Omnia SanaPlant Comparison
Goldenseal vs Blackberry Leaf
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Goldenseal and Blackberry Leaf: they share 7 indicated uses (arthritis / joint pain, diarrhoea, infection (general), …); 3 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Goldenseal | Blackberry Leaf | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 5/10 | 2/10 | Stronger for Goldenseal |
| Diarrhoea | 5/10 | 2/10 | Stronger for Goldenseal |
| Infection (general) | 5/10 | 2/10 | Stronger for Goldenseal |
| Inflammation (general) | 5/10 | 2/10 | Stronger for Goldenseal |
| Skin irritation | 5/10 | 2/10 | Stronger for Goldenseal |
| Sore throat | 5/10 | 2/10 | Stronger for Goldenseal |
| Wounds | 5/10 | 2/10 | Stronger for Goldenseal |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Berberine is the main antimicrobial, hypoglycaemic and hypolipidaemic constituent. Notably, whole-leaf extracts are more potent against MRSA than isolated berberine (owing to efflux-pump-inhibitory flavonoids) and show quorum-quenching, anti-virulence activity.
Pharmacological Actions
Anti-inflammatory and astringent for inflamed mucous membranes (sore-throat gargle, mouth)
Antimicrobial (berberine) - supports skin, mucosal and gastrointestinal infections and sore throat
Anti-inflammatory and astringent for inflamed mucous membranes (sore-throat gargle, mouth)
Anti-inflammatory gargle / mouthwash for sore throat and oral mucosa inflammation
Astringent for mild diarrhoea (tannins tighten the gut lining and reduce excess secretion)
Traditional & Indicated Uses
inferred from anti-inflammatory action
Digestive / gastrointestinal support (traditional for dyspepsia and ulcers)
Antimicrobial (berberine) - supports skin, mucosal and gastrointestinal infections and sore throat; Topical for skin infections and irritation - whole-leaf extract is active in vitro against methicillin-resistant Staphylococcus aureus (MRSA)
inferred from anti-inflammatory action
inferred from anti-inflammatory action
Anti-inflammatory and astringent for inflamed mucous membranes (sore-throat gargle, mouth); Antimicrobial (berberine) - supports skin, mucosal and gastrointestinal infections and sore throat
inferred from anti-inflammatory action
inferred from anticancer action
Astringent for mild diarrhoea (tannins tighten the gut lining and reduce excess secretion)
inferred from antimicrobial action
Anti-inflammatory gargle / mouthwash for sore throat and oral mucosa inflammation
Anti-inflammatory gargle / mouthwash for sore throat and oral mucosa inflammation
inferred from astringent action
Anti-inflammatory gargle / mouthwash for sore throat and oral mucosa inflammation
Safety, Cautions & Contraindications
Contraindicated in pregnancy and breastfeeding: berberine crosses the placenta and into milk and can cause or worsen newborn jaundice (risk of kernicterus); do not give to infants.
Berberine strongly inhibits drug-metabolising enzymes (especially CYP3A4 and CYP2D6), so it can raise the blood levels of many medicines - a significant herb-drug-interaction risk. In a screen of commercial herbal products, goldenseal was among the most potent CYP2D6 inhibitors and also inhibited CYP3A4. High doses have shown possible liver, nerve and photo-toxicity.
Tannin-rich: high or prolonged intake may cause stomach upset or constipation and can reduce the absorption of iron and some medicines taken at the same time.
Traditional use only; diarrhoea that persists (especially in children) needs medical assessment and attention to rehydration.
