Plant Comparison
Tea vs Selfheal
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Tea and Selfheal: they share 9 indicated uses (arthritis / joint pain, blood sugar / diabetes support, cancer (anticancer research), …); 6 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Tea | Selfheal | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 1/10 | 2/10 | Comparable evidence |
| Blood sugar / diabetes support | 1/10 | 2/10 | Comparable evidence |
| Cancer (anticancer research) | 8/10 | 7/10 | Comparable evidence |
| Cardiovascular / heart health | 1/10 | 2/10 | Comparable evidence |
| Cognitive function | 1/10 | 2/10 | Comparable evidence |
| Infection (general) | 1/10 | 2/10 | Comparable evidence |
| Inflammation (general) | 1/10 | 2/10 | Comparable evidence |
| Skin irritation | 1/10 | 2/10 | Comparable evidence |
| Wounds | 1/10 | 2/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Principal antioxidant polyphenols, most concentrated in minimally oxidised green tea; epigallocatechin gallate (EGCG) is the best studied.
Caffeine gives tea its mild stimulant effect; L-theanine, a unique amino acid, is associated with calm alertness and modulates caffeine's effects.
Oxidative polymerisation products of catechins formed during black tea processing, contributing to black tea's colour and its own antioxidant profile.
Pentacyclic triterpenoids (ursolic, oleanolic and betulinic acids), the phenolic acid rosmarinic acid, coumarins (umbelliferone, scopoletin, esculetin) and the flavonoid luteolin are the main bioactives behind self-heal's antioxidant, anti-inflammatory and antimicrobial activity.
Water-extracted polysaccharides — including a partially sulphated arabinogalactomannan (PSP-2B) and polyphenolic-protein-polysaccharide conjugates (PVG/PVE30) — are the principal antiviral and immunomodulatory constituents, blocking herpes simplex virus attachment and modulating innate immune signalling.
Pharmacological Actions
Traditional & Indicated Uses
inferred from anti-inflammatory action
inferred from antidiabetic action
inferred from anticancer action
inferred from neuroprotective action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from antiviral action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from antimicrobial action
inferred from anticancer action
Safety, Cautions & Contraindications
Generally safe in moderate consumption. High caffeine intake may cause insomnia, anxiety, palpitations, or dependence. Large amounts of green tea extract supplements may be hepatotoxic (rare). May reduce iron absorption if consumed with meals. Avoid very high supplement doses during pregnancy.
Duke (2002) rates tea (Camellia sinensis) as ++ and notes anti-aggregant, antioxidant, anticariogenic, and antibacterial activities at the experimental level (score 1). The catechins (EGCG, ECG) and polyphenols are responsible for the antioxidant and anticancer properties under research investigation. Duke notes that green tea preserves more polyphenols than black tea due to less oxidation. Regular tea consumption is associated with reduced cardiovascular risk. Excess consumption (>10 cups daily) may cause fluoride-related bone changes. Caffeine content is relevant for sleep disturbance, anxiety, and interactions with cardiovascular medications (Duke, 2002).
Generally very safe and well tolerated. No significant known toxicity or drug interactions. Safe for topical and internal use in normal medicinal doses. Suitable for most adults including children in appropriate doses.
Duke (2002) rates self-heal as +++ and notes antioxidant (score 2), anti-inflammatory, antiviral, and COX-2 inhibitory activities. The plant contains luteolin, rosmarinic acid, and hyperoside — all with well-documented bioactivities. Hepatoprotective activity has been experimentally demonstrated. Duke notes that self-heal has a broad antimicrobial spectrum and an impressive antioxidant profile, supporting its traditional reputation as a versatile wound-healing herb. No significant safety concerns at normal herbal doses (Duke, 2002).
