Plant Comparison
Gotu Kola vs Cumin
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Gotu Kola and Cumin: both belong to the Apiaceae family; they share 4 indicated uses (arthritis / joint pain, inflammation (general), skin irritation, …); 2 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Gotu Kola | Cumin | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 2/10 | 9/10 | Stronger for Cumin |
| Inflammation (general) | 2/10 | 9/10 | Stronger for Cumin |
| Skin irritation | 2/10 | 9/10 | Stronger for Cumin |
| Wounds | 2/10 | 9/10 | Stronger for Cumin |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
The marker compounds and principal actives for wound healing, vascular and neuroprotective effects.
Antioxidant and aromatic supporting constituents.
Cuminaldehyde (4-isopropylbenzaldehyde) is the dominant constituent of cumin-seed essential oil (around two-thirds of the oil) and the main driver of its antimicrobial, antifungal (anti-aflatoxigenic) and antioxidant activity.
Pharmacological Actions
Anti-inflammatory and antioxidant; supports inflammatory skin conditions (eczema, psoriasis, ulcers)
Improves venous tone and microcirculation - supports chronic venous insufficiency / varicose veins and reduces leg swelling
Anti-inflammatory and antioxidant; supports inflammatory skin conditions (eczema, psoriasis, ulcers)
Anxiolytic / calming (anxiety)
Improves venous tone and microcirculation - supports chronic venous insufficiency / varicose veins and reduces leg swelling
Antispasmodic (cramp easing)
Traditional & Indicated Uses
inferred from anti-inflammatory action
Improves alertness and mood (raises alertness, reduces anger); a meta-analysis found no significant improvement in specific cognitive-function domains versus placebo
Anti-inflammatory and antioxidant; supports inflammatory skin conditions (eczema, psoriasis, ulcers)
inferred from anti-inflammatory action
inferred from anxiolytic action
Anti-inflammatory and antioxidant; supports inflammatory skin conditions (eczema, psoriasis, ulcers)
inferred from anti-inflammatory action
Improves venous tone and microcirculation - supports chronic venous insufficiency / varicose veins and reduces leg swelling
Improves venous tone and microcirculation - supports chronic venous insufficiency / varicose veins and reduces leg swelling
inferred from anti-inflammatory action
inferred from digestive action
inferred from digestive action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from antispasmodic action
inferred from antispasmodic action
Safety, Cautions & Contraindications
Generally well tolerated topically and orally; it can occasionally cause allergic contact dermatitis and, rarely, reversible elevation of liver enzymes with prolonged high oral doses.
May add to the effect of sedatives; use caution with other liver-affecting medicines. Safety in pregnancy and breastfeeding is not established, so avoid medicinal doses.
Food amounts are generally considered safe; in the US it’s listed as GRAS as a spice/flavoring (LactMed, 2025).
Allergy risk: cumin can trigger allergic reactions in sensitive people; cross-reactivity is reported within Apiaceae spices (e.g., celery/coriander/fennel/cumin) and in “pollen–spice” allergy patterns (Lisiecka et al., 2025; Berghea et al., 2025).
Duke (2002) rates cumin as +++ and notes carminative, digestive, and aperitif activities at experimental levels (score 1). The plant demonstrates estrogenic activity in animal studies and has antifungal and antioxidant properties. Photodermatitic potential (phototoxicity) of the essential oil is noted — users should avoid sun exposure after topical application. Duke advises caution in pregnancy due to potential emmenagogue and antifertility effects at high medicinal doses (Duke, 2002).
External Ids
Botanical Description
Low, creeping perennial herb rooting at the nodes along slender, prostrate stems. The leaves are long-stalked, rounded to kidney- or fan-shaped, with a gently scalloped (crenate) margin, arising in small clusters at each node. Tiny, pinkish-white flowers are borne in small, inconspicuous clusters hidden near the base of the leaf stalks, close to the ground.[12]
Slender annual herb with finely divided, thread-like leaves similar to dill or fennel but smaller. Small white or pale pink flowers are borne in small compound umbels, followed by small, ridged, boat-shaped, strongly aromatic seeds.
Habitat
Grows in damp, shaded ground, lawns, ditches and wetland margins throughout tropical and subtropical Asia (China, India, Southeast Asia) and parts of Africa, Australia and the Pacific.[12]
Believed native to the eastern Mediterranean and Central Asia; cultivated widely in warm, dry climates including India, the Middle East and North Africa as a major spice crop.
