-inflammatory and astringent for inflamed mucous membranes (sore-throat gargle, mouth)

Digestive aid^{[1, 5]}

Digestive / gastrointestinal support (traditional for dyspepsia and ulcers)

Anti-inflammatory^{[11, 12, 13]}

Anticancer (preclinical)^{[1, 2, 3, 4, 5, 6, 9, 10, 11, 12, 13]}

Antimicrobial^{[11, 12, 13]}

Antioxidant^{[8, 9, 10, 11, 12, 13]}

Antiviral^{[11, 12, 13]}

Immunomodulator / immune support^{[1, 2, 3, 4, 5, 6, 7, 9, 11, 12, 13]}

Traditional & Indicated Uses

Arthritis / joint pain^[1]Moderate · 5/10

inferred from anti-inflammatory action

Evidence: 5

Label: Arthritis / joint pain

Bloating^[1]Moderate · 5/10

inferred from digestive action

Evidence: 5

Label: Bloating

Diarrhoea^[1]Moderate · 5/10

inferred from astringent action

Evidence: 5

Label: Diarrhoea

Indigestion^[1]Moderate · 5/10

Digestive / gastrointestinal support (traditional for dyspepsia and ulcers)

Evidence: 5

Label: Indigestion

Infection (general)^{[1, 4, 12]}Moderate · 5/10

Antimicrobial (berberine) - supports skin, mucosal and gastrointestinal infections and sore throat; Topical for skin infections and irritation - whole-leaf extract is active in vitro against methicillin-resistant Staphylococcus aureus (MRSA)

Evidence: 5

Label: Infection (general)

Inflammation (general)^[1]Moderate · 5/10

inferred from anti-inflammatory action

Evidence: 5

Label: Inflammation (general)

Skin irritation^[1]Moderate · 5/10

inferred from anti-inflammatory action

Evidence: 5

Label: Skin irritation

Sore throat^{[1, 4, 12]}Moderate · 5/10

Anti-inflammatory and astringent for inflamed mucous membranes (sore-throat gargle, mouth); Antimicrobial (berberine) - supports skin, mucosal and gastrointestinal infections and sore throat

Evidence: 5

Label: Sore throat

Wounds^{[1, 4, 12]}Moderate · 5/10

inferred from antimicrobial action

Evidence: 5

Label: Wounds

Arthritis / joint pain^{[11, 12, 13]}Moderate · 5/10

inferred from anti-inflammatory action

Evidence: 5

Label: Arthritis / joint pain

Cancer (anticancer research)^{[1, 2, 3, 4, 6, 12]}Strong · 9/10

inferred from anticancer action

Evidence: 9

Label: Cancer (anticancer research)

Cold & flu^{[11, 12, 13]}Moderate · 5/10

inferred from antiviral action

Evidence: 5

Label: Cold & flu

Immune support^{[11, 12, 13]}Moderate · 5/10

Evidence: 5

Label: Immune support

Infection (general)^{[11, 12, 13]}Moderate · 5/10

inferred from antimicrobial action

Evidence: 5

Label: Infection (general)

Inflammation (general)^{[11, 12, 13]}Moderate · 5/10

inferred from anti-inflammatory action

Evidence: 5

Label: Inflammation (general)

Skin irritation^{[11, 12, 13]}Moderate · 5/10

inferred from anti-inflammatory action

Evidence: 5

Label: Skin irritation

Wounds^{[11, 12, 13]}Moderate · 5/10

inferred from antimicrobial action

Evidence: 5

Label: Wounds

Safety, Cautions & Contraindications

Safety note^[1]Caution

Contraindicated in pregnancy and breastfeeding: berberine crosses the placenta and into milk and can cause or worsen newborn jaundice (risk of kernicterus); do not give to infants.

Safety note^{[1, 14]}Caution

Berberine strongly inhibits drug-metabolising enzymes (especially CYP3A4 and CYP2D6), so it can raise the blood levels of many medicines - a significant herb-drug-interaction risk. In a screen of commercial herbal products, goldenseal was among the most potent CYP2D6 inhibitors and also inhibited CYP3A4. High doses have shown possible liver, nerve and photo-toxicity.

