Omnia SanaPlant Comparison
Tea vs Lions mane
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Tea and Lions mane: they share 6 indicated uses (arthritis / joint pain, cancer (anticancer research), cognitive function, …); 3 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Tea | Lions mane | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 1/10 | 5/10 | Stronger for Lions mane |
| Cancer (anticancer research) | 8/10 | 1/10 | Stronger for Tea |
| Cognitive function | 1/10 | 7/10 | Stronger for Lions mane |
| Inflammation (general) | 1/10 | 5/10 | Stronger for Lions mane |
| Memory | 1/10 | 7/10 | Stronger for Lions mane |
| Skin irritation | 1/10 | 5/10 | Stronger for Lions mane |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Principal antioxidant polyphenols, most concentrated in minimally oxidised green tea; epigallocatechin gallate (EGCG) is the best studied.
Caffeine gives tea its mild stimulant effect; L-theanine, a unique amino acid, is associated with calm alertness and modulates caffeine's effects.
Oxidative polymerisation products of catechins formed during black tea processing, contributing to black tea's colour and its own antioxidant profile.
Diterpenoid erinacines (concentrated in the mycelium) and aromatic hericenones (in the fruiting body) are the signature low-molecular-weight compounds that stimulate nerve growth factor synthesis and underlie the mushroom's neurotrophic and neuroprotective effects.
Pharmacological Actions
Traditional & Indicated Uses
inferred from anti-inflammatory action
inferred from antidiabetic action
inferred from anticancer action
inferred from neuroprotective action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from anticancer action
inferred from neuroprotective action
inferred from immunomodulator action
inferred from digestive action
inferred from anti-inflammatory action
Safety, Cautions & Contraindications
Generally safe in moderate consumption. High caffeine intake may cause insomnia, anxiety, palpitations, or dependence. Large amounts of green tea extract supplements may be hepatotoxic (rare). May reduce iron absorption if consumed with meals. Avoid very high supplement doses during pregnancy.
Duke (2002) rates tea (Camellia sinensis) as ++ and notes anti-aggregant, antioxidant, anticariogenic, and antibacterial activities at the experimental level (score 1). The catechins (EGCG, ECG) and polyphenols are responsible for the antioxidant and anticancer properties under research investigation. Duke notes that green tea preserves more polyphenols than black tea due to less oxidation. Regular tea consumption is associated with reduced cardiovascular risk. Excess consumption (>10 cups daily) may cause fluoride-related bone changes. Caffeine content is relevant for sleep disturbance, anxiety, and interactions with cardiovascular medications (Duke, 2002).
Mild gastrointestinal upset (nausea, bloating, diarrhoea) is the most common side effect. Rare allergic reactions can occur, particularly in individuals sensitive to mushrooms, and it may slightly lower blood sugar or have mild blood-thinning effects, so caution is advised for people on diabetes or anticoagulant medications.
External Ids
Botanical Description
Evergreen shrub or small tree with glossy, dark green, leathery, finely toothed leaves. Small, fragrant, white flowers with a prominent central boss of yellow stamens are borne singly or in small clusters in the leaf axils. Commercial tea is made from the young leaves and unopened leaf buds ('sprouts'), processed differently to yield green, black, white or oolong tea from the same species.[15]
Wood-decay fungus (not a true plant) forming a distinctive rounded, cushion-like fruiting body covered in long, dangling, tooth-like spines rather than gills or pores, resembling a white or cream 'lion's mane' or icicle cluster. It grows as a single mass rather than a typical cap-and-stem mushroom, on wounds or dead wood of hardwood trees.
Habitat
Native to the subtropical and tropical forests and hillsides of East and South Asia (China, India, Myanmar); cultivated extensively across Asia, Africa and elsewhere on well-drained, acidic upland soils.[15]
Grows on wounds, dead or dying wood of hardwood trees (notably oak and beech) in temperate forests of the Northern Hemisphere; also widely cultivated commercially on hardwood logs or sawdust substrate.
Harvesting
The youngest leaves and unopened leaf buds ('flush') are hand- or machine-picked repeatedly through the growing season; how the fresh leaf is subsequently processed (withered, rolled, oxidised, fixed and dried) determines whether it becomes green, black, white or oolong tea.[15]
Wild fruiting bodies are collected once mature; cultivated material is harvested from logs or substrate at maturity, then used fresh, dried, or processed into mycelium-based supplements.
