Plant Comparison

Goldenseal vs Flaxseed

A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.

First plant
Second plant
Show:
Plant AGoldensealHydrastis canadensisRanunculaceaeFull monograph →
Plant BFlaxseedLinum usitatissimumLinaceaeFull monograph →

At a glance

Goldenseal and Flaxseed: they share 5 indicated uses (arthritis / joint pain, bloating, indigestion, …); 2 pharmacological actions in common.

GoldensealFlaxseed
Constituents14
Pharmacological actions44
Indicated uses98
Safety notes24
Cited sources2020
Indicated uses
Only Goldenseal
DiarrhoeaInfection (general)Sore throatWounds
Shared (5)
Arthritis / joint painBloatingIndigestionInflammation (general)Skin irritation
Only Flaxseed
Cancer (anticancer research)Cardiovascular / heart healthMetabolic support
Pharmacological actions
Only Goldenseal
AntimicrobialAstringent
Shared (2)
Anti-inflammatoryDigestive aid
Only Flaxseed
Anticancer (preclinical)Antioxidant

Evidence face-off — shared uses

ConditionGoldensealFlaxseedVerdict
Arthritis / joint pain5/103/10Stronger for Goldenseal
Bloating5/103/10Stronger for Goldenseal
Indigestion5/103/10Stronger for Goldenseal
Inflammation (general)5/103/10Stronger for Goldenseal
Skin irritation5/103/10Stronger for Goldenseal

Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.

Key Constituents

Isoquinoline alkaloids - berberine (principal), hydrastine and canadine[1, 4, 12]

Berberine is the main antimicrobial, hypoglycaemic and hypolipidaemic constituent. Notably, whole-leaf extracts are more potent against MRSA than isolated berberine (owing to efflux-pump-inhibitory flavonoids) and show quorum-quenching, anti-virulence activity.

FlavonoidsAlkaloidsBerberine
Lignans (secoisolariciresinol diglucoside, SDG)[3]

Flax is the richest dietary source of SDG-type lignans, converted by gut bacteria to the mammalian lignans enterodiol and enterolactone; studied for antioxidant and hormone-modulating activity.

Lignans
Alpha-linolenic acid (omega-3 fatty acid)[2, 5]

The dominant fatty acid of the seed oil (~50-55% of total oil), a plant-based omega-3 studied for cardiovascular and anti-inflammatory effects.

Mucilage polysaccharides[5]

Concentrated in the seed coat; gives flaxseed its demulcent, laxative, bulk-forming action.

MucilagePolysaccharides
Cyanogenic glycosides (linamarin, linustatin)[7]

Present at low levels; cooking/roasting reduces them to negligible amounts in normal food use - a theoretical concern only at high raw intakes.

Glycosides

Pharmacological Actions

Anti-inflammatory[1]

Anti-inflammatory and astringent for inflamed mucous membranes (sore-throat gargle, mouth)

Antimicrobial[1, 2, 3, 4, 5, 6, 12]

Antimicrobial (berberine) - supports skin, mucosal and gastrointestinal infections and sore throat

Astringent[1]

Anti-inflammatory and astringent for inflamed mucous membranes (sore-throat gargle, mouth)

Digestive aid[1, 5]

Digestive / gastrointestinal support (traditional for dyspepsia and ulcers)

Anti-inflammatory[2, 4, 5, 8, 9, 12, 14, 15, 16, 18]
Anticancer (preclinical)[7]
Antioxidant[3, 5, 7, 12, 14, 15, 16, 18]
Digestive aid[2, 4, 12, 14, 15, 16, 18]

Traditional & Indicated Uses

Arthritis / joint pain[1]Moderate · 5/10

inferred from anti-inflammatory action

Evidence: 5
Label: Arthritis / joint pain
Bloating[1]Moderate · 5/10

inferred from digestive action

Evidence: 5
Label: Bloating
Diarrhoea[1]Moderate · 5/10

inferred from astringent action

Evidence: 5
Label: Diarrhoea
Indigestion[1]Moderate · 5/10

Digestive / gastrointestinal support (traditional for dyspepsia and ulcers)