Safety note^{[11, 12, 13]}Caution

Generally very safe and well tolerated. Rare cases of digestive upset or allergic reaction. No significant known drug interactions at normal doses. The PSK pharmaceutical form is used safely alongside standard cancer treatments. Suitable for most adults.

Safety note^{[11, 12, 13, 14]}Info

Duke (2002) does not include a dedicated entry for Turkey tail mushroom (Trametes versicolor) in the Handbook of Medicinal Herbs, Second Edition.

External Ids

Gbif: 3033110

Wikidata: Q1051710

Gbif: 2548311

Wikidata: Q753833

Botanical Description

Low, woodland perennial herb rising from a knotted, bright yellow rhizome with wiry yellow roots. Each stem bears two ragged, palmately lobed, maple-like leaves and a single small, inconspicuous greenish-white flower, followed by a raspberry-like cluster of red berries.^[1]

Height: 15-30 cm

Habit: Low, woodland perennial herb

Leaves: Two per stem, ragged, palmately lobed, maple-like

Flowers: Single, small, inconspicuous, greenish-white, petal-less

Stem: Hairy, upright, bearing two leaves

Root: Knotted, bright yellow rhizome with wiry yellow roots (the medicinal part)

Fruit: Raspberry-like cluster of red berries

Flowering Period: April-May

Bracket fungus (not a true plant) forming thin, tough, fan-shaped, overlapping shelves on dead or decaying hardwood, with a velvety, concentrically zoned upper surface in bands of brown, tan, cream, blue-grey and rust, and a white, minutely pored underside.

Height: Individual brackets 2-8 cm across, forming overlapping clusters

Habit: Bracket (shelf) fungus growing directly from dead wood, in tiered, overlapping clusters

Leaves: Not applicable (fungus); the fruiting body is a thin, tough bracket

Flowers: Not applicable (fungus); reproduces via spores released from pores on the underside

Stem: No true stem; the bracket attaches directly to the wood

Root: Not applicable; mycelium threads through the wood substrate

Fruit: Fan-shaped fruiting body (bracket) with a white, densely pored underside

Flowering Period: Fruiting bodies present year-round, most abundant in autumn

Habitat

Grows in rich, shaded deciduous woodland with humus-rich soil; native to eastern North America, now scarce in the wild due to overharvesting and largely supplied by cultivation.^[1]

Grows on dead, dying or fallen hardwood logs, stumps and branches in woodlands worldwide, including Europe, Asia and North America.

Harvesting

The rhizome and root are dug in autumn from plants at least three to four years old, when berberine content is highest, then cleaned and dried; because wild populations are depleted, cultivated or sustainably sourced material is strongly preferred, and careful identification against the toxic mayapple and bloodroot, which share its woodland habitat, is essential before any wild-harvesting.^[1]

Parts: Rhizome and root

Season: Autumn, from mature (3-4+ year) plants

Fresh brackets are harvested by cutting from the wood; for medicinal use the tough fruiting body is typically dried and then decocted (simmered) for a long time, or extracted, since the beneficial polysaccharides are not well-extracted by simple infusion.

Parts: Mycelium, Whole Plant

Season: Year-round, most abundant in autumn

Traditional Uses

Goldenseal root has a Native American and, after adoption by Eclectic physicians, wider North American tradition as a bitter tonic and antimicrobial remedy for mucous-membrane infections, sore throat, digestive upset and topical skin infections, directly reflecting its high berberine content.^[1]

Turkey tail has a long history of use in traditional Chinese medicine (as yun zhi) and is one of the most researched medicinal mushrooms, with standardized polysaccharide-K (PSK) and polysaccharopeptide (PSP) extracts used clinically in Japan and China alongside conventional cancer treatment to support immune function.^{[11, 12, 13]}

Preparations

Decoction^[1]

Dried rhizome and root simmered in water as a traditional bitter antimicrobial tea, or used as a gargle for sore throat.

Tincture^[13]

Tincture 1:10 in 60% ethanol of the dried rhizome and root, 2-4 ml three times daily per the WHO monograph Rhizoma Hydrastis. Educational reference only, not a prescription.

Standardised extract^[4]

Extract standardised to berberine/hydrastine content, taken as capsules; whole-leaf extracts have shown stronger antimicrobial activity than isolated berberine in some studies.