External Ids
Botanical Description
Evergreen shrub or small tree with glossy, dark green, leathery, finely toothed leaves. Small, fragrant, white flowers with a prominent central boss of yellow stamens are borne singly or in small clusters in the leaf axils. Commercial tea is made from the young leaves and unopened leaf buds ('sprouts'), processed differently to yield green, black, white or oolong tea from the same species.[15]
Low, creeping to semi-erect perennial herb (Lamiaceae), 5-30 cm tall, with square, often purplish stems. Leaves are opposite, ovate with slightly toothed margins. Small, two-lipped, violet-purple flowers are densely packed into a compact, club-shaped terminal spike subtended by purplish bracts.[1]
Habitat
Native to the subtropical and tropical forests and hillsides of East and South Asia (China, India, Myanmar); cultivated extensively across Asia, Africa and elsewhere on well-drained, acidic upland soils.[15]
Native throughout Europe, Asia and North America (circumboreal), extremely common in lawns, meadows, woodland clearings, roadsides and waste ground, tolerating mowing and a wide range of soils.[1]
Harvesting
The youngest leaves and unopened leaf buds ('flush') are hand- or machine-picked repeatedly through the growing season; how the fresh leaf is subsequently processed (withered, rolled, oxidised, fixed and dried) determines whether it becomes green, black, white or oolong tea.[15]
Whole flowering aerial parts (flower, leaf and stem) are cut during flowering (summer) and dried.[1]
Traditional Uses
Selfheal has an extremely broad folk-medicine reputation across European, North American and Traditional Chinese Medicine traditions - as its name suggests, used as an all-purpose wound herb, gargle for sore throat, and internal remedy for fevers and inflammation. Modern research on its triterpenoid, phenolic and polysaccharide constituents supports wide-ranging antioxidant, anti-inflammatory, antimicrobial and antiviral activity.[1]
Preparations
Young leaf, minimally oxidised, infused in hot water; the least-processed and most-studied form for antioxidant polyphenol content.
Concentrated leaf extract standardised to catechin (e.g. EGCG) content, taken as capsules; used in some clinical studies, though high-dose extracts carry rare hepatotoxicity concerns.
Dried aerial parts steeped in hot water, taken internally or used as a gargle or wash.
Dosage
The EU herbal monograph on green tea leaf (Camelliae sinensis non fermentatum folium) gives, for adults and elderly, 1.8-2.2 g of the whole or comminuted leaf in 100-150 mL of boiling water as an infusion, 3-5 times daily; a powdered herbal substance at 390 mg three times daily (up to 5 if necessary) is also listed. Contraindicated in gastric and duodenal ulcers, cardiovascular disorders such as hypertension and arrhythmia, and hyperthyroidism. Not recommended under 18 years. Educational reference only, not a prescription.
Traditional guidance suggests roughly 2-4 g dried herb per cup as an infusion, up to three times daily, or an equivalent tincture; used topically as a wash or gargle at similar strength. Educational reference only, not a prescription.
References
Drug Class Interactions
Not documented
Lookalikes Review
References & Sources
- Mancini, E., Beglinger, C., Drewe, J., Zanchi, D. et al (2017) 'Green tea effects on cognition, mood and human brain function: A systematic review', Phytomedicine, 34, pp. 26-37. doi:10.1016/j.phymed.2017.07.008 Meta-analysis / review