Harvesting
The aerial parts (leaves and trailing stems) are harvested during active growth, cut a short distance above the soil to allow regrowth, and used fresh or dried.
The seed heads are cut when the fruit has ripened but before it shatters, usually in mid- to late summer, then dried and threshed.
Traditional Uses
Gotu kola is a cornerstone herb of Ayurvedic and traditional Chinese medicine, valued as a 'rasayana' (rejuvenating) tonic for skin healing, memory and mental clarity, and calming the mind; it has a particularly strong traditional and modern reputation for wound healing and connective-tissue/vascular support, reflected in its widespread use for scars, minor wounds and varicose veins.[12]
Cumin seed has an ancient culinary and medicinal history across the Middle East, South Asia and the Mediterranean as a warming digestive carminative for indigestion, bloating and cramping, and is one of the most widely used spices worldwide.
Preparations
Extract titrated to triterpenoid (asiaticoside/madecassoside) content, taken orally as capsules/tablets for venous and cognitive support, or applied topically for wound and scar care.
Standardised extract or fresh leaf preparation applied topically to wounds, scars and inflamed skin.
Not documented
Dosage
Clinical studies commonly use extracts providing around 60-180 mg total triterpenoids daily, in divided doses. Educational reference only, not a prescription.
The EU herbal monograph on Centella asiatica herba is for CUTANEOUS USE ONLY and gives, for adults and elderly, a single dose of 0.6 g of the comminuted herb infused in a small amount of boiling water, the still-warm infusion applied as an impregnated dressing 3 times daily (daily dose 1.8 g); or 0.6 g of the powdered herb applied to the affected area 3 times daily. Not to be used for more than 1 week, and not recommended under 18 years. The monograph gives no oral posology - see the separate standardised-extract entry. Educational reference only, not a prescription.
Not documented
References
Not documented
Lookalikes Review
Dangerous Lookalikes
Not documented
References & Sources
- Bylka, W., Znajdek-Awizen, P., Studzinska-Sroka, E., Danczak-Pazdrowska, A. and Brzezinska, M (2014) 'Centella asiatica in dermatology: an overview', Phytotherapy Research, 28(8), pp. 1117-1124. doi:10.1002/ptr.5110 Meta-analysis / review
https://doi.org/10.1002/ptr.5110 - Bylka, W., Znajdek-Awizen, P., Studzinska-Sroka, E. and Brzezinska, M (2013) 'Centella asiatica in cosmetology', Postepy Dermatologii i Alergologii, 30(1), pp. 46-49. doi:10.5114/pdia.2013.33378 Meta-analysis / review
https://doi.org/10.5114/pdia.2013.33378 - Park, K.S (2021) 'Pharmacological effects of Centella asiatica on skin diseases: evidence and possible mechanisms', Evidence-Based Complementary and Alternative Medicine, 2021, pp. 5462633. doi:10.1155/2021/5462633 Meta-analysis / review
https://doi.org/10.1155/2021/5462633 - Diniz, L.R.L., Calado, L.L., Duarte, A.B.S. and de Sousa, D.P (2023) 'Centella asiatica and its metabolite asiatic acid: wound healing effects and therapeutic potential', Metabolites, 13(2), pp. 276. doi:10.3390/metabo13020276 Meta-analysis / review
https://doi.org/10.3390/metabo13020276 - Arribas-Lopez, E., Zand, N., Ojo, O., Snowden, M.J. and Kochhar, T (2022) 'A systematic review of the effect of Centella asiatica on wound healing', International Journal of Environmental Research and Public Health, 19(6), pp. 3266. doi:10.3390/ijerph19063266 Meta-analysis / review
https://doi.org/10.3390/ijerph19063266 - Lin, P., Shi, H., Lu, Y. and Lin, J (2023) 'Centella asiatica alleviates psoriasis through JAK/STAT3-mediated inflammation: an in vitro and in vivo study', Journal of Ethnopharmacology, 317, pp. 116746. doi:10.1016/j.jep.2023.116746 Preclinical