Long decoction^[11]

Dried fruiting body simmered in water for an extended period (often 1-2 hours) to extract the beta-glucan polysaccharides, then strained.

Standardized extract (PSK/PSP)^[12]

Standardized polysaccharide-K (PSK) or polysaccharopeptide (PSP) extract, the pharmaceutical-grade forms used in clinical research.

Dosage

Decoction/tincture^[13]

The WHO monograph on Rhizoma Hydrastis gives a daily dose of 0.5-1.0 g of the dried rhizome and root three times, or taken as a decoction; a 1:1 liquid extract in 60% ethanol at 0.3-1.0 mL three times; or a 1:10 tincture in 60% ethanol at 2-4 mL three times. For short-term use only, given goldenseal's potent CYP-enzyme inhibition and its contraindication in pregnancy. Educational reference only, not a prescription.

Standardized extract^[12]

Clinical research on PSK commonly uses around 3 g daily in divided doses. Educational reference only, not a prescription.

References

REF-0455, REF-1849, REF-1850, REF-0588, REF-1851, REF-1852, REF-1853, REF-1854, REF-1855, REF-1856, REF-1857

REF-1582, REF-1583, REF-1584, REF-1585, REF-1586, REF-1587, REF-1588, REF-1589, REF-1590, REF-1591

Drug Class Interactions

Safety note^{[15, 16]}Caution

Drug Class: cyp3a4-substrates

Mechanism: Goldenseal's berberine and hydrastine strongly inhibit CYP3A4 (and also CYP2D6), enzymes that clear many medicines. In a controlled study in healthy volunteers, 28 days of goldenseal cut CYP3A4/5 and CYP2D6 activity by roughly 40%, so it can raise the blood levels and side effects of drugs handled by these pathways - for example some statins, calcium-channel blockers and sedatives (CYP3A4), and certain antidepressants, beta-blockers and opioids (CYP2D6). Separate dosing and monitor, or avoid combining with narrow-margin medicines.

Reviewed By: Omnia Sana (owner-authorized)

Reviewed Date: 2026-07-03

Safety note^[17]Caution

Drug Class: antidiabetics

Mechanism: Goldenseal is rich in berberine, its main alkaloid, which lowers blood glucose - meta-analyses of randomised trials show berberine significantly reduces fasting glucose and HbA1c. Taken with diabetes medicines, goldenseal may therefore add to blood-sugar lowering, so monitor blood glucose.

Reviewed By: Omnia Sana (owner-authorized)

Reviewed Date: 2026-07-03

Not documented

Lookalikes Review

Outcome: has-lookalikes

Reviewed By: Omnia Sana (owner-authorized)

Reviewed Date: 2026-07-07

Outcome: has-lookalikes

Reviewed By: Omnia Sana (owner-authorized)

Reviewed Date: 2026-07-07

Dangerous Lookalikes

Safety note^{[18, 19]}Dangerous

Dangerous Plant: podophyllum-peltatum

Confused Part: Woodland rhizome dug as goldenseal; mayapple shares the same rich woods and has similar lobed, maple-like leaves.

Confusion Context: Goldenseal (Hydrastis canadensis) is dug from rich woodland for its yellow rhizome. Mayapple (Podophyllum peltatum) grows in the same rich-woods habitat and, once its leaves expand, its lobed maple-like leaves resemble goldenseal, so novice foragers confuse them. Mayapple contains podophyllotoxin (a potent cell poison) in all parts except the ripe fruit; ingestion causes severe vomiting and diarrhoea and can cause serious systemic toxicity. Because the plants share habitat and leaf shape, this is a genuine hazard when digging goldenseal.

Distinguishing Features: Whole plant: goldenseal has a hairy upright stem bearing usually two ragged, maple-like lobed leaves and a single small flower, with a knotted BRIGHT-YELLOW rhizome. Mayapple has one or two large, smooth, umbrella-like lobed leaves on a hairless stalk and a white flower nodding beneath, with a white-ish creeping rhizome., Rhizome colour (decisive): goldenseal's rhizome and root are vivid yellow inside (berberine). Mayapple's rhizome is not bright yellow., Leaf texture: goldenseal leaves are hairy and puckered; mayapple leaves are large, smooth and shield-like (the stalk joins near the centre).