Evidence: 5
Label: Indigestion
Infection (general)[1, 4, 12]Moderate · 5/10

Antimicrobial (berberine) - supports skin, mucosal and gastrointestinal infections and sore throat; Topical for skin infections and irritation - whole-leaf extract is active in vitro against methicillin-resistant Staphylococcus aureus (MRSA)

Evidence: 5
Label: Infection (general)
Inflammation (general)[1]Moderate · 5/10

inferred from anti-inflammatory action

Evidence: 5
Label: Inflammation (general)
Skin irritation[1]Moderate · 5/10

inferred from anti-inflammatory action

Evidence: 5
Label: Skin irritation
Sore throat[1, 4, 12]Moderate · 5/10

Anti-inflammatory and astringent for inflamed mucous membranes (sore-throat gargle, mouth); Antimicrobial (berberine) - supports skin, mucosal and gastrointestinal infections and sore throat

Evidence: 5
Label: Sore throat
Wounds[1, 4, 12]Moderate · 5/10

inferred from antimicrobial action

Evidence: 5
Label: Wounds
Arthritis / joint pain[12, 14, 15, 16, 18]Limited · 3/10

inferred from anti-inflammatory action

Evidence: 3
Label: Arthritis / joint pain
Bloating[12, 14, 15, 16, 18]Limited · 3/10

inferred from digestive action

Evidence: 3
Label: Bloating
Cancer (anticancer research)[7]Good · 7/10

inferred from anticancer action

Evidence: 7
Label: Cancer (anticancer research)
Cardiovascular / heart health[12, 13, 14, 15, 16, 18]Moderate · 6/10
Evidence: 6
Label: Cardiovascular / heart health
Indigestion[12, 14, 15, 16, 18]Limited · 3/10

inferred from digestive action

Evidence: 3
Label: Indigestion
Inflammation (general)[12, 14, 15, 16, 18]Limited · 3/10

inferred from anti-inflammatory action

Evidence: 3
Label: Inflammation (general)
Metabolic support[12, 14, 15, 16, 17, 18]Moderate · 6/10
Evidence: 6
Label: Metabolic support
Skin irritation[12, 14, 15, 16, 18]Limited · 3/10

inferred from anti-inflammatory action

Evidence: 3
Label: Skin irritation

Safety, Cautions & Contraindications

Safety note[1]Caution

Contraindicated in pregnancy and breastfeeding: berberine crosses the placenta and into milk and can cause or worsen newborn jaundice (risk of kernicterus); do not give to infants.

Safety note[1, 14]Caution

Berberine strongly inhibits drug-metabolising enzymes (especially CYP3A4 and CYP2D6), so it can raise the blood levels of many medicines - a significant herb-drug-interaction risk. In a screen of commercial herbal products, goldenseal was among the most potent CYP2D6 inhibitors and also inhibited CYP3A4. High doses have shown possible liver, nerve and photo-toxicity.

Safety note[12, 13, 14, 15, 16, 17, 18]Info

Flaxseeds are safe for most people at recommended food amounts (1–2 tablespoons ground/day). They must be ground or milled to be bioavailable — whole seeds largely pass through the gut undigested. High fibre content may cause bloating, flatulence, and loose stools, especially if fibre intake is increased rapidly without adequate hydration. Flaxseeds contain cyanogenic glycosides (linamarin, linustatin); cooking or roasting reduces these to negligible levels in normal food amounts. Raw seeds in very large quantities are a theoretical concern, but typical use is safe (EFSA, 2017).

Safety note[12, 13, 14, 15, 16, 17, 18]Caution

Medication interactions: Flaxseed may reduce absorption of oral medications if taken simultaneously — space flaxseed supplementation 1–2 hours from medications. Omega-3 ALA and lignans may mildly enhance anticoagulant/antiplatelet effects; use caution with blood thinners. Some sources suggest caution with hormone-sensitive conditions due to phytoestrogen (lignan) content, though dietary amounts are unlikely to pose risk (Adolphe et al., 2010).

Safety note[12, 13, 14, 15, 16, 17, 18]Caution

Pregnancy: Food amounts are generally considered safe; high-dose supplements should be discussed with a clinician due to limited safety data.

