Plant Comparison
Borage vs Flaxseed
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Borage and Flaxseed: they share 6 indicated uses (arthritis / joint pain, bloating, cancer (anticancer research), …); 4 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Borage | Flaxseed | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 1/10 | 3/10 | Stronger for Flaxseed |
| Bloating | 1/10 | 3/10 | Stronger for Flaxseed |
| Cancer (anticancer research) | 2/10 | 7/10 | Stronger for Flaxseed |
| Indigestion | 1/10 | 3/10 | Stronger for Flaxseed |
| Inflammation (general) | 1/10 | 3/10 | Stronger for Flaxseed |
| Skin irritation | 1/10 | 3/10 | Stronger for Flaxseed |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Borage seed oil has one of the highest known GLA contents of any plant oil (typically 20-26%), the basis of its anti-inflammatory reputation.
Unsaturated pyrrolizidine alkaloids present in the whole herb are hepatotoxic and genotoxic on cumulative exposure, limiting internal whole-herb use; the refined seed oil is largely free of them.
Contribute to the plant's traditional demulcent and astringent properties.
Flax is the richest dietary source of SDG-type lignans, converted by gut bacteria to the mammalian lignans enterodiol and enterolactone; studied for antioxidant and hormone-modulating activity.
The dominant fatty acid of the seed oil (~50-55% of total oil), a plant-based omega-3 studied for cardiovascular and anti-inflammatory effects.
Concentrated in the seed coat; gives flaxseed its demulcent, laxative, bulk-forming action.
Present at low levels; cooking/roasting reduces them to negligible amounts in normal food use - a theoretical concern only at high raw intakes.
Pharmacological Actions
Traditional & Indicated Uses
inferred from anti-inflammatory action
inferred from anticancer action
inferred from immunomodulator action
inferred from digestive action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from anticancer action
inferred from digestive action
inferred from anti-inflammatory action
Safety, Cautions & Contraindications
Pyrrolizidine alkaloids (PAs): Many Boraginaceae can produce PAs; unsaturated PAs are hepatotoxic and genotoxic (risk increases with cumulative exposure). Borage as food/tea: PA presence in borage consumed as herb/tea has been specifically studied; EU has set PA maximum levels for certain foods including borage (context for why sourcing/limits matter). Pregnancy/breastfeeding: avoid internal use of borage herb products due to PA-related concerns and risk uncertainty. Liver disease / long-term use: avoid (PA risk + cumulative exposure logic). Seed oil vs herb: refined/quality-controlled seed oil is generally the preferred form when borage is used medicinally, because the main target compound is GLA; however, product quality and contamination control still matter. Drug interactions (caution): GLA oils have been discussed with anticoagulants (bleeding risk caution is better established for evening primrose oil; borage oil is often grouped in the same “GLA oil” category). Use caution if on anticoagulants/antiplatelets.
Duke (2002) rates borage as a single-plus herb (+) with predominantly folklore-level evidence. Borage seed oil is rich in gamma-linolenic acid (GLA) and has been used for inflammatory conditions such as arthritis and PMS, and for cardiovascular support; typical dose is one 300 mg softgel containing 24% GLA or 2-4 ml liquid leaf extract. Commission E does not approve borage for any indication, and the herb contains hepatotoxic and carcinogenic pyrrolizidine alkaloids, making long-term use inadvisable (Duke, 2002).
Flaxseeds are safe for most people at recommended food amounts (1–2 tablespoons ground/day). They must be ground or milled to be bioavailable — whole seeds largely pass through the gut undigested. High fibre content may cause bloating, flatulence, and loose stools, especially if fibre intake is increased rapidly without adequate hydration. Flaxseeds contain cyanogenic glycosides (linamarin, linustatin); cooking or roasting reduces these to negligible levels in normal food amounts. Raw seeds in very large quantities are a theoretical concern, but typical use is safe (EFSA, 2017).