Key Test: Dig only after matching the whole plant, and check the rhizome. A hairy stem with ragged maple-like leaves over a BRIGHT-YELLOW knotted rhizome = goldenseal. Large smooth umbrella-like leaves over a pale rhizome (no yellow) = mayapple - toxic, do not use. If the root is not bright yellow inside, do not use it.

Reviewed By: Omnia Sana (owner-authorized)

Reviewed Date: 2026-07-07

Safety note^{[18, 20]}Dangerous

Dangerous Plant: sanguinaria-canadensis

Confused Part: Woodland rhizome dug as goldenseal; bloodroot grows in the same rich woods and its rhizome is gathered in mistake for goldenseal.

Confusion Context: Bloodroot (Sanguinaria canadensis) shares the same rich-woods spring habitat as goldenseal and is listed among goldenseal's harvesting look-alikes. Bloodroot is a high-severity poison: its rhizome contains isoquinoline alkaloids (sanguinarine) and, when broken, oozes a bright red-orange sap; ingestion causes vomiting, faintness, dizziness, dilated pupils and, in serious cases, heart failure, and the sap is destructive to tissue. Because both are dug for their rhizomes from the same woodland, this is a genuine hazard.

Distinguishing Features: Sap colour (decisive): a broken bloodroot rhizome bleeds a bright RED-ORANGE sap. Goldenseal's rhizome is BRIGHT YELLOW inside, not red., Leaf: bloodroot has a single, rounded, deeply scalloped/lobed grey-green leaf that wraps the flower stalk, and a white flower; goldenseal has a hairy stem with two ragged maple-like leaves., Whole plant: confirm goldenseal by its paired hairy maple-like leaves and yellow root before digging.

Key Test: Break the rhizome and look at the sap and leaves. Bright YELLOW root with paired hairy maple-like leaves = goldenseal. A single scalloped leaf and a rhizome bleeding RED-ORANGE sap = bloodroot - a high-severity poison, do not use. If the sap is red, it is not goldenseal.

Reviewed By: Omnia Sana (owner-authorized)

Reviewed Date: 2026-07-07

Safety note^{[15, 16, 17]}Caution

Dangerous Plant: stereum-hirsutum

Confused Part: The whole fan-shaped bracket (the concentrically zoned shelf growing on dead hardwood), especially the top surface, which looks almost identical from above.

Confusion Context: False turkey tail (Stereum hirsutum, and the near-identical Stereum ostrea) is the commonest fungus mistaken for medicinal turkey tail. Seen from above the two are near-identical: overlapping, fan-shaped, concentrically banded, fuzzy-topped brackets on dead wood. Stereum is NOT poisonous - it is simply inedible (too thin and leathery) and there are no documented poisonings. The problem is that it is a crust fungus lacking the medicinal polysaccharides of true turkey tail, so anyone who brews it gets a worthless tea. This record exists to prevent a wasted, ineffective harvest, not to warn of poisoning.

Distinguishing Features: UNDERSIDE (decisive): true turkey tail has a whitish PORE surface underneath, densely covered with tiny pores/tubes (about 2-5 per mm, visible with a hand lens). False turkey tail (Stereum) has a completely SMOOTH, poreless underside - it is a crust fungus, not a polypore., Underside colour: true turkey tail's pore surface is white to off-white. Stereum's smooth underside is typically tan, yellowish, greyish or pale reddish-brown; a coloured, non-white underside is a red flag., Texture: true turkey tail is thin and flexible; Stereum tends to be tougher, more leathery and often wavier at the margin.

Key Test: Turn the bracket over and look at the underside with a hand lens. Genuine turkey tail shows a white surface densely covered in tiny pores (roughly 2-5 per mm). If the underside is SMOOTH and poreless (and often tan/orange/brown rather than white), it is false turkey tail (Stereum) - discard it. Smooth underside = not turkey tail.

