Omnia SanaPlant Comparison
Water Hyssop vs Dog-rose
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Water Hyssop and Dog-rose: they share 5 indicated uses (arthritis / joint pain, cancer (anticancer research), cognitive function, …); 3 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Water Hyssop | Dog-rose | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 1/10 | 10/10 | Stronger for Dog-rose |
| Cancer (anticancer research) | 2/10 | 2/10 | Comparable evidence |
| Cognitive function | 6/10 | 2/10 | Stronger for Water Hyssop |
| Inflammation (general) | 1/10 | 8/10 | Stronger for Dog-rose |
| Skin irritation | 1/10 | 7/10 | Stronger for Dog-rose |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
The hip is exceptionally rich in vitamin C and carotenoids, underpinning its traditional tonic use. Quantified in commercial dried fruit at beta-carotene 7.25 mg/100 g and lycopene 2.34 mg/100 g fresh weight.
A specific galactolipid fraction studied as the likely active anti-inflammatory constituent in osteoarthritis trials of standardised rosehip powder.
Contribute to antioxidant activity. Leaves carry a higher total phenolic, flavonoid and phenolic-acid content than the hips, and leaf infusions were the only preparation to show antibacterial activity in vitro.
Cold-pressed rose hip seed oil is high in linolenic acid, with phytosterols up to 6485 mg/kg, tocopherols up to 1125 mg/kg and carotenoids up to 108 mg/kg; p-coumaric acid methyl ester predominates among its phenolics.
Pharmacological Actions
Bacopa monnieri (Brahmi) extract and its saponins (bacopaside II, bacopasaponins) inhibit proliferation and induce apoptosis in colon and lung cancer cells (preclinical).
In vitro, the lipophilic (n-hexane and dichloromethane) rose hip extracts inhibited COX-1, COX-2 and 5-LOX-mediated leukotriene B4 formation; the aqueous and methanol extracts were inactive.
Traditional & Indicated Uses
inferred from anti-inflammatory action
Bacopaside II from Bacopa monnieri inhibits colon cancer cell growth via cell-cycle arrest and apoptosis (aquaporin-1 blockade), and its bacopasaponins are cytotoxic to lung (PC9) and colon (SW620) cancer cells (preclinical).
inferred from neuroprotective action
inferred from anti-inflammatory action
inferred from sedative action
inferred from anti-inflammatory action
Two placebo-controlled crossover RCTs of standardised rosehip powder (5 g/day) report reduced WOMAC pain and reduced rescue-medication use in knee/hip osteoarthritis, consistent with the existing meta-analysis.
inferred from anticancer action
Animal evidence only. In high-fat-diet/streptozotocin diabetic rats, R. canina ethanol extract (250 mg/kg) improved recall and long-term memory and reduced hippocampal insulin resistance, amyloid-beta and acetylcholinesterase activity. No human data; the effect is reported in a diabetes model, not in healthy or cognitively impaired people.
inferred from anti-inflammatory action
inferred from anti-inflammatory action
One triple-blind placebo-controlled RCT (n=400) found that 500 mg R. canina fruit capsules twice daily for 20 days after caesarean section reduced the incidence of urinary tract infection. The incidence of cystitis specifically did not differ significantly between groups. Prevention in a post-surgical population; not evidence for treating an established UTI.
Safety, Cautions & Contraindications
Generally well tolerated at standard doses. The most commonly reported side effects are gastrointestinal — nausea, stomach cramps, and increased bowel movements — which can be reduced by taking with food. Not recommended during pregnancy. May interact with medications that increase acetylcholine levels (e.g. Alzheimer's medications). Use with caution in thyroid conditions, as bacopa may increase thyroid hormone levels.
Rosa canina (dog rose) hips are generally recognized as safe (GRAS) for consumption, widely used in teas, jams, and supplements. They are highly nutritious but may cause minor digestive upset (nausea, diarrhea) in some users. The small, irritating hairs around the seeds should be removed before consumption.
Duke (2002) rates dog rose hips as +++ with clinical evidence (score 2) for astringent activity and experimental support for antioxidant and diuretic effects. Dog rose hips are exceptionally rich in vitamin C and bioflavonoids. They are traditionally used for cold and influenza prevention, urinary tract health, and mild diarrhea. Duke notes the diuretic (score 1) and lipoxygenase-inhibitory activities as experimentally documented. The fruit is considered food-grade safe (Duke, 2002).