https://doi.org/10.1016/j.phymed.2017.07.008 - Musial, C., Kuban-Jankowska, A. and Gorska-Ponikowska, M (2020) 'Beneficial Properties of Green Tea Catechins', International Journal of Molecular Sciences, 21(5), pp. 1744. doi:10.3390/ijms21051744 Traditional / reference
https://doi.org/10.3390/ijms21051744 - Ohishi, T., Goto, S., Monira, P., Isemura, M. and Nakamura, Y (2016) 'Anti-inflammatory Action of Green Tea', Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry, 15(2), pp. 74-90. doi:10.2174/1871523015666160915154443 Traditional / reference
https://doi.org/10.2174/1871523015666160915154443 - Zhao, T., Li, C., Wang, S. and Song, X (2022) 'Green Tea (Camellia sinensis): A Review of Its Phytochemistry, Pharmacology, and Toxicology', Molecules, 27(12), pp. 3909. doi:10.3390/molecules27123909 Meta-analysis / review
https://doi.org/10.3390/molecules27123909 - Filippini, T., Malavolti, M., Borrelli, F., Izzo, A.A., Fairweather-Tait, S.J., Horneber, M. and Vinceti, M (2020) 'Green tea (Camellia sinensis) for the prevention of cancer', Cochrane Database of Systematic Reviews, 3(3), pp. CD005004. doi:10.1002/14651858.CD005004.pub3 Meta-analysis / review
https://doi.org/10.1002/14651858.CD005004.pub3 - Prasanth, M.I., Sivamaruthi, B.S., Chaiyasut, C. and Tencomnao, T (2019) 'A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy', Nutrients, 11(2), pp. 474. doi:10.3390/nu11020474 Meta-analysis / review
https://doi.org/10.3390/nu11020474 - Bedrood, Z., Rameshrad, M. and Hosseinzadeh, H (2018) 'Toxicological effects of Camellia sinensis (green tea): A review', Phytotherapy Research, 32(7), pp. 1163-1180. doi:10.1002/ptr.6063 Meta-analysis / review
https://doi.org/10.1002/ptr.6063 - Hamilton-Miller, J.M.T (2001) 'Anti-cariogenic properties of tea (Camellia sinensis)', Journal of Medical Microbiology, 50(4), pp. 299-302. doi:10.1099/0022-1317-50-4-299 Meta-analysis / review
https://doi.org/10.1099/0022-1317-50-4-299 - Conde, V.R., Alves, M.G., Oliveira, P.F. and Silva, B.M (2015) 'Tea (Camellia sinensis (L.)): a putative anticancer agent in bladder carcinoma?', Anti-Cancer Agents in Medicinal Chemistry, 15(1), pp. 26-36. doi:10.2174/1566524014666141203143143 Meta-analysis / review
https://doi.org/10.2174/1566524014666141203143143 - Moore, R.J., Jackson, K.G. and Minihane, A.M (2009) 'Green tea (Camellia sinensis) catechins and vascular function', British Journal of Nutrition, 102(12), pp. 1790-1802. doi:10.1017/S0007114509991218 Meta-analysis / review
https://doi.org/10.1017/S0007114509991218 - Gaur, R. and Bao, G.H (2021) 'Chemistry and Pharmacology of Natural Catechins from Camellia sinensis as Anti-MRSA Agents', Current Topics in Medicinal Chemistry, 21(17), pp. 1519-1537. doi:10.2174/1568026621666210524100632 Meta-analysis / review
https://doi.org/10.2174/1568026621666210524100632 - Tafazoli, A. and Tafazoli Moghadam, E (2020) 'Camellia Sinensis Mouthwashes in Oral Care: a Systematic Review', Journal of Dentistry (Shiraz), 21(4), pp. 249-262. doi:10.30476/DENTJODS.2020.83204.1045 Meta-analysis / review
https://doi.org/10.30476/DENTJODS.2020.83204.1045 - Albassam, A.A. and Markowitz, J.S (2017) 'An Appraisal of Drug-Drug Interactions with Green Tea (Camellia sinensis)', Planta Medica, 83(6), pp. 496-508. doi:10.1055/s-0043-100934 Meta-analysis / review
https://doi.org/10.1055/s-0043-100934 - Gramza-Michalowska, A (2014) 'Caffeine in tea Camellia sinensis - content, absorption, benefits and risks of consumption', Journal of Nutrition, Health & Aging, 18(2), pp. 143-149. doi:10.1007/s12603-013-0404-1 Meta-analysis / review