Reviewed By: Omnia Sana (owner-authorized)

Reviewed Date: 2026-07-07

References & Sources

Mandal, S.K., Maji, A.K., Mishra, S.K., Ishfaq, P.M., Devkota, H.P., Silva, A.S. and Das, N (2020) 'Goldenseal (Hydrastis canadensis L.) and its active constituents: A critical review of their efficacy and toxicological issues', Pharmacological Research. doi:10.1016/j.phrs.2020.105085 Randomized trial
https://doi.org/10.1016/j.phrs.2020.105085
Corn, J., Tibbitts, D., Ito, H., Schafer, M. and Vasilevsky, N (2021) 'Effects of Hydrastis Canadensis, Commiphora Habessinica, Phytolacca Americana, and Echinacea Purpurea on Bacterial Growth', Alternative Therapies in Health and Medicine, 27(4), pp. 24-27. Preclinical
https://scholar.google.com/scholar?q=Effects%20of%20Hydrastis%20Canadensis%2C%20Commiphora%20Habessinica%2C%20Phytolacca%20Americana%2C%20and%20Echinacea%20Purpurea%20on%20Bacterial%20Growth
Ettefagh, K.A., Burns, J.T., Junio, H.A., Kaatz, G.W. and Cech, N.B (2010) 'Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition', Planta Medica, 77(8), pp. 835-840. doi:10.1055/s-0030-1250606 Preclinical
https://doi.org/10.1055/s-0030-1250606
Cech, N.B., Junio, H.A., Ackermann, L.W., Kavanaugh, J.S. and Horswill, A.R (2012) 'Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA)', Planta Medica, 78(14), pp. 1556--1561. doi:10.1055/s-0032-1315042 Traditional / reference
https://doi.org/10.1055/s-0032-1315042
Mahady, G.B., Pendland, S.L., Stoia, A. and Chadwick, L.R (2003) 'In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis', Phytotherapy Research, 17(3), pp. 217-221. doi:10.1002/ptr.1108 Preclinical
https://doi.org/10.1002/ptr.1108
Junio, H.A., Sy-Cordero, A.A., Ettefagh, K.A., Burns, J.T., Micko, K.T., Graf, T.N., Richter, S.J., Cannon, R.E., Oberlies, N.H. and Cech, N.B (2011) 'Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis)', Journal of Natural Products, 74(7), pp. 1621-1629. doi:10.1021/np200336g Preclinical
https://doi.org/10.1021/np200336g
Britton, E.R., Kellogg, J.J., Kvalheim, O.M. and Cech, N.B (2017) 'Biochemometrics to Identify Synergists and Additives from Botanical Medicines: A Case Study with Hydrastis canadensis (Goldenseal)', Journal of Natural Products, 81(3), pp. 484-493. doi:10.1021/acs.jnatprod.7b00654 Preclinical
https://doi.org/10.1021/acs.jnatprod.7b00654
Leyte-Lugo, M., Britton, E.R., Foil, D.H., Brown, A.R., Todd, D.A., Rivera-Chavez, J., Oberlies, N.H. and Cech, N.B (2017) 'Secondary Metabolites from the Leaves of the Medicinal Plant Goldenseal (Hydrastis canadensis)', Phytochemistry Letters, 20, pp. 54-60. doi:10.1016/j.phytol.2017.03.012 Preclinical
https://doi.org/10.1016/j.phytol.2017.03.012
Gurley, B.J., Swain, A., Hubbard, M.A., Hartsfield, F., Thaden, J., Williams, D.K., Gentry, W.B. and Tong, Y (2007) 'Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo', Clinical Pharmacology and Therapeutics, 83(1), pp. 61-69. doi:10.1038/sj.clpt.6100222 Randomized trial
https://doi.org/10.1038/sj.clpt.6100222
