Plant Comparison
Pot marigold vs Selfheal
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Pot marigold and Selfheal: they share 7 indicated uses (arthritis / joint pain, bruising, cancer (anticancer research), …); 5 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Pot marigold | Selfheal | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 5/10 | 2/10 | Stronger for Pot marigold |
| Bruising | 5/10 | 2/10 | Stronger for Pot marigold |
| Cancer (anticancer research) | 7/10 | 7/10 | Comparable evidence |
| Infection (general) | 5/10 | 2/10 | Stronger for Pot marigold |
| Inflammation (general) | 5/10 | 2/10 | Stronger for Pot marigold |
| Skin irritation | 5/10 | 2/10 | Stronger for Pot marigold |
| Wounds | 5/10 | 2/10 | Stronger for Pot marigold |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Principal wound-healing and anti-inflammatory constituents of the flower.
Antioxidant flavonoids and carotenoids give the flower its orange-yellow colour and contribute to its antioxidant activity.
Minor aromatic and resinous constituents of the flower head.
Pentacyclic triterpenoids (ursolic, oleanolic and betulinic acids), the phenolic acid rosmarinic acid, coumarins (umbelliferone, scopoletin, esculetin) and the flavonoid luteolin are the main bioactives behind self-heal's antioxidant, anti-inflammatory and antimicrobial activity.
Water-extracted polysaccharides — including a partially sulphated arabinogalactomannan (PSP-2B) and polyphenolic-protein-polysaccharide conjugates (PVG/PVE30) — are the principal antiviral and immunomodulatory constituents, blocking herpes simplex virus attachment and modulating innate immune signalling.
Pharmacological Actions
Calendula officinalis extracts show cytotoxic antitumor, pro-apoptotic and antimetastatic activity across many cancer cell lines and in animal models (preclinical).
Traditional & Indicated Uses
inferred from anti-inflammatory action
A Calendula officinalis (LACE) aqueous extract inhibits proliferation (70-100%) of leukemia, melanoma, breast, prostate, lung and colon cancer cell lines via G0/G1 arrest and caspase-3 apoptosis and inhibits melanoma growth in nude mice; a systematic review documents its cytotoxic and antimetastatic antitumour activity (preclinical).
inferred from antifungal action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from antiviral action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from antimicrobial action
inferred from anticancer action
Safety, Cautions & Contraindications
Generally very safe for topical use. May cause contact dermatitis in rare cases (Asteraceae family allergy). Internal use is safe in normal doses. Avoid during pregnancy at therapeutic doses (uterine stimulant potential). Generally safe during breastfeeding for topical use.
Duke (2002) rates calendula (Calendula officinalis) and notes anti-inflammatory, wound-healing (vulnerary), antifungal, and antispasmodic activities at experimental levels. Commission E (KOM) approves calendula flower for wound healing and anti-inflammatory uses, both topically and as a gargle. The plant contains flavonoids, triterpene saponins (oleanolic acid glycosides), and essential oils. Dose: 1–2 g dried flower as tea (for mouth rinse/gargle); or as cream/ointment containing 2–5% calendula extract for topical use. Duke notes that calendula is generally very well-tolerated, though Asteraceae sensitivity can occasionally cause allergic reactions (Duke, 2002).
Generally very safe and well tolerated. No significant known toxicity or drug interactions. Safe for topical and internal use in normal medicinal doses. Suitable for most adults including children in appropriate doses.
Duke (2002) rates self-heal as +++ and notes antioxidant (score 2), anti-inflammatory, antiviral, and COX-2 inhibitory activities. The plant contains luteolin, rosmarinic acid, and hyperoside — all with well-documented bioactivities. Hepatoprotective activity has been experimentally demonstrated. Duke notes that self-heal has a broad antimicrobial spectrum and an impressive antioxidant profile, supporting its traditional reputation as a versatile wound-healing herb. No significant safety concerns at normal herbal doses (Duke, 2002).
