Plant Comparison

Witch Hazel vs Turkey tail

A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.

First plant
Second plant
Show:
Plant AWitch HazelHamamelis virginianaHamamelidaceaeFull monograph →
Plant BTurkey tailTrametes versicolorPolyporaceaeFull monograph →

At a glance

Witch Hazel and Turkey tail: they share 5 indicated uses (arthritis / joint pain, cancer (anticancer research), inflammation (general), …); 3 pharmacological actions in common.

Witch HazelTurkey tail
Constituents23
Pharmacological actions56
Indicated uses98
Safety notes22
Cited sources1617
Indicated uses
Only Witch Hazel
BruisingDiarrhoeaHaemorrhoidsOral & throat health
Shared (5)
Arthritis / joint painCancer (anticancer research)Inflammation (general)Skin irritationWounds
Only Turkey tail
Cold & fluImmune supportInfection (general)
Pharmacological actions
Only Witch Hazel
AstringentVulnerary (wound healing)
Shared (3)
Anti-inflammatoryAnticancer (preclinical)Antioxidant
Only Turkey tail
AntimicrobialAntiviralImmunomodulator / immune support

Evidence face-off — shared uses

ConditionWitch HazelTurkey tailVerdict
Arthritis / joint pain5/105/10Comparable evidence
Cancer (anticancer research)2/109/10Stronger for Turkey tail
Inflammation (general)5/105/10Comparable evidence
Skin irritation5/105/10Comparable evidence
Wounds1/105/10Stronger for Turkey tail

Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.

Key Constituents

Tannins (4-10%, including hamamelitannin and gallotannins)[14, 15]

The principal astringent and anti-inflammatory constituents.

Tannins
Flavonoids, catechins, proanthocyanidins and phenolic acids[15]

Antioxidant and anti-inflammatory constituents of the bark and leaf.

ProanthocyanidinsPhenolic acidsFlavonoidsCatechins
Beta-glucan polysaccharides[11, 12]

The principal immunomodulating constituents, forming the basis of PSK/PSP extracts.

Polysaccharides
Polysaccharopeptide (PSK/PSP, protein-bound polysaccharide)[12]

Protein-bound polysaccharide complex studied extensively as an adjunct immunotherapy.

Polysaccharides
Phenolic compounds and triterpenes[13]

Minor antioxidant constituents.

Phenolic compoundsTerpenes / terpenoids

Pharmacological Actions

Anti-inflammatory[2, 4, 5, 6, 14, 15, 16]

Anti-inflammatory and antioxidant (supports irritated/atopic skin); Relief of haemorrhoid symptoms (astringent and anti-inflammatory)

Anticancer (preclinical)[11]
Antioxidant[2, 15]

Anti-inflammatory and antioxidant (supports irritated/atopic skin)

Astringent[6, 8, 9, 14, 15, 16]

Astringent for skin irritation and minor inflammation of the skin and oral mucosa (tannins), applied topically; Relief of haemorrhoid symptoms (astringent and anti-inflammatory)

Vulnerary (wound healing)[7, 14, 16]

Vulnerary for minor wounds, bruises and insect bites

Anti-inflammatory[11, 12, 13]
Anticancer (preclinical)[1, 2, 3, 4, 5, 6, 9, 10, 11, 12, 13]
Antimicrobial[11, 12, 13]
Antioxidant[8, 9, 10, 11, 12, 13]
Antiviral[11, 12, 13]
Immunomodulator / immune support[1, 2, 3, 4, 5, 6, 7, 9, 11, 12, 13]

Traditional & Indicated Uses

Arthritis / joint pain[14, 15, 16]Moderate · 5/10

inferred from anti-inflammatory action

Evidence: 5
Label: Arthritis / joint pain
Bruising[14, 16]Traditional · 1/10

Vulnerary for minor wounds, bruises and insect bites

Evidence: 1
Label: Bruising
Cancer (anticancer research)[11]Traditional · 2/10

inferred from anticancer action

Evidence: 2
Label: Cancer (anticancer research)
Diarrhoea[14, 15, 16]Moderate · 5/10

inferred from astringent action

Evidence: 5
Label: Diarrhoea
Haemorrhoids[14, 16]Traditional · 1/10

Relief of haemorrhoid symptoms (astringent and anti-inflammatory)