https://doi.org/10.1007/s12603-013-0404-1 - Chacko, S.M. et al (2010) 'Beneficial effects of green tea: a literature review'. Traditional / reference
https://scholar.google.com/scholar?q=Beneficial%20effects%20of%20green%20tea%3A%20a%20literature%20review - European Medicines Agency (HMPC) (2013) 'Community herbal monograph on Camellia sinensis (L.) Kuntze, non fermentatum folium'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-camellia-sinensis-l-kuntze-non-fermentatum-folium_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-camellia-sinensis-l-kuntze-non-fermentatum-folium_en.pdf - Drake, V.J (2015) 'Tea catechins and cardiovascular disease risk', 74(1), pp. 39--46. Traditional / reference
https://scholar.google.com/scholar?q=Tea%20catechins%20and%20cardiovascular%20disease%20risk - Nobre, A.C., Rao, A. and Owen, G.N (2008) 'L-theanine, a natural constituent in tea, and its effect on mental state', pp. 167--168. Traditional / reference
https://scholar.google.com/scholar?q=L-theanine%2C%20a%20natural%20constituent%20in%20tea%2C%20and%20its%20effect%20on%20mental%20state - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Misaka, S., Yatabe, J., Muller, F., Takano, K., Kawabe, K., Glaeser, H., Yatabe, M.S., Onoue, S., Werba, J.P., Watanabe, H., Yamada, S., Fromm, M.F. and Kimura, J (2014) 'Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects', Clinical Pharmacology and Therapeutics, 95(4), pp. 432-438. doi:10.1038/clpt.2013.241 Randomized trial
https://doi.org/10.1038/clpt.2013.241 - Werba, J.P., Misaka, S., Giroli, M.G., Shimomura, K., Amato, M., Simonelli, N., Vigo, L. and Tremoli, E (2018) 'Update of green tea interactions with cardiovascular drugs and putative mechanisms', Journal of Food and Drug Analysis, 26(2S), pp. S72-S77. doi:10.1016/j.jfda.2018.01.008 Meta-analysis / review
https://doi.org/10.1016/j.jfda.2018.01.008
- Mir, R.H., Bhat, M.F., Sawhney, G., Kumar, P., Andrabi, N.I., Shaikh, M., Mohi-Ud-Din, R. and Masoodi, M.H (2022) 'Prunella vulgaris L.: Critical Pharmacological, Expository Traditional Uses and Extensive Phytochemistry: A Review', Current Drug Discovery Technologies, 19(1). doi:10.2174/1570163818666210203181542 Traditional / reference
https://doi.org/10.2174/1570163818666210203181542 - Pan, J. and Wang, H. and Chen, Y (2022) 'Prunella vulgaris L. - A Review of its Ethnopharmacology, Phytochemistry, Quality Control and Pharmacological Effects', Frontiers in Pharmacology, 13, pp. 903171. doi:10.3389/fphar.2022.903171 Meta-analysis / review
https://doi.org/10.3389/fphar.2022.903171 - Wang, S.J. and Wang, X.H. and Dai, Y.Y. and Ma, M.H. and Rahman, K. and Nian, H. and Zhang, H (2019) 'Prunella vulgaris: A Comprehensive Review of Chemical Constituents, Pharmacological Effects and Clinical Applications', Current Pharmaceutical Design, 25(3), pp. 359-369. doi:10.2174/1381612825666190313121608 Meta-analysis / review
https://doi.org/10.2174/1381612825666190313121608 - Zhu, M.J. and Song, Y.J. and Rao, P.L. and Gu, W.Y. and Xu, Y. and Xu, H.X (2025) 'Therapeutic role of Prunella vulgaris L. polysaccharides in non-alcoholic steatohepatitis and gut dysbiosis', Journal of Integrative Medicine, 23(3), pp. 297-308. doi:10.1016/j.joim.2025.03.002 Preclinical
https://doi.org/10.1016/j.joim.2025.03.002 - Zhang, Y. and Qu, X. and Xu, N. and He, H. and Li, Q. and Wei, X. and Chen, Y. and Xu, Y. and Li, X. and Zhang, R. and Zhong, R. and Liu, C. and Xiang, P. and Zhu, F (2024) 'Mechanism of Prunella vulgaris L. and luteolin in restoring Tfh/Tfr balance and alleviating oxidative stress in Graves' disease', Phytomedicine, 132, pp. 155818. doi:10.1016/j.phymed.2024.155818 Preclinical
