Plant Comparison
Pot marigold vs Gotu Kola
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Pot marigold and Gotu Kola: they share 6 indicated uses (arthritis / joint pain, bruising, eczema, …); 3 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Pot marigold | Gotu Kola | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 5/10 | 2/10 | Stronger for Pot marigold |
| Bruising | 5/10 | 2/10 | Stronger for Pot marigold |
| Eczema | 5/10 | 2/10 | Stronger for Pot marigold |
| Inflammation (general) | 5/10 | 2/10 | Stronger for Pot marigold |
| Skin irritation | 5/10 | 2/10 | Stronger for Pot marigold |
| Wounds | 5/10 | 2/10 | Stronger for Pot marigold |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Principal wound-healing and anti-inflammatory constituents of the flower.
Antioxidant flavonoids and carotenoids give the flower its orange-yellow colour and contribute to its antioxidant activity.
Minor aromatic and resinous constituents of the flower head.
The marker compounds and principal actives for wound healing, vascular and neuroprotective effects.
Antioxidant and aromatic supporting constituents.
Pharmacological Actions
Calendula officinalis extracts show cytotoxic antitumor, pro-apoptotic and antimetastatic activity across many cancer cell lines and in animal models (preclinical).
Anti-inflammatory and antioxidant; supports inflammatory skin conditions (eczema, psoriasis, ulcers)
Improves venous tone and microcirculation - supports chronic venous insufficiency / varicose veins and reduces leg swelling
Anti-inflammatory and antioxidant; supports inflammatory skin conditions (eczema, psoriasis, ulcers)
Anxiolytic / calming (anxiety)
Improves venous tone and microcirculation - supports chronic venous insufficiency / varicose veins and reduces leg swelling
Traditional & Indicated Uses
inferred from anti-inflammatory action
A Calendula officinalis (LACE) aqueous extract inhibits proliferation (70-100%) of leukemia, melanoma, breast, prostate, lung and colon cancer cell lines via G0/G1 arrest and caspase-3 apoptosis and inhibits melanoma growth in nude mice; a systematic review documents its cytotoxic and antimetastatic antitumour activity (preclinical).
inferred from antifungal action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
Improves alertness and mood (raises alertness, reduces anger); a meta-analysis found no significant improvement in specific cognitive-function domains versus placebo
Anti-inflammatory and antioxidant; supports inflammatory skin conditions (eczema, psoriasis, ulcers)
inferred from anti-inflammatory action
inferred from anxiolytic action
Anti-inflammatory and antioxidant; supports inflammatory skin conditions (eczema, psoriasis, ulcers)
inferred from anti-inflammatory action
Improves venous tone and microcirculation - supports chronic venous insufficiency / varicose veins and reduces leg swelling
Improves venous tone and microcirculation - supports chronic venous insufficiency / varicose veins and reduces leg swelling
Safety, Cautions & Contraindications
Generally very safe for topical use. May cause contact dermatitis in rare cases (Asteraceae family allergy). Internal use is safe in normal doses. Avoid during pregnancy at therapeutic doses (uterine stimulant potential). Generally safe during breastfeeding for topical use.
Duke (2002) rates calendula (Calendula officinalis) and notes anti-inflammatory, wound-healing (vulnerary), antifungal, and antispasmodic activities at experimental levels. Commission E (KOM) approves calendula flower for wound healing and anti-inflammatory uses, both topically and as a gargle. The plant contains flavonoids, triterpene saponins (oleanolic acid glycosides), and essential oils. Dose: 1–2 g dried flower as tea (for mouth rinse/gargle); or as cream/ointment containing 2–5% calendula extract for topical use. Duke notes that calendula is generally very well-tolerated, though Asteraceae sensitivity can occasionally cause allergic reactions (Duke, 2002).
Generally well tolerated topically and orally; it can occasionally cause allergic contact dermatitis and, rarely, reversible elevation of liver enzymes with prolonged high oral doses.
May add to the effect of sedatives; use caution with other liver-affecting medicines. Safety in pregnancy and breastfeeding is not established, so avoid medicinal doses.