Medication interactions: Flaxseed may reduce absorption of oral medications if taken simultaneously — space flaxseed supplementation 1–2 hours from medications. Omega-3 ALA and lignans may mildly enhance anticoagulant/antiplatelet effects; use caution with blood thinners. Some sources suggest caution with hormone-sensitive conditions due to phytoestrogen (lignan) content, though dietary amounts are unlikely to pose risk (Adolphe et al., 2010).
Pregnancy: Food amounts are generally considered safe; high-dose supplements should be discussed with a clinician due to limited safety data.
Duke (2002) rates flaxseed as +++ with clinical evidence (score 2) for antiatherogenic, hypocholesterolemic, laxative, lipolytic (fat-dissolving), and demulcent activities. Flaxseed's omega-3 fatty acids (ALA) and lignans are associated with reduced cardiovascular risk. Commission E approves flaxseed as a laxative and for mucilaginous protection of inflamed gastrointestinal mucosa. Dose: 1–2 tablespoons ground seed with ample water, twice daily. Whole seeds should be chewed or ground for full medicinal effect. Cyanogenic glycosides are present but at safe levels in normal dietary amounts (Duke, 2002).
External Ids
Botanical Description
Robust, bristly annual herb with hollow, branching stems covered in coarse, stiff hairs. The leaves are large, oval and wrinkled, also coarsely hairy, and smell of cucumber when crushed. The flowers are strikingly bright blue, star-shaped with five pointed petals and a prominent black central cone of anthers, borne in nodding clusters.[1]
Erect annual herb, slender and often branched near the top, growing 30-80 (up to 100) cm tall from a fine taproot. Leaves are alternate, sessile, narrowly lanceolate to linear, blue-green and entire-margined. Flowers are pale blue (occasionally white or pink), five-petalled and borne on slender stalks in loose terminal cymes. The fruit is a small globular capsule ('boll') that splits into ten compartments, each containing one flattened, glossy, red-brown seed.[5]
Habitat
Grows readily on disturbed, nutrient-rich ground, gardens, waste places and field margins; native to the Mediterranean region and widely naturalised and cultivated across Europe and elsewhere as a culinary and oil-seed crop.[1]
Native to the Mediterranean region and the Fertile Crescent, cultivated since prehistory for fibre and oil and now grown worldwide in temperate regions with well-drained, fertile soils and a cool, moist growing season; occasionally found as a naturalised escape on waste and cultivated ground.[5]
Harvesting
Leaves and flowers are picked fresh through the growing season, at their best just as the flowers open; the seed is collected in late summer once the seed heads have dried, pressed for its gamma-linolenic-acid-rich oil.[1]
Grown as an annual crop, seed is harvested once the capsules ('bolls') have dried and turned brown, typically in late summer, by cutting or combining the whole plant and threshing out the seed. Whole seed stores well; it should only be ground shortly before use, since the oil in ground seed oxidises and turns rancid quickly.[2]
Traditional Uses
Borage has a long folk reputation, reflected in the old saying 'borage for courage', as a mood-lifting, cooling herb for feverish colds and respiratory complaints, and as a digestive and anti-inflammatory remedy; the fresh leaves and flowers have also been used culinarily. Modern use is centred on the seed oil, rich in gamma-linolenic acid (GLA), for inflammatory and skin conditions.[1]
Flaxseed has a long history of traditional use as a bulk-forming laxative and demulcent for constipation and irritated gut mucosa, and as a poultice for boils and inflamed skin. Modern interest centres on its lignan (secoisolariciresinol diglucoside) and alpha-linolenic acid content, studied for cardiovascular, metabolic and hormone-related outcomes.[2, 4, 5]
Preparations
Whole seed freshly ground (milled) and taken with plenty of liquid, or stirred into food; grinding is needed to make the oil and lignans bioavailable, as whole seeds largely pass through the gut undigested.
Cold-pressed oil taken as a concentrated source of alpha-linolenic acid (omega-3); lacks the fibre and lignan content of the whole ground seed.
Dosage
A phase-two randomised placebo-controlled trial in moderate persistent asthma used Borago officinalis extract at 5 mL three times daily for one month. Because of pyrrolizidine alkaloid content, whole-herb (leaf/flower) preparations should only be used short-term and from PA-controlled sources; avoid in pregnancy, breastfeeding and liver disease. Educational reference only, not a prescription.