Traditional Uses
Lion's mane has a long East Asian culinary and medicinal tradition, valued in Chinese and Japanese medicine as a digestive tonic and, more recently, intensively studied for its unique ability to stimulate nerve growth factor, giving it a modern reputation as a neurotrophic and cognitive-support mushroom.[1]
Preparations
Young leaf, minimally oxidised, infused in hot water; the least-processed and most-studied form for antioxidant polyphenol content.
Concentrated leaf extract standardised to catechin (e.g. EGCG) content, taken as capsules; used in some clinical studies, though high-dose extracts carry rare hepatotoxicity concerns.
Fruiting-body or mycelium extract standardised to erinacine or hericenone content, taken as capsules or powder; the form used in most clinical cognitive-support studies.
Dosage
The EU herbal monograph on green tea leaf (Camelliae sinensis non fermentatum folium) gives, for adults and elderly, 1.8-2.2 g of the whole or comminuted leaf in 100-150 mL of boiling water as an infusion, 3-5 times daily; a powdered herbal substance at 390 mg three times daily (up to 5 if necessary) is also listed. Contraindicated in gastric and duodenal ulcers, cardiovascular disorders such as hypertension and arrhythmia, and hyperthyroidism. Not recommended under 18 years. Educational reference only, not a prescription.
A 49-week double-blind randomised trial in mild Alzheimer's disease used three erinacine A-enriched H. erinaceus mycelia capsules per day at 350 mg per capsule, i.e. 1050 mg daily. Other clinical studies of cognitive support commonly use around 1-3 g of dried fruiting body extract daily. Educational reference only, not a prescription.
References
Drug Class Interactions
Not documented
Lookalikes Review
References & Sources
- Mancini, E., Beglinger, C., Drewe, J., Zanchi, D. et al (2017) 'Green tea effects on cognition, mood and human brain function: A systematic review', Phytomedicine, 34, pp. 26-37. doi:10.1016/j.phymed.2017.07.008 Meta-analysis / review
https://doi.org/10.1016/j.phymed.2017.07.008 - Musial, C., Kuban-Jankowska, A. and Gorska-Ponikowska, M (2020) 'Beneficial Properties of Green Tea Catechins', International Journal of Molecular Sciences, 21(5), pp. 1744. doi:10.3390/ijms21051744 Traditional / reference
https://doi.org/10.3390/ijms21051744 - Ohishi, T., Goto, S., Monira, P., Isemura, M. and Nakamura, Y (2016) 'Anti-inflammatory Action of Green Tea', Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry, 15(2), pp. 74-90. doi:10.2174/1871523015666160915154443 Traditional / reference
https://doi.org/10.2174/1871523015666160915154443 - Zhao, T., Li, C., Wang, S. and Song, X (2022) 'Green Tea (Camellia sinensis): A Review of Its Phytochemistry, Pharmacology, and Toxicology', Molecules, 27(12), pp. 3909. doi:10.3390/molecules27123909 Meta-analysis / review
https://doi.org/10.3390/molecules27123909 - Filippini, T., Malavolti, M., Borrelli, F., Izzo, A.A., Fairweather-Tait, S.J., Horneber, M. and Vinceti, M (2020) 'Green tea (Camellia sinensis) for the prevention of cancer', Cochrane Database of Systematic Reviews, 3(3), pp. CD005004. doi:10.1002/14651858.CD005004.pub3 Meta-analysis / review
https://doi.org/10.1002/14651858.CD005004.pub3 - Prasanth, M.I., Sivamaruthi, B.S., Chaiyasut, C. and Tencomnao, T (2019) 'A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy', Nutrients, 11(2), pp. 474. doi:10.3390/nu11020474 Meta-analysis / review
https://doi.org/10.3390/nu11020474 - Bedrood, Z., Rameshrad, M. and Hosseinzadeh, H (2018) 'Toxicological effects of Camellia sinensis (green tea): A review', Phytotherapy Research, 32(7), pp. 1163-1180. doi:10.1002/ptr.6063 Meta-analysis / review