External Ids
Botanical Description
Low, woodland perennial herb rising from a knotted, bright yellow rhizome with wiry yellow roots. Each stem bears two ragged, palmately lobed, maple-like leaves and a single small, inconspicuous greenish-white flower, followed by a raspberry-like cluster of red berries.[1]
Scrambling, thorny deciduous shrub (Rosaceae) forming dense thickets, with arching prickly stems that root at the tip. Leaves are palmately compound, usually with 3-5 toothed leaflets. White to pale pink, five-petalled flowers are followed by clusters of small drupelets forming the blackberry fruit, ripening from red to glossy black.[8]
Habitat
Grows in rich, shaded deciduous woodland with humus-rich soil; native to eastern North America, now scarce in the wild due to overharvesting and largely supplied by cultivation.[1]
Native throughout Europe and widely naturalised elsewhere, an aggressive coloniser of hedgerows, woodland edges, scrub and waste ground. 'Rubus fruticosus' is a taxonomically complex aggregate comprising hundreds of closely related microspecies.[8]
Harvesting
The rhizome and root are dug in autumn from plants at least three to four years old, when berberine content is highest, then cleaned and dried; because wild populations are depleted, cultivated or sustainably sourced material is strongly preferred, and careful identification against the toxic mayapple and bloodroot, which share its woodland habitat, is essential before any wild-harvesting.[1]
Leaves are picked fresh throughout the growing season and dried for tea; berries are picked in late summer once fully ripe.[8]
Traditional Uses
Goldenseal root has a Native American and, after adoption by Eclectic physicians, wider North American tradition as a bitter tonic and antimicrobial remedy for mucous-membrane infections, sore throat, digestive upset and topical skin infections, directly reflecting its high berberine content.[1]
Blackberry leaf has a long European folk-medicine tradition as an astringent gargle for sore throat and mouth ulcers, and as a remedy for mild diarrhoea, reflecting its high tannin content; the berries themselves are valued as a nutritious, antioxidant-rich food.[8]
Preparations
Dried rhizome and root simmered in water as a traditional bitter antimicrobial tea, or used as a gargle for sore throat.
Tincture 1:10 in 60% ethanol of the dried rhizome and root, 2-4 ml three times daily per the WHO monograph Rhizoma Hydrastis. Educational reference only, not a prescription.
Extract standardised to berberine/hydrastine content, taken as capsules; whole-leaf extracts have shown stronger antimicrobial activity than isolated berberine in some studies.
Dosage
The WHO monograph on Rhizoma Hydrastis gives a daily dose of 0.5-1.0 g of the dried rhizome and root three times, or taken as a decoction; a 1:1 liquid extract in 60% ethanol at 0.3-1.0 mL three times; or a 1:10 tincture in 60% ethanol at 2-4 mL three times. For short-term use only, given goldenseal's potent CYP-enzyme inhibition and its contraindication in pregnancy. Educational reference only, not a prescription.
Traditional guidance suggests roughly 2-4 g dried leaf per cup as an infusion, up to three times daily, or used as a gargle at similar strength. Educational reference only, not a prescription.
References
Drug Class Interactions
Not documented
Lookalikes Review
Dangerous Lookalikes
Not documented
References & Sources
- Mandal, S.K., Maji, A.K., Mishra, S.K., Ishfaq, P.M., Devkota, H.P., Silva, A.S. and Das, N (2020) 'Goldenseal (Hydrastis canadensis L.) and its active constituents: A critical review of their efficacy and toxicological issues', Pharmacological Research. doi:10.1016/j.phrs.2020.105085 Randomized trial
https://doi.org/10.1016/j.phrs.2020.105085 - Corn, J., Tibbitts, D., Ito, H., Schafer, M. and Vasilevsky, N (2021) 'Effects of Hydrastis Canadensis, Commiphora Habessinica, Phytolacca Americana, and Echinacea Purpurea on Bacterial Growth', Alternative Therapies in Health and Medicine, 27(4), pp. 24-27. Preclinical