Evidence: 1
Label: Haemorrhoids
Inflammation (general)[14, 15]Moderate · 5/10

Astringent for skin irritation and minor inflammation of the skin and oral mucosa (tannins), applied topically

Evidence: 5
Label: Inflammation (general)
Oral & throat health[14, 15]Moderate · 5/10

Astringent for skin irritation and minor inflammation of the skin and oral mucosa (tannins), applied topically

Evidence: 5
Label: Oral & throat health
Skin irritation[14, 15]Moderate · 5/10

Astringent for skin irritation and minor inflammation of the skin and oral mucosa (tannins), applied topically

Evidence: 5
Label: Skin irritation
Wounds[14, 16]Traditional · 1/10

Vulnerary for minor wounds, bruises and insect bites

Evidence: 1
Label: Wounds
Arthritis / joint pain[11, 12, 13]Moderate · 5/10

inferred from anti-inflammatory action

Evidence: 5
Label: Arthritis / joint pain
Cancer (anticancer research)[1, 2, 3, 4, 6, 12]Strong · 9/10

inferred from anticancer action

Evidence: 9
Label: Cancer (anticancer research)
Cold & flu[11, 12, 13]Moderate · 5/10

inferred from antiviral action

Evidence: 5
Label: Cold & flu
Immune support[11, 12, 13]Moderate · 5/10
Evidence: 5
Label: Immune support
Infection (general)[11, 12, 13]Moderate · 5/10

inferred from antimicrobial action

Evidence: 5
Label: Infection (general)
Inflammation (general)[11, 12, 13]Moderate · 5/10

inferred from anti-inflammatory action

Evidence: 5
Label: Inflammation (general)
Skin irritation[11, 12, 13]Moderate · 5/10

inferred from anti-inflammatory action

Evidence: 5
Label: Skin irritation
Wounds[11, 12, 13]Moderate · 5/10

inferred from antimicrobial action

Evidence: 5
Label: Wounds

Safety, Cautions & Contraindications

Safety note[16]Caution

For topical use. Do not apply to deep wounds, serious burns or severe rectal bleeding - these need medical care.

Safety note[15, 16]Caution

Oral use is not recommended in pregnancy or breastfeeding without professional guidance, and swallowing tannin-rich preparations can upset the stomach. Mild skin irritation or contact allergy is possible.

Safety note[11, 12, 13]Caution

Generally very safe and well tolerated. Rare cases of digestive upset or allergic reaction. No significant known drug interactions at normal doses. The PSK pharmaceutical form is used safely alongside standard cancer treatments. Suitable for most adults.

Safety note[11, 12, 13, 14]Info

Duke (2002) does not include a dedicated entry for Turkey tail mushroom (Trametes versicolor) in the Handbook of Medicinal Herbs, Second Edition.

External Ids

Gbif: 3152827
Powo: urn:lsid:ipni.org:names:430697-1
Wikidata: Q913129
Gbif: 2548311
Wikidata: Q753833

Botanical Description

Large, multi-stemmed deciduous shrub or small tree with broad, oval, wavy-toothed leaves, asymmetrical at the base. Unusually, it flowers in late autumn to winter after the leaves have fallen, bearing clusters of small, spidery, bright yellow flowers with narrow, crinkled, ribbon-like petals. The woody seed capsule matures the following autumn and explosively ejects its seeds ('snapping hazelnut').[14]

Height: 3-8 m
Habit: Large, multi-stemmed deciduous shrub or small tree
Leaves: Broad, oval, wavy-toothed, asymmetrical at the base
Flowers: Small, spidery, bright yellow, with narrow crinkled ribbon-like petals, blooming in late autumn/winter
Stem: Multiple woody stems with smooth, grey-brown bark
Root: Woody root system
Fruit: Woody capsule maturing the following autumn, explosively ejecting seeds
Flowering Period: October-December (after leaf-fall)

Bracket fungus (not a true plant) forming thin, tough, fan-shaped, overlapping shelves on dead or decaying hardwood, with a velvety, concentrically zoned upper surface in bands of brown, tan, cream, blue-grey and rust, and a white, minutely pored underside.

