Omnia SanaPlant Comparison
Tea vs Shiitake (mushroom)
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Tea and Shiitake (mushroom): they share 6 indicated uses (blood sugar / diabetes support, cancer (anticancer research), cardiovascular / heart health, …); 4 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Tea | Shiitake (mushroom) | Verdict |
|---|---|---|---|
| Blood sugar / diabetes support | 1/10 | 5/10 | Stronger for Shiitake (mushroom) |
| Cancer (anticancer research) | 8/10 | 2/10 | Stronger for Tea |
| Cardiovascular / heart health | 1/10 | 5/10 | Stronger for Shiitake (mushroom) |
| Infection (general) | 1/10 | 5/10 | Stronger for Shiitake (mushroom) |
| Metabolic support | 1/10 | 5/10 | Stronger for Shiitake (mushroom) |
| Wounds | 1/10 | 5/10 | Stronger for Shiitake (mushroom) |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Principal antioxidant polyphenols, most concentrated in minimally oxidised green tea; epigallocatechin gallate (EGCG) is the best studied.
Caffeine gives tea its mild stimulant effect; L-theanine, a unique amino acid, is associated with calm alertness and modulates caffeine's effects.
Oxidative polymerisation products of catechins formed during black tea processing, contributing to black tea's colour and its own antioxidant profile.
The principal immunomodulatory polysaccharide, used clinically in Japan as an injectable cancer-adjuvant therapy.
A unique amino-acid-derived compound studied for cholesterol-lowering activity.
Pharmacological Actions
Traditional & Indicated Uses
inferred from anti-inflammatory action
inferred from antidiabetic action
inferred from anticancer action
inferred from neuroprotective action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from antidiabetic action
inferred from anticancer action
inferred from antimicrobial action
inferred from antidiabetic action
Safety, Cautions & Contraindications
Generally safe in moderate consumption. High caffeine intake may cause insomnia, anxiety, palpitations, or dependence. Large amounts of green tea extract supplements may be hepatotoxic (rare). May reduce iron absorption if consumed with meals. Avoid very high supplement doses during pregnancy.
Duke (2002) rates tea (Camellia sinensis) as ++ and notes anti-aggregant, antioxidant, anticariogenic, and antibacterial activities at the experimental level (score 1). The catechins (EGCG, ECG) and polyphenols are responsible for the antioxidant and anticancer properties under research investigation. Duke notes that green tea preserves more polyphenols than black tea due to less oxidation. Regular tea consumption is associated with reduced cardiovascular risk. Excess consumption (>10 cups daily) may cause fluoride-related bone changes. Caffeine content is relevant for sleep disturbance, anxiety, and interactions with cardiovascular medications (Duke, 2002).
Generally very safe as a food. Raw or undercooked shiitake can cause a rare skin rash (shiitake dermatitis / flagellate dermatitis) in sensitive individuals — fully cooking eliminates this risk. May have mild anticoagulant effects. Rarely causes digestive upset. Well tolerated in normal culinary quantities.
Duke (2002) rates shiitake as +++ and notes immunostimulant, hypocholesterolemic, antibacterial, and anti-HIV activities at the experimental level (score 1). The key active compound is lentinan, a beta-1,3-glucan polysaccharide, which is used as an injectable anticancer drug in Japan. Duke notes clinical applications of shiitake preparations for immune support, cancer adjuvant therapy, and cholesterol management. Dose: 1–3 (606 mg) capsules up to three times daily for standardized preparations. Shiitake dermatitis (flagellate erythema) is a rare but recognized adverse effect from eating raw or undercooked shiitake — cooking prevents this (Duke, 2002).
External Ids
Botanical Description
Evergreen shrub or small tree with glossy, dark green, leathery, finely toothed leaves. Small, fragrant, white flowers with a prominent central boss of yellow stamens are borne singly or in small clusters in the leaf axils. Commercial tea is made from the young leaves and unopened leaf buds ('sprouts'), processed differently to yield green, black, white or oolong tea from the same species.[15]
Wood-decay fungus (not a true plant) with a classic cap-and-stem mushroom form. The cap is broad, brown to dark brown, often with pale scale-like markings, with a fringed or curled margin when young; the underside bears numerous cream-coloured gills radiating from a central or slightly off-centre fibrous stem.