External Ids
Botanical Description
Aromatic annual or short-lived perennial herb with soft, hairy, oblong leaves and branching, slightly sticky stems. The flower heads are bright orange to yellow, daisy-like, with numerous narrow ray florets surrounding a darker central disc, opening in sunlight and closing at dusk.[1]
Low, creeping to semi-erect perennial herb (Lamiaceae), 5-30 cm tall, with square, often purplish stems. Leaves are opposite, ovate with slightly toothed margins. Small, two-lipped, violet-purple flowers are densely packed into a compact, club-shaped terminal spike subtended by purplish bracts.[1]
Habitat
Widely cultivated as a garden and medicinal plant; believed native to southern Europe and the Mediterranean, now naturalised in gardens and waste ground worldwide.[1]
Native throughout Europe, Asia and North America (circumboreal), extremely common in lawns, meadows, woodland clearings, roadsides and waste ground, tolerating mowing and a wide range of soils.[1]
Harvesting
The flower heads (or just the ray-floret petals) are picked by hand as they open, through the flowering season, and dried quickly in a warm, shaded, airy place to preserve colour and resin content.[1]
Whole flowering aerial parts (flower, leaf and stem) are cut during flowering (summer) and dried.[1]
Traditional Uses
Calendula flower is one of the most widely used topical wound-healing and skin-soothing herbs in Western herbal medicine, applied to cuts, grazes, minor burns and skin inflammation, and used internally as a gentle anti-inflammatory and antimicrobial remedy and as a gargle for mouth and throat irritation.[1]
Selfheal has an extremely broad folk-medicine reputation across European, North American and Traditional Chinese Medicine traditions - as its name suggests, used as an all-purpose wound herb, gargle for sore throat, and internal remedy for fevers and inflammation. Modern research on its triterpenoid, phenolic and polysaccharide constituents supports wide-ranging antioxidant, anti-inflammatory, antimicrobial and antiviral activity.[1]
Preparations
Dried petals infused in a carrier oil, used as a soothing base for topical creams and balms for skin healing.
Standardised flower extract formulated into a cream or ointment for topical wound and skin care; the best-studied modern form.
Dried flower infused in hot water, 1-2 g in 150 ml, used still warm as a mouth rinse or gargle 2-4 times daily. The EU herbal monograph's posology for this preparation is OROMUCOSAL only - it does not support taking the infusion internally. Educational reference only, not a prescription.
Dried aerial parts steeped in hot water, taken internally or used as a gargle or wash.
Dosage
The EU herbal monograph gives semi-solid preparations containing the equivalent of 2-10% herbal substance, applied as a thin layer to the affected area 2 to 4 times daily. Educational reference only, not a prescription.
The EU herbal monograph gives 1-2 g of the flower in 150 mL water as an infusion, used still warm for rinsing and gargling 2 to 4 times daily, or to prepare impregnated dressings for the skin. This is an oromucosal and cutaneous preparation, not an oral tea. Educational reference only, not a prescription.
Traditional guidance suggests roughly 2-4 g dried herb per cup as an infusion, up to three times daily, or an equivalent tincture; used topically as a wash or gargle at similar strength. Educational reference only, not a prescription.
References
Lookalikes Review
References & Sources
- Givol, O., Kornhaber, R., Visentin, D., Cleary, M. et al (2019) 'A systematic review of Calendula officinalis extract for wound healing', Wound Repair and Regeneration, 27(5), pp. 548-561. doi:10.1111/wrr.12737 Meta-analysis / review
https://doi.org/10.1111/wrr.12737 - Shahane, K., Kshirsagar, M., Tambe, S., Jain, D. et al (2023) 'An Updated Review on the Multifaceted Therapeutic Potential of Calendula officinalis L', Pharmaceuticals (Basel), 16(4), pp. 611. doi:10.3390/ph16040611 Traditional / reference