Traditional guidance and Duke (2002) suggest 1-2 tablespoons of ground seed with ample water, once or twice daily. Educational reference only, not a prescription.
A randomised placebo-controlled trial titrated flax oil capsules (550 mg alpha-linolenic acid per 1 g of oil) to 12 capsules per day, i.e. up to roughly 12 g of oil daily, over 16 weeks - broadly matching the 1-2 tablespoons (about 10-15 mL) daily often cited for omega-3 intake. That trial was in children and adolescents with bipolar disorder and its primary outcomes were null; it is cited here only as a source for an administered human dose of the oil, not as evidence of benefit. Note the EU herbal monograph on Lini semen covers the SEED, not the oil. Educational reference only, not a prescription.
References
Lookalikes Review
Dangerous Lookalikes
Not documented
References & Sources
- Slama, M., Slougui, N., Benaissa, A., Nekkaa, A. et al (2024) 'Borago officinalis L.: A Review on Extraction, Phytochemical, and Pharmacological Activities', Chemistry & Biodiversity, 21(5), pp. e202301822. doi:10.1002/cbdv.202301822 Traditional / reference
https://doi.org/10.1002/cbdv.202301822 - Michalak, M., Zagórska-Dziok, M., Klimek-Szczykutowicz, M. and Szopa, A (2023) 'Phenolic Profile and Comparison of the Antioxidant, Anti-Ageing, Anti-Inflammatory, and Protective Activities of Borago officinalis Extracts on Skin Cells', Molecules, 28(2), pp. 868. doi:10.3390/molecules28020868 Preclinical
https://doi.org/10.3390/molecules28020868 - Ghasemian, M., Owlia, S. and Owlia, M.B (2016) 'Review of Anti-Inflammatory Herbal Medicines', Advances in Pharmacological Sciences, 2016, pp. 9130979. doi:10.1155/2016/9130979 Traditional / reference
https://doi.org/10.1155/2016/9130979 - Di Cerbo, A., Carnevale, G., Avallone, R., Zavatti, M. and Corsi, L (2020) 'Protective Effects of Borago officinalis (Borago) on Cold Restraint Stress-Induced Gastric Ulcers in Rats: A Pilot Study', Frontiers in Veterinary Science, 7, pp. 427. doi:10.3389/fvets.2020.00427 Preclinical
https://doi.org/10.3389/fvets.2020.00427 - Seo, S.A., Park, B., Hwang, E., Park, S. and Yi, T (2018) 'Borago officinalis L. attenuates UVB-induced skin photodamage via regulation of AP-1 and Nrf2/ARE pathway in normal human dermal fibroblasts and promotion of collagen synthesis in hairless mice', Experimental Gerontology, 107, pp. 178-186. doi:10.1016/j.exger.2018.02.017 Preclinical
https://doi.org/10.1016/j.exger.2018.02.017 - Mirsadraee, M., Khashkhashi Moghaddam, S., Saeedi, P. and Ghaffari, S (2016) 'Effect of Borago Officinalis Extract on Moderate Persistent Asthma: A Phase two Randomized, Double Blind, Placebo-Controlled Clinical Trial', Tanaffos, 15(3), pp. 168-174. doi:10.1183/13993003.congress-2016.pa4116 Randomized trial
https://doi.org/10.1183/13993003.congress-2016.pa4116 - Lozano-Baena, M., Tasset, I., Munoz-Serrano, A., Alonso-Moraga, A. and de Haro-Bailon, A (2016) 'Cancer Prevention and Health Benefices of Traditionally Consumed Borago officinalis Plants', Nutrients, 8(1), pp. 48. doi:10.3390/nu8010048 Preclinical
https://doi.org/10.3390/nu8010048 - Rodriguez-Magana, M.P., Cordero-Perez, P., Rivas-Morales, C., Oranday-Cardenas, M.A., Moreno-Pena, D.P., Garcia-Hernandez, D.G. and Leos-Rivas, C (2019) 'Hypoglycemic Activity of Tilia americana, Borago officinalis, Chenopodium nuttalliae, and Piper sanctum on Wistar Rats', Journal of Diabetes Research, 2019, pp. 7836820. doi:10.1155/2019/7836820 Preclinical