External Ids
Botanical Description
Low, creeping, succulent perennial herb that roots at the nodes as it spreads across wet ground. The leaves are small, fleshy, spatula-shaped and arranged oppositely along the trailing stems. Small, pale lavender to white, four- to five-petalled flowers are borne singly in the leaf axils.[4]
Scrambling, thorny deciduous shrub (Rosaceae), 1-5 m, with arching, prickly stems bearing hooked thorns. Leaves are pinnate with 5-7 oval, toothed leaflets. Pale pink to white, five-petalled flowers are followed by bright red-orange, egg-shaped hips (the fleshy hip is an accessory fruit; the true fruits are small hairy achenes inside it) that ripen in autumn and often persist into winter.[2]
Habitat
Grows in wet, marshy ground, muddy shorelines, rice paddies and shallow water throughout tropical and subtropical regions of Asia, and also found in parts of Africa, Australia and the Americas.[4]
Native throughout Europe, north-west Africa and western Asia, common in hedgerows, woodland edges, scrub and roadside verges on a wide range of soils.[2]
Harvesting
The whole plant (leaf and trailing stem) is harvested during active growth, typically cut a few centimetres above the mud or water line, and dried or used fresh.
Hips are picked in autumn once fully coloured, then dried for tea or powder, or processed fresh for syrup. The fine, irritant hairs surrounding the seeds inside the hip must be removed before consumption.[5]
Traditional Uses
Bacopa (brahmi) is a classic Ayurvedic 'medhya rasayana' (brain-nourishing) herb, traditionally used to support memory, learning and mental clarity, and as a calming nervine for anxiety and disturbed sleep. This traditional cognitive reputation is now supported by randomised controlled trials of standardised extracts.[1, 4]
Rosehip has a long European folk tradition as a vitamin-C-rich tonic for colds and general immunity, and as a mild diuretic and astringent for urinary and digestive complaints. Modern clinical trials on standardised rosehip powder show a modest, reproducible benefit for osteoarthritis pain and stiffness.[1, 2]
Preparations
Dosage
Clinical trials for osteoarthritis have most often used around 5 g/day of standardised rosehip powder. Educational reference only, not a prescription.
References
Drug Class Interactions
Not documented
Lookalikes Review
References & Sources
- Calabrese, C., Gregory, W.L., Leo, M., Kraemer, D. et al (2008) 'Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial', Journal of Alternative and Complementary Medicine, 14(6), pp. 707-713. doi:10.1089/acm.2008.0018 Randomized trial
https://doi.org/10.1089/acm.2008.0018 - Lorca, C., Mulet, M., Arévalo-Caro, C., Sanchez, M.Á. et al (2022) 'Plant-derived nootropics and human cognition: A systematic review', Critical Reviews in Food Science and Nutrition, 63(22), pp. 5521-5545. doi:10.1080/10408398.2021.2021137 Meta-analysis / review
https://doi.org/10.1080/10408398.2021.2021137 - Fatima, U., Roy, S., Ahmad, S., Ali, S. et al (2022) 'Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation', Frontiers in Nutrition, 9, pp. 972379. doi:10.3389/fnut.2022.972379 Traditional / reference
https://doi.org/10.3389/fnut.2022.972379 - Kongkeaw, C., Dilokthornsakul, P., Thanarangsarit, P., Limpeanchob, N. and Norman Scholfield, C (2014) 'Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract', Journal of Ethnopharmacology, 151(1), pp. 528-535. doi:10.1016/j.jep.2013.11.008 Meta-analysis / review
https://doi.org/10.1016/j.jep.2013.11.008 - Vinod, A., Sathianarayanan, S., Babu, A.E., Sadanandan, P., Venu, A.K. and Venkidasamy, B (2022) 'Bacopa monnieri for disorders affecting brain: current perspectives', Current Topics in Medicinal Chemistry, 22(23), pp. 1909-1929. doi:10.2174/1568026622666220119111538 Meta-analysis / review