https://doi.org/10.1016/j.phymed.2024.155818 - Zhang, S. and Wang, Y. and Wang, M. and Jiang, L. and Ma, X. and Huang, Y. and Liu, T. and Zheng, L. and Li, Y (2024) 'Construction and anti-pancreatic cancer activity of selenium nanoparticles stabilized by Prunella vulgaris polysaccharide', Int J Biol Macromol, 278(Pt 3), pp. 134924. doi:10.1016/j.ijbiomac.2024.134924 Preclinical
https://doi.org/10.1016/j.ijbiomac.2024.134924 - Ning, N. and Nan, Y. and Chen, G. and Huang, S. and Lu, D. and Yang, Y. and Meng, F. and Yuan, L (2024) 'Anti-Tumor Effects and Toxicity Reduction Mechanisms of Prunella vulgaris: A Comprehensive Review', Molecules, 29(8). doi:10.3390/molecules29081843 Meta-analysis / review
https://doi.org/10.3390/molecules29081843 - Han, Q. and Xu, N. and Chen, B. and Wu, W. and Sheng, L (2021) 'Safety and efficacy of Prunella vulgaris preparation in adjuvant treatment of thyroid nodules: A meta-analysis', Medicine (Baltimore), 100(41), pp. e27490. doi:10.1097/MD.0000000000027490 Meta-analysis / review
https://doi.org/10.1097/MD.0000000000027490 - Li, P. and Lv, X. and Wang, J. and Zhang, C. and Zhao, J. and Yang, Y (2023) 'Research on the anti-ageing mechanism of Prunella vulgaris L', Sci Rep, 13(1), pp. 12398. doi:10.1038/s41598-023-39609-1 Preclinical
https://doi.org/10.1038/s41598-023-39609-1 - Zhang, Q. and Chen, X. and Palen, K. and Johnson, B. and Bui, D. and Xiong, D. and Pan, J. and Hu, M. and Wang, Y. and You, M (2023) 'Cancer chemoprevention with PV-1, a novel Prunella vulgaris-containing herbal mixture that remodels the tumor immune microenvironment in mice', Front Immunol, 14, pp. 1196434. doi:10.3389/fimmu.2023.1196434 Preclinical
https://doi.org/10.3389/fimmu.2023.1196434 - Ma, F. and Deng, Q. and Lou, H. and Li, J. and Xu, S. and Wu, W. and Wen, Q. and Tang, L. and Wang, X. and Pan, W (2022) 'Vulgarisin-type diterpenoids from self-heal (Prunella vulgaris) and their neuroprotective effects against ischemia/reperfusion (I/R) via a mitochondria-related pathway', Food Funct, 13(13), pp. 7062-7074. doi:10.1039/d2fo00150k Preclinical
https://doi.org/10.1039/d2fo00150k - Xie, J. and Xiong, S. and Yu, J. and Ma, X. and Xiang, F. and Chen, Y. and Xia, B. and Li, Y. and Zhang, Z. and Liao, D. and Lin, L (2025) 'Prunella vulgaris polyphenols alleviate liver injury-uveitis comorbidity by regulating acylcarnitine via the S100A9-PP2A-AMPK pathway', Phytomedicine, 141, pp. 156675. doi:10.1016/j.phymed.2025.156675 Preclinical
https://doi.org/10.1016/j.phymed.2025.156675 - Li, Y. and Luo, H. and Lin, X. and Hua, L. and Wang, J. and Xie, J. and Zhang, Z. and Shi, Z. and Li, M. and Peng, Q. and Lin, L. and Liao, D. and Xia, B (2025) 'Triterpenes of Prunella vulgaris Inhibit Triple-Negative Breast Cancer by Regulating PTP1B/PI3K/AKT/mTOR and IL-24/CXCL12/CXCR4 Pathways', Int J Mol Sci, 26(5). doi:10.3390/ijms26051959 Preclinical
https://doi.org/10.3390/ijms26051959 - Zeng, S. and Liu, B. and Ge, R. and Yuan, Z. and Yang, Y. and Zhu, W. and Wang, Z (2025) 'An integrative analysis reveals mechanisms of Prunella vulgaris in thyroid cancer metastasis', Phytomedicine, 145, pp. 157051. doi:10.1016/j.phymed.2025.157051 Preclinical
https://doi.org/10.1016/j.phymed.2025.157051 - Zhu, Q. and Muyayalo, K.P. and Xu, Q.H. and Wang, J. and Wang, H. and Liao, A.H (2021) 'Prunella vulgaris can improve the pregnancy outcomes of experimental autoimmune thyroiditis rats by inhibiting Th1/Th17 immune responses', J Reprod Immunol, 149, pp. 103469. doi:10.1016/j.jri.2021.103469 Preclinical
