Plant Comparison
Andrographis vs Blackcurrant
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Andrographis and Blackcurrant: they share 6 indicated uses (arthritis / joint pain, cold & flu, immune support, …); 3 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Andrographis | Blackcurrant | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 5/10 | 5/10 | Comparable evidence |
| Cold & flu | 8/10 | 5/10 | Stronger for Andrographis |
| Immune support | 5/10 | 5/10 | Comparable evidence |
| Infection (general) | 8/10 | 5/10 | Stronger for Andrographis |
| Inflammation (general) | 5/10 | 5/10 | Comparable evidence |
| Skin irritation | 5/10 | 5/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Give the berries their deep colour and are the principal antioxidant constituents.
The fruit is exceptionally rich in vitamin C, contributing to its traditional cold/flu use.
The seed oil is a well-known plant source of the omega-6 fatty acid GLA.
Pharmacological Actions
Andrographolide, the principal diterpene lactone of Andrographis paniculata, suppresses proliferation and induces apoptosis across breast, lung, colon, cervical, hepatic and haematological cancers via NF-kappaB and PI3K/Akt inhibition (preclinical).
Traditional & Indicated Uses
inferred from anti-inflammatory action
Andrographolide (from Andrographis paniculata) acts as a chemopreventive and antitumour agent against breast, lung, colorectal, cervical, prostate and hepatocellular cancers and leukaemia, inducing apoptosis and inhibiting NF-kappaB and PI3K/AKT signalling (preclinical).
Symptomatic relief of the common cold and acute upper respiratory tract infection (reduces symptom severity and duration)
Immunostimulant / immune support
Symptomatic relief of the common cold and acute upper respiratory tract infection (reduces symptom severity and duration)
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from antiviral action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from diuretic action
inferred from diuretic action
Safety, Cautions & Contraindications
Avoid in pregnancy and when trying to conceive: high doses have shown reproductive toxicity in animals and the herb has a traditional reputation as an abortifacient.
High doses have caused nephrotoxicity and reproductive toxicity in studies; use standardized products at recommended doses and avoid prolonged high-dose use.
Fruit (berries) • Generally safe as food for most people; adverse effects mainly GI discomfort or allergy in sensitive individuals. • If using high-dose extracts, use extra caution with blood-thinners/anticoagulants (evidence is not definitive, but polyphenol-rich supplements are often treated cautiously in practice). Leaf (folium) • EMA classifies blackcurrant leaf as a traditional herbal medicinal product (not “well-established use”): minor joint pain and urinary-tract flushing. • Typical label cautions (EMA-style): not recommended <18, avoid if you have edema due to impaired heart/kidney function, and seek medical advice if urinary symptoms persist/worsen. • Pregnancy/lactation: food use is fine, but medicinal leaf dosing is generally used cautiously due to limited robust safety data. Seed (seed oil) • Usually well tolerated, but may cause GI upset in some people. • Caution with anticoagulants/antiplatelet drugs (PUFA supplements are often used cautiously here). • Note: some trials explored maternal/infant contexts, but that does not automatically mean “recommended in pregnancy” outside medical supervision.
Duke (2002) rates blackcurrant fruit highly (+++), with evidence for anti-inflammatory, angioprotective, and antioxidant activities. Ribes nigrum extracts showed the richest anthocyanin and polyphenol content in antioxidant studies, outperforming many other common berries. Clinical use is supported for diarrhea, colds, and flu. The high vitamin C and anthocyanin content underpin its vasoprotective effects. The fruit is treated as food-grade medicine and is classified as generally safe (Duke, 2002).
External Ids
Botanical Description
Erect, branching annual herb with a slender, quadrangular (square-sectioned), dark green stem. The leaves are opposite, lance-shaped and glabrous, with a short stalk. Small, two-lipped, white flowers with purple-pink markings are borne in loose, spreading axillary and terminal racemes. The whole plant, and especially the leaves, is intensely and characteristically bitter.[11]
Deciduous shrub (Grossulariaceae), 1-2 m tall, aromatic when the leaves are crushed. Leaves are palmately lobed (3-5 lobes), toothed, with resinous glands on the underside. Small, greenish-white to dull purple, bell-shaped flowers are borne in drooping racemes, followed by clusters of glossy black berries.
Habitat
Native to India and Sri Lanka and widely distributed through South and Southeast Asia, growing wild in plains, hillsides, roadsides and cultivated fields; also grown commercially as a medicinal crop.[11]
Native to central and northern Europe and Siberia, growing in damp woodland, fens, riverbanks and hedgerows; widely cultivated commercially as a fruit crop in cool-temperate climates.
Harvesting
The aerial parts (leaves and tender stems) are cut just before or at the onset of flowering, when andrographolide content is typically highest, and dried in shade to preserve the bitter diterpenoid lactones.[11]
Berries are hand- or machine-harvested in mid- to late summer once fully ripe and black. Leaves are gathered in late spring to early summer, before flowering fades, for the medicinal leaf preparation. Seed oil is cold-pressed from the seeds after juicing.
