Omnia SanaPlant Comparison
Field Horsetail vs Selfheal
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Field Horsetail and Selfheal: they share 7 indicated uses (arthritis / joint pain, bruising, cancer (anticancer research), …); 4 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Field Horsetail | Selfheal | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 5/10 | 2/10 | Stronger for Field Horsetail |
| Bruising | 5/10 | 2/10 | Stronger for Field Horsetail |
| Cancer (anticancer research) | 2/10 | 7/10 | Stronger for Selfheal |
| Infection (general) | 5/10 | 2/10 | Stronger for Field Horsetail |
| Inflammation (general) | 5/10 | 2/10 | Stronger for Field Horsetail |
| Skin irritation | 5/10 | 2/10 | Stronger for Field Horsetail |
| Wounds | 5/10 | 2/10 | Stronger for Field Horsetail |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Field horsetail is exceptionally rich in silica, concentrated in the stem, and is a signature source of this mineral in Western herbal medicine.
Antioxidant flavonoids contributing to the plant's anti-inflammatory activity.
An enzyme that degrades vitamin B1 (thiamine); the basis of the caution against prolonged or excessive use.
Pentacyclic triterpenoids (ursolic, oleanolic and betulinic acids), the phenolic acid rosmarinic acid, coumarins (umbelliferone, scopoletin, esculetin) and the flavonoid luteolin are the main bioactives behind self-heal's antioxidant, anti-inflammatory and antimicrobial activity.
Water-extracted polysaccharides — including a partially sulphated arabinogalactomannan (PSP-2B) and polyphenolic-protein-polysaccharide conjugates (PVG/PVE30) — are the principal antiviral and immunomodulatory constituents, blocking herpes simplex virus attachment and modulating innate immune signalling.
Pharmacological Actions
Traditional & Indicated Uses
inferred from anti-inflammatory action
inferred from anti-rheumatic action
inferred from anticancer action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from diuretic action
inferred from diuretic action
inferred from diuretic action
inferred from anti-inflammatory action
inferred from antiviral action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from antimicrobial action
inferred from anticancer action
Safety, Cautions & Contraindications
Field horsetail contains thiaminase, an enzyme that degrades thiamine (vitamin B1); prolonged or excessive use can cause thiamine deficiency — symptoms include neurological problems and weight loss. This risk is greatest with repeated large doses or prolonged use. The plant also contains nicotine at low levels and silica compounds. Not recommended for children or during pregnancy and breastfeeding. People with impaired kidney function should avoid use, as diuretic effects may worsen fluid and electrolyte imbalance. Caution with concurrent diuretic medications. The EMA herbal monograph recognises traditional use at appropriate short-term doses in adults only (European Medicines Agency, 2016; Sandhu et al., 2010).
Duke (2002) rates horsetail as + (moderate caution) and notes clinical evidence (score 2) for its diuretic and wound-healing (vulnerary) activities, consistent with Commission E approval. High silica content may strengthen connective tissue, hair, and nails. Dose: 6 g dried herb daily as tea or in capsules. Horsetail contains thiaminase (breaks down vitamin B1) and an unidentified neurotoxin — it should not be taken long-term or in large quantities. Not for use in patients with edema due to cardiac or renal insufficiency, and avoid in children under 12 (Duke, 2002).
Generally very safe and well tolerated. No significant known toxicity or drug interactions. Safe for topical and internal use in normal medicinal doses. Suitable for most adults including children in appropriate doses.
Duke (2002) rates self-heal as +++ and notes antioxidant (score 2), anti-inflammatory, antiviral, and COX-2 inhibitory activities. The plant contains luteolin, rosmarinic acid, and hyperoside — all with well-documented bioactivities. Hepatoprotective activity has been experimentally demonstrated. Duke notes that self-heal has a broad antimicrobial spectrum and an impressive antioxidant profile, supporting its traditional reputation as a versatile wound-healing herb. No significant safety concerns at normal herbal doses (Duke, 2002).
External Ids
Botanical Description
Perennial, spore-bearing (non-flowering) plant with two distinct stem types arising from a deep, black, jointed rhizome. In early spring, unbranched, pale brownish fertile stems appear first, each topped with a spore-bearing cone, and die back once spores are shed; these are followed by the familiar green, hollow, jointed, ridged sterile stems bearing whorls of thin, needle-like branches at each node, giving a bottlebrush appearance.