Safety note[12, 13, 14, 15, 16, 17, 18, 20]Info

Duke (2002) rates flaxseed as +++ with clinical evidence (score 2) for antiatherogenic, hypocholesterolemic, laxative, lipolytic (fat-dissolving), and demulcent activities. Flaxseed's omega-3 fatty acids (ALA) and lignans are associated with reduced cardiovascular risk. Commission E approves flaxseed as a laxative and for mucilaginous protection of inflamed gastrointestinal mucosa. Dose: 1–2 tablespoons ground seed with ample water, twice daily. Whole seeds should be chewed or ground for full medicinal effect. Cyanogenic glycosides are present but at safe levels in normal dietary amounts (Duke, 2002).

External Ids

Gbif: 3033110
Wikidata: Q1051710
Gbif: 2873861
Wikidata: Q45108

Botanical Description

Low, woodland perennial herb rising from a knotted, bright yellow rhizome with wiry yellow roots. Each stem bears two ragged, palmately lobed, maple-like leaves and a single small, inconspicuous greenish-white flower, followed by a raspberry-like cluster of red berries.[1]

Height: 15-30 cm
Habit: Low, woodland perennial herb
Leaves: Two per stem, ragged, palmately lobed, maple-like
Flowers: Single, small, inconspicuous, greenish-white, petal-less
Stem: Hairy, upright, bearing two leaves
Root: Knotted, bright yellow rhizome with wiry yellow roots (the medicinal part)
Fruit: Raspberry-like cluster of red berries
Flowering Period: April-May

Erect annual herb, slender and often branched near the top, growing 30-80 (up to 100) cm tall from a fine taproot. Leaves are alternate, sessile, narrowly lanceolate to linear, blue-green and entire-margined. Flowers are pale blue (occasionally white or pink), five-petalled and borne on slender stalks in loose terminal cymes. The fruit is a small globular capsule ('boll') that splits into ten compartments, each containing one flattened, glossy, red-brown seed.[5]

Height: 30-80 (up to 100) cm
Habit: Erect, slender annual herb
Leaves: Alternate, sessile, narrowly lanceolate to linear, blue-green, entire
Flowers: Pale blue (occasionally white or pink), five-petalled, in loose terminal cymes
Stem: Slender, erect, often branched above
Root: Fine taproot
Fruit: Globular capsule ('boll') splitting into ten compartments, each with one flattened glossy red-brown seed
Flowering Period: June-August

Habitat

Grows in rich, shaded deciduous woodland with humus-rich soil; native to eastern North America, now scarce in the wild due to overharvesting and largely supplied by cultivation.[1]

Native to the Mediterranean region and the Fertile Crescent, cultivated since prehistory for fibre and oil and now grown worldwide in temperate regions with well-drained, fertile soils and a cool, moist growing season; occasionally found as a naturalised escape on waste and cultivated ground.[5]

Harvesting

The rhizome and root are dug in autumn from plants at least three to four years old, when berberine content is highest, then cleaned and dried; because wild populations are depleted, cultivated or sustainably sourced material is strongly preferred, and careful identification against the toxic mayapple and bloodroot, which share its woodland habitat, is essential before any wild-harvesting.[1]

Parts: Rhizome and root
Season: Autumn, from mature (3-4+ year) plants

Grown as an annual crop, seed is harvested once the capsules ('bolls') have dried and turned brown, typically in late summer, by cutting or combining the whole plant and threshing out the seed. Whole seed stores well; it should only be ground shortly before use, since the oil in ground seed oxidises and turns rancid quickly.[2]

Parts: Seed
Season: Late summer, once bolls have dried

Traditional Uses

Goldenseal root has a Native American and, after adoption by Eclectic physicians, wider North American tradition as a bitter tonic and antimicrobial remedy for mucous-membrane infections, sore throat, digestive upset and topical skin infections, directly reflecting its high berberine content.[1]

Flaxseed has a long history of traditional use as a bulk-forming laxative and demulcent for constipation and irritated gut mucosa, and as a poultice for boils and inflamed skin. Modern interest centres on its lignan (secoisolariciresinol diglucoside) and alpha-linolenic acid content, studied for cardiovascular, metabolic and hormone-related outcomes.[2, 4, 5]

Preparations

Decoction[1]

Dried rhizome and root simmered in water as a traditional bitter antimicrobial tea, or used as a gargle for sore throat.