https://doi.org/10.2174/1568026622666220119111538 - Dubey, T., Kushwaha, P., Thulasiram, H.V., Chandrashekar, M. and Chinnathambi, S (2023) 'Bacopa monnieri reduces Tau aggregation and Tau-mediated toxicity in cells', International Journal of Biological Macromolecules, 234, pp. 123171. doi:10.1016/j.ijbiomac.2023.123171 Preclinical
https://doi.org/10.1016/j.ijbiomac.2023.123171 - Shalini, V.T., Neelakanta, S.J. and Sriranjini, J.S (2021) 'Neuroprotection with Bacopa monnieri - a review of experimental evidence', Molecular Biology Reports, 48(3), pp. 2653-2668. doi:10.1007/s11033-021-06236-w Meta-analysis / review
https://doi.org/10.1007/s11033-021-06236-w - Simpson, T., Pase, M. and Stough, C (2015) 'Bacopa monnieri as an antioxidant therapy to reduce oxidative stress in the aging brain', Evidence-Based Complementary and Alternative Medicine, 2015, pp. 615384. doi:10.1155/2015/615384 Meta-analysis / review
https://doi.org/10.1155/2015/615384 - Saini, N., Singh, D. and Sandhir, R (2019) 'Bacopa monnieri prevents colchicine-induced dementia by anti-inflammatory action', Metabolic Brain Disease, 34(2), pp. 505-518. doi:10.1007/s11011-018-0332-1 Preclinical
https://doi.org/10.1007/s11011-018-0332-1 - Dubey, T. and Chinnathambi, S (2019) 'Brahmi (Bacopa monnieri): an ayurvedic herb against the Alzheimer's disease', Archives of Biochemistry and Biophysics, 676, pp. 108153. doi:10.1016/j.abb.2019.108153 Meta-analysis / review
https://doi.org/10.1016/j.abb.2019.108153 - Bhandari, P., Kumar, N., Singh, B. and Kaul, V.K (2007) 'Cucurbitacins from Bacopa monnieri', Phytochemistry, 68(9), pp. 1248-1254. doi:10.1016/j.phytochem.2007.03.013 Preclinical
https://doi.org/10.1016/j.phytochem.2007.03.013 - Sivaramakrishna, C., Rao, C.V., Trimurtulu, G., Vanisree, M. and Subbaraju, G.V (2005) 'Triterpenoid glycosides from Bacopa monnieri', Phytochemistry, 66(23), pp. 2719-2728. doi:10.1016/j.phytochem.2005.09.016 Preclinical
https://doi.org/10.1016/j.phytochem.2005.09.016 - World Health Organization (2002) 'WHO Monographs on Selected Medicinal Plants'. Traditional / reference
https://scholar.google.com/scholar?q=WHO%20Monographs%20on%20Selected%20Medicinal%20Plants - Smith, E. and Palethorpe, H.M. and Tomita, Y. and Pei, J.V. and Townsend, A.R. and Price, T.J. and Young, J.P. and Yool, A.J. and Hardingham, J.E (2018) 'The Purified Extract from the Medicinal Plant Bacopa monnieri, Bacopaside II, Inhibits Growth of Colon Cancer Cells In Vitro by Inducing Cell Cycle Arrest and Apoptosis', Cells, 7(7), pp. 81. doi:10.3390/cells7070081 Preclinical
https://doi.org/10.3390/cells7070081 - Yen, D.T.H. and Cuc, N.T. and Tai, B.H. and Van Kiem, P. and Hoang Duc, M. and Nhiem, N.X. and Cho, S.-H. and Jeong, S.B. and Seo, Y. and Park, S (2022) 'Two new triterpenoid glycosides from Bacopa monnieri and their cytotoxic activity', Natural Product Research, 38(7), pp. 1120-1126. doi:10.1080/14786419.2022.2132498 Preclinical
https://doi.org/10.1080/14786419.2022.2132498 - Calabrese, C., Gregory, W.L., Leo, M., Kraemer, D., Bone, K. and Oken, B (2008) 'Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly', 14(6), pp. 707--713. Randomized trial
https://scholar.google.com/scholar?q=Effects%20of%20a%20standardized%20Bacopa%20monnieri%20extract%20on%20cognitive%20performance%2C%20anxiety%2C%20and%20depression%20in%20the%20elderly - Stough, C., Lloyd, J., Clarke, J., Downey, L.A., Hutchison, C.W., Rodgers, T. and Nathan, P.J (2001) 'The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects', 156(4), pp. 481--484. doi:10.1007/s002130100815 Randomized trial
https://doi.org/10.1007/s002130100815 - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition - Ghasemzadeh Rahbardar, M. and Hosseinzadeh, H (2024) 'Therapeutic potential of hypnotic herbal medicines: A comprehensive review', Phytotherapy Research, 38(6), pp. 3037-3059. doi:10.1002/ptr.8201 Meta-analysis / review