https://doi.org/10.1002/ptr.6063 - Hamilton-Miller, J.M.T (2001) 'Anti-cariogenic properties of tea (Camellia sinensis)', Journal of Medical Microbiology, 50(4), pp. 299-302. doi:10.1099/0022-1317-50-4-299 Meta-analysis / review
https://doi.org/10.1099/0022-1317-50-4-299 - Conde, V.R., Alves, M.G., Oliveira, P.F. and Silva, B.M (2015) 'Tea (Camellia sinensis (L.)): a putative anticancer agent in bladder carcinoma?', Anti-Cancer Agents in Medicinal Chemistry, 15(1), pp. 26-36. doi:10.2174/1566524014666141203143143 Meta-analysis / review
https://doi.org/10.2174/1566524014666141203143143 - Moore, R.J., Jackson, K.G. and Minihane, A.M (2009) 'Green tea (Camellia sinensis) catechins and vascular function', British Journal of Nutrition, 102(12), pp. 1790-1802. doi:10.1017/S0007114509991218 Meta-analysis / review
https://doi.org/10.1017/S0007114509991218 - Gaur, R. and Bao, G.H (2021) 'Chemistry and Pharmacology of Natural Catechins from Camellia sinensis as Anti-MRSA Agents', Current Topics in Medicinal Chemistry, 21(17), pp. 1519-1537. doi:10.2174/1568026621666210524100632 Meta-analysis / review
https://doi.org/10.2174/1568026621666210524100632 - Tafazoli, A. and Tafazoli Moghadam, E (2020) 'Camellia Sinensis Mouthwashes in Oral Care: a Systematic Review', Journal of Dentistry (Shiraz), 21(4), pp. 249-262. doi:10.30476/DENTJODS.2020.83204.1045 Meta-analysis / review
https://doi.org/10.30476/DENTJODS.2020.83204.1045 - Albassam, A.A. and Markowitz, J.S (2017) 'An Appraisal of Drug-Drug Interactions with Green Tea (Camellia sinensis)', Planta Medica, 83(6), pp. 496-508. doi:10.1055/s-0043-100934 Meta-analysis / review
https://doi.org/10.1055/s-0043-100934 - Gramza-Michalowska, A (2014) 'Caffeine in tea Camellia sinensis - content, absorption, benefits and risks of consumption', Journal of Nutrition, Health & Aging, 18(2), pp. 143-149. doi:10.1007/s12603-013-0404-1 Meta-analysis / review
https://doi.org/10.1007/s12603-013-0404-1 - Chacko, S.M. et al (2010) 'Beneficial effects of green tea: a literature review'. Traditional / reference
https://scholar.google.com/scholar?q=Beneficial%20effects%20of%20green%20tea%3A%20a%20literature%20review - European Medicines Agency (HMPC) (2013) 'Community herbal monograph on Camellia sinensis (L.) Kuntze, non fermentatum folium'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-camellia-sinensis-l-kuntze-non-fermentatum-folium_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-camellia-sinensis-l-kuntze-non-fermentatum-folium_en.pdf - Drake, V.J (2015) 'Tea catechins and cardiovascular disease risk', 74(1), pp. 39--46. Traditional / reference
https://scholar.google.com/scholar?q=Tea%20catechins%20and%20cardiovascular%20disease%20risk - Nobre, A.C., Rao, A. and Owen, G.N (2008) 'L-theanine, a natural constituent in tea, and its effect on mental state', pp. 167--168. Traditional / reference
https://scholar.google.com/scholar?q=L-theanine%2C%20a%20natural%20constituent%20in%20tea%2C%20and%20its%20effect%20on%20mental%20state - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Misaka, S., Yatabe, J., Muller, F., Takano, K., Kawabe, K., Glaeser, H., Yatabe, M.S., Onoue, S., Werba, J.P., Watanabe, H., Yamada, S., Fromm, M.F. and Kimura, J (2014) 'Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects', Clinical Pharmacology and Therapeutics, 95(4), pp. 432-438. doi:10.1038/clpt.2013.241 Randomized trial
https://doi.org/10.1038/clpt.2013.241 - Werba, J.P., Misaka, S., Giroli, M.G., Shimomura, K., Amato, M., Simonelli, N., Vigo, L. and Tremoli, E (2018) 'Update of green tea interactions with cardiovascular drugs and putative mechanisms', Journal of Food and Drug Analysis, 26(2S), pp. S72-S77. doi:10.1016/j.jfda.2018.01.008 Meta-analysis / review
https://doi.org/10.1016/j.jfda.2018.01.008