https://doi.org/10.1016/j.jep.2023.116746 - Ratz-Lyko, A., Arct, J. and Pytkowska, K (2016) 'Moisturizing and antiinflammatory properties of cosmetic formulations containing Centella asiatica extract', Indian Journal of Pharmaceutical Sciences, 78(1), pp. 27-33. doi:10.4103/0250-474x.180247 Preclinical
https://doi.org/10.4103/0250-474x.180247 - Sun, B., Wu, L., Wu, Y., Zhang, C., Qin, L., Hayashi, M., Kudo, M., Gao, M. and Liu, T (2020) 'Therapeutic potential of Centella asiatica and its triterpenes: a review', Frontiers in Pharmacology, 11, pp. 568032. doi:10.3389/fphar.2020.568032 Meta-analysis / review
https://doi.org/10.3389/fphar.2020.568032 - Razali, N.N.M., Ng, C.T. and Fong, L.Y (2019) 'Cardiovascular protective effects of Centella asiatica and its triterpenes: a review', Planta Medica, 85(16), pp. 1203-1215. doi:10.1055/a-1008-6138 Meta-analysis / review
https://doi.org/10.1055/a-1008-6138 - Sharma, R., Banerjee, S. and Sharma, R (2024) 'Role of Mandukparni (Centella asiatica Linn Urban) in neurological disorders: evidence from ethnopharmacology and clinical studies to network enrichment analysis', Neurochemistry International, 180, pp. 105865. doi:10.1016/j.neuint.2024.105865 Meta-analysis / review
https://doi.org/10.1016/j.neuint.2024.105865 - Banerjee, O., Singh, S., Paul, T., Maji, B.K. and Mukherjee, S (2024) 'Centella asiatica mitigates the detrimental effects of Bisphenol-A (BPA) on pancreatic islets', Scientific Reports, 14(1), pp. 8043. doi:10.1038/s41598-024-58545-2 Preclinical
https://doi.org/10.1038/s41598-024-58545-2 - Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N.K., Kumar, M., Radha, Ghosh, A., Prockow, J., Perez de la Lastra, J.M. and Dey, A (2023) 'Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review', Journal of Cellular and Molecular Medicine. doi:10.1111/jcmm.17635 Traditional / reference
https://doi.org/10.1111/jcmm.17635 - European Medicines Agency (HMPC) (2018) 'European Union herbal monograph on Centella asiatica (L.) Urb., herba, Revision 1'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/european-union-herbal-monograph-centella-asiatica-l-urb-herba-revision-1_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/herbal-monograph/european-union-herbal-monograph-centella-asiatica-l-urb-herba-revision-1_en.pdf - Belcaro, G., Maquart, F.-X., Scoccianti, M., Dugall, M., Hosoi, M., Cesarone, M.R., Luzzi, R., Cornelli, U., Ledda, A. and Feragalli, B (2011) 'TECA (Titrated Extract of Centella Asiatica): new microcirculatory, biomolecular, and vascular application in preventive and clinical medicine. A status paper', Panminerva Medica. Preclinical
https://scholar.google.com/scholar?q=TECA%20%28Titrated%20Extract%20of%20Centella%20Asiatica%29%3A%20new%20microcirculatory%2C%20biomolecular%2C%20and%20vascular%20application%20in%20preventive%20and%20clinical%20medicine.%20A%20status%20paper - Chong, N.J. and Aziz, Z (2013) 'A Systematic Review of the Efficacy of Centella asiatica for Improvement of the Signs and Symptoms of Chronic Venous Insufficiency', Evidence-Based Complementary and Alternative Medicine. doi:10.1155/2013/627182 Meta-analysis / review
https://doi.org/10.1155/2013/627182 - Martinez-Zapata, M.J., Vernooij, R.W., Simancas-Racines, D., Uriona Tuma, S.M., Stein, A.T. and others (2020) 'Phlebotonics for venous insufficiency', Cochrane Database of Systematic Reviews. doi:10.1002/14651858.CD003229.pub4 Meta-analysis / review