Habitat
Native to the subtropical and tropical forests and hillsides of East and South Asia (China, India, Myanmar); cultivated extensively across Asia, Africa and elsewhere on well-drained, acidic upland soils.[15]
Grows naturally as a wood-decay fungus on fallen broadleaf trees (notably shii, oak and chestnut) in East Asian forests; almost all commercial shiitake today is cultivated on hardwood logs or sawdust blocks.
Harvesting
The youngest leaves and unopened leaf buds ('flush') are hand- or machine-picked repeatedly through the growing season; how the fresh leaf is subsequently processed (withered, rolled, oxidised, fixed and dried) determines whether it becomes green, black, white or oolong tea.[15]
Fruiting bodies are hand-picked once the cap has opened but before the margin fully flattens, then used fresh or dried; mycelium-based extracts are cultivated separately in liquid or grain culture.
Traditional Uses
Shiitake has a very long East Asian culinary and medicinal tradition, used in Chinese and Japanese medicine as a tonic for vitality and longevity and to support healthy qi and blood; its polysaccharide lentinan, isolated from the fruiting body, has been used clinically in Japan as an adjunct immunotherapy, directly building on this traditional immune-tonic reputation.[11]
Preparations
Young leaf, minimally oxidised, infused in hot water; the least-processed and most-studied form for antioxidant polyphenol content.
Concentrated leaf extract standardised to catechin (e.g. EGCG) content, taken as capsules; used in some clinical studies, though high-dose extracts carry rare hepatotoxicity concerns.
Fruiting-body or mycelium extract standardised to polysaccharide (lentinan/beta-glucan) content, taken as capsules for immune support.
Dosage
The EU herbal monograph on green tea leaf (Camelliae sinensis non fermentatum folium) gives, for adults and elderly, 1.8-2.2 g of the whole or comminuted leaf in 100-150 mL of boiling water as an infusion, 3-5 times daily; a powdered herbal substance at 390 mg three times daily (up to 5 if necessary) is also listed. Contraindicated in gastric and duodenal ulcers, cardiovascular disorders such as hypertension and arrhythmia, and hyperthyroidism. Not recommended under 18 years. Educational reference only, not a prescription.
Not documented
References
Drug Class Interactions
Not documented
Lookalikes Review
References & Sources
- Mancini, E., Beglinger, C., Drewe, J., Zanchi, D. et al (2017) 'Green tea effects on cognition, mood and human brain function: A systematic review', Phytomedicine, 34, pp. 26-37. doi:10.1016/j.phymed.2017.07.008 Meta-analysis / review
https://doi.org/10.1016/j.phymed.2017.07.008 - Musial, C., Kuban-Jankowska, A. and Gorska-Ponikowska, M (2020) 'Beneficial Properties of Green Tea Catechins', International Journal of Molecular Sciences, 21(5), pp. 1744. doi:10.3390/ijms21051744 Traditional / reference
https://doi.org/10.3390/ijms21051744 - Ohishi, T., Goto, S., Monira, P., Isemura, M. and Nakamura, Y (2016) 'Anti-inflammatory Action of Green Tea', Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry, 15(2), pp. 74-90. doi:10.2174/1871523015666160915154443 Traditional / reference
https://doi.org/10.2174/1871523015666160915154443 - Zhao, T., Li, C., Wang, S. and Song, X (2022) 'Green Tea (Camellia sinensis): A Review of Its Phytochemistry, Pharmacology, and Toxicology', Molecules, 27(12), pp. 3909. doi:10.3390/molecules27123909 Meta-analysis / review
https://doi.org/10.3390/molecules27123909 - Filippini, T., Malavolti, M., Borrelli, F., Izzo, A.A., Fairweather-Tait, S.J., Horneber, M. and Vinceti, M (2020) 'Green tea (Camellia sinensis) for the prevention of cancer', Cochrane Database of Systematic Reviews, 3(3), pp. CD005004. doi:10.1002/14651858.CD005004.pub3 Meta-analysis / review