https://doi.org/10.3390/ph16040611 - Saffari, E., Mohammad-Alizadeh-Charandabi, S., Adibpour, M., Mirghafourvand, M. et al (2016) 'Comparing the effects of Calendula officinalis and clotrimazole on vaginal Candidiasis: A randomized controlled trial', Women & Health, 57(10), pp. 1145-1160. doi:10.1080/03630242.2016.1263272 Randomized trial
https://doi.org/10.1080/03630242.2016.1263272 - Cruceriu, D., Balacescu, O. and Rakosy, E (2018) 'Calendula officinalis: potential roles in cancer treatment and palliative care', Integrative Cancer Therapies, 17(4), pp. 1068-1078. doi:10.1177/1534735418803766 Meta-analysis / review
https://doi.org/10.1177/1534735418803766 - Rezai, S., Rahzani, K., Hekmatpou, D. and Rostami, A (2023) 'Effect of oral Calendula officinalis on second-degree burn wound healing', Scars, Burns & Healing, 9, pp. 20595131221134053. doi:10.1177/20595131221134053 Randomized trial
https://doi.org/10.1177/20595131221134053 - Kadowaki, W., Miyata, R., Mizuno, S., Fujinami, M., Sato, Y. and Kumazawa, S (2023) 'Prenylated acetophenones from the roots of Calendula officinalis and their anti-inflammatory activity', Bioscience, Biotechnology, and Biochemistry, 87(7), pp. 683-687. doi:10.1093/bbb/zbad042 Preclinical
https://doi.org/10.1093/bbb/zbad042 - Samra, R.M., Maatooq, G.T. and Zaki, A.A (2022) 'A new antiprotozoal compound from Calendula officinalis', Natural Product Research, 36(22), pp. 5747-5752. doi:10.1080/14786419.2021.2023868 Preclinical
https://doi.org/10.1080/14786419.2021.2023868 - Kaur, J., Sidhu, S., Chopra, K. and Khan, M.U (2016) 'Calendula officinalis ameliorates l-arginine-induced acute necrotizing pancreatitis in rats', Pharmaceutical Biology, 54(12), pp. 2951-2959. doi:10.1080/13880209.2016.1195848 Preclinical
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https://doi.org/10.1002/ar.23057 - Zhang, X., Wang, R., Finiuk, N., Stoika, R., Lin, H., Wang, X. and Jin, M (2023) 'Active compounds from Calendula officinalis flowers act via PI3K and ERK signaling pathways to offer neuroprotective effects against Parkinson's disease', Food Science & Nutrition, 12(1), pp. 450-458. doi:10.1002/fsn3.3792 Preclinical
https://doi.org/10.1002/fsn3.3792 - Kadowaki, W., Miyata, R., Fujinami, M., Sato, Y. and Kumazawa, S (2023) 'Catechol-O-methyltransferase inhibitors from Calendula officinalis leaf', Molecules, 28(3), pp. 1333. doi:10.3390/molecules28031333 Preclinical
https://doi.org/10.3390/molecules28031333 - European Medicines Agency (HMPC) (2018) 'European Union herbal monograph on Calendula officinalis L., flos, Revision 1'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-calendula-officinalis-l-flos-revision-1_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-calendula-officinalis-l-flos-revision-1_en.pdf - Hoffmann, D (2003) 'Medical Herbalism'. Traditional / reference
https://scholar.google.com/scholar?q=Medical%20Herbalism - Nicolaus, C. et al (2017) 'A double-blind, randomized controlled trial to investigate the efficacy and safety of a monograph-based Calendula cream versus a comparator cream', 35(1), pp. 81--89. Randomized trial
https://scholar.google.com/scholar?q=A%20double-blind%2C%20randomized%20controlled%20trial%20to%20investigate%20the%20efficacy%20and%20safety%20of%20a%20monograph-based%20Calendula%20cream%20versus%20a%20comparator%20cream - Preethi, K.C. and Kuttan, R (2009) 'Wound healing activity of flower extract of Calendula officinalis', 20(1), pp. 73--79. doi:10.1515/jbcpp.2009.20.1.73 Preclinical
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https://doi.org/10.3389/fphar.2022.903171 - Wang, S.J. and Wang, X.H. and Dai, Y.Y. and Ma, M.H. and Rahman, K. and Nian, H. and Zhang, H (2019) 'Prunella vulgaris: A Comprehensive Review of Chemical Constituents, Pharmacological Effects and Clinical Applications', Current Pharmaceutical Design, 25(3), pp. 359-369. doi:10.2174/1381612825666190313121608 Meta-analysis / review
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https://doi.org/10.1016/j.joim.2025.03.002 - Zhang, Y. and Qu, X. and Xu, N. and He, H. and Li, Q. and Wei, X. and Chen, Y. and Xu, Y. and Li, X. and Zhang, R. and Zhong, R. and Liu, C. and Xiang, P. and Zhu, F (2024) 'Mechanism of Prunella vulgaris L. and luteolin in restoring Tfh/Tfr balance and alleviating oxidative stress in Graves' disease', Phytomedicine, 132, pp. 155818. doi:10.1016/j.phymed.2024.155818 Preclinical