Traditional Uses
Andrographis, the 'king of bitters', is a cornerstone bitter tonic of Ayurvedic and traditional Chinese medicine (Chuan xin lian), used for fevers, colds, sore throat, infections and liver complaints. This traditional reputation for treating the common cold and upper respiratory infections is now supported by clinical trials of standardised extracts.[10, 12]
Blackcurrant has a long northern-European food-medicine tradition: the vitamin-C- and anthocyanin-rich berries have traditionally been used for colds, flu and general vitality, while the leaf has an official EU traditional-use registration for minor joint pain and as a urinary-tract flush, and the seed oil is valued as a source of gamma-linolenic acid (GLA). Modern research confirms broad antioxidant, anti-inflammatory, immunomodulatory and vasoprotective activity across the fruit, leaf and seed oil.[11, 12, 13]
Preparations
Dried aerial parts infused or lightly decocted in hot water as a very bitter traditional fever and cold remedy.
Dosage
Clinical trials for upper respiratory infection commonly use extracts standardised to around 60-120 mg andrographolide daily, in divided doses, for up to 5-7 days. Educational reference only, not a prescription.
The WHO monograph on Herba Andrographidis gives, by indication - for the common cold, 1.5-3.0 g of the powdered crude drug three times daily, after meals and at bedtime; for pyrexia, a decoction from 3 g of the crude drug twice daily; for diarrhoea, a decoction from 3-9 g as a single dose as needed, or two 500 mg tablets four times daily. Note that the EMA HMPC assessed this herb and issued a public statement rather than a monograph, so there is no EU posology. Educational reference only, not a prescription.
EMA-style traditional-use guidance for the leaf suggests roughly 2-4 g dried leaf per cup as an infusion, up to three times daily, for short-term joint or urinary support (not recommended under 18, or with fluid retention linked to heart/kidney disease). Berries and juice are food-safe at normal dietary amounts. Educational reference only, not a prescription.
References
Lookalikes Review
References & Sources
- Okonogi, R. and others (2023) 'Efficacy of Andrographis paniculata spray in acute pharyngitis: A randomized controlled trial', Drug Discoveries & Therapeutics, 17(5), pp. 315-321. doi:10.5582/ddt.2023.01053 Randomized trial
https://doi.org/10.5582/ddt.2023.01053 - Hossain, S., Urbi, Z., Karuniawati, H., Mohiuddin, R.B. and others (2018) 'Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide', Critical Reviews in Food Science and Nutrition, 61(10), pp. 1635-1652. doi:10.1080/10408398.2018.1501657 Meta-analysis / review
https://doi.org/10.1080/10408398.2018.1501657 - Worakunphanich, W. and others (2021) 'Andrographis paniculata Formulations: Impact on Diterpene Lactone Oral Bioavailability', European Journal of Drug Metabolism and Pharmacokinetics, 46(5), pp. 565-581. doi:10.1007/s13318-021-00736-7 Meta-analysis / review
https://doi.org/10.1007/s13318-021-00736-7 - Worakunphanich, W., Thavorncharoensap, M., Youngkong, S., Thakkinstian, A. and Chaikledkaew, U (2021) 'Safety of Andrographis paniculata: A systematic review and meta-analysis', Pharmacoepidemiology and Drug Safety, 30(6), pp. 727-739. doi:10.1002/pds.5190 Meta-analysis / review
https://doi.org/10.1002/pds.5190 - Kumar, S., Singh, B. and Bajpai, V (2021) 'Andrographis paniculata (Burm.f.) Nees and its major constituent andrographolide as potential antiviral agents', Journal of Ethnopharmacology, 274, pp. 113954. doi:10.1016/j.jep.2021.113954 Meta-analysis / review
https://doi.org/10.1016/j.jep.2021.113954 - Barbosa, F.L. and others (2021) 'Andrographis paniculata (Burm. f.) Wall. ex Nees: An Updated Review of Phytochemistry, Antimicrobial Pharmacology, and Clinical Safety and Efficacy', Life, 11(4), pp. 348. doi:10.3390/life11040348 Meta-analysis / review
https://doi.org/10.3390/life11040348 - Singh, P. and others (2022) 'Andrographis paniculata mitigates first-line anti-tubercular drugs-induced nephrotoxicity in Wistar rats', Biomarkers, 27(4), pp. 385-394. doi:10.1080/1354750X.2022.2043444 Preclinical
https://doi.org/10.1080/1354750X.2022.2043444 - Coon, J.T. and Ernst, E (2004) 'Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials', Journal of Clinical Pharmacy and Therapeutics, 29(1), pp. 37-45. doi:10.1046/j.1365-2710.2003.00534.x Meta-analysis / review
https://doi.org/10.1046/j.1365-2710.2003.00534.x - Rondee, N. and others (2023) 'The Effects of Andrographis paniculata (Burm.F.) Wall. Ex Nees and Andrographolide on Neuroinflammation in the Treatment of Neurodegenerative Diseases', Nutrients, 15(15), pp. 3428. doi:10.3390/nu15153428 Meta-analysis / review
https://doi.org/10.3390/nu15153428 - Zeng, B., Wei, A., Zhou, Q., Yuan, M., Lei