https://doi.org/10.1002/14651858.CD005004.pub3 - Prasanth, M.I., Sivamaruthi, B.S., Chaiyasut, C. and Tencomnao, T (2019) 'A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy', Nutrients, 11(2), pp. 474. doi:10.3390/nu11020474 Meta-analysis / review
https://doi.org/10.3390/nu11020474 - Bedrood, Z., Rameshrad, M. and Hosseinzadeh, H (2018) 'Toxicological effects of Camellia sinensis (green tea): A review', Phytotherapy Research, 32(7), pp. 1163-1180. doi:10.1002/ptr.6063 Meta-analysis / review
https://doi.org/10.1002/ptr.6063 - Hamilton-Miller, J.M.T (2001) 'Anti-cariogenic properties of tea (Camellia sinensis)', Journal of Medical Microbiology, 50(4), pp. 299-302. doi:10.1099/0022-1317-50-4-299 Meta-analysis / review
https://doi.org/10.1099/0022-1317-50-4-299 - Conde, V.R., Alves, M.G., Oliveira, P.F. and Silva, B.M (2015) 'Tea (Camellia sinensis (L.)): a putative anticancer agent in bladder carcinoma?', Anti-Cancer Agents in Medicinal Chemistry, 15(1), pp. 26-36. doi:10.2174/1566524014666141203143143 Meta-analysis / review
https://doi.org/10.2174/1566524014666141203143143 - Moore, R.J., Jackson, K.G. and Minihane, A.M (2009) 'Green tea (Camellia sinensis) catechins and vascular function', British Journal of Nutrition, 102(12), pp. 1790-1802. doi:10.1017/S0007114509991218 Meta-analysis / review
https://doi.org/10.1017/S0007114509991218 - Gaur, R. and Bao, G.H (2021) 'Chemistry and Pharmacology of Natural Catechins from Camellia sinensis as Anti-MRSA Agents', Current Topics in Medicinal Chemistry, 21(17), pp. 1519-1537. doi:10.2174/1568026621666210524100632 Meta-analysis / review
https://doi.org/10.2174/1568026621666210524100632 - Tafazoli, A. and Tafazoli Moghadam, E (2020) 'Camellia Sinensis Mouthwashes in Oral Care: a Systematic Review', Journal of Dentistry (Shiraz), 21(4), pp. 249-262. doi:10.30476/DENTJODS.2020.83204.1045 Meta-analysis / review
https://doi.org/10.30476/DENTJODS.2020.83204.1045 - Albassam, A.A. and Markowitz, J.S (2017) 'An Appraisal of Drug-Drug Interactions with Green Tea (Camellia sinensis)', Planta Medica, 83(6), pp. 496-508. doi:10.1055/s-0043-100934 Meta-analysis / review
https://doi.org/10.1055/s-0043-100934 - Gramza-Michalowska, A (2014) 'Caffeine in tea Camellia sinensis - content, absorption, benefits and risks of consumption', Journal of Nutrition, Health & Aging, 18(2), pp. 143-149. doi:10.1007/s12603-013-0404-1 Meta-analysis / review
https://doi.org/10.1007/s12603-013-0404-1 - Chacko, S.M. et al (2010) 'Beneficial effects of green tea: a literature review'. Traditional / reference
https://scholar.google.com/scholar?q=Beneficial%20effects%20of%20green%20tea%3A%20a%20literature%20review - European Medicines Agency (HMPC) (2013) 'Community herbal monograph on Camellia sinensis (L.) Kuntze, non fermentatum folium'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-camellia-sinensis-l-kuntze-non-fermentatum-folium_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-camellia-sinensis-l-kuntze-non-fermentatum-folium_en.pdf - Drake, V.J (2015) 'Tea catechins and cardiovascular disease risk', 74(1), pp. 39--46. Traditional / reference
https://scholar.google.com/scholar?q=Tea%20catechins%20and%20cardiovascular%20disease%20risk - Nobre, A.C., Rao, A. and Owen, G.N (2008) 'L-theanine, a natural constituent in tea, and its effect on mental state', pp. 167--168. Traditional / reference
https://scholar.google.com/scholar?q=L-theanine%2C%20a%20natural%20constituent%20in%20tea%2C%20and%20its%20effect%20on%20mental%20state - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Misaka, S., Yatabe, J., Muller, F., Takano, K., Kawabe, K., Glaeser, H., Yatabe, M.S., Onoue, S., Werba, J.P., Watanabe, H., Yamada, S., Fromm, M.F. and Kimura, J (2014) 'Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects', Clinical Pharmacology and Therapeutics, 95(4), pp. 432-438. doi:10.1038/clpt.2013.241 Randomized trial
