Plant Comparison
Andrographis vs Dandelion
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Andrographis and Dandelion: they share 7 indicated uses (arthritis / joint pain, cancer (anticancer research), immune support, …); 5 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Andrographis | Dandelion | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 5/10 | 1/10 | Stronger for Andrographis |
| Cancer (anticancer research) | 2/10 | 2/10 | Comparable evidence |
| Immune support | 5/10 | 2/10 | Stronger for Andrographis |
| Infection (general) | 8/10 | 1/10 | Stronger for Andrographis |
| Inflammation (general) | 5/10 | 1/10 | Stronger for Andrographis |
| Skin irritation | 5/10 | 1/10 | Stronger for Andrographis |
| Wounds | 5/10 | 1/10 | Stronger for Andrographis |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Bitter principles (e.g. taraxacin) responsible for the characteristic bitterness and bitter-tonic action.
Including taraxasterol; contribute to anti-inflammatory and hepatoprotective signals.
Antioxidant constituents (e.g. chicoric acid, luteolin derivatives).
Pharmacological Actions
Andrographolide, the principal diterpene lactone of Andrographis paniculata, suppresses proliferation and induces apoptosis across breast, lung, colon, cervical, hepatic and haematological cancers via NF-kappaB and PI3K/Akt inhibition (preclinical).
Traditional & Indicated Uses
inferred from anti-inflammatory action
Andrographolide (from Andrographis paniculata) acts as a chemopreventive and antitumour agent against breast, lung, colorectal, cervical, prostate and hepatocellular cancers and leukaemia, inducing apoptosis and inhibiting NF-kappaB and PI3K/AKT signalling (preclinical).
Symptomatic relief of the common cold and acute upper respiratory tract infection (reduces symptom severity and duration)
Immunostimulant / immune support
Symptomatic relief of the common cold and acute upper respiratory tract infection (reduces symptom severity and duration)
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from bitter-tonic action
inferred from anti-inflammatory action
inferred from anticancer action
inferred from hepatoprotective action
inferred from antimicrobial action
inferred from anti-inflammatory action
inferred from choleretic action
inferred from anti-inflammatory action
inferred from diuretic action
inferred from diuretic action
inferred from diuretic action
Dandelion root and leaf lowered serum lipids and oxidative stress (preclinical).
Safety, Cautions & Contraindications
Avoid in pregnancy and when trying to conceive: high doses have shown reproductive toxicity in animals and the herb has a traditional reputation as an abortifacient.
High doses have caused nephrotoxicity and reproductive toxicity in studies; use standardized products at recommended doses and avoid prolonged high-dose use.
Allergy risk in individuals sensitive to Asteraceae (daisy family) plants such as ragweed and chamomile.
Avoid medicinal use in anyone with a blocked bile duct or gallstones; use caution with gallbladder or serious liver disease.
May potentiate prescription diuretics; possible interactions with lithium and drugs metabolised by the liver.
Can accumulate soil pollutants and heavy metals; harvest from clean, unpolluted sites.
Use during pregnancy or breastfeeding should be guided by a qualified practitioner. Herbal use should support, not replace, conventional medical care.