https://doi.org/10.1002/14651858.CD003229.pub4 - Puttarak, P., Dilokthornsakul, P., Saokaew, S., Dhippayom, T., Kongkaew, C. and others (2017) 'Effects of Centella asiatica (L.) Urb. on cognitive function and mood related outcomes: A Systematic Review and Meta-analysis', Scientific Reports, 7(1). doi:10.1038/s41598-017-09823-9 Meta-analysis / review
https://doi.org/10.1038/s41598-017-09823-9 - Haupt, H (2001) 'Poisonous and less poisonous plants. 52', Kinderkrankenschwester, 20(8), pp. 335. Available at: https://pubmed.ncbi.nlm.nih.gov/14584174/ Traditional / reference
https://pubmed.ncbi.nlm.nih.gov/14584174/ - North Carolina Extension Gardener Plant Toolbox 'Centella asiatica (Gotu Kola, Asiatic Pennywort)'. Available at: https://plants.ces.ncsu.edu/plants/centella-asiatica/ Traditional / reference
https://plants.ces.ncsu.edu/plants/centella-asiatica/
- Ben Miri, Y. and Djenane, D (2018) 'Evaluation of Protective Impact of Algerian Cuminum cyminum L. and Coriandrum sativum L. Essential Oils on Aspergillus flavus Growth and Aflatoxin B1 Production', Pakistan Journal of Biological Sciences, 21(2), pp. 67--77. doi:10.3923/pjbs.2018.67.77 Preclinical
https://doi.org/10.3923/pjbs.2018.67.77 - Allaq, A.A. and Sidik, N.J (2020) 'Cumin (Cuminum cyminum L.): A review of its ethnopharmacology, phytochemistry and biological activities'. Available at: https://bmrat.org/index.php/BMRAT/article/view/634 Traditional / reference
https://bmrat.org/index.php/BMRAT/article/view/634 - Berghea, E.C. et al (2025) 'Spices, herbs and allergic reactions in children: myth or reality?'. doi:10.3389/falgy.2025.1698559/full Clinical study
https://doi.org/10.3389/falgy.2025.1698559/full - Britannica (2025) 'Cumin'. Available at: https://www.britannica.com/plant/cumin Traditional / reference
https://www.britannica.com/plant/cumin - EUR-Lex (2015) 'Official Journal of the European Union C 76/2015 (Latvian text; includes “Romiešu ķimenes (cumin)'. Available at: https://eur-lex.europa.eu/legal-content/LV/TXT/HTML/?uri=OJ%3AC%3A2015%3A076%3AFULL Traditional / reference
https://eur-lex.europa.eu/legal-content/LV/TXT/HTML/?uri=OJ%3AC%3A2015%3A076%3AFULL - EUR-Lex (2020) 'Official Journal of the European Union C 108/2020 (Latvian text; includes “kumins (romiešu ķimenes)'. Available at: https://eur-lex.europa.eu/legal-content/LV/TXT/HTML/?uri=CELEX%3A52020XC0401%2804%29 Traditional / reference
https://eur-lex.europa.eu/legal-content/LV/TXT/HTML/?uri=CELEX%3A52020XC0401%2804%29 - http://letonika.lv/ (2021) 'Latviešu—angļu vārdnīca: ķimenes (includes “Romiešu ķimenes = cumin'. Available at: http://letonika.lv/ Traditional / reference
http://letonika.lv/ - Karimian, J. et al (2021) 'The effects of cumin (Cuminum cyminum L.) supplementation on glycemic indices: a systematic review and meta-analysis'. doi:10.1002/ptr.7075 Meta-analysis / review
https://doi.org/10.1002/ptr.7075 - KPBS (2015) 'Cumin: The Ancient Spice That'. Available at: https://www.kpbs.org/news/2015/03/11/cumin-the-ancient-spice-thats-traveled-the-globe Traditional / reference
https://www.kpbs.org/news/2015/03/11/cumin-the-ancient-spice-thats-traveled-the-globe - LactMed (2025) 'Cumin'. Available at: https://www.ncbi.nlm.nih.gov/books/NBK501873/ Traditional / reference
https://www.ncbi.nlm.nih.gov/books/NBK501873/ - Lisiecka, M.F. et al (2025) 'Allergic reactions to spices: a review of sensitivities to pepper, cumin, oregano, anise, mustard and other spices'. Available at: https://pubmed.ncbi.nlm.nih.gov/40341008/ Traditional / reference
https://pubmed.ncbi.nlm.nih.gov/40341008/ - Liu, M. et al (2025) 'Potential benefits of Cuminum cyminum L'. doi:10.3389/fnut.2025.1618108/full Meta-analysis / review
https://doi.org/10.3389/fnut.2025.1618108/full - Morshedi, D. et al (2015) 'Cuminaldehyde as the Major Component of Cuminum cyminum…', 80(10), pp. H2336--H2345. doi:10.1111/1750-3841.13016 Preclinical