External Ids
Botanical Description
Aromatic annual or short-lived perennial herb with soft, hairy, oblong leaves and branching, slightly sticky stems. The flower heads are bright orange to yellow, daisy-like, with numerous narrow ray florets surrounding a darker central disc, opening in sunlight and closing at dusk.[1]
Low, creeping perennial herb rooting at the nodes along slender, prostrate stems. The leaves are long-stalked, rounded to kidney- or fan-shaped, with a gently scalloped (crenate) margin, arising in small clusters at each node. Tiny, pinkish-white flowers are borne in small, inconspicuous clusters hidden near the base of the leaf stalks, close to the ground.[12]
Habitat
Widely cultivated as a garden and medicinal plant; believed native to southern Europe and the Mediterranean, now naturalised in gardens and waste ground worldwide.[1]
Grows in damp, shaded ground, lawns, ditches and wetland margins throughout tropical and subtropical Asia (China, India, Southeast Asia) and parts of Africa, Australia and the Pacific.[12]
Harvesting
The flower heads (or just the ray-floret petals) are picked by hand as they open, through the flowering season, and dried quickly in a warm, shaded, airy place to preserve colour and resin content.[1]
The aerial parts (leaves and trailing stems) are harvested during active growth, cut a short distance above the soil to allow regrowth, and used fresh or dried.
Traditional Uses
Calendula flower is one of the most widely used topical wound-healing and skin-soothing herbs in Western herbal medicine, applied to cuts, grazes, minor burns and skin inflammation, and used internally as a gentle anti-inflammatory and antimicrobial remedy and as a gargle for mouth and throat irritation.[1]
Gotu kola is a cornerstone herb of Ayurvedic and traditional Chinese medicine, valued as a 'rasayana' (rejuvenating) tonic for skin healing, memory and mental clarity, and calming the mind; it has a particularly strong traditional and modern reputation for wound healing and connective-tissue/vascular support, reflected in its widespread use for scars, minor wounds and varicose veins.[12]
Preparations
Dried petals infused in a carrier oil, used as a soothing base for topical creams and balms for skin healing.
Standardised flower extract formulated into a cream or ointment for topical wound and skin care; the best-studied modern form.
Dried flower infused in hot water, 1-2 g in 150 ml, used still warm as a mouth rinse or gargle 2-4 times daily. The EU herbal monograph's posology for this preparation is OROMUCOSAL only - it does not support taking the infusion internally. Educational reference only, not a prescription.
Extract titrated to triterpenoid (asiaticoside/madecassoside) content, taken orally as capsules/tablets for venous and cognitive support, or applied topically for wound and scar care.
Standardised extract or fresh leaf preparation applied topically to wounds, scars and inflamed skin.
Dosage
The EU herbal monograph gives semi-solid preparations containing the equivalent of 2-10% herbal substance, applied as a thin layer to the affected area 2 to 4 times daily. Educational reference only, not a prescription.
The EU herbal monograph gives 1-2 g of the flower in 150 mL water as an infusion, used still warm for rinsing and gargling 2 to 4 times daily, or to prepare impregnated dressings for the skin. This is an oromucosal and cutaneous preparation, not an oral tea. Educational reference only, not a prescription.
Clinical studies commonly use extracts providing around 60-180 mg total triterpenoids daily, in divided doses. Educational reference only, not a prescription.
The EU herbal monograph on Centella asiatica herba is for CUTANEOUS USE ONLY and gives, for adults and elderly, a single dose of 0.6 g of the comminuted herb infused in a small amount of boiling water, the still-warm infusion applied as an impregnated dressing 3 times daily (daily dose 1.8 g); or 0.6 g of the powdered herb applied to the affected area 3 times daily. Not to be used for more than 1 week, and not recommended under 18 years. The monograph gives no oral posology - see the separate standardised-extract entry. Educational reference only, not a prescription.