Tincture[13]

Tincture 1:10 in 60% ethanol of the dried rhizome and root, 2-4 ml three times daily per the WHO monograph Rhizoma Hydrastis. Educational reference only, not a prescription.

Standardised extract[4]

Extract standardised to berberine/hydrastine content, taken as capsules; whole-leaf extracts have shown stronger antimicrobial activity than isolated berberine in some studies.

Ground seed ('flax meal')[2]

Whole seed freshly ground (milled) and taken with plenty of liquid, or stirred into food; grinding is needed to make the oil and lignans bioavailable, as whole seeds largely pass through the gut undigested.

Flaxseed oil[5]

Cold-pressed oil taken as a concentrated source of alpha-linolenic acid (omega-3); lacks the fibre and lignan content of the whole ground seed.

Dosage

Decoction/tincture[13]

The WHO monograph on Rhizoma Hydrastis gives a daily dose of 0.5-1.0 g of the dried rhizome and root three times, or taken as a decoction; a 1:1 liquid extract in 60% ethanol at 0.3-1.0 mL three times; or a 1:10 tincture in 60% ethanol at 2-4 mL three times. For short-term use only, given goldenseal's potent CYP-enzyme inhibition and its contraindication in pregnancy. Educational reference only, not a prescription.

Ground seed[12, 13, 14, 15, 16, 17, 18]

Traditional guidance and Duke (2002) suggest 1-2 tablespoons of ground seed with ample water, once or twice daily. Educational reference only, not a prescription.

Flaxseed oil[19]

A randomised placebo-controlled trial titrated flax oil capsules (550 mg alpha-linolenic acid per 1 g of oil) to 12 capsules per day, i.e. up to roughly 12 g of oil daily, over 16 weeks - broadly matching the 1-2 tablespoons (about 10-15 mL) daily often cited for omega-3 intake. That trial was in children and adolescents with bipolar disorder and its primary outcomes were null; it is cited here only as a source for an administered human dose of the oil, not as evidence of benefit. Note the EU herbal monograph on Lini semen covers the SEED, not the oil. Educational reference only, not a prescription.

References

REF-0455, REF-1849, REF-1850, REF-0588, REF-1851, REF-1852, REF-1853, REF-1854, REF-1855, REF-1856, REF-1857
REF-2216, REF-2217, REF-2218, REF-2219, REF-2220, REF-2221, REF-2222, REF-2223, REF-2224, REF-2225, REF-0288

Drug Class Interactions

Safety note[15, 16]Caution
Drug Class: cyp3a4-substrates
Mechanism: Goldenseal's berberine and hydrastine strongly inhibit CYP3A4 (and also CYP2D6), enzymes that clear many medicines. In a controlled study in healthy volunteers, 28 days of goldenseal cut CYP3A4/5 and CYP2D6 activity by roughly 40%, so it can raise the blood levels and side effects of drugs handled by these pathways - for example some statins, calcium-channel blockers and sedatives (CYP3A4), and certain antidepressants, beta-blockers and opioids (CYP2D6). Separate dosing and monitor, or avoid combining with narrow-margin medicines.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03
Safety note[17]Caution
Drug Class: antidiabetics
Mechanism: Goldenseal is rich in berberine, its main alkaloid, which lowers blood glucose - meta-analyses of randomised trials show berberine significantly reduces fasting glucose and HbA1c. Taken with diabetes medicines, goldenseal may therefore add to blood-sugar lowering, so monitor blood glucose.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-03

Not documented

Lookalikes Review

Outcome: has-lookalikes
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07
Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