Wallace, E.D., Oberlies, N.H., Cech, N.B. and Kellogg, J.J (2018) 'Detection of adulteration in Hydrastis canadensis (goldenseal) dietary supplements via untargeted mass spectrometry-based metabolomics', Food and Chemical Toxicology, 120, pp. 439-447. doi:10.1016/j.fct.2018.07.033 Preclinical
https://doi.org/10.1016/j.fct.2018.07.033
Douglas, J.A., Follett, J.M., Parmenter, G.A., Sansom, C.E., Perry, N.B. and Littler, R.A (2010) 'Seasonal variation of biomass and bioactive alkaloid content of goldenseal, Hydrastis canadensis', Fitoterapia, 81(7), pp. 925-928. doi:10.1016/j.fitote.2010.06.006 Preclinical
https://doi.org/10.1016/j.fitote.2010.06.006
Singh, S., Pathak, N., Fatima, E. and Negi, A.S (2021) 'Plant isoquinoline alkaloids: Advances in the chemistry and biology of berberine', European Journal of Medicinal Chemistry. doi:10.1016/j.ejmech.2021.113839 Preclinical
https://doi.org/10.1016/j.ejmech.2021.113839
World Health Organization (2007) 'Rhizoma Hydrastis'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37
Sevior, D.K., Hokkanen, J., Tolonen, A., Abass, K., Tursas, L., Pelkonen, O. and Ahokas, J.T (2010) 'Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail', Xenobiotica, 40(4), pp. 245--254. doi:10.3109/00498251003592683 Preclinical
https://doi.org/10.3109/00498251003592683
Gurley, B.J., Gardner, S.F., Hubbard, M.A., Williams, D.K., Gentry, W.B., Khan, I.A. and Shah, A (2005) 'In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes', Clinical Pharmacology and Therapeutics, 77(5), pp. 415-426. doi:10.1016/j.clpt.2005.01.009 Randomized trial
https://doi.org/10.1016/j.clpt.2005.01.009
McDonald, M.G., Tian, D.D., Thummel, K.E., Paine, M.F. and Rettie, A.E (2020) 'Modulation of major human liver microsomal cytochromes P450 by component alkaloids of goldenseal: time-dependent inhibition and allosteric effects', Drug Metabolism and Disposition, 48(10), pp. 1018-1027. doi:10.1124/dmd.120.091041 Preclinical
https://doi.org/10.1124/dmd.120.091041
Guo, J., Chen, H., Zhang, X., Lou, W., Zhang, P., Qiu, Y., Zhang, C., Wang, Y. and Liu, W.J (2021) 'The effect of berberine on metabolic profiles in type 2 diabetic patients: a systematic review and meta-analysis of randomized controlled trials', Oxidative Medicine and Cellular Longevity, 2021, pp. 2074610. doi:10.1155/2021/2074610 Meta-analysis / review
https://doi.org/10.1155/2021/2074610
Forest Farming (Cooperative Extension) 'Goldenseal (Hydrastis canadensis L.)'. Available at: https://forest-farming.extension.org/goldenseal-hydrastis-canadensis-l/ Traditional / reference
https://forest-farming.extension.org/goldenseal-hydrastis-canadensis-l/
Frasca, T. and Brett, A.S. and Yoo, S.D (1997) 'Mandrake toxicity. A case of mistaken identity', Archives of Internal Medicine, 157(17), pp. 2007-9. doi:10.1001/archinte.157.17.2007 Clinical study
https://doi.org/10.1001/archinte.157.17.2007
North Carolina Extension Gardener Plant Toolbox 'Sanguinaria canadensis (Bloodroot)'. Available at: https://plants.ces.ncsu.edu/plants/sanguinaria-canadensis/ Traditional / reference
https://plants.ces.ncsu.edu/plants/sanguinaria-canadensis/