References
Lookalikes Review
Dangerous Lookalikes
Not documented
References & Sources
- Givol, O., Kornhaber, R., Visentin, D., Cleary, M. et al (2019) 'A systematic review of Calendula officinalis extract for wound healing', Wound Repair and Regeneration, 27(5), pp. 548-561. doi:10.1111/wrr.12737 Meta-analysis / review
https://doi.org/10.1111/wrr.12737 - Shahane, K., Kshirsagar, M., Tambe, S., Jain, D. et al (2023) 'An Updated Review on the Multifaceted Therapeutic Potential of Calendula officinalis L', Pharmaceuticals (Basel), 16(4), pp. 611. doi:10.3390/ph16040611 Traditional / reference
https://doi.org/10.3390/ph16040611 - Saffari, E., Mohammad-Alizadeh-Charandabi, S., Adibpour, M., Mirghafourvand, M. et al (2016) 'Comparing the effects of Calendula officinalis and clotrimazole on vaginal Candidiasis: A randomized controlled trial', Women & Health, 57(10), pp. 1145-1160. doi:10.1080/03630242.2016.1263272 Randomized trial
https://doi.org/10.1080/03630242.2016.1263272 - Cruceriu, D., Balacescu, O. and Rakosy, E (2018) 'Calendula officinalis: potential roles in cancer treatment and palliative care', Integrative Cancer Therapies, 17(4), pp. 1068-1078. doi:10.1177/1534735418803766 Meta-analysis / review
https://doi.org/10.1177/1534735418803766 - Rezai, S., Rahzani, K., Hekmatpou, D. and Rostami, A (2023) 'Effect of oral Calendula officinalis on second-degree burn wound healing', Scars, Burns & Healing, 9, pp. 20595131221134053. doi:10.1177/20595131221134053 Randomized trial
https://doi.org/10.1177/20595131221134053 - Kadowaki, W., Miyata, R., Mizuno, S., Fujinami, M., Sato, Y. and Kumazawa, S (2023) 'Prenylated acetophenones from the roots of Calendula officinalis and their anti-inflammatory activity', Bioscience, Biotechnology, and Biochemistry, 87(7), pp. 683-687. doi:10.1093/bbb/zbad042 Preclinical
https://doi.org/10.1093/bbb/zbad042 - Samra, R.M., Maatooq, G.T. and Zaki, A.A (2022) 'A new antiprotozoal compound from Calendula officinalis', Natural Product Research, 36(22), pp. 5747-5752. doi:10.1080/14786419.2021.2023868 Preclinical
https://doi.org/10.1080/14786419.2021.2023868 - Kaur, J., Sidhu, S., Chopra, K. and Khan, M.U (2016) 'Calendula officinalis ameliorates l-arginine-induced acute necrotizing pancreatitis in rats', Pharmaceutical Biology, 54(12), pp. 2951-2959. doi:10.1080/13880209.2016.1195848 Preclinical
https://doi.org/10.1080/13880209.2016.1195848 - Aro, A.A., Perez, M.O., Vieira, C.P., Esquisatto, M.A.M., Rodrigues, R.A.F., Gomes, L. and Pimentel, E.R (2014) 'Effect of Calendula officinalis cream on achilles tendon healing', Anatomical Record, 298(2), pp. 428-435. doi:10.1002/ar.23057 Preclinical
https://doi.org/10.1002/ar.23057 - Zhang, X., Wang, R., Finiuk, N., Stoika, R., Lin, H., Wang, X. and Jin, M (2023) 'Active compounds from Calendula officinalis flowers act via PI3K and ERK signaling pathways to offer neuroprotective effects against Parkinson's disease', Food Science & Nutrition, 12(1), pp. 450-458. doi:10.1002/fsn3.3792 Preclinical
https://doi.org/10.1002/fsn3.3792 - Kadowaki, W., Miyata, R., Fujinami, M., Sato, Y. and Kumazawa, S (2023) 'Catechol-O-methyltransferase inhibitors from Calendula officinalis leaf', Molecules, 28(3), pp. 1333. doi:10.3390/molecules28031333 Preclinical
https://doi.org/10.3390/molecules28031333 - European Medicines Agency (HMPC) (2018) 'European Union herbal monograph on Calendula officinalis L., flos, Revision 1'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-calendula-officinalis-l-flos-revision-1_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-calendula-officinalis-l-flos-revision-1_en.pdf - Hoffmann, D (2003) 'Medical Herbalism'. Traditional / reference