Dangerous Lookalikes

Safety note[18, 19]Dangerous
Dangerous Plant: podophyllum-peltatum
Confused Part: Woodland rhizome dug as goldenseal; mayapple shares the same rich woods and has similar lobed, maple-like leaves.
Confusion Context: Goldenseal (Hydrastis canadensis) is dug from rich woodland for its yellow rhizome. Mayapple (Podophyllum peltatum) grows in the same rich-woods habitat and, once its leaves expand, its lobed maple-like leaves resemble goldenseal, so novice foragers confuse them. Mayapple contains podophyllotoxin (a potent cell poison) in all parts except the ripe fruit; ingestion causes severe vomiting and diarrhoea and can cause serious systemic toxicity. Because the plants share habitat and leaf shape, this is a genuine hazard when digging goldenseal.
Distinguishing Features: Whole plant: goldenseal has a hairy upright stem bearing usually two ragged, maple-like lobed leaves and a single small flower, with a knotted BRIGHT-YELLOW rhizome. Mayapple has one or two large, smooth, umbrella-like lobed leaves on a hairless stalk and a white flower nodding beneath, with a white-ish creeping rhizome., Rhizome colour (decisive): goldenseal's rhizome and root are vivid yellow inside (berberine). Mayapple's rhizome is not bright yellow., Leaf texture: goldenseal leaves are hairy and puckered; mayapple leaves are large, smooth and shield-like (the stalk joins near the centre).
Key Test: Dig only after matching the whole plant, and check the rhizome. A hairy stem with ragged maple-like leaves over a BRIGHT-YELLOW knotted rhizome = goldenseal. Large smooth umbrella-like leaves over a pale rhizome (no yellow) = mayapple - toxic, do not use. If the root is not bright yellow inside, do not use it.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07
Safety note[18, 20]Dangerous
Dangerous Plant: sanguinaria-canadensis
Confused Part: Woodland rhizome dug as goldenseal; bloodroot grows in the same rich woods and its rhizome is gathered in mistake for goldenseal.
Confusion Context: Bloodroot (Sanguinaria canadensis) shares the same rich-woods spring habitat as goldenseal and is listed among goldenseal's harvesting look-alikes. Bloodroot is a high-severity poison: its rhizome contains isoquinoline alkaloids (sanguinarine) and, when broken, oozes a bright red-orange sap; ingestion causes vomiting, faintness, dizziness, dilated pupils and, in serious cases, heart failure, and the sap is destructive to tissue. Because both are dug for their rhizomes from the same woodland, this is a genuine hazard.
Distinguishing Features: Sap colour (decisive): a broken bloodroot rhizome bleeds a bright RED-ORANGE sap. Goldenseal's rhizome is BRIGHT YELLOW inside, not red., Leaf: bloodroot has a single, rounded, deeply scalloped/lobed grey-green leaf that wraps the flower stalk, and a white flower; goldenseal has a hairy stem with two ragged maple-like leaves., Whole plant: confirm goldenseal by its paired hairy maple-like leaves and yellow root before digging.
Key Test: Break the rhizome and look at the sap and leaves. Bright YELLOW root with paired hairy maple-like leaves = goldenseal. A single scalloped leaf and a rhizome bleeding RED-ORANGE sap = bloodroot - a high-severity poison, do not use. If the sap is red, it is not goldenseal.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