Low, creeping to semi-erect perennial herb (Lamiaceae), 5-30 cm tall, with square, often purplish stems. Leaves are opposite, ovate with slightly toothed margins. Small, two-lipped, violet-purple flowers are densely packed into a compact, club-shaped terminal spike subtended by purplish bracts.[1]
Habitat
Grows in damp grassland, waste ground, riverbanks, roadsides and disturbed soil on a wide range of soils; native and common across the temperate Northern Hemisphere (Europe, Asia, North America).
Native throughout Europe, Asia and North America (circumboreal), extremely common in lawns, meadows, woodland clearings, roadsides and waste ground, tolerating mowing and a wide range of soils.[1]
Harvesting
The green sterile stems are cut in summer, at their most vigorous, and dried quickly in a warm, shaded, airy place; careful identification against the more toxic marsh horsetail (Equisetum palustre), which grows in similar damp ground, is essential before wild-harvesting.
Whole flowering aerial parts (flower, leaf and stem) are cut during flowering (summer) and dried.[1]
Traditional Uses
Field horsetail has a long European folk history as a diuretic remedy for urinary gravel and mild fluid retention, as an astringent, anti-inflammatory and vulnerary herb for wounds and connective-tissue support, and, owing to its very high silica content, as a traditional tonic for hair, nails and skin.[11]
Selfheal has an extremely broad folk-medicine reputation across European, North American and Traditional Chinese Medicine traditions - as its name suggests, used as an all-purpose wound herb, gargle for sore throat, and internal remedy for fevers and inflammation. Modern research on its triterpenoid, phenolic and polysaccharide constituents supports wide-ranging antioxidant, anti-inflammatory, antimicrobial and antiviral activity.[1]
Preparations
Dosage
The EU herbal monograph gives a single dose of 1-4 g of the comminuted herb in 150 mL of boiling water as an infusion or decoction (5-15 minutes), 3-4 times daily, for a daily dose of 3-12 g, in adolescents, adults and elderly; traditionally used over a period of 2 to 4 weeks. For cutaneous use, 10 g in 1 L of water as a decoction for impregnated dressings and irrigation. Not recommended under 12 years. Educational reference only, not a prescription.
Traditional guidance suggests roughly 2-4 g dried herb per cup as an infusion, up to three times daily, or an equivalent tincture; used topically as a wash or gargle at similar strength. Educational reference only, not a prescription.
References
Lookalikes Review
Dangerous Lookalikes
Not documented
References & Sources
- Hegedus, C., Muresan, M., Badale, A., Bombicz, M. and others (2020) 'SIRT1 Activation by Equisetum arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats', Molecules, 25(11), pp. 2541. doi:10.3390/molecules25112541 Preclinical
https://doi.org/10.3390/molecules25112541 - Dragos, D., Gilca, M., Gaman, L., Vlad, A., Iosif, L. et al (2017) 'Phytomedicine in Joint Disorders', Nutrients, 9(1), pp. 70. doi:10.3390/nu9010070 Traditional / reference
https://doi.org/10.3390/nu9010070 - Grundemann, C., Lengen, K., Sauer, B., Garcia-Kaufer, M. and others (2014) 'Equisetum arvense (common horsetail) modulates the function of inflammatory immunocompetent cells', BMC Complementary and Alternative Medicine, 14, pp. 283. doi:10.1186/1472-6882-14-283 Preclinical
https://doi.org/10.1186/1472-6882-14-283 - Wang, L., Zhang, L., Zheng, G. and Luo, H (2021) 'Equisetum arvense L aqueous extract: a novel chemotherapeutic supplement for treatment of human colon carcinoma', Archives of Medical Science, 19(5), pp. 1472-1478. doi:10.5114/aoms/138146 Preclinical