https://scholar.google.com/scholar?q=Medical%20Herbalism - Nicolaus, C. et al (2017) 'A double-blind, randomized controlled trial to investigate the efficacy and safety of a monograph-based Calendula cream versus a comparator cream', 35(1), pp. 81--89. Randomized trial
https://scholar.google.com/scholar?q=A%20double-blind%2C%20randomized%20controlled%20trial%20to%20investigate%20the%20efficacy%20and%20safety%20of%20a%20monograph-based%20Calendula%20cream%20versus%20a%20comparator%20cream - Preethi, K.C. and Kuttan, R (2009) 'Wound healing activity of flower extract of Calendula officinalis', 20(1), pp. 73--79. doi:10.1515/jbcpp.2009.20.1.73 Preclinical
https://doi.org/10.1515/jbcpp.2009.20.1.73 - Jimenez-Medina, E. and Garcia-Lora, A. and Paco, L. and Algarra, I. and Collado, A. and Garrido, F (2006) 'A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation', BMC Cancer, 6, pp. 119. doi:10.1186/1471-2407-6-119 Preclinical
https://doi.org/10.1186/1471-2407-6-119 - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
- Bylka, W., Znajdek-Awizen, P., Studzinska-Sroka, E., Danczak-Pazdrowska, A. and Brzezinska, M (2014) 'Centella asiatica in dermatology: an overview', Phytotherapy Research, 28(8), pp. 1117-1124. doi:10.1002/ptr.5110 Meta-analysis / review
https://doi.org/10.1002/ptr.5110 - Bylka, W., Znajdek-Awizen, P., Studzinska-Sroka, E. and Brzezinska, M (2013) 'Centella asiatica in cosmetology', Postepy Dermatologii i Alergologii, 30(1), pp. 46-49. doi:10.5114/pdia.2013.33378 Meta-analysis / review
https://doi.org/10.5114/pdia.2013.33378 - Park, K.S (2021) 'Pharmacological effects of Centella asiatica on skin diseases: evidence and possible mechanisms', Evidence-Based Complementary and Alternative Medicine, 2021, pp. 5462633. doi:10.1155/2021/5462633 Meta-analysis / review
https://doi.org/10.1155/2021/5462633 - Diniz, L.R.L., Calado, L.L., Duarte, A.B.S. and de Sousa, D.P (2023) 'Centella asiatica and its metabolite asiatic acid: wound healing effects and therapeutic potential', Metabolites, 13(2), pp. 276. doi:10.3390/metabo13020276 Meta-analysis / review
https://doi.org/10.3390/metabo13020276 - Arribas-Lopez, E., Zand, N., Ojo, O., Snowden, M.J. and Kochhar, T (2022) 'A systematic review of the effect of Centella asiatica on wound healing', International Journal of Environmental Research and Public Health, 19(6), pp. 3266. doi:10.3390/ijerph19063266 Meta-analysis / review
https://doi.org/10.3390/ijerph19063266 - Lin, P., Shi, H., Lu, Y. and Lin, J (2023) 'Centella asiatica alleviates psoriasis through JAK/STAT3-mediated inflammation: an in vitro and in vivo study', Journal of Ethnopharmacology, 317, pp. 116746. doi:10.1016/j.jep.2023.116746 Preclinical
https://doi.org/10.1016/j.jep.2023.116746 - Ratz-Lyko, A., Arct, J. and Pytkowska, K (2016) 'Moisturizing and antiinflammatory properties of cosmetic formulations containing Centella asiatica extract', Indian Journal of Pharmaceutical Sciences, 78(1), pp. 27-33. doi:10.4103/0250-474x.180247 Preclinical
https://doi.org/10.4103/0250-474x.180247 - Sun, B., Wu, L., Wu, Y., Zhang, C., Qin, L., Hayashi, M., Kudo, M., Gao, M. and Liu, T (2020) 'Therapeutic potential of Centella asiatica and its triterpenes: a review', Frontiers in Pharmacology, 11, pp. 568032. doi:10.3389/fphar.2020.568032 Meta-analysis / review
https://doi.org/10.3389/fphar.2020.568032 - Razali, N.N.M., Ng, C.T. and Fong, L.Y (2019) 'Cardiovascular protective effects of Centella asiatica and its triterpenes: a review', Planta Medica, 85(16), pp. 1203-1215. doi:10.1055/a-1008-6138 Meta-analysis / review