Not documented

References & Sources

  1. Mandal, S.K., Maji, A.K., Mishra, S.K., Ishfaq, P.M., Devkota, H.P., Silva, A.S. and Das, N (2020) 'Goldenseal (Hydrastis canadensis L.) and its active constituents: A critical review of their efficacy and toxicological issues', Pharmacological Research. doi:10.1016/j.phrs.2020.105085 Randomized trial
    https://doi.org/10.1016/j.phrs.2020.105085
  2. Corn, J., Tibbitts, D., Ito, H., Schafer, M. and Vasilevsky, N (2021) 'Effects of Hydrastis Canadensis, Commiphora Habessinica, Phytolacca Americana, and Echinacea Purpurea on Bacterial Growth', Alternative Therapies in Health and Medicine, 27(4), pp. 24-27. Preclinical
    https://scholar.google.com/scholar?q=Effects%20of%20Hydrastis%20Canadensis%2C%20Commiphora%20Habessinica%2C%20Phytolacca%20Americana%2C%20and%20Echinacea%20Purpurea%20on%20Bacterial%20Growth
  3. Ettefagh, K.A., Burns, J.T., Junio, H.A., Kaatz, G.W. and Cech, N.B (2010) 'Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition', Planta Medica, 77(8), pp. 835-840. doi:10.1055/s-0030-1250606 Preclinical
    https://doi.org/10.1055/s-0030-1250606
  4. Cech, N.B., Junio, H.A., Ackermann, L.W., Kavanaugh, J.S. and Horswill, A.R (2012) 'Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA)', Planta Medica, 78(14), pp. 1556--1561. doi:10.1055/s-0032-1315042 Traditional / reference
    https://doi.org/10.1055/s-0032-1315042
  5. Mahady, G.B., Pendland, S.L., Stoia, A. and Chadwick, L.R (2003) 'In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis', Phytotherapy Research, 17(3), pp. 217-221. doi:10.1002/ptr.1108 Preclinical
    https://doi.org/10.1002/ptr.1108
  6. Junio, H.A., Sy-Cordero, A.A., Ettefagh, K.A., Burns, J.T., Micko, K.T., Graf, T.N., Richter, S.J., Cannon, R.E., Oberlies, N.H. and Cech, N.B (2011) 'Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis)', Journal of Natural Products, 74(7), pp. 1621-1629. doi:10.1021/np200336g Preclinical
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  7. Britton, E.R., Kellogg, J.J., Kvalheim, O.M. and Cech, N.B (2017) 'Biochemometrics to Identify Synergists and Additives from Botanical Medicines: A Case Study with Hydrastis canadensis (Goldenseal)', Journal of Natural Products, 81(3), pp. 484-493. doi:10.1021/acs.jnatprod.7b00654 Preclinical
    https://doi.org/10.1021/acs.jnatprod.7b00654
  8. Leyte-Lugo, M., Britton, E.R., Foil, D.H., Brown, A.R., Todd, D.A., Rivera-Chavez, J., Oberlies, N.H. and Cech, N.B (2017) 'Secondary Metabolites from the Leaves of the Medicinal Plant Goldenseal (Hydrastis canadensis)', Phytochemistry Letters, 20, pp. 54-60. doi:10.1016/j.phytol.2017.03.012 Preclinical
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  9. Gurley, B.J., Swain, A., Hubbard, M.A., Hartsfield, F., Thaden, J., Williams, D.K., Gentry, W.B. and Tong, Y (2007) 'Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo', Clinical Pharmacology and Therapeutics, 83(1), pp. 61-69. doi:10.1038/sj.clpt.6100222 Randomized trial
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  10. Wallace, E.D., Oberlies, N.H., Cech, N.B. and Kellogg, J.J (2018) 'Detection of adulteration in Hydrastis canadensis (goldenseal) dietary supplements via untargeted mass spectrometry-based metabolomics', Food and Chemical Toxicology, 120, pp. 439-447. doi:10.1016/j.fct.2018.07.033 Preclinical
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  11. Douglas, J.A., Follett, J.M., Parmenter, G.A., Sansom, C.E., Perry, N.B. and Littler, R.A (2010) 'Seasonal variation of biomass and bioactive alkaloid content of goldenseal, Hydrastis canadensis', Fitoterapia, 81(7), pp. 925-928. doi:10.1016/j.fitote.2010.06.006 Preclinical
    https://doi.org/10.1016/j.fitote.2010.06.006
  12. Singh, S., Pathak, N., Fatima, E. and Negi, A.S (2021) 'Plant isoquinoline alkaloids: Advances in the chemistry and biology of berberine', European Journal of Medicinal Chemistry. doi:10.1016/j.ejmech.2021.113839 Preclinical
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  13. World Health Organization (2007) 'Rhizoma Hydrastis'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