https://doi.org/10.1016/j.phymed.2024.155818 - Zhang, S. and Wang, Y. and Wang, M. and Jiang, L. and Ma, X. and Huang, Y. and Liu, T. and Zheng, L. and Li, Y (2024) 'Construction and anti-pancreatic cancer activity of selenium nanoparticles stabilized by Prunella vulgaris polysaccharide', Int J Biol Macromol, 278(Pt 3), pp. 134924. doi:10.1016/j.ijbiomac.2024.134924 Preclinical
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https://doi.org/10.3390/molecules29081843 - Han, Q. and Xu, N. and Chen, B. and Wu, W. and Sheng, L (2021) 'Safety and efficacy of Prunella vulgaris preparation in adjuvant treatment of thyroid nodules: A meta-analysis', Medicine (Baltimore), 100(41), pp. e27490. doi:10.1097/MD.0000000000027490 Meta-analysis / review
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https://doi.org/10.3389/fimmu.2023.1196434 - Ma, F. and Deng, Q. and Lou, H. and Li, J. and Xu, S. and Wu, W. and Wen, Q. and Tang, L. and Wang, X. and Pan, W (2022) 'Vulgarisin-type diterpenoids from self-heal (Prunella vulgaris) and their neuroprotective effects against ischemia/reperfusion (I/R) via a mitochondria-related pathway', Food Funct, 13(13), pp. 7062-7074. doi:10.1039/d2fo00150k Preclinical
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https://doi.org/10.1016/j.biopha.2016.09.095 - Qu, Z. and Zhang, J. and Yang, H. and Gao, J. and Chen, H. and Liu, C. and Gao, W (2016) 'Prunella vulgaris L., an Edible and Medicinal Plant, Attenuates Scopolamine-Induced Memory Impairment in Rats', Journal of Agricultural and Food Chemistry, 65(2), pp. 291-300. doi:10.1021/acs.jafc.6b04597 Preclinical
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https://doi.org/10.1016/j.jep.2022.115411 - Yu, F. and Zhang, L. and Ma, R. and Liu, C. and Wang, Q. and Yin, D (2021) 'The Antitumour Effect of Prunella vulgaris Extract on Thyroid Cancer Cells In Vitro and In Vivo', Evidence-based Complementary and Alternative Medicine, 2021, pp. 1-12. doi:10.1155/2021/8869323 Preclinical
https://doi.org/10.1155/2021/8869323 - Zhong, X., Zhang, Y., Yuan, M., Xu, L., Luo, X., Wu, R., Xi, Z., Li, Y. and Xu, H (2024) 'Prunella vulgaris polysaccharide inhibits herpes simplex virus infection by blocking TLR-mediated NF-kB activation', Chinese Medicine, 19(1). doi:10.1186/s13020-023-00865-y Preclinical
https://doi.org/10.1186/s13020-023-00865-y - Zhang, Q., Li, Y., Zhong, X., Fu, W., Luo, X., Feng, J., Yuan, M., Xiao, L. and Xu, H (2021) 'Polyphenolic-protein-polysaccharide conjugates from Spica of Prunella vulgaris: Chemical profile and anti-herpes simplex virus activities', International Journal of Biological Macromolecules. doi:10.1016/j.ijbiomac.2021.11.200 Preclinical
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https://scholar.google.com/scholar?q=A%20Modern%20Herbal - Psotova, J. et al (2003) 'Biological activities of Prunella vulgaris extract', 17(9), pp. 1082--1087. doi:10.1002/ptr.1324 Preclinical
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https://scholar.google.com/scholar?q=Antiviral%20activity%20of%20aqueous%20extract%20of%20Prunella%20vulgaris%20L - Haarberg, K.M.K., Wymore Brand, M.J., Overstreet, A.M.C., Hauck, C.C., Murphy, P.A., Hostetter, J.M., Ramer-Tait, A.E. and Wannemuehler, M.J (2015) 'Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a(-/-) mice', World Journal of Gastrointestinal Pharmacology and Therapeutics, 6(4), pp. 223--237. doi:10.4292/wjgpt.v6.i4.223 Preclinical
https://doi.org/10.4292/wjgpt.v6.i4.223 - Zhang, Y.B., Xu, L., Yuan, M., Liu, M.F., Li, Y., Zhong, X.L., Lin, Z.X., Xian, Y.F., Lu, P., Xi, Z.C. and Xu, H.X (2025) 'Protective effects of Prunella vulgaris polysaccharides against herpes simplex virus type 1 infection through the STING-TBK1-IRF3 pathway', Journal of Integrative Medicine, 24(3), pp. 454--465. doi:10.1016/j.joim.2025.12.008 Preclinical
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Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.