https://doi.org/10.1055/a-1008-6138 - Sharma, R., Banerjee, S. and Sharma, R (2024) 'Role of Mandukparni (Centella asiatica Linn Urban) in neurological disorders: evidence from ethnopharmacology and clinical studies to network enrichment analysis', Neurochemistry International, 180, pp. 105865. doi:10.1016/j.neuint.2024.105865 Meta-analysis / review
https://doi.org/10.1016/j.neuint.2024.105865 - Banerjee, O., Singh, S., Paul, T., Maji, B.K. and Mukherjee, S (2024) 'Centella asiatica mitigates the detrimental effects of Bisphenol-A (BPA) on pancreatic islets', Scientific Reports, 14(1), pp. 8043. doi:10.1038/s41598-024-58545-2 Preclinical
https://doi.org/10.1038/s41598-024-58545-2 - Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N.K., Kumar, M., Radha, Ghosh, A., Prockow, J., Perez de la Lastra, J.M. and Dey, A (2023) 'Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review', Journal of Cellular and Molecular Medicine. doi:10.1111/jcmm.17635 Traditional / reference
https://doi.org/10.1111/jcmm.17635 - European Medicines Agency (HMPC) (2018) 'European Union herbal monograph on Centella asiatica (L.) Urb., herba, Revision 1'. Available at: https://www.ema.europa.eu/en/documents/herbal-monograph/european-union-herbal-monograph-centella-asiatica-l-urb-herba-revision-1_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/herbal-monograph/european-union-herbal-monograph-centella-asiatica-l-urb-herba-revision-1_en.pdf - Belcaro, G., Maquart, F.-X., Scoccianti, M., Dugall, M., Hosoi, M., Cesarone, M.R., Luzzi, R., Cornelli, U., Ledda, A. and Feragalli, B (2011) 'TECA (Titrated Extract of Centella Asiatica): new microcirculatory, biomolecular, and vascular application in preventive and clinical medicine. A status paper', Panminerva Medica. Preclinical
https://scholar.google.com/scholar?q=TECA%20%28Titrated%20Extract%20of%20Centella%20Asiatica%29%3A%20new%20microcirculatory%2C%20biomolecular%2C%20and%20vascular%20application%20in%20preventive%20and%20clinical%20medicine.%20A%20status%20paper - Chong, N.J. and Aziz, Z (2013) 'A Systematic Review of the Efficacy of Centella asiatica for Improvement of the Signs and Symptoms of Chronic Venous Insufficiency', Evidence-Based Complementary and Alternative Medicine. doi:10.1155/2013/627182 Meta-analysis / review
https://doi.org/10.1155/2013/627182 - Martinez-Zapata, M.J., Vernooij, R.W., Simancas-Racines, D., Uriona Tuma, S.M., Stein, A.T. and others (2020) 'Phlebotonics for venous insufficiency', Cochrane Database of Systematic Reviews. doi:10.1002/14651858.CD003229.pub4 Meta-analysis / review
https://doi.org/10.1002/14651858.CD003229.pub4 - Puttarak, P., Dilokthornsakul, P., Saokaew, S., Dhippayom, T., Kongkaew, C. and others (2017) 'Effects of Centella asiatica (L.) Urb. on cognitive function and mood related outcomes: A Systematic Review and Meta-analysis', Scientific Reports, 7(1). doi:10.1038/s41598-017-09823-9 Meta-analysis / review
https://doi.org/10.1038/s41598-017-09823-9 - Haupt, H (2001) 'Poisonous and less poisonous plants. 52', Kinderkrankenschwester, 20(8), pp. 335. Available at: https://pubmed.ncbi.nlm.nih.gov/14584174/ Traditional / reference
https://pubmed.ncbi.nlm.nih.gov/14584174/ - North Carolina Extension Gardener Plant Toolbox 'Centella asiatica (Gotu Kola, Asiatic Pennywort)'. Available at: https://plants.ces.ncsu.edu/plants/centella-asiatica/ Traditional / reference
https://plants.ces.ncsu.edu/plants/centella-asiatica/
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.