https://doi.org/10.1002/ptr.8201 - Block, K.I., Gyllenhaal, C. and Mead, M.N (2004) 'Safety and efficacy of herbal sedatives in cancer care', Integrative Cancer Therapies, 3(2), pp. 128-148. doi:10.1177/1534735404265003 Meta-analysis / review
https://doi.org/10.1177/1534735404265003
- Christensen, R., Bartels, E.M., Altman, R.D., Astrup, A. and Bliddal, H (2008) 'Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients? - a meta-analysis of randomized controlled trials', Osteoarthritis and Cartilage, 16(9), pp. 965-972. doi:10.1016/j.joca.2008.03.001 Meta-analysis / review
https://doi.org/10.1016/j.joca.2008.03.001 - Gruenwald, J., Uebelhack, R. and More, M.I (2019) 'Rosa canina - Rose hip pharmacological ingredients and molecular mechanics counteracting osteoarthritis - A systematic review', Phytomedicine, 60, pp. 152958. doi:10.1016/j.phymed.2019.152958 Meta-analysis / review
https://doi.org/10.1016/j.phymed.2019.152958 - Sanz-Lamora, H., Nicola-Llorente, M., Torres-Oteros, D., Perez-Marti, A. and others (2024) 'The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High-Fat Diet-Fed Mice', Molecular Nutrition & Food Research, 68(5), pp. e2300539. doi:10.1002/mnfr.202300539 Preclinical
https://doi.org/10.1002/mnfr.202300539 - Tumbas, V.T., Canadanovic-Brunet, J.M., Cetojevic-Simin, D.D., Cetkovic, G.S. and others (2011) 'Effect of rosehip (Rosa canina L.) phytochemicals on stable free radicals and human cancer cells', Journal of the Science of Food and Agriculture, 92(6), pp. 1273-1281. doi:10.1002/jsfa.4695 Preclinical
https://doi.org/10.1002/jsfa.4695 - Pena, F., Valencia, S., Tereucan, G., Nahuelcura, J. and others (2023) 'Bioactive Compounds and Antioxidant Activity in the Fruit of Rosehip (Rosa canina L. and Rosa rubiginosa L.)', Molecules, 28(8), pp. 3544. doi:10.3390/molecules28083544 Preclinical
https://doi.org/10.3390/molecules28083544 - Hendrysiak, A., Brzezowska, J., Nicolet, N., Bocquel, D. and others (2023) 'Juice Powders from Rosehip (Rosa canina L.): Physical, Chemical, and Antiglycation Properties', Molecules, 28(4), pp. 1674. doi:10.3390/molecules28041674 Preclinical
https://doi.org/10.3390/molecules28041674 - Igual, M., Garcia-Herrera, P., Camara, R.M., Martinez-Monzo, J. and others (2022) 'Bioactive Compounds in Rosehip (Rosa canina) Powder with Encapsulating Agents', Molecules, 27(15), pp. 4737. doi:10.3390/molecules27154737 Preclinical
https://doi.org/10.3390/molecules27154737 - Truong, V.L. and Jeong, W.S (2023) 'Hair Growth-Promoting Effects of Rosehip (Rosa canina L.) Seed Oil in C57BL/6 Mice', Preventive Nutrition and Food Science, 28(4), pp. 411-417. doi:10.3746/pnf.2023.28.4.411 Preclinical
https://doi.org/10.3746/pnf.2023.28.4.411 - Michalska-Ciechanowska, A., Brzezowska, J., Nicolet, N., Haladyn, K. and others (2025) 'Valorization of Rosehip (Rosa canina L.) Pomace Using Unconventional Carbohydrate Carriers for Beverage Obtainment', Molecules, 30(1), pp. 141. doi:10.3390/molecules30010141 Preclinical
https://doi.org/10.3390/molecules30010141 - Vlaicu, P.A., Untea, A.E., Turcu, R.P., Panaite, T.D. and Saracila, M (2022) 'Rosehip (Rosa canina L.) Meal as a Natural Antioxidant on Lipid and Protein Quality and Shelf-Life of Polyunsaturated Fatty Acids Enriched Eggs', Antioxidants (Basel), 11(10), pp. 1948. doi:10.3390/antiox11101948 Preclinical
https://doi.org/10.3390/antiox11101948 - Phetcharat, L. and Wongsuphasawat, K. and Winther, K (2015) 'The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity', Clinical Interventions in Aging, 10, pp. 1849--1856. doi:10.2147/CIA.S90092 Randomized trial
