Omnia SanaPlant Comparison
Licorice root vs Chaga
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Licorice root and Chaga: they share 7 indicated uses (arthritis / joint pain, cold & flu, immune support, …); 3 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Licorice root | Chaga | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 1/10 | 1/10 | Comparable evidence |
| Cold & flu | 1/10 | 1/10 | Comparable evidence |
| Immune support | 1/10 | 2/10 | Comparable evidence |
| Infection (general) | 1/10 | 1/10 | Comparable evidence |
| Inflammation (general) | 1/10 | 1/10 | Comparable evidence |
| Skin irritation | 1/10 | 1/10 | Comparable evidence |
| Wounds | 1/10 | 1/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
The principal sweet-tasting compound, about 50 times sweeter than sucrose; responsible for the anti-inflammatory, antiviral and gastroprotective activity and also for the pseudoaldosteronism risk on prolonged high-dose use.
Antioxidant and antimicrobial polyphenols, including the skin-lightening compound glabridin.
Minor supporting constituents of the root.
Chaga's dark colour comes from melanin-like pigments; it also concentrates betulinic-acid-type triterpenes absorbed from its birch host, associated with antioxidant and anticancer research interest.
Immunomodulatory polysaccharides contributing to the traditional tonic and immune-support use.
Antioxidant phenolics contributing to chaga's free-radical-scavenging activity.
Pharmacological Actions
Traditional & Indicated Uses
inferred from gastroprotective action
inferred from anti-inflammatory action
inferred from expectorant action
inferred from gastroprotective action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from antispasmodic action
inferred from antispasmodic action
inferred from expectorant action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from anticancer action
inferred from immunomodulator action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
Chaga-derived 3,4-DHBA protected against Parkinson's-related neurotoxicity (preclinical).
Chaga polysaccharide lowered lipids in vivo and in vitro.
Safety, Cautions & Contraindications
Avoid prolonged use of whole licorice root in large doses. May cause pseudoaldosteronism (hypertension, oedema, hypokalaemia). Contraindicated in hypertension, renal failure, liver disease, hypokalaemia, and pregnancy. DGL form is safer for prolonged gastric use. Interactions with antihypertensives, diuretics, and corticosteroids.
Duke (2002) rates licorice as ++ and documents extensive activities. Glycyrrhizin (the key compound) has anti-inflammatory, antiulcer, antiviral, and adrenal-stimulant properties. Duke highlights an important safety concern: chronic use of licorice can cause pseudoaldosteronism — sodium retention, potassium loss, edema, and hypertension — due to glycyrrhizin's inhibition of cortisol metabolism. This effect is typically seen with >50 g licorice/day for more than 6 weeks. Deglycyrrhizinated licorice (DGL) avoids this side effect. Dose: 5–15 g dried root daily. Contraindicated in hypertension, kidney disease, low potassium, liver cirrhosis, and in combination with diuretics or corticosteroids (Duke, 2002).
Autoimmune conditions: Chaga can stimulate parts of the immune system—people with autoimmune diseases should be cautious.Blood thinners: Chaga contains compounds that may affect clotting—avoid large doses if on anticoagulants.Blood sugar meds: May slightly lower glucose—monitor if taking diabetes medication.Pregnancy & breastfeeding: Limited safety data—best avoided unless guided by a professional.Quality matters: Wild-harvested Chaga can accumulate heavy metals from trees and soil—source from reputable suppliers.
External Ids
Botanical Description
Herbaceous perennial legume with pinnately compound leaves of small, oval, slightly sticky leaflets. Pale blue-violet to lilac pea-like flowers are borne in loose spikes, followed by small, flattened, oblong pods. The sweet-tasting rhizome and root system, brownish-grey outside and bright yellow inside, is the medicinal part, spreading extensively underground via stolons.[1]
Parasitic wood-decay fungus (not a true plant) that grows almost entirely inside the trunk of living birch trees, visible externally only as a hard, black, cracked, charcoal-like mass (a sclerotium, sometimes called a 'conk') erupting through the bark. Unlike typical mushrooms, chaga has no true cap, gills or stem; its fertile spore-producing surface develops later, hidden beneath the bark after the tree dies.[1]
Habitat
Grows in dry, sunny, deep-soiled sites, riverbanks and open scrub; native to the Mediterranean region and Western to Central Asia, and cultivated widely for its root.[1]
Grows almost exclusively as a parasite on living birch trees in cold, northern temperate and boreal forests of Europe, Russia, North America and Asia.[1]
Harvesting
The root and rhizome are dug in autumn from plants at least three to four years old, when glycyrrhizin content is highest, then cleaned and dried; sold whole, cut, or as processed extract.[1]
The hard black external mass (conk) is chopped or broken away from the living birch trunk, ideally without killing the tree, then dried and broken into pieces or ground for use; sustainable harvesting (leaving part of the conk to regrow) is recommended given the fungus's slow growth.