https://doi.org/10.1111/1750-3841.13016 - Nabhan, G.P (2014) 'Cumin, Camels, and Caravans: A Spice Odyssey'. Available at: https://www.ucpress.edu/book/9780520379244/cumin-camels-and-caravans Traditional / reference
https://www.ucpress.edu/book/9780520379244/cumin-camels-and-caravans - Nouri, A. et al (2024) 'Phytochemical composition… (includes GC–MS profile of cumin seed essential oil)'. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11606850/ Traditional / reference
https://pmc.ncbi.nlm.nih.gov/articles/PMC11606850/ - PubChem (n.d.). Available at: https://pubchem.ncbi.nlm.nih.gov/compound/Cumin-Oil Traditional / reference
https://pubchem.ncbi.nlm.nih.gov/compound/Cumin-Oil - Royal Botanic Gardens, Kew (n.d.) 'Cuminum cyminum L'. Available at: https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:840882-1 Traditional / reference
https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:840882-1 - SekoEko (n.d.) 'Kumīns, ķimenes un citi līdzinieki!'. Available at: https://sekoeko.lv/lv/kumins-kimenes-un-citi-lidzinieki Traditional / reference
https://sekoeko.lv/lv/kumins-kimenes-un-citi-lidzinieki - Tavakoli-Rouzbehani, O.M. et al (2022) 'The effects of cumin supplementation on lipid parameters: a systematic review and meta-analysis of RCTs'. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC9881733/ Meta-analysis / review
https://pmc.ncbi.nlm.nih.gov/articles/PMC9881733/ - Vikipēdija (n.d.). Available at: https://lv.wikipedia.org/wiki/Kum%C4%ABns Traditional / reference
https://lv.wikipedia.org/wiki/Kum%C4%ABns - Wikisource (2018) '1911 Encyclopædia Britannica: Cumin'. Available at: https://en.wikisource.org/wiki/1911_Encyclop%C3%A6dia_Britannica/Cumin Traditional / reference
https://en.wikisource.org/wiki/1911_Encyclop%C3%A6dia_Britannica/Cumin - Amin, E.A., Ismail, E., Mahboobeh, R. and Tabandeh, S (2024) 'The effect of Cuminum cyminum on the return of bowel motility after abdominal surgery: a triple-blind randomized clinical trial', BMC Complementary Medicine and Therapies, 24(1). doi:10.1186/s12906-024-04530-1 Randomized trial
https://doi.org/10.1186/s12906-024-04530-1 - Hadi, A., Mohammadi, H., Hadi, Z., Roshanravan, N. and Kafeshani, M (2018) 'Cumin (Cuminum cyminum L.) is a safe approach for management of lipid parameters: A systematic review and meta-analysis of randomized controlled trials', Phytotherapy Research, 32(11), pp. 2146--2154. doi:10.1002/ptr.6162 Meta-analysis / review
https://doi.org/10.1002/ptr.6162 - Tavakoli-Rouzbehani, O.M., Faghfouri, A.H., Anbari, M., Papi, S., Shojaei, F.S., Ghaffari, M. and Alizadeh, M (2021) 'The effects of Cuminum cyminum on glycemic parameters: A systematic review and meta-analysis of controlled clinical trials', Journal of Ethnopharmacology, pp. 2021. doi:10.1016/j.jep.2021.114510 Meta-analysis / review
https://doi.org/10.1016/j.jep.2021.114510 - Karimian, J., Farrokhzad, A. and Jalili, C (2021) 'The effect of cumin (Cuminum cyminum L.) supplementation on glycemic indices: A systematic review and meta-analysis of randomized controlled trials', Phytotherapy Research, 35(8), pp. 4127--4135. doi:10.1002/ptr.7075 Meta-analysis / review
https://doi.org/10.1002/ptr.7075 - Morovati, A., Pourghassem Gargari, B. and Sarbakhsh, P (2019) 'Effects of cumin (Cuminum cyminum L.) essential oil supplementation on metabolic syndrome components: A randomized, triple-blind, placebo-controlled clinical trial', Phytotherapy Research, 33(12), pp. 3261--3269. doi:10.1002/ptr.6500 Randomized trial
https://doi.org/10.1002/ptr.6500 - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.