https://doi.org/10.1155/2019/7836820 - Navarro-Herrera, D., Aranaz, P., Eder-Azanza, L., Zabala, M., Romo-Hualde, A., Hurtado, C., Calavia, D., Lopez-Yoldi, M., Martinez, J.A., Gonzalez-Navarro, C.J. and Vizmanos, J.L (2018) 'Borago officinalis seed oil (BSO), a natural source of omega-6 fatty acids, attenuates fat accumulation by activating peroxisomal beta-oxidation both in C. elegans and in diet-induced obese rats', Food & Function, 9(8), pp. 4340-4351. doi:10.1039/c8fo00423d Preclinical
https://doi.org/10.1039/c8fo00423d - Moliner, C., Casedas, G., Barros, L., Finimundy, T.C., Gomez-Rincon, C. and Lopez, V (2022) 'Neuroprotective Profile of Edible Flowers of Borage (Borago officinalis L.) in Two Different Models: Caenorhabditis elegans and Neuro-2a Cells', Antioxidants, 11(7), pp. 1244. doi:10.3390/antiox11071244 Preclinical
https://doi.org/10.3390/antiox11071244 - Samy, M.N., Hamed, A.N.E., Sugimoto, S., Otsuka, H., Kamel, M.S. and Matsunami, K (2015) 'Officinalioside, a new lignan glucoside from Borago officinalis L', Natural Product Research, 30(8), pp. 967-972. doi:10.1080/14786419.2015.1088540 Preclinical
https://doi.org/10.1080/14786419.2015.1088540 - Yue, Y., Jin, F. and Yue, X (2021) 'The effect of Borago officinalis on the signaling pathway of the NLRP3 inflammasome complex, TLR4 and some inflammatory cytokines in type II diabetic patients with acute respiratory distress syndrome', Cellular and Molecular Biology, 67(3), pp. 178-183. doi:10.14715/cmb/2021.67.3.28 Clinical study
https://doi.org/10.14715/cmb/2021.67.3.28 - Fernandes, L., Pereira, J.A., Saraiva, J.A., Ramalhosa, E. and Casal, S (2019) 'Phytochemical characterization of Borago officinalis L. and Centaurea cyanus L. during flower development', Food Research International, 123, pp. 771-778. doi:10.1016/j.foodres.2019.05.014 Preclinical
https://doi.org/10.1016/j.foodres.2019.05.014 - European Medicines Agency (HMPC) (2021) 'Public statement on the use of herbal medicinal products containing toxic, unsaturated pyrrolizidine alkaloids (PAs), including recommendations regarding contamination of herbal medicinal products with PAs, Revision 1'. Available at: https://www.ema.europa.eu/en/documents/public-statement/public-statement-use-herbal-medicinal-products-containing-toxic-unsaturated-pyrrolizidine-alkaloids-pas-including-recommendations-regarding-contamination-herbal-medicinal-products-pyrrolizidine_en.pdf Traditional / reference
https://www.ema.europa.eu/en/documents/public-statement/public-statement-use-herbal-medicinal-products-containing-toxic-unsaturated-pyrrolizidine-alkaloids-pas-including-recommendations-regarding-contamination-herbal-medicinal-products-pyrrolizidine_en.pdf - Kapoor, R. and Huang, Y.S (2006) 'Gamma linolenic acid: an antiinflammatory omega-6 fatty acid', 7(6), pp. 531--534. doi:10.2174/138920106779116874 Traditional / reference
https://doi.org/10.2174/138920106779116874 - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - World Health Organization (2002) 'WHO Monographs on Selected Medicinal Plants'. Traditional / reference