https://doi.org/10.1038/clpt.2013.241 - Werba, J.P., Misaka, S., Giroli, M.G., Shimomura, K., Amato, M., Simonelli, N., Vigo, L. and Tremoli, E (2018) 'Update of green tea interactions with cardiovascular drugs and putative mechanisms', Journal of Food and Drug Analysis, 26(2S), pp. S72-S77. doi:10.1016/j.jfda.2018.01.008 Meta-analysis / review
https://doi.org/10.1016/j.jfda.2018.01.008
- Jafari, M., Boskabady, M.H., Rezaee, S.A., Rezaeian, S. and others (2023) 'Lentinan and beta-glucan extract from shiitake mushroom, Lentinula edodes, alleviate acute LPS-induced hematological changes in mice', Iranian Journal of Basic Medical Sciences, 26(7), pp. 836-842. doi:10.22038/IJBMS.2023.67669.14820 Preclinical
https://doi.org/10.22038/IJBMS.2023.67669.14820 - Ahn, H., Jeon, E., Kim, J.C., Kang, S.G. and others (2017) 'Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production', Scientific Reports, 7(1), pp. 1314. doi:10.1038/s41598-017-01462-4 Preclinical
https://doi.org/10.1038/s41598-017-01462-4 - Okamoto, T., Kodoi, R., Nonaka, Y., Fukuda, I. and others (2004) 'Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver', BioFactors, 21(1-4), pp. 407-409. doi:10.1002/biof.552210180 Preclinical
https://doi.org/10.1002/biof.552210180 - Ng, M.L. and Yap, A.T (2002) 'Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes)', Journal of Alternative and Complementary Medicine, 8(5), pp. 581-589. doi:10.1089/107555302320825093 Preclinical
https://doi.org/10.1089/107555302320825093 - Bisen, P.S., Baghel, R.K., Sanodiya, B.S., Thakur, G.S. and Prasad, G.B.K.S (2010) 'Lentinus edodes: a macrofungus with pharmacological activities', Current Medicinal Chemistry, 17(22), pp. 2419-2430. doi:10.2174/092986710791698495 Meta-analysis / review
https://doi.org/10.2174/092986710791698495 - Stephany, M.P., Chung, S., Handler, M.Z., Handler, N.S. and others (2016) 'Shiitake Mushroom Dermatitis: A Review', American Journal of Clinical Dermatology, 17(5), pp. 485-489. doi:10.1007/s40257-016-0212-6 Meta-analysis / review
https://doi.org/10.1007/s40257-016-0212-6 - Nguyen, A.H., Gonzaga, M.I., Lim, V.M., Adler, M.J. and others (2017) 'Clinical features of shiitake dermatitis: a systematic review', International Journal of Dermatology, 56(6), pp. 610-616. doi:10.1111/ijd.13433 Meta-analysis / review
https://doi.org/10.1111/ijd.13433 - Djordjevic, B., Skugor, S., Jorgensen, S.M., Overland, M. and others (2009) 'Modulation of splenic immune responses to bacterial lipopolysaccharide in rainbow trout (Oncorhynchus mykiss) fed lentinan, a beta-glucan from mushroom Lentinula edodes', Fish & Shellfish Immunology, 26(2), pp. 201-209. doi:10.1016/j.fsi.2008.10.012 Preclinical
https://doi.org/10.1016/j.fsi.2008.10.012 - Kaleta, B., Gorski, A., Zagozdzon, R., Cieslak, M. and others (2019) 'Selenium-containing polysaccharides from Lentinula edodes-Biological activity', Carbohydrate Polymers, 223, pp. 115078. doi:10.1016/j.carbpol.2019.115078 Preclinical
https://doi.org/10.1016/j.carbpol.2019.115078 - Money, N.P (2016) 'Are mushrooms medicinal?', Fungal Biology, 120(4), pp. 449-453. doi:10.1016/j.funbio.2016.01.006 Meta-analysis / review
https://doi.org/10.1016/j.funbio.2016.01.006 - Vethanayagam, R.R. et al (1996) 'Lentinan — a novel immunomodulator', 54(2), pp. 25--30. Traditional / reference
https://scholar.google.com/scholar?q=Lentinan%20%E2%80%94%20a%20novel%20immunomodulator - Wasser, S.P (2011) 'Current findings, future trends, and unsolved problems in studies of medicinal mushrooms', 89(5), pp. 1323--1332. doi:10.1007/s00253-010-3067-4 Randomized trial
https://doi.org/10.1007/s00253-010-3067-4 - Yokota, M (1989) 'Observatory trial of anti-obesity activity of Eritadenine', pp. 1--4. Traditional / reference
https://scholar.google.com/scholar?q=Observatory%20trial%20of%20anti-obesity%20activity%20of%20Eritadenine - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.