External Ids
Botanical Description
Erect, branching annual herb with a slender, quadrangular (square-sectioned), dark green stem. The leaves are opposite, lance-shaped and glabrous, with a short stalk. Small, two-lipped, white flowers with purple-pink markings are borne in loose, spreading axillary and terminal racemes. The whole plant, and especially the leaves, is intensely and characteristically bitter.[11]
Perennial herb (Asteraceae) with a deep taproot, forming a basal rosette of deeply toothed, lance-shaped leaves - the name 'dandelion' comes from the French 'dent-de-lion', lion's tooth. Hollow flowering stalks each bear a single, bright yellow composite flower head made entirely of ray florets, followed by the familiar spherical 'clock' of parachute-tufted seeds (achenes) that disperse on the wind.[50]
Habitat
Native to India and Sri Lanka and widely distributed through South and Southeast Asia, growing wild in plains, hillsides, roadsides and cultivated fields; also grown commercially as a medicinal crop.[11]
Native to Europe and Asia, now a cosmopolitan weed found on every continent except Antarctica; grows in lawns, meadows, roadsides, waste ground and disturbed soil of almost any type.[50]
Harvesting
The aerial parts (leaves and tender stems) are cut just before or at the onset of flowering, when andrographolide content is typically highest, and dried in shade to preserve the bitter diterpenoid lactones.[11]
Leaves are picked young in spring for the mildest flavour; the root is dug in autumn (traditionally after the first frost), when its inulin and bitter-principle content is considered optimal; flowers are picked as they open.[50, 53]
Traditional Uses
Andrographis, the 'king of bitters', is a cornerstone bitter tonic of Ayurvedic and traditional Chinese medicine (Chuan xin lian), used for fevers, colds, sore throat, infections and liver complaints. This traditional reputation for treating the common cold and upper respiratory infections is now supported by clinical trials of standardised extracts.[10, 12]
Dandelion is one of the most widely used bitter tonic herbs worldwide, traditionally taken as a digestive bitter and mild diuretic - the French name 'pissenlit' (wet-the-bed) reflects this - and the root specifically as a liver and gallbladder tonic. Every part is also used as food: spring greens, roasted-root coffee substitute, and flower wine.[50]
Preparations
Dried aerial parts infused or lightly decocted in hot water as a very bitter traditional fever and cold remedy.
Dosage
Clinical trials for upper respiratory infection commonly use extracts standardised to around 60-120 mg andrographolide daily, in divided doses, for up to 5-7 days. Educational reference only, not a prescription.
The WHO monograph on Herba Andrographidis gives, by indication - for the common cold, 1.5-3.0 g of the powdered crude drug three times daily, after meals and at bedtime; for pyrexia, a decoction from 3 g of the crude drug twice daily; for diarrhoea, a decoction from 3-9 g as a single dose as needed, or two 500 mg tablets four times daily. Note that the EMA HMPC assessed this herb and issued a public statement rather than a monograph, so there is no EU posology. Educational reference only, not a prescription.
Traditional guidance suggests roughly 4-10 g dried leaf, or 2-8 g dried root, per day as an infusion or decoction, divided into 2-3 doses. Educational reference only, not a prescription; avoid in bile-duct obstruction or gallstones, and harvest away from polluted ground.
References
Lookalikes Review
References & Sources
- Okonogi, R. and others (2023) 'Efficacy of Andrographis paniculata spray in acute pharyngitis: A randomized controlled trial', Drug Discoveries & Therapeutics, 17(5), pp. 315-321. doi:10.5582/ddt.2023.01053 Randomized trial
https://doi.org/10.5582/ddt.2023.01053 - Hossain, S., Urbi, Z., Karuniawati, H., Mohiuddin, R.B. and others (2018) 'Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide', Critical Reviews in Food Science and Nutrition, 61(10), pp. 1635-1652. doi:10.1080/10408398.2018.1501657 Meta-analysis / review
https://doi.org/10.1080/10408398.2018.1501657 - Worakunphanich, W. and others (2021) 'Andrographis paniculata Formulations: Impact on Diterpene Lactone Oral Bioavailability', European Journal of Drug Metabolism and Pharmacokinetics, 46(5), pp. 565-581. doi:10.1007/s13318-021-00736-7 Meta-analysis / review