https://doi.org/10.5114/aoms/138146 - Jeong, S.Y., Yu, H.S., Ra, M.J., Jung, S.M. and others (2023) 'Phytochemical Investigation of Equisetum arvense and Evaluation of Their Anti-Inflammatory Potential in TNFalpha/INFgamma-Stimulated Keratinocytes', Pharmaceuticals, 16(10), pp. 1478. doi:10.3390/ph16101478 Preclinical
https://doi.org/10.3390/ph16101478 - Klncalp, S., Ekiz, F., Basar, O., Coban, S. and others (2012) 'Equisetum arvense (Field Horsetail)-induced liver injury', European Journal of Gastroenterology & Hepatology, 24(2), pp. 213-214. doi:10.1097/MEG.0b013e32834e7ff0 Preclinical
https://doi.org/10.1097/MEG.0b013e32834e7ff0 - Maeda, H., Miyamoto, K. and Sano, T (1997) 'Occurrence of dermatitis in rats fed a cholesterol diet containing field horsetail (Equisetum arvense L.)', Journal of Nutritional Science and Vitaminology, 43(5), pp. 553-563. doi:10.3177/jnsv.43.553 Preclinical
https://doi.org/10.3177/jnsv.43.553 - Saslis-Lagoudakis, C.H., Bruun-Lund, S., Iwanycki, N.E., Seberg, O. and others (2015) 'Identification of common horsetail (Equisetum arvense L.; Equisetaceae) using Thin Layer Chromatography versus DNA barcoding', Scientific Reports, 5, pp. 11942. doi:10.1038/srep11942 Preclinical
https://doi.org/10.1038/srep11942 - Mimica-Dukic, N., Simin, N., Cvejic, J., Jovin, E. and others (2008) 'Phenolic compounds in field horsetail (Equisetum arvense L.) as natural antioxidants', Molecules, 13(7), pp. 1455-1464. doi:10.3390/molecules13071455 Preclinical
https://doi.org/10.3390/molecules13071455 - Tufarelli, V., Baghban-Kanani, P., Azimi-Youvalari, S., Hosseintabar-Ghasemabad, B. and others (2021) 'Effects of Horsetail (Equisetum arvense) and Spirulina (Spirulina platensis) Dietary Supplementation on Laying Hens Productivity and Oxidative Status', Animals, 11(2), pp. 335. doi:10.3390/ani11020335 Preclinical
https://doi.org/10.3390/ani11020335 - Carneiro, D.M., Marques, L.C., Velasques, L.O. et al (2016) 'Randomized, double-blind clinical trial to assess the acute diuretic effect of Equisetum arvense (Field Horsetail) in healthy volunteers'. doi:10.1155/2014/760683 Randomized trial
https://doi.org/10.1155/2014/760683 - European Medicines Agency (2016) 'European Union herbal monograph on Equisetum arvense L., herba'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-equisetum-arvense-l-herba_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-equisetum-arvense-l-herba_en.pdf - http://LatvijasDaba.lv (n.d.) 'tīruma kosa – Equisetum arvense L'. Available at: http://LatvijasDaba.lv Traditional / reference
http://LatvijasDaba.lv - Royal Botanic Gardens, Kew (n.d.) 'Equisetum arvense L'. Available at: https://powo.science.kew.org/taxon/urn:lsid:http://ipni.org:names:17003330-1 Traditional / reference
https://powo.science.kew.org/taxon/urn:lsid:http://ipni.org:names:17003330-1 - Sandhu, N.S., Kaur, S. and Chopra, D (2010) 'Equisetum arvense: pharmacology and phytochemistry — a review', 3(3), pp. 146--150. Traditional / reference
https://scholar.google.com/scholar?q=Equisetum%20arvense%3A%20pharmacology%20and%20phytochemistry%20%E2%80%94%20a%20review - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - NatureSpot 'Marsh Horsetail - Equisetum palustre'. Available at: https://www.naturespot.org/species/marsh-horsetail Traditional / reference
https://www.naturespot.org/species/marsh-horsetail - Muller, J. and Puttich, P.M. and Beuerle, T (2020) 'Variation of the Main Alkaloid Content in Equisetum palustre L. in the Light of Its Ontogeny', Toxins, 12(11), pp. 710. doi:10.3390/toxins12110710 Preclinical
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https://doi.org/10.3390/plants11192562
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https://doi.org/10.2174/1570163818666210203181542 - Pan, J. and Wang, H. and Chen, Y (2022) 'Prunella vulgaris L. - A Review of its Ethnopharmacology, Phytochemistry, Quality Control and Pharmacological Effects', Frontiers in Pharmacology, 13, pp. 903171. doi:10.3389/fphar.2022.903171 Meta-analysis / review