https://scholar.google.com/scholar?q=Effects%20of%20Hydrastis%20Canadensis%2C%20Commiphora%20Habessinica%2C%20Phytolacca%20Americana%2C%20and%20Echinacea%20Purpurea%20on%20Bacterial%20Growth - Ettefagh, K.A., Burns, J.T., Junio, H.A., Kaatz, G.W. and Cech, N.B (2010) 'Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition', Planta Medica, 77(8), pp. 835-840. doi:10.1055/s-0030-1250606 Preclinical
https://doi.org/10.1055/s-0030-1250606 - Cech, N.B., Junio, H.A., Ackermann, L.W., Kavanaugh, J.S. and Horswill, A.R (2012) 'Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA)', Planta Medica, 78(14), pp. 1556--1561. doi:10.1055/s-0032-1315042 Traditional / reference
https://doi.org/10.1055/s-0032-1315042 - Mahady, G.B., Pendland, S.L., Stoia, A. and Chadwick, L.R (2003) 'In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis', Phytotherapy Research, 17(3), pp. 217-221. doi:10.1002/ptr.1108 Preclinical
https://doi.org/10.1002/ptr.1108 - Junio, H.A., Sy-Cordero, A.A., Ettefagh, K.A., Burns, J.T., Micko, K.T., Graf, T.N., Richter, S.J., Cannon, R.E., Oberlies, N.H. and Cech, N.B (2011) 'Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis)', Journal of Natural Products, 74(7), pp. 1621-1629. doi:10.1021/np200336g Preclinical
https://doi.org/10.1021/np200336g - Britton, E.R., Kellogg, J.J., Kvalheim, O.M. and Cech, N.B (2017) 'Biochemometrics to Identify Synergists and Additives from Botanical Medicines: A Case Study with Hydrastis canadensis (Goldenseal)', Journal of Natural Products, 81(3), pp. 484-493. doi:10.1021/acs.jnatprod.7b00654 Preclinical
https://doi.org/10.1021/acs.jnatprod.7b00654 - Leyte-Lugo, M., Britton, E.R., Foil, D.H., Brown, A.R., Todd, D.A., Rivera-Chavez, J., Oberlies, N.H. and Cech, N.B (2017) 'Secondary Metabolites from the Leaves of the Medicinal Plant Goldenseal (Hydrastis canadensis)', Phytochemistry Letters, 20, pp. 54-60. doi:10.1016/j.phytol.2017.03.012 Preclinical
https://doi.org/10.1016/j.phytol.2017.03.012 - Gurley, B.J., Swain, A., Hubbard, M.A., Hartsfield, F., Thaden, J., Williams, D.K., Gentry, W.B. and Tong, Y (2007) 'Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo', Clinical Pharmacology and Therapeutics, 83(1), pp. 61-69. doi:10.1038/sj.clpt.6100222 Randomized trial
https://doi.org/10.1038/sj.clpt.6100222 - Wallace, E.D., Oberlies, N.H., Cech, N.B. and Kellogg, J.J (2018) 'Detection of adulteration in Hydrastis canadensis (goldenseal) dietary supplements via untargeted mass spectrometry-based metabolomics', Food and Chemical Toxicology, 120, pp. 439-447. doi:10.1016/j.fct.2018.07.033 Preclinical
https://doi.org/10.1016/j.fct.2018.07.033 - Douglas, J.A., Follett, J.M., Parmenter, G.A., Sansom, C.E., Perry, N.B. and Littler, R.A (2010) 'Seasonal variation of biomass and bioactive alkaloid content of goldenseal, Hydrastis canadensis', Fitoterapia, 81(7), pp. 925-928. doi:10.1016/j.fitote.2010.06.006 Preclinical
https://doi.org/10.1016/j.fitote.2010.06.006 - Singh, S., Pathak, N., Fatima, E. and Negi, A.S (2021) 'Plant isoquinoline alkaloids: Advances in the chemistry and biology of berberine', European Journal of Medicinal Chemistry. doi:10.1016/j.ejmech.2021.113839 Preclinical
https://doi.org/10.1016/j.ejmech.2021.113839 - World Health Organization (2007) 'Rhizoma Hydrastis'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 - Sevior, D.K., Hokkanen, J., Tolonen, A., Abass, K., Tursas, L., Pelkonen, O. and Ahokas, J.T (2010) 'Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail', Xenobiotica, 40(4), pp. 245--254. doi:10.3109/00498251003592683 Preclinical
https://doi.org/10.3109/00498251003592683 - Gurley, B.J., Gardner, S.F., Hubbard, M.A., Williams, D.K., Gentry, W.B., Khan, I.A. and Shah, A (2005) 'In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes', Clinical Pharmacology and Therapeutics, 77(5), pp. 415-426. doi:10.1016/j.clpt.2005.01.009 Randomized trial
https://doi.org/10.1016/j.clpt.2005.01.009 - McDonald, M.G., Tian, D.D., Thummel, K.E., Paine, M.F. and Rettie, A.E (2020) 'Modulation of major human liver microsomal cytochromes P450 by component alkaloids of goldenseal: time-dependent inhibition and allosteric effects', Drug Metabolism and Disposition, 48(10), pp. 1018-1027. doi:10.1124/dmd.120.091041 Preclinical