https://doi.org/10.2147/CIA.S90092 - Golsorkhi, H. and Montazerlotfelahi, H. and Abniki, E. and Vafaee-Shahi, M. and Kamalinejad, M. and Qorbani, M. and Bahrami, M. and Dadmehr, M (2025) 'Efficacy and safety of Rosa canina L. and a traditional polyherbal formulation syrup in children and adolescents with attention-deficit/hyperactivity disorder: a factorial randomized double-blind placebo-controlled clinical trial', Phytotherapy Research, 39(9), pp. 4116--4125. doi:10.1002/ptr.70061 Randomized trial
https://doi.org/10.1002/ptr.70061 - Miljkovi\'c, V. M. and Nikoli\'c, L. and Mrmo\v sanin, J. and Gaji\'c, I. and Mihajilov-Krstev, T. and Zvezdanovi\'c, J. and Miljkovi\'c, M (2024) 'Chemical profile and antioxidant and antimicrobial activity of Rosa canina L. dried fruit commercially available in Serbia', International Journal of Molecular Sciences, 25(5), pp. 2518. doi:10.3390/ijms25052518 Preclinical
https://doi.org/10.3390/ijms25052518 - Polumackanycz, M. and Kaszuba, M. and Konopacka, A. and Marzec-Wr\'oblewska, U. and Wesolowski, M. and Waleron, K. and Buci\'nski, A. and Viapiana, A (2020) 'Phenolic composition and biological properties of wild and commercial dog rose (Rosa canina L.) fruits and leaves', Molecules, 25(22), pp. 5272. doi:10.3390/molecules25225272 Preclinical
https://doi.org/10.3390/molecules25225272 - Grajzer, M. and Prescha, A. and Korzonek, K. and Wojakowska, A. and Dziadas, M. and Kulma, A. and Grajeta, H (2015) 'Characteristics of rose hip (Rosa canina L.) cold-pressed oil and its oxidative stability studied by the differential scanning calorimetry method', Food Chemistry, 188, pp. 459--466. doi:10.1016/j.foodchem.2015.05.034 Preclinical
https://doi.org/10.1016/j.foodchem.2015.05.034 - Chrubasik, C., Roufogalis, B.D., Müller-Ladner, U. and Chrubasik, S (2008) 'A systematic review on the Rosa canina effect and efficacy profiles', 22(6), pp. 725--733. doi:10.1002/ptr.2400 Meta-analysis / review
https://doi.org/10.1002/ptr.2400 - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - Wenzig, E. M. and Widowitz, U. and Kunert, O. and Chrubasik, S. and Bucar, F. and Knauder, E. and Bauer, R (2008) 'Phytochemical composition and in vitro pharmacological activity of two rose hip (Rosa canina L.) preparations', Phytomedicine, 15(10), pp. 826--835. doi:10.1016/j.phymed.2008.06.012 Preclinical
https://doi.org/10.1016/j.phymed.2008.06.012 - Winther, K. and Apel, K. and Thamsborg, G (2005) 'A powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial', Scandinavian Journal of Rheumatology, 34(4), pp. 302--308. doi:10.1080/03009740510018624 Randomized trial
https://doi.org/10.1080/03009740510018624 - Rein, E. and Kharazmi, A. and Winther, K (2004) 'A herbal remedy, Hyben Vital (stand. powder of a subspecies of Rosa canina fruits), reduces pain and improves general wellbeing in patients with osteoarthritis: a double-blind, placebo-controlled, randomised trial', Phytomedicine, 11(5), pp. 383--391. doi:10.1016/j.phymed.2004.01.001 Randomized trial
https://doi.org/10.1016/j.phymed.2004.01.001 - Ertas, B. and Hazar-Yavuz, A. N. and Topal, F. and Keles-Kaya, R. and Karakus, \"O. and Ozcan, G. S. and Taskin, T. and Cam, M. E (2023) 'Rosa canina L. improves learning and memory-associated cognitive impairment by regulating glucose levels and reducing hippocampal insulin resistance in high-fat diet/streptozotocin-induced diabetic rats', Journal of Ethnopharmacology, 313, pp. 116541. doi:10.1016/j.jep.2023.116541 Preclinical
https://doi.org/10.1016/j.jep.2023.116541 - Seifi, M. and Abbasalizadeh, S. and Mohammad-Alizadeh-Charandabi, S. and Khodaie, L. and Mirghafourvand, M (2017) 'The effect of Rosa (L. Rosa canina) on the incidence of urinary tract infection in the puerperium: a randomized placebo-controlled trial', Phytotherapy Research, 32(1), pp. 76--83. doi:10.1002/ptr.5950 Randomized trial
https://doi.org/10.1002/ptr.5950 - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.