    https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37
  14. Sevior, D.K., Hokkanen, J., Tolonen, A., Abass, K., Tursas, L., Pelkonen, O. and Ahokas, J.T (2010) 'Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail', Xenobiotica, 40(4), pp. 245--254. doi:10.3109/00498251003592683 Preclinical
    https://doi.org/10.3109/00498251003592683
  15. Gurley, B.J., Gardner, S.F., Hubbard, M.A., Williams, D.K., Gentry, W.B., Khan, I.A. and Shah, A (2005) 'In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes', Clinical Pharmacology and Therapeutics, 77(5), pp. 415-426. doi:10.1016/j.clpt.2005.01.009 Randomized trial
    https://doi.org/10.1016/j.clpt.2005.01.009
  16. McDonald, M.G., Tian, D.D., Thummel, K.E., Paine, M.F. and Rettie, A.E (2020) 'Modulation of major human liver microsomal cytochromes P450 by component alkaloids of goldenseal: time-dependent inhibition and allosteric effects', Drug Metabolism and Disposition, 48(10), pp. 1018-1027. doi:10.1124/dmd.120.091041 Preclinical
    https://doi.org/10.1124/dmd.120.091041
  17. Guo, J., Chen, H., Zhang, X., Lou, W., Zhang, P., Qiu, Y., Zhang, C., Wang, Y. and Liu, W.J (2021) 'The effect of berberine on metabolic profiles in type 2 diabetic patients: a systematic review and meta-analysis of randomized controlled trials', Oxidative Medicine and Cellular Longevity, 2021, pp. 2074610. doi:10.1155/2021/2074610 Meta-analysis / review
    https://doi.org/10.1155/2021/2074610
  18. Forest Farming (Cooperative Extension) 'Goldenseal (Hydrastis canadensis L.)'. Available at: https://forest-farming.extension.org/goldenseal-hydrastis-canadensis-l/ Traditional / reference
    https://forest-farming.extension.org/goldenseal-hydrastis-canadensis-l/
  19. Frasca, T. and Brett, A.S. and Yoo, S.D (1997) 'Mandrake toxicity. A case of mistaken identity', Archives of Internal Medicine, 157(17), pp. 2007-9. doi:10.1001/archinte.157.17.2007 Clinical study
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  20. North Carolina Extension Gardener Plant Toolbox 'Sanguinaria canadensis (Bloodroot)'. Available at: https://plants.ces.ncsu.edu/plants/sanguinaria-canadensis/ Traditional / reference
    https://plants.ces.ncsu.edu/plants/sanguinaria-canadensis/
  1. Picur, B., Cebrat, M., Zabrocki, J. and Siemion, I.Z (2006) 'Cyclopeptides of Linum usitatissimum', Journal of Peptide Science, 12(9), pp. 569-574. doi:10.1002/psc.779 Preclinical
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  2. Basch, E., Bent, S., Collins, J., Dacey, C., Hammerness, P., Harrison, M., Smith, M., Szapary, P., Ulbricht, C., Vora, M. and Weissner, W (2007) 'Flax and flaxseed oil (Linum usitatissimum): a review by the Natural Standard Research Collaboration', Journal of the Society for Integrative Oncology, 5(3), pp. 92-105. doi:10.2310/7200.2007.005 Meta-analysis / review
    https://doi.org/10.2310/7200.2007.005
  3. Chhillar, H., Chopra, P. and Ashfaq, M.A (2020) 'Lignans from linseed (Linum usitatissimum L.) and its allied species: retrospect, introspect and prospect', Critical Reviews in Food Science and Nutrition, 61(16), pp. 2719-2741. doi:10.1080/10408398.2020.1784840 Meta-analysis / review
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  4. Ansari, R., Zarshenas, M.M. and Dadbakhsh, A.H (2019) 'A review on pharmacological and clinical aspects of Linum usitatissimum L', Current Drug Discovery Technologies, 16(2), pp. 148-158. doi:10.2174/1570163815666180521101136 Meta-analysis / review
    https://doi.org/10.2174/1570163815666180521101136
  5. Akter, Y., Junaid, M., Afrose, S.S., Nahrin, A., Alam, M.S., Sharmin, T., Akter, R. and Hosen, S.M.Z (2021) 'A comprehensive review on Linum usitatissimum medicinal plant: its phytochemistry, pharmacology, and ethnomedicinal uses', Mini Reviews in Medicinal Chemistry, 21(18), pp. 2801-2834. doi:10.2174/1389557521666210203153436 Meta-analysis / review
    https://doi.org/10.2174/1389557521666210203153436