https://doi.org/10.1016/j.jri.2021.103469 - Lin, J. and Zhou, J. and Ye, K. and Xie, F (2025) 'Prunella vulgaris: A potential molecule for the treatment of hepatocellular carcinoma', Medicine (Baltimore), 104(17), pp. e42267. doi:10.1097/MD.0000000000042267 Preclinical
https://doi.org/10.1097/MD.0000000000042267 - Li, L. and Lin, L. and Deng, J. and Lin, X. and Li, Y. and Xia, B (2021) 'The therapeutic effects of Prunella vulgaris against fluoride‐induced oxidative damage by using the metabolomics method', Environmental Toxicology, 36(9), pp. 1802-1816. doi:10.1002/tox.23301 Preclinical
https://doi.org/10.1002/tox.23301 - Wei, J. and Leng, L. and Sui, Y. and Song, S. and Owusu, F.B. and Li, X. and Cao, Y. and Li, P. and Wang, H. and Li, R. and Yang, W. and Gao, X. and Wang, Q (2023) 'Phenolic acids from Prunella vulgaris alleviate cardiac remodeling following myocardial infarction partially by suppressing NLRP3 activation', Phytotherapy Research, 38(1), pp. 384-399. doi:10.1002/ptr.8024 Preclinical
https://doi.org/10.1002/ptr.8024 - Jiao, X. and Liu, H. and Lu, Q. and Wang, Y. and Zhao, Y. and Liu, X. and Liu, F. and Zuo, Y. and Wang, W. and Li, Y (2021) 'Study on the Mechanism of Prunella Vulgaris L on Diabetes Mellitus Complicated with Hypertension Based on Network Pharmacology and Molecular Docking Analyses', Journal of Diabetes Research, 2021, pp. 1-14. doi:10.1155/2021/9949302 Preclinical
https://doi.org/10.1155/2021/9949302 - Namgung, S. and Yoon, J.J. and Yoon, C. and Han, B.H. and Choi, E.S. and Oh, H. and Kim, Y. and Lee, Y.J. and Kang, D.G. and Lee, H.S (2017) 'Prunella vulgarisAttenuates Diabetic Renal Injury by Suppressing Glomerular Fibrosis and Inflammation', The American Journal of Chinese Medicine, 45(03), pp. 475-495. doi:10.1142/s0192415x1750029x Preclinical
https://doi.org/10.1142/s0192415x1750029x - Lim, G. and Sung, J.Y. and Yu, S. and Kim, Y. and Kim, Y. and Shim, J. and Kim, H.J. and Cho, M.L. and Lee, J. and Kim, Y. and Kim, Y (2020) 'Pygenic Acid A (PA) Sensitizes Metastatic Breast Cancer Cells to Anoikis and Inhibits Metastasis In Vivo', International Journal of Molecular Sciences, 21(22), pp. 8444-8444. doi:10.3390/ijms21228444 Preclinical
https://doi.org/10.3390/ijms21228444 - Lin, Y. and Yang, C. and Tang, J. and Li, Q. and Zhang, Z. and Xia, B. and Li, Y. and He, Q. and Lin, L. and Liao, D (2020) 'Characterization and anti-uterine tumor effect of extract from Prunella vulgaris L', BMC Complementary Medicine and Therapies, 20(1), pp. 189-189. doi:10.1186/s12906-020-02986-5 Preclinical
https://doi.org/10.1186/s12906-020-02986-5 - Chen, Y. and Jiang, B. and Qu, C. and Jiang, C. and Zhang, C. and Wang, Y. and Chen, F. and Sun, X. and Su, L. and Luo, Y (2024) 'Bioactive components in prunella vulgaris for treating Hashimoto's disease via regulation of innate immune response in human thyrocytes', Heliyon, 10(16), pp. e36103-e36103. doi:10.1016/j.heliyon.2024.e36103 Preclinical
https://doi.org/10.1016/j.heliyon.2024.e36103 - Raafat, K. and Wurglics, M. and Schubert‐Zsilavecz, M (2016) 'Prunella vulgaris L. active components and their hypoglycemic and antinociceptive effects in alloxan-induced diabetic mice', Biomedicine & Pharmacotherapy, 84, pp. 1008-1018. doi:10.1016/j.biopha.2016.09.095 Preclinical