https://scholar.google.com/scholar?q=WHO%20Monographs%20on%20Selected%20Medicinal%20Plants - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Negroni, M.S., Marengo, A., Caruso, D., et al (2019) 'A case report of accidental intoxication following ingestion of foxglove confused with borage: high digoxinemia without major complications', Case Reports in Cardiology, 2019, pp. 9707428. doi:10.1155/2019/9707428 Clinical study
https://doi.org/10.1155/2019/9707428 - Iraci, F. and Herdeg, C. and Holzwarth, M. and Storz, M.A (2023) 'Of mixed vegetables and cardiac arrhythmias - Digitalis purpurea confused with Borago officinalis: a case series of accidental digitoxin intoxications', Journal of Cardiology Cases, 28(2), pp. 86-90. doi:10.1016/j.jccase.2023.04.007 Clinical study
https://doi.org/10.1016/j.jccase.2023.04.007
- Picur, B., Cebrat, M., Zabrocki, J. and Siemion, I.Z (2006) 'Cyclopeptides of Linum usitatissimum', Journal of Peptide Science, 12(9), pp. 569-574. doi:10.1002/psc.779 Preclinical
https://doi.org/10.1002/psc.779 - Basch, E., Bent, S., Collins, J., Dacey, C., Hammerness, P., Harrison, M., Smith, M., Szapary, P., Ulbricht, C., Vora, M. and Weissner, W (2007) 'Flax and flaxseed oil (Linum usitatissimum): a review by the Natural Standard Research Collaboration', Journal of the Society for Integrative Oncology, 5(3), pp. 92-105. doi:10.2310/7200.2007.005 Meta-analysis / review
https://doi.org/10.2310/7200.2007.005 - Chhillar, H., Chopra, P. and Ashfaq, M.A (2020) 'Lignans from linseed (Linum usitatissimum L.) and its allied species: retrospect, introspect and prospect', Critical Reviews in Food Science and Nutrition, 61(16), pp. 2719-2741. doi:10.1080/10408398.2020.1784840 Meta-analysis / review
https://doi.org/10.1080/10408398.2020.1784840 - Ansari, R., Zarshenas, M.M. and Dadbakhsh, A.H (2019) 'A review on pharmacological and clinical aspects of Linum usitatissimum L', Current Drug Discovery Technologies, 16(2), pp. 148-158. doi:10.2174/1570163815666180521101136 Meta-analysis / review
https://doi.org/10.2174/1570163815666180521101136 - Akter, Y., Junaid, M., Afrose, S.S., Nahrin, A., Alam, M.S., Sharmin, T., Akter, R. and Hosen, S.M.Z (2021) 'A comprehensive review on Linum usitatissimum medicinal plant: its phytochemistry, pharmacology, and ethnomedicinal uses', Mini Reviews in Medicinal Chemistry, 21(18), pp. 2801-2834. doi:10.2174/1389557521666210203153436 Meta-analysis / review
https://doi.org/10.2174/1389557521666210203153436 - Musazadeh, V., Abolghasemian, M., Kavyani, Z., Moridpour, A.H., Nazari, A. and Faghfouri, A.H (2024) 'The effects of flaxseed (Linum usitatissimum) supplementation on anthropometric indices: an updated systematic review and meta-analysis of randomized clinical trials', Complementary Therapies in Medicine, 84, pp. 103066. doi:10.1016/j.ctim.2024.103066 Meta-analysis / review
https://doi.org/10.1016/j.ctim.2024.103066 - Mueed, A., Shibli, S., Jahangir, M., Jabbar, S. and Deng, Z (2022) 'A comprehensive review of flaxseed (Linum usitatissimum L.): health-affecting compounds, mechanism of toxicity, detoxification, anticancer and potential risk', Critical Reviews in Food Science and Nutrition, 63(32), pp. 11081-11104. doi:10.1080/10408398.2022.2092718 Meta-analysis / review