  6. Musazadeh, V., Abolghasemian, M., Kavyani, Z., Moridpour, A.H., Nazari, A. and Faghfouri, A.H (2024) 'The effects of flaxseed (Linum usitatissimum) supplementation on anthropometric indices: an updated systematic review and meta-analysis of randomized clinical trials', Complementary Therapies in Medicine, 84, pp. 103066. doi:10.1016/j.ctim.2024.103066 Meta-analysis / review
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  7. Mueed, A., Shibli, S., Jahangir, M., Jabbar, S. and Deng, Z (2022) 'A comprehensive review of flaxseed (Linum usitatissimum L.): health-affecting compounds, mechanism of toxicity, detoxification, anticancer and potential risk', Critical Reviews in Food Science and Nutrition, 63(32), pp. 11081-11104. doi:10.1080/10408398.2022.2092718 Meta-analysis / review
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  8. Kaithwas, G., Mukherjee, A., Chaurasia, A.K. and Majumdar, D.K (2011) 'Anti-inflammatory, analgesic and antipyretic activities of Linum usitatissimum L. (flaxseed/linseed) fixed oil', Indian Journal of Experimental Biology, 49(12), pp. 932-938. Preclinical
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  9. Rafieian-Kopaei, M., Shakiba, A., Sedighi, M. and Bahmani, M (2017) 'The analgesic and anti-inflammatory activity of Linum usitatissimum in Balb/c mice', Journal of Evidence-Based Complementary & Alternative Medicine, 22(4), pp. 892-896. doi:10.1177/2156587217717416 Preclinical
    https://doi.org/10.1177/2156587217717416
  10. Sirotkin, A.V (2023) 'Influence of flaxseed (Linum usitatissimum) on female reproduction', Planta Medica, 89(6), pp. 608-615. doi:10.1055/a-2013-2966 Meta-analysis / review
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  11. Thompson, L.U., Chen, J.M., Li, T., Strasser-Weippl, K. and Goss, P.E (2006) 'Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer', 11(10), pp. 3828--3835. doi:10.1158/1078-0432.CCR-04-2326 Randomized trial
    https://doi.org/10.1158/1078-0432.CCR-04-2326
  12. Adolphe, J.L., Whiting, S.J., Juurlink, B.H.J., Thorpe, L.U. and Alcorn, J (2010) 'Health effects with consumption of the flax lignan secoisolariciresinol diglucoside', 103(7), pp. 929--938. doi:10.1017/S0007114509992753 Clinical study
    https://doi.org/10.1017/S0007114509992753
  13. Caligiuri, S.P.B., Edel, A.L., Aliani, M. and Pierce, G.N (2014) 'Flaxseed for hypertension: implications for improved cardiovascular risk', 16(12), pp. 499. doi:10.1007/s11906-014-0499-8 Randomized trial
    https://doi.org/10.1007/s11906-014-0499-8
  14. European Food Safety Authority (2017) 'Safety of cyanogenic glycosides from flaxseed consumed as part of a usual diet', 15(11). doi:10.2903/j.efsa.2017.5026 Preclinical
    https://doi.org/10.2903/j.efsa.2017.5026
  15. Harris, W.S (2012) 'Stearidonic acid as a surrogate for eicosapentaenoic acid in cardiovascular risk reduction: update and recommendation', 70(10), pp. 565--574. Traditional / reference
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  16. Latvijas valsts mežzinātnes institūts (n.d.) 'Linsēkla Latvijā'. Available at: https://www.silava.lv Traditional / reference
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  17. Pan, A., Sun, J., Chen, Y. et al (2009) 'Effects of a flaxseed-derived lignan supplement in type 2 diabetic patients: a randomized, double-blind, cross-over trial', 4(11). doi:10.1371/journal.pone.0007654 Randomized trial
    https://doi.org/10.1371/journal.pone.0007654
  18. Royal Botanic Gardens, Kew (n.d.) 'Linum usitatissimum L'. Available at: https://powo.science.kew.org/taxon/urn:lsid:http://ipni.org:names:381313-1 Traditional / reference
    https://powo.science.kew.org/taxon/urn:lsid:http://ipni.org:names:381313-1
  19. Gracious, B.L., Chirieac, M.C., Costescu, S., Finucane, T.L., Youngstrom, E.A. and Hibbeln, J.R (2010) 'Randomized, placebo-controlled trial of flax oil in pediatric bipolar disorder', Bipolar Disorders, 12(2), pp. 142-154. doi:10.1111/j.1399-5618.2010.00799.x Randomized trial
    https://doi.org/10.1111/j.1399-5618.2010.00799.x
  20. Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
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Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.