Traditional Uses
Licorice root is one of the oldest and most widely used herbs in the world, with a documented history across Chinese, Ayurvedic, Greek and European traditional medicine as a soothing demulcent and expectorant for coughs and sore throat, a gastroprotective remedy for stomach discomfort and ulcers, and a harmonising, sweetening addition to herbal formulas.[1]
Chaga has a long traditional use in Russian, Siberian, Baltic and Scandinavian folk medicine as a tonic remedy for digestive complaints, immune support and general vitality, traditionally taken as a dark, tea-like decoction; this traditional tonic reputation is now studied for its antioxidant, immunomodulatory and anti-inflammatory properties.[1, 4]
Preparations
Dosage
The EU herbal monograph gives, for adults and elderly, 1.5-2 g of the comminuted root in 150 mL of boiling water as an infusion or decoction 2 to 4 times daily, taken one cup after meals; a soft extract (DER 1:0.4-0.5) at 32 mg 2-3 times daily, not exceeding 160 mg daily, is also listed. The monograph directs that it is NOT to be used for more than 4 weeks, and is not recommended under 18 years - the duration limit matters because prolonged licorice use causes pseudoaldosteronism (sodium and water retention, potassium loss, raised blood pressure). Deglycyrrhizinated licorice (DGL) is preferred where prolonged use is intended. Educational reference only, not a prescription.
Not documented
References
Drug Class Interactions
Not documented
Lookalikes Review
References & Sources
- Pastorino, G., Cornara, L., Soares, S., Rodrigues, F. and Oliveira, M.B.P.P (2018) 'Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review', Phytotherapy Research, 32(12), pp. 2323-2339. doi:10.1002/ptr.6178 Traditional / reference
https://doi.org/10.1002/ptr.6178 - Nazari, S., Rameshrad, M. and Hosseinzadeh, H (2017) 'Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review', Phytotherapy Research, 31(11), pp. 1635-1650. doi:10.1002/ptr.5893 Traditional / reference
https://doi.org/10.1002/ptr.5893 - El-Saber Batiha, G., Magdy Beshbishy, A., El-Mleeh, A., Abdel-Daim, M.M. and Prasad Devkota, H (2020) 'Traditional Uses, Bioactive Chemical Constituents, and Pharmacological and Toxicological Activities of Glycyrrhiza glabra L. (Fabaceae)', Biomolecules, 10(3), pp. 352. doi:10.3390/biom10030352 Traditional / reference
https://doi.org/10.3390/biom10030352 - Wahab, S., Annadurai, S., Abullais, S.S., Das, G., Ahmad, W., Ahmad, M.F., Kandasamy, G., Vasudevan, R., Ali, M.S. and Amir, M (2021) 'Glycyrrhiza glabra (licorice): a comprehensive review on its phytochemistry, biological activities, clinical evidence and toxicology', Plants, 10(12), pp. 2751. doi:10.3390/plants10122751 Meta-analysis / review
https://doi.org/10.3390/plants10122751 - Markina, Y.V., Kirichenko, T.V., Markin, A.M., Yudina, I.Y., Starodubova, A.V., Sobenin, I.A. and Orekhov, A.N (2022) 'Atheroprotective effects of Glycyrrhiza glabra L', Molecules, 27(15), pp. 4697. doi:10.3390/molecules27154697 Meta-analysis / review
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https://doi.org/10.1007/978-3-030-73234-9_25 - Schmid, C., Dawid, C., Peters, V. and Hofmann, T (2018) 'Saponins from European licorice roots (Glycyrrhiza glabra)', Journal of Natural Products, 81(8), pp. 1734-1744. doi:10.1021/acs.jnatprod.8b00022 Preclinical
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https://scholar.google.com/scholar?q=Review%20-%20Glycyrrhiza%20glabra%20L.%20%28liquorice%29 - European Medicines Agency (HMPC) (2013) 'Community herbal monograph on Glycyrrhiza glabra L. and/or Glycyrrhiza inflata Bat. and/or Glycyrrhiza uralensis Fisch., radix'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-glycyrrhiza-glabra-l-andor-glycyrrhiza-inflata-bat-andor-glycyrrhiza-uralensis-fisch-radix-first-version_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-glycyrrhiza-glabra-l-andor-glycyrrhiza-inflata-bat-andor-glycyrrhiza-uralensis-fisch-radix-first-version_en.pdf - Asl, M.N. and Hosseinzadeh, H (2008) 'Review of pharmacological effects of Glycyrrhiza sp', 22(6), pp. 709--724. Traditional / reference