https://doi.org/10.1124/dmd.120.091041 - Guo, J., Chen, H., Zhang, X., Lou, W., Zhang, P., Qiu, Y., Zhang, C., Wang, Y. and Liu, W.J (2021) 'The effect of berberine on metabolic profiles in type 2 diabetic patients: a systematic review and meta-analysis of randomized controlled trials', Oxidative Medicine and Cellular Longevity, 2021, pp. 2074610. doi:10.1155/2021/2074610 Meta-analysis / review
https://doi.org/10.1155/2021/2074610 - Forest Farming (Cooperative Extension) 'Goldenseal (Hydrastis canadensis L.)'. Available at: https://forest-farming.extension.org/goldenseal-hydrastis-canadensis-l/ Traditional / reference
https://forest-farming.extension.org/goldenseal-hydrastis-canadensis-l/ - Frasca, T. and Brett, A.S. and Yoo, S.D (1997) 'Mandrake toxicity. A case of mistaken identity', Archives of Internal Medicine, 157(17), pp. 2007-9. doi:10.1001/archinte.157.17.2007 Clinical study
https://doi.org/10.1001/archinte.157.17.2007 - North Carolina Extension Gardener Plant Toolbox 'Sanguinaria canadensis (Bloodroot)'. Available at: https://plants.ces.ncsu.edu/plants/sanguinaria-canadensis/ Traditional / reference
https://plants.ces.ncsu.edu/plants/sanguinaria-canadensis/
- Zia-Ul-Haq, M., Riaz, M., De Feo, V., Jaafar, H.Z.E. and Moga, M (2014) 'Rubus fruticosus L.: constituents, biological activities and health related uses', Molecules, 19(8), pp. 10998-11029. doi:10.3390/molecules190810998 Traditional / reference
https://doi.org/10.3390/molecules190810998 - Monforte, M.T., Smeriglio, A., Germanò, M.P., Pergolizzi, S., Circosta, C. and Galati, E.M (2018) 'Evaluation of antioxidant, antiinflammatory, and gastroprotective properties of Rubus fruticosus L. fruit juice', Phytotherapy Research, 32(7), pp. 1404-1414. doi:10.1002/ptr.6078 Preclinical
https://doi.org/10.1002/ptr.6078 - Barbieri, F., Montanari, C., Šimat, V., Skroza, D., Čagalj, M. et al (2022) 'Effects of Rubus fruticosus and Juniperus oxycedrus derivatives on culturability and viability of Listeria monocytogenes', Scientific Reports, 12(1), pp. 13158. doi:10.1038/s41598-022-17408-4 Preclinical
https://doi.org/10.1038/s41598-022-17408-4 - Sung, N.S., Uhm, S.H., Kang, H.B., Lee, N.S., Jeong, Y.G., Kim, D.K., Sung, N.Y., Kim, D.S., Yoo, Y.C. and Han, S.Y (2023) 'Rubus fruticosus leaf extract inhibits vascular dementia-induced memory impairment and neuronal loss by attenuating neuroinflammation', Anatomy & Cell Biology, 56(4), pp. 494-507. doi:10.5115/acb.23.195 Preclinical
https://doi.org/10.5115/acb.23.195 - Verma, R., Gangrade, T., Punasiya, R. and Ghulaxe, C (2014) 'Rubus fruticosus (blackberry) use as an herbal medicine', Pharmacognosy Reviews, 8(16), pp. 101-104. doi:10.4103/0973-7847.134239 Traditional / reference
https://doi.org/10.4103/0973-7847.134239 - Gil-Martinez, L., Mut-Salud, N., Ruiz-Garcia, J.A., Falcon-Pineiro, A., Maijo-Ferre, M., Banos, A., De la Torre-Ramirez, J.M., Guillamon, E., Verardo, V. and Gomez-Caravaca, A.M (2023) 'Phytochemicals Determination, and Antioxidant, Antimicrobial, Anti-Inflammatory and Anticancer Activities of Blackberry Fruits', Foods, 12(7), pp. 1505. doi:10.3390/foods12071505 Preclinical
https://doi.org/10.3390/foods12071505 - Van de Velde, F., Esposito, D., Grace, M.H., Pirovani, M.E. and Lila, M.A (2018) 'Anti-inflammatory and wound healing properties of polyphenolic extracts from strawberry and blackberry fruits', Food Research International, 121, pp. 453-462. doi:10.1016/j.foodres.2018.11.059 Preclinical
https://doi.org/10.1016/j.foodres.2018.11.059 - Verma, R., Gangrade, T., Punasiya, R. and Ghulaxe, C (2014) 'Rubus fruticosus (blackberry) use as an herbal medicine', Pharmacognosy Reviews. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC4127818/ Preclinical
https://pmc.ncbi.nlm.nih.gov/articles/PMC4127818/ - Grabek-Lejko, D., Milek, M., Sidor, E., Puchalski, C. and Dzugan, M (2022) 'Antiviral and Antibacterial Effect of Honey Enriched with Rubus spp. as a Functional Food with Enhanced Antioxidant Properties', Molecules, pp. as. doi:10.3390/molecules27154859 Preclinical
https://doi.org/10.3390/molecules27154859
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.