Height: Individual brackets 2-8 cm across, forming overlapping clusters
Habit: Bracket (shelf) fungus growing directly from dead wood, in tiered, overlapping clusters
Leaves: Not applicable (fungus); the fruiting body is a thin, tough bracket
Flowers: Not applicable (fungus); reproduces via spores released from pores on the underside
Stem: No true stem; the bracket attaches directly to the wood
Root: Not applicable; mycelium threads through the wood substrate
Fruit: Fan-shaped fruiting body (bracket) with a white, densely pored underside
Flowering Period: Fruiting bodies present year-round, most abundant in autumn

Habitat

Native to woodland understorey and forest margins of eastern North America; widely cultivated as an ornamental and medicinal shrub.[14]

Grows on dead, dying or fallen hardwood logs, stumps and branches in woodlands worldwide, including Europe, Asia and North America.

Harvesting

Bark is stripped from branches (not the main trunk, to avoid harming the plant) and leaves are picked in summer; both are dried for use, or steam-distilled together with twigs to produce distilled witch-hazel water, the most common commercial form.[14]

Parts: Bark, leaf and distilled witch-hazel water
Season: Bark and leaf in summer

Fresh brackets are harvested by cutting from the wood; for medicinal use the tough fruiting body is typically dried and then decocted (simmered) for a long time, or extracted, since the beneficial polysaccharides are not well-extracted by simple infusion.

Parts: Mycelium, Whole Plant
Season: Year-round, most abundant in autumn

Traditional Uses

Witch hazel has a long Native American and, after adoption by European settlers, worldwide reputation as a topical astringent and anti-inflammatory remedy for skin irritation, minor wounds, bruises, insect bites and haemorrhoids, and as a soothing wash for irritated skin and mucous membranes.[14]

Turkey tail has a long history of use in traditional Chinese medicine (as yun zhi) and is one of the most researched medicinal mushrooms, with standardized polysaccharide-K (PSK) and polysaccharopeptide (PSP) extracts used clinically in Japan and China alongside conventional cancer treatment to support immune function.[11, 12, 13]

Preparations

Distilled witch-hazel water[14]

Steam-distilled preparation of the bark and twigs, applied topically as a soothing, astringent skin toner and wound wash; the most widely used commercial form.

Decoction (bark/leaf)[14]

Dried bark or leaf simmered in water and used as a cooled topical wash or compress.

Long decoction[11]

Dried fruiting body simmered in water for an extended period (often 1-2 hours) to extract the beta-glucan polysaccharides, then strained.

Standardized extract (PSK/PSP)[12]

Standardized polysaccharide-K (PSK) or polysaccharopeptide (PSP) extract, the pharmaceutical-grade forms used in clinical research.

Dosage

Topical preparations[14]

The EU herbal monograph on Hamamelis virginiana L., cortex gives, for cutaneous use, tincture at a strength corresponding to 5-10% in semi-solid preparations several times daily, or a dry extract (5-7.7:1, ethanol 30% m/m) at a strength corresponding to 1.3% as an ointment several times daily; for anorectal use, a decoction of 5-10 g per 250 mL up to 3 times daily as impregnated dressings. For topical use only. Educational reference only, not a prescription.

Standardized extract[12]

Clinical research on PSK commonly uses around 3 g daily in divided doses. Educational reference only, not a prescription.