https://doi.org/10.1080/10408398.2022.2092718 - Kaithwas, G., Mukherjee, A., Chaurasia, A.K. and Majumdar, D.K (2011) 'Anti-inflammatory, analgesic and antipyretic activities of Linum usitatissimum L. (flaxseed/linseed) fixed oil', Indian Journal of Experimental Biology, 49(12), pp. 932-938. Preclinical
https://scholar.google.com/scholar?q=Anti-inflammatory%2C%20analgesic%20and%20antipyretic%20activities%20of%20Linum%20usitatissimum%20L.%20%28flaxseed/linseed%29%20fixed%20oil - Rafieian-Kopaei, M., Shakiba, A., Sedighi, M. and Bahmani, M (2017) 'The analgesic and anti-inflammatory activity of Linum usitatissimum in Balb/c mice', Journal of Evidence-Based Complementary & Alternative Medicine, 22(4), pp. 892-896. doi:10.1177/2156587217717416 Preclinical
https://doi.org/10.1177/2156587217717416 - Sirotkin, A.V (2023) 'Influence of flaxseed (Linum usitatissimum) on female reproduction', Planta Medica, 89(6), pp. 608-615. doi:10.1055/a-2013-2966 Meta-analysis / review
https://doi.org/10.1055/a-2013-2966 - Thompson, L.U., Chen, J.M., Li, T., Strasser-Weippl, K. and Goss, P.E (2006) 'Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer', 11(10), pp. 3828--3835. doi:10.1158/1078-0432.CCR-04-2326 Randomized trial
https://doi.org/10.1158/1078-0432.CCR-04-2326 - Adolphe, J.L., Whiting, S.J., Juurlink, B.H.J., Thorpe, L.U. and Alcorn, J (2010) 'Health effects with consumption of the flax lignan secoisolariciresinol diglucoside', 103(7), pp. 929--938. doi:10.1017/S0007114509992753 Clinical study
https://doi.org/10.1017/S0007114509992753 - Caligiuri, S.P.B., Edel, A.L., Aliani, M. and Pierce, G.N (2014) 'Flaxseed for hypertension: implications for improved cardiovascular risk', 16(12), pp. 499. doi:10.1007/s11906-014-0499-8 Randomized trial
https://doi.org/10.1007/s11906-014-0499-8 - European Food Safety Authority (2017) 'Safety of cyanogenic glycosides from flaxseed consumed as part of a usual diet', 15(11). doi:10.2903/j.efsa.2017.5026 Preclinical
https://doi.org/10.2903/j.efsa.2017.5026 - Harris, W.S (2012) 'Stearidonic acid as a surrogate for eicosapentaenoic acid in cardiovascular risk reduction: update and recommendation', 70(10), pp. 565--574. Traditional / reference
https://scholar.google.com/scholar?q=Stearidonic%20acid%20as%20a%20surrogate%20for%20eicosapentaenoic%20acid%20in%20cardiovascular%20risk%20reduction%3A%20update%20and%20recommendation - Latvijas valsts mežzinātnes institūts (n.d.) 'Linsēkla Latvijā'. Available at: https://www.silava.lv Traditional / reference
https://www.silava.lv - Pan, A., Sun, J., Chen, Y. et al (2009) 'Effects of a flaxseed-derived lignan supplement in type 2 diabetic patients: a randomized, double-blind, cross-over trial', 4(11). doi:10.1371/journal.pone.0007654 Randomized trial
https://doi.org/10.1371/journal.pone.0007654 - Royal Botanic Gardens, Kew (n.d.) 'Linum usitatissimum L'. Available at: https://powo.science.kew.org/taxon/urn:lsid:http://ipni.org:names:381313-1 Traditional / reference
https://powo.science.kew.org/taxon/urn:lsid:http://ipni.org:names:381313-1 - Gracious, B.L., Chirieac, M.C., Costescu, S., Finucane, T.L., Youngstrom, E.A. and Hibbeln, J.R (2010) 'Randomized, placebo-controlled trial of flax oil in pediatric bipolar disorder', Bipolar Disorders, 12(2), pp. 142-154. doi:10.1111/j.1399-5618.2010.00799.x Randomized trial
https://doi.org/10.1111/j.1399-5618.2010.00799.x - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.