https://scholar.google.com/scholar?q=Review%20of%20pharmacological%20effects%20of%20Glycyrrhiza%20sp. - Fiore, C. et al (2008) 'A history of the therapeutic use of liquorice in Europe', 99(3), pp. 317--324. doi:10.1016/j.jep.2005.04.015 Traditional / reference
https://doi.org/10.1016/j.jep.2005.04.015 - WHO (1999) 'WHO Monographs on Selected Medicinal Plants'. Traditional / reference
https://scholar.google.com/scholar?q=WHO%20Monographs%20on%20Selected%20Medicinal%20Plants - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Takahashi, K., Yoshino, T., Maki, Y., Ishiuchi, K., Namiki, T., Ogawa-Ochiai, K., Minamizawa, K., Makino, T., Nakamura, T., Mimura, M. and Watanabe, K (2019) 'Identification of glycyrrhizin metabolites in humans and of a potential biomarker of liquorice-induced pseudoaldosteronism', Archives of Toxicology, 93(11), pp. 3111-3119. doi:10.1007/s00204-019-02588-2 Clinical study
https://doi.org/10.1007/s00204-019-02588-2 - Penninkilampi, R., Eslick, E.M. and Eslick, G.D (2017) 'The association between consistent licorice ingestion, hypertension and hypokalaemia: a systematic review and meta-analysis', Journal of Human Hypertension, 31(11), pp. 699-707. doi:10.1038/jhh.2017.45 Meta-analysis / review
https://doi.org/10.1038/jhh.2017.45 - Wu, T., Yang, J., Xia, J. and Sun, G (2024) 'Effects of licorice functional components intakes on blood pressure: a systematic review with meta-analysis and network toxicology', Nutrients, 16(21), pp. 3768. doi:10.3390/nu16213768 Meta-analysis / review
https://doi.org/10.3390/nu16213768 - af Geijerstam, P., Joelsson, A., Radholm, K. and Nystrom, F.H (2024) 'A low dose of daily licorice intake affects renin, aldosterone, and home blood pressure in a randomized crossover trial', The American Journal of Clinical Nutrition, 119(3), pp. 682-691. doi:10.1016/j.ajcnut.2024.01.011 Randomized trial
https://doi.org/10.1016/j.ajcnut.2024.01.011
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https://doi.org/10.1371/journal.pone.0180476 - Giridharan, V.V. and Thandavarayan, R.A. and Konishi, T (2011) 'Amelioration of scopolamine induced cognitive dysfunction and oxidative stress by Inonotus obliquus– a medicinal mushroom', Food & Function. doi:10.1039/c1fo10037h Preclinical
https://doi.org/10.1039/c1fo10037h - Lee, J. and Hyun, C (2014) 'Insulin‐Sensitizing and Beneficial Lipid‐Metabolic Effects of the Water‐Soluble Melanin Complex Extracted from Inonotus obliquus', Phytotherapy Research. doi:10.1002/ptr.5131 Preclinical
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https://doi.org/10.4489/myco.2005.33.3.158 - Géry, A., Dubreule, C., André, V., Rioult, J.P., Bouchart, V., Heutte, N., Eldin de Pécoulas, P., Krivomaz, T. and Garon, D (2018) 'Chaga (Inonotus obliquus), a future potential medicinal fungus in oncology? A chemical study and a comparison of the cytotoxicity against human lung adenocarcinoma cells (A549) and human bronchial epithelial cells (BEAS-2B)', 17(3), pp. 832--843. doi:10.1177/1534735418757912 Traditional / reference
https://doi.org/10.1177/1534735418757912 - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - Shashkina, M.Ya., Shashkin, P.N. and Sergeev, A.V (2006) 'Chemical and medicobiological properties of chaga', 40(10), pp. 560--568. Traditional / reference
https://scholar.google.com/scholar?q=Chemical%20and%20medicobiological%20properties%20of%20chaga - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
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Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.