References

REF-0830, REF-0831, REF-0832, REF-2049, REF-2050, REF-2051, REF-2052, REF-2053, REF-2054, REF-2055, REF-2056, REF-2057, REF-2058
REF-1582, REF-1583, REF-1584, REF-1585, REF-1586, REF-1587, REF-1588, REF-1589, REF-1590, REF-1591

Lookalikes Review

Outcome: none-known
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07
Outcome: has-lookalikes
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

Dangerous Lookalikes

Not documented

Safety note[15, 16, 17]Caution
Dangerous Plant: stereum-hirsutum
Confused Part: The whole fan-shaped bracket (the concentrically zoned shelf growing on dead hardwood), especially the top surface, which looks almost identical from above.
Confusion Context: False turkey tail (Stereum hirsutum, and the near-identical Stereum ostrea) is the commonest fungus mistaken for medicinal turkey tail. Seen from above the two are near-identical: overlapping, fan-shaped, concentrically banded, fuzzy-topped brackets on dead wood. Stereum is NOT poisonous - it is simply inedible (too thin and leathery) and there are no documented poisonings. The problem is that it is a crust fungus lacking the medicinal polysaccharides of true turkey tail, so anyone who brews it gets a worthless tea. This record exists to prevent a wasted, ineffective harvest, not to warn of poisoning.
Distinguishing Features: UNDERSIDE (decisive): true turkey tail has a whitish PORE surface underneath, densely covered with tiny pores/tubes (about 2-5 per mm, visible with a hand lens). False turkey tail (Stereum) has a completely SMOOTH, poreless underside - it is a crust fungus, not a polypore., Underside colour: true turkey tail's pore surface is white to off-white. Stereum's smooth underside is typically tan, yellowish, greyish or pale reddish-brown; a coloured, non-white underside is a red flag., Texture: true turkey tail is thin and flexible; Stereum tends to be tougher, more leathery and often wavier at the margin.
Key Test: Turn the bracket over and look at the underside with a hand lens. Genuine turkey tail shows a white surface densely covered in tiny pores (roughly 2-5 per mm). If the underside is SMOOTH and poreless (and often tan/orange/brown rather than white), it is false turkey tail (Stereum) - discard it. Smooth underside = not turkey tail.
Reviewed By: Omnia Sana (owner-authorized)
Reviewed Date: 2026-07-07