- Szucko-Kociuba, I., Trzeciak-Ryczek, A., Kupnicka, P. and Chlubek, D (2023) 'Neurotrophic and Neuroprotective Effects of Hericium erinaceus', International Journal of Molecular Sciences, 24(21). doi:10.3390/ijms242115960 Preclinical
https://doi.org/10.3390/ijms242115960 - Contato, A.G. and Conte-Junior, C.A (2025) 'Lion's Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential - A Narrative Review', Nutrients, 17(8), pp. 1307. doi:10.3390/nu17081307 Meta-analysis / review
https://doi.org/10.3390/nu17081307 - Li, I.C. and Chang, H.H. and Lin, C.H. and Chen, W.P. and Lu, T.H. and Lee, L.Y. and Chen, Y.W. and Chen, Y.P. and Chen, C.C. and Lin, D.P (2020) 'Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study', Frontiers in Aging Neuroscience, 12, pp. 155. doi:10.3389/fnagi.2020.00155 Clinical study
https://doi.org/10.3389/fnagi.2020.00155 - Friedman, M (2015) 'Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds', Journal of Agricultural and Food Chemistry, 63(32), pp. 7108-7123. doi:10.1021/acs.jafc.5b02914 Meta-analysis / review
https://doi.org/10.1021/acs.jafc.5b02914 - Xie, G. and Tang, L. and Xie, Y. and Xie, L (2022) 'Secondary Metabolites from Hericium erinaceus and Their Anti-Inflammatory Activities', Molecules, 27(7), pp. 2157. doi:10.3390/molecules27072157 Preclinical
https://doi.org/10.3390/molecules27072157 - Li, H., Feng, J., Liu, C., Hou, S., Meng, J., Liu, J.Y. and others (2024) 'Polysaccharides from an edible mushroom, Hericium erinaceus, alleviate ulcerative colitis in mice by inhibiting the NLRP3 inflammasomes and reestablish intestinal homeostasis', International Journal of Biological Macromolecules. doi:10.1016/j.ijbiomac.2024.131251 Preclinical
https://doi.org/10.1016/j.ijbiomac.2024.131251 - Shi, X.Z., Zhang, X.Y., Wang, Y.Y., Zhao, Y.M. and Wang, J (2024) 'Polysaccharides from Hericium erinaceus and its immunomodulatory effects on RAW 264.7 macrophages', International Journal of Biological Macromolecules. doi:10.1016/j.ijbiomac.2024.134947 Preclinical
https://doi.org/10.1016/j.ijbiomac.2024.134947 - Liu, J.H., Li, L., Shang, X.D., Zhang, J.L. and Tan, Q (2016) 'An experimental research on the anti-gastric-cancer activity of hericenone B extracted from Hericium erinaceus', 37(1), pp. 1--8. Traditional / reference
https://scholar.google.com/scholar?q=An%20experimental%20research%20on%20the%20anti-gastric-cancer%20activity%20of%20hericenone%20B%20extracted%20from%20Hericium%20erinaceus - Mori, K., Inatomi, S., Ouchi, K., Azumi, Y. and Tuchida, T (2009) 'Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial', 23(3), pp. 367--372. doi:10.1002/ptr.2634 Randomized trial
https://doi.org/10.1002/ptr.2634 - National Institutes of Health (2023) 'Hericium erinaceus'. Available at: https://pubmed.ncbi.nlm.nih.gov/?term=hericium+erinaceus Traditional / reference
https://pubmed.ncbi.nlm.nih.gov/?term=hericium+erinaceus - Pellegrino, R. and Gravina, A.G (2025) 'Potential of traditional Chinese medicine in gastrointestinal disorders: Hericium erinaceus in chronic atrophic gastritis', World Journal of Gastroenterology, 31(20). doi:10.3748/wjg.v31.i20.106615 Traditional / reference
https://doi.org/10.3748/wjg.v31.i20.106615 - Docherty, S., Doughty, F.L. and Smith, E.F (2023) 'The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study', Nutrients, 15(22). doi:10.3390/nu15224842 Randomized trial
https://doi.org/10.3390/nu15224842 - Surendran, G., Saye, J., Binti Mohd Jalil, S., Spreadborough, J., Duong, K., Shatwan, I.M. and others (2025) 'Acute effects of a standardised extract of Hericium erinaceus (Lion's Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study', Frontiers in Nutrition. doi:10.3389/fnut.2025.1405796 Randomized trial
https://doi.org/10.3389/fnut.2025.1405796 - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.