https://doi.org/10.3389/fphar.2022.903171 - Wang, S.J. and Wang, X.H. and Dai, Y.Y. and Ma, M.H. and Rahman, K. and Nian, H. and Zhang, H (2019) 'Prunella vulgaris: A Comprehensive Review of Chemical Constituents, Pharmacological Effects and Clinical Applications', Current Pharmaceutical Design, 25(3), pp. 359-369. doi:10.2174/1381612825666190313121608 Meta-analysis / review
https://doi.org/10.2174/1381612825666190313121608 - Zhu, M.J. and Song, Y.J. and Rao, P.L. and Gu, W.Y. and Xu, Y. and Xu, H.X (2025) 'Therapeutic role of Prunella vulgaris L. polysaccharides in non-alcoholic steatohepatitis and gut dysbiosis', Journal of Integrative Medicine, 23(3), pp. 297-308. doi:10.1016/j.joim.2025.03.002 Preclinical
https://doi.org/10.1016/j.joim.2025.03.002 - Zhang, Y. and Qu, X. and Xu, N. and He, H. and Li, Q. and Wei, X. and Chen, Y. and Xu, Y. and Li, X. and Zhang, R. and Zhong, R. and Liu, C. and Xiang, P. and Zhu, F (2024) 'Mechanism of Prunella vulgaris L. and luteolin in restoring Tfh/Tfr balance and alleviating oxidative stress in Graves' disease', Phytomedicine, 132, pp. 155818. doi:10.1016/j.phymed.2024.155818 Preclinical
https://doi.org/10.1016/j.phymed.2024.155818 - Zhang, S. and Wang, Y. and Wang, M. and Jiang, L. and Ma, X. and Huang, Y. and Liu, T. and Zheng, L. and Li, Y (2024) 'Construction and anti-pancreatic cancer activity of selenium nanoparticles stabilized by Prunella vulgaris polysaccharide', Int J Biol Macromol, 278(Pt 3), pp. 134924. doi:10.1016/j.ijbiomac.2024.134924 Preclinical
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https://doi.org/10.3389/fimmu.2023.1196434 - Ma, F. and Deng, Q. and Lou, H. and Li, J. and Xu, S. and Wu, W. and Wen, Q. and Tang, L. and Wang, X. and Pan, W (2022) 'Vulgarisin-type diterpenoids from self-heal (Prunella vulgaris) and their neuroprotective effects against ischemia/reperfusion (I/R) via a mitochondria-related pathway', Food Funct, 13(13), pp. 7062-7074. doi:10.1039/d2fo00150k Preclinical
https://doi.org/10.1039/d2fo00150k - Xie, J. and Xiong, S. and Yu, J. and Ma, X. and Xiang, F. and Chen, Y. and Xia, B. and Li, Y. and Zhang, Z. and Liao, D. and Lin, L (2025) 'Prunella vulgaris polyphenols alleviate liver injury-uveitis comorbidity by regulating acylcarnitine via the S100A9-PP2A-AMPK pathway', Phytomedicine, 141, pp. 156675. doi:10.1016/j.phymed.2025.156675 Preclinical
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https://doi.org/10.1155/2021/8869323 - Zhong, X., Zhang, Y., Yuan, M., Xu, L., Luo, X., Wu, R., Xi, Z., Li, Y. and Xu, H (2024) 'Prunella vulgaris polysaccharide inhibits herpes simplex virus infection by blocking TLR-mediated NF-kB activation', Chinese Medicine, 19(1). doi:10.1186/s13020-023-00865-y Preclinical
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https://scholar.google.com/scholar?q=Antiviral%20activity%20of%20aqueous%20extract%20of%20Prunella%20vulgaris%20L - Haarberg, K.M.K., Wymore Brand, M.J., Overstreet, A.M.C., Hauck, C.C., Murphy, P.A., Hostetter, J.M., Ramer-Tait, A.E. and Wannemuehler, M.J (2015) 'Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a(-/-) mice', World Journal of Gastrointestinal Pharmacology and Therapeutics, 6(4), pp. 223--237. doi:10.4292/wjgpt.v6.i4.223 Preclinical
https://doi.org/10.4292/wjgpt.v6.i4.223 - Zhang, Y.B., Xu, L., Yuan, M., Liu, M.F., Li, Y., Zhong, X.L., Lin, Z.X., Xian, Y.F., Lu, P., Xi, Z.C. and Xu, H.X (2025) 'Protective effects of Prunella vulgaris polysaccharides against herpes simplex virus type 1 infection through the STING-TBK1-IRF3 pathway', Journal of Integrative Medicine, 24(3), pp. 454--465. doi:10.1016/j.joim.2025.12.008 Preclinical
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Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.