Pilkington, K., Wieland, L.S., Teng, L., Jin, X.Y. and others (2022) 'Coriolus (Trametes) versicolor mushroom to reduce adverse effects from chemotherapy or radiotherapy in people with colorectal cancer', Cochrane Database of Systematic Reviews, 11(11), pp. CD012053. doi:10.1002/14651858.CD012053.pub2 Meta-analysis / review
https://doi.org/10.1002/14651858.CD012053.pub2
Habtemariam, S (2020) 'Trametes versicolor (Synn. Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy', Biomedicines, 8(5), pp. 135. doi:10.3390/biomedicines8050135 Meta-analysis / review
https://doi.org/10.3390/biomedicines8050135
Fritz, H., Kennedy, D.A., Ishii, M., Fergusson, D. and others (2015) 'Polysaccharide K and Coriolus versicolor extracts for lung cancer: a systematic review', Integrative Cancer Therapies, 14(3), pp. 201-211. doi:10.1177/1534735415572883 Meta-analysis / review
https://doi.org/10.1177/1534735415572883
Tsang, K.W., Lam, C.L., Yan, C., Mak, J.C. and others (2003) 'Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer', Respiratory Medicine, 97(6), pp. 618-624. doi:10.1053/rmed.2003.1490 Randomized trial
https://doi.org/10.1053/rmed.2003.1490
Ng, T.B (1998) 'A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae)', General Pharmacology, 30(1), pp. 1-4. doi:10.1016/s0306-3623(97)00076-1 Meta-analysis / review
https://doi.org/10.1016/s0306-3623(97)00076-1
Kowalczewska, M., Piotrowski, J., Jedrzejewski, T. and Kozak, W (2016) 'Polysaccharide peptides from Coriolus versicolor exert differential immunomodulatory effects on blood lymphocytes and breast cancer cell line MCF-7 in vitro', Immunology Letters, 174, pp. 37-44. doi:10.1016/j.imlet.2016.04.010 Preclinical
https://doi.org/10.1016/j.imlet.2016.04.010
Jedrzejewski, T., Piotrowski, J., Kowalczewska, M., Wrotek, S. and Kozak, W (2015) 'Polysaccharide peptide from Coriolus versicolor induces interleukin 6-related extension of endotoxin fever in rats', International Journal of Hyperthermia, 31(6), pp. 626-634. doi:10.3109/02656736.2015.1046953 Preclinical
https://doi.org/10.3109/02656736.2015.1046953
Scarpari, M., Reverberi, M., Parroni, A., Scala, V. and others (2017) 'Tramesan, a novel polysaccharide from Trametes versicolor. Structural characterization and biological effects', PLoS One, 12(8), pp. e0171412. doi:10.1371/journal.pone.0171412 Preclinical
https://doi.org/10.1371/journal.pone.0171412
Lysakowska, P., Sobota, A. and Wirkijowska, A (2023) 'Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production - A Review', Molecules, 28(14), pp. 5393. doi:10.3390/molecules28145393 Meta-analysis / review
https://doi.org/10.3390/molecules28145393
Wang, K.F., Sui, K.Y., Guo, C. and Liu, C.Z (2017) 'Quorum sensing molecule-farnesol increased the production and biological activities of extracellular polysaccharide from Trametes versicolor', International Journal of Biological Macromolecules, 104(Pt A), pp. 377-383. doi:10.1016/j.ijbiomac.2017.06.053 Preclinical
https://doi.org/10.1016/j.ijbiomac.2017.06.053
Chu, K.K., Ho, S.S. and Chow, A.H (2002) 'Coriolus versicolor: a medicinal mushroom with promising immunotherapeutic values', 42(9), pp. 976--984. doi:10.1177/0091270002042009004 Traditional / reference
https://doi.org/10.1177/0091270002042009004
Standish, L.J., Wenner, C.A., Sweet, E.S., Bridge, C., Nelson, A., Martzen, M., Novack, J. and Torkelson, C (2008) 'Trametes versicolor mushroom immune therapy in breast cancer', 6(3), pp. 122--128. Traditional / reference
https://scholar.google.com/scholar?q=Trametes%20versicolor%20mushroom%20immune%20therapy%20in%20breast%20cancer
Wasser, S.P (2011) 'Current findings, future trends, and unsolved problems in studies of medicinal mushrooms', 89(5), pp. 1323--1332. doi:10.1007/s00253-010-3067-4 Randomized trial
https://doi.org/10.1007/s00253-010-3067-4
Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
Macalester College, Katharine Ordway Natural History Study Area 'Turkey Tail Fungus (Trametes versicolor)'. Available at: https://www.macalester.edu/ordway/biodiversity/inventory/turkeytailfungus/ Traditional / reference
https://www.macalester.edu/ordway/biodiversity/inventory/turkeytailfungus/
Missouri Department of Conservation 'False Turkey Tail (Stereum ostrea)'. Available at: https://mdc.mo.gov/discover-nature/field-guide/false-turkey-tail Traditional / reference
https://mdc.mo.gov/discover-nature/field-guide/false-turkey-tail
Kuo, Michael 'Stereum ostrea (False Turkey Tail)'. Available at: https://www.mushroomexpert.com/stereum_ostrea.html Traditional / reference
https://www.mushroomexpert.com/stereum_ostrea.html

Goldenseal monograph Turkey tail monograph Compare other plants

Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.