https://doi.org/10.1007/s13318-021-00736-7 - Worakunphanich, W., Thavorncharoensap, M., Youngkong, S., Thakkinstian, A. and Chaikledkaew, U (2021) 'Safety of Andrographis paniculata: A systematic review and meta-analysis', Pharmacoepidemiology and Drug Safety, 30(6), pp. 727-739. doi:10.1002/pds.5190 Meta-analysis / review
https://doi.org/10.1002/pds.5190 - Kumar, S., Singh, B. and Bajpai, V (2021) 'Andrographis paniculata (Burm.f.) Nees and its major constituent andrographolide as potential antiviral agents', Journal of Ethnopharmacology, 274, pp. 113954. doi:10.1016/j.jep.2021.113954 Meta-analysis / review
https://doi.org/10.1016/j.jep.2021.113954 - Barbosa, F.L. and others (2021) 'Andrographis paniculata (Burm. f.) Wall. ex Nees: An Updated Review of Phytochemistry, Antimicrobial Pharmacology, and Clinical Safety and Efficacy', Life, 11(4), pp. 348. doi:10.3390/life11040348 Meta-analysis / review
https://doi.org/10.3390/life11040348 - Singh, P. and others (2022) 'Andrographis paniculata mitigates first-line anti-tubercular drugs-induced nephrotoxicity in Wistar rats', Biomarkers, 27(4), pp. 385-394. doi:10.1080/1354750X.2022.2043444 Preclinical
https://doi.org/10.1080/1354750X.2022.2043444 - Coon, J.T. and Ernst, E (2004) 'Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials', Journal of Clinical Pharmacy and Therapeutics, 29(1), pp. 37-45. doi:10.1046/j.1365-2710.2003.00534.x Meta-analysis / review
https://doi.org/10.1046/j.1365-2710.2003.00534.x - Rondee, N. and others (2023) 'The Effects of Andrographis paniculata (Burm.F.) Wall. Ex Nees and Andrographolide on Neuroinflammation in the Treatment of Neurodegenerative Diseases', Nutrients, 15(15), pp. 3428. doi:10.3390/nu15153428 Meta-analysis / review
https://doi.org/10.3390/nu15153428 - Zeng, B., Wei, A., Zhou, Q., Yuan, M., Lei, K., Liu, Y., Song, J., Guo, L. and Ye, Q (2021) 'Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches', Phytotherapy Research. doi:10.1002/ptr.7324 Randomized trial
https://doi.org/10.1002/ptr.7324 - Gonde, D.P., Bhole, B.K. and Kakad, K.S (2023) 'Andrographolide, diterpenoid constituent of Andrographis paniculata: Review on botany, phytochemistry, molecular docking analysis, and pharmacology', Annales Pharmaceutiques Francaises. doi:10.1016/j.pharma.2023.10.001 Preclinical
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https://doi.org/10.1371/journal.pone.0181780 - World Health Organization (2002) 'Herba Andrographidis'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
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https://www.mskcc.org/cancer-care/integrative-medicine/herbs/andrographis
- Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - Botanical Society of Britain and Ireland (n.d.) 'Dandelion identification (Taraxacum)'. Available at: https://bsbi.org/identification/taraxacum Traditional / reference
https://bsbi.org/identification/taraxacum - Farm and Dairy (2021) 'How to harvest and use dandelion roots, leaves and flowers'. Available at: https://www.farmanddairy.com/news/top-stories/how-to-harvest-and-use-dandelion-roots-leaves-and-flowers/656605.html Traditional / reference
https://www.farmanddairy.com/news/top-stories/how-to-harvest-and-use-dandelion-roots-leaves-and-flowers/656605.html - First Nature (n.d.) 'Taraxacum officinale, Dandelion: identification, distribution, habitat'. Available at: https://www.first-nature.com/flowers/taraxacum-officinale.php Traditional / reference
https://www.first-nature.com/flowers/taraxacum-officinale.php - Flora of the Southeastern United States (n.d.) 'Taraxacum officinale (Common Dandelion)'. Available at: https://fsus.ncbg.unc.edu/main.php?pg=show-taxon.php&plantname=taraxacum+officinale Traditional / reference
https://fsus.ncbg.unc.edu/main.php?pg=show-taxon.php&plantname=taraxacum+officinale - Good Grub (n.d.) 'Plant of the Month: Dandelion!'. Available at: https://www.goodgrub.org/post/plant-of-the-month-dandelion Traditional / reference
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https://underatinroof.com/blog/the-ultimate-guide-to-foraging-dandelions-how-to-harvest-flowers-greens-and-roots - University of Massachusetts (n.d.) 'Taraxacum officinale'. Available at: https://extension.umass.edu/weed-herbarium/weeds/taraxacum-officinale/ Traditional / reference
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Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.