References & Sources

  1. Skowrońska, W., Pawłowska, K.A., Obrębski, M., Piwowarski, J.P. et al (2025) 'Chemical composition, skin microbiota metabolism, antimicrobial potential and anti-inflammatory properties of witch hazel bark (Hamamelis virginiana L.)', Journal of Ethnopharmacology, 353(Pt B), pp. 120433. doi:10.1016/j.jep.2025.120433 Preclinical
    https://doi.org/10.1016/j.jep.2025.120433
  2. Piazza, S., Martinelli, G., Vrhovsek, U., Masuero, D. et al (2022) 'Anti-Inflammatory and Anti-Acne Effects of Hamamelis virginiana Bark in Human Keratinocytes', Antioxidants (Basel), 11(6), pp. 1119. doi:10.3390/antiox11061119 Preclinical
    https://doi.org/10.3390/antiox11061119
  3. Janarthanam, V.A., Rajan, P.S.S., Panda, S.P., Panigrahy, U.P. et al (2025) 'Hamamelitannin from Hamamelis virginiana Attenuates Ethanol-Induced Oxidative and Inflammatory Responses in Danio rerio Larvae', Molecular Biotechnology, 68(5), pp. 2369-2385. doi:10.1007/s12033-025-01502-9 Preclinical
    https://doi.org/10.1007/s12033-025-01502-9
  4. Piazza, S., Martinelli, G., Magnavacca, A., Fumagalli, M., Pozzoli, C., Terno, M., Canilli, L., Angarano, M., Maranta, N., Dell'Agli, M. and Sangiovanni, E (2022) 'Unveiling the Ability of Witch Hazel (Hamamelis virginiana L.) Bark Extract to Impair Keratinocyte Inflammatory Cascade Typical of Atopic Eczema', International Journal of Molecular Sciences, 23(16), pp. 9279. doi:10.3390/ijms23169279 Preclinical
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  5. Amendola, I., Viegas, D.J., Freitas, E.T., Oliveira, J.R., Santos, J.G., Oliveira, F.E., Lagareiro Netto, A.A., Marcucci, M.C., Oliveira, L.D. and Back-Brito, G.N (2024) 'Hamamelis virginiana L. extract presents antimicrobial and antibiofilm effects, absence of cytotoxicity, anti-inflammatory action, and potential to fight infections through the nitric oxide production by macrophages', Anais da Academia Brasileira de Ciencias, 96(1), pp. e20200031. doi:10.1590/0001-3765202320200031 Preclinical
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  6. Habtemariam, S (2002) 'Hamamelitannin from Hamamelis virginiana inhibits the tumour necrosis factor-alpha (TNF)-induced endothelial cell death in vitro', Toxicon, 40(1), pp. 83-88. doi:10.1016/s0041-0101(01)00195-7 Preclinical
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  7. Natella, F., Guantario, B., Ambra, R., Ranaldi, G., Intorre, F., Burki, C. and Canali, R (2021) 'Human Metabolites of Hamamelis virginiana (Extract) Modulate Fibroblast Extracellular Matrix Components in Response to UV-A Irradiation', Frontiers in Pharmacology, 12, pp. 747638. doi:10.3389/fphar.2021.747638 Randomized trial
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  8. Dauer, A., Rimpler, H. and Hensel, A (2003) 'Polymeric proanthocyanidins from the bark of Hamamelis virginiana', Planta Medica, 69(1), pp. 89-91. doi:10.1055/s-2003-37022 Preclinical
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  9. Vennat, B., Pourrat, H., Pouget, M.P., Gross, D. and Pourrat, A (1988) 'Tannins from Hamamelis virginiana: identification of proanthocyanidins and hamamelitannin quantification in leaf, bark, and stem extracts', Planta Medica, 54(5), pp. 454-457. doi:10.1055/s-2006-962499 Preclinical
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  10. Duckstein, S.M., Lorenz, P. and Stintzing, F.C (2012) 'Conversion of phenolic constituents in aqueous Hamamelis virginiana leaf extracts during fermentation', Phytochemical Analysis, 23(6), pp. 588-597. doi:10.1002/pca.2359 Preclinical
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  11. Sanchez-Tena, S., Fernandez-Cachon, M.L., Carreras, A., Mateos-Martin, M.L., Costoya, N., Moyer, M.P., Nunez, M.J., Torres, J.L. and Cascante, M (2012) 'Hamamelitannin from witch hazel (Hamamelis virginiana) displays specific cytotoxic activity against colon cancer cells', Journal of Natural Products, 75(1), pp. 26-33. doi:10.1021/np200426k Preclinical
    https://doi.org/10.1021/np200426k
  12. Theisen, L.L., Erdelmeier, C.A.J., Spoden, G.A., Boukhallouk, F., Sausy, A., Florin, L. and Muller, C.P (2014) 'Tannins from Hamamelis virginiana bark extract: characterization and improvement of the antiviral efficacy against influenza A virus and human papillomavirus', PLoS One, 9(1), pp. e88062. doi:10.1371/journal.pone.0088062 Preclinical
    https://doi.org/10.1371/journal.pone.0088062