https://doi.org/10.1016/j.biopha.2016.09.095 - Qu, Z. and Zhang, J. and Yang, H. and Gao, J. and Chen, H. and Liu, C. and Gao, W (2016) 'Prunella vulgaris L., an Edible and Medicinal Plant, Attenuates Scopolamine-Induced Memory Impairment in Rats', Journal of Agricultural and Food Chemistry, 65(2), pp. 291-300. doi:10.1021/acs.jafc.6b04597 Preclinical
https://doi.org/10.1021/acs.jafc.6b04597 - Guo, Q. and Qu, H. and Zhang, H. and Zhong, X (2021) 'Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling', Drug Design Development and Therapy, Volume 15, pp. 4559-4574. doi:10.2147/dddt.s325814 Preclinical
https://doi.org/10.2147/dddt.s325814 - Akkol, E.K. and Renda, G. and İlhan, M. and Bektaş, N.Y (2022) 'Wound healing acceleration and anti-inflammatory potential of Prunella vulgaris L.: From conventional use to preclinical scientific verification', Journal of Ethnopharmacology, 295, pp. 115411-115411. doi:10.1016/j.jep.2022.115411 Preclinical
https://doi.org/10.1016/j.jep.2022.115411 - Yu, F. and Zhang, L. and Ma, R. and Liu, C. and Wang, Q. and Yin, D (2021) 'The Antitumour Effect of Prunella vulgaris Extract on Thyroid Cancer Cells In Vitro and In Vivo', Evidence-based Complementary and Alternative Medicine, 2021, pp. 1-12. doi:10.1155/2021/8869323 Preclinical
https://doi.org/10.1155/2021/8869323 - Zhong, X., Zhang, Y., Yuan, M., Xu, L., Luo, X., Wu, R., Xi, Z., Li, Y. and Xu, H (2024) 'Prunella vulgaris polysaccharide inhibits herpes simplex virus infection by blocking TLR-mediated NF-kB activation', Chinese Medicine, 19(1). doi:10.1186/s13020-023-00865-y Preclinical
https://doi.org/10.1186/s13020-023-00865-y - Zhang, Q., Li, Y., Zhong, X., Fu, W., Luo, X., Feng, J., Yuan, M., Xiao, L. and Xu, H (2021) 'Polyphenolic-protein-polysaccharide conjugates from Spica of Prunella vulgaris: Chemical profile and anti-herpes simplex virus activities', International Journal of Biological Macromolecules. doi:10.1016/j.ijbiomac.2021.11.200 Preclinical
https://doi.org/10.1016/j.ijbiomac.2021.11.200 - Ma, F.W., Kong, S.Y., Tan, H.S., Wu, R., Xia, B., Zhou, Y. and Xu, H.X (2016) 'Structural characterization and antiviral effect of a novel polysaccharide PSP-2B from Prunellae Spica', Carbohydrate Polymers, pp. 699--709. doi:10.1016/j.carbpol.2016.07.062 Preclinical
https://doi.org/10.1016/j.carbpol.2016.07.062 - Grieve, M (1931) 'A Modern Herbal'. Traditional / reference
https://scholar.google.com/scholar?q=A%20Modern%20Herbal - Psotova, J. et al (2003) 'Biological activities of Prunella vulgaris extract', 17(9), pp. 1082--1087. doi:10.1002/ptr.1324 Preclinical
https://doi.org/10.1002/ptr.1324 - Yang, Y.Q. et al (2007) 'Antiviral activity of aqueous extract of Prunella vulgaris L', 73(3), pp. 157--162. Traditional / reference
https://scholar.google.com/scholar?q=Antiviral%20activity%20of%20aqueous%20extract%20of%20Prunella%20vulgaris%20L - Haarberg, K.M.K., Wymore Brand, M.J., Overstreet, A.M.C., Hauck, C.C., Murphy, P.A., Hostetter, J.M., Ramer-Tait, A.E. and Wannemuehler, M.J (2015) 'Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a(-/-) mice', World Journal of Gastrointestinal Pharmacology and Therapeutics, 6(4), pp. 223--237. doi:10.4292/wjgpt.v6.i4.223 Preclinical
https://doi.org/10.4292/wjgpt.v6.i4.223 - Zhang, Y.B., Xu, L., Yuan, M., Liu, M.F., Li, Y., Zhong, X.L., Lin, Z.X., Xian, Y.F., Lu, P., Xi, Z.C. and Xu, H.X (2025) 'Protective effects of Prunella vulgaris polysaccharides against herpes simplex virus type 1 infection through the STING-TBK1-IRF3 pathway', Journal of Integrative Medicine, 24(3), pp. 454--465. doi:10.1016/j.joim.2025.12.008 Preclinical
https://doi.org/10.1016/j.joim.2025.12.008 - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.