  13. Cheesman, M.J., Alcorn, S.R., White, A. and Cock, I.E (2023) 'Hamamelis virginiana L. Leaf Extracts Inhibit the Growth of Antibiotic-Resistant Gram-Positive and Gram-Negative Bacteria', Antibiotics, 12(7), pp. 1195. doi:10.3390/antibiotics12071195 Preclinical
    https://doi.org/10.3390/antibiotics12071195
  14. European Medicines Agency (HMPC) (n.d.) 'European Union herbal monograph on Hamamelis virginiana L., cortex/folium/aqua (Hamamelidis cortex)'. Available at: https://www.ema.europa.eu/en/medicines/herbal/hamamelidis-cortex Traditional / reference
    https://www.ema.europa.eu/en/medicines/herbal/hamamelidis-cortex
  15. (2025) 'Hamamelis virginiana L. in Skin Care: A Review of Its Pharmacological Properties and Cosmetological Applications', Molecules. doi:10.3390/molecules30132744 Randomized trial
    https://doi.org/10.3390/molecules30132744
  16. Herbal Reality (n.d.) 'Witch Hazel (Hamamelis virginiana): Benefits, Safety, Uses'. Available at: https://www.herbalreality.com/herb/witch-hazel/ Traditional / reference
    https://www.herbalreality.com/herb/witch-hazel/
  1. Pilkington, K., Wieland, L.S., Teng, L., Jin, X.Y. and others (2022) 'Coriolus (Trametes) versicolor mushroom to reduce adverse effects from chemotherapy or radiotherapy in people with colorectal cancer', Cochrane Database of Systematic Reviews, 11(11), pp. CD012053. doi:10.1002/14651858.CD012053.pub2 Meta-analysis / review
    https://doi.org/10.1002/14651858.CD012053.pub2
  2. Habtemariam, S (2020) 'Trametes versicolor (Synn. Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy', Biomedicines, 8(5), pp. 135. doi:10.3390/biomedicines8050135 Meta-analysis / review
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  3. Fritz, H., Kennedy, D.A., Ishii, M., Fergusson, D. and others (2015) 'Polysaccharide K and Coriolus versicolor extracts for lung cancer: a systematic review', Integrative Cancer Therapies, 14(3), pp. 201-211. doi:10.1177/1534735415572883 Meta-analysis / review
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  7. Jedrzejewski, T., Piotrowski, J., Kowalczewska, M., Wrotek, S. and Kozak, W (2015) 'Polysaccharide peptide from Coriolus versicolor induces interleukin 6-related extension of endotoxin fever in rats', International Journal of Hyperthermia, 31(6), pp. 626-634. doi:10.3109/02656736.2015.1046953 Preclinical
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  8. Scarpari, M., Reverberi, M., Parroni, A., Scala, V. and others (2017) 'Tramesan, a novel polysaccharide from Trametes versicolor. Structural characterization and biological effects', PLoS One, 12(8), pp. e0171412. doi:10.1371/journal.pone.0171412 Preclinical
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  10. Wang, K.F., Sui, K.Y., Guo, C. and Liu, C.Z (2017) 'Quorum sensing molecule-farnesol increased the production and biological activities of extracellular polysaccharide from Trametes versicolor', International Journal of Biological Macromolecules, 104(Pt A), pp. 377-383. doi:10.1016/j.ijbiomac.2017.06.053 Preclinical
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  12. Standish, L.J., Wenner, C.A., Sweet, E.S., Bridge, C., Nelson, A., Martzen, M., Novack, J. and Torkelson, C (2008) 'Trametes versicolor mushroom immune therapy in breast cancer', 6(3), pp. 122--128. Traditional / reference
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  13. Wasser, S.P (2011) 'Current findings, future trends, and unsolved problems in studies of medicinal mushrooms', 89(5), pp. 1323--1332. doi:10.1007/s00253-010-3067-4 Randomized trial
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  15. Macalester College, Katharine Ordway Natural History Study Area 'Turkey Tail Fungus (Trametes versicolor)'. Available at: https://www.macalester.edu/ordway/biodiversity/inventory/turkeytailfungus/ Traditional / reference
    https://www.macalester.edu/ordway/biodiversity/inventory/turkeytailfungus/
  16. Missouri Department of Conservation 'False Turkey Tail (Stereum ostrea)'. Available at: https://mdc.mo.gov/discover-nature/field-guide/false-turkey-tail Traditional / reference
    https://mdc.mo.gov/discover-nature/field-guide/false-turkey-tail
  17. Kuo, Michael 'Stereum ostrea (False Turkey Tail)'. Available at: https://www.mushroomexpert.com/stereum_ostrea.html Traditional / reference
    https://www.mushroomexpert.com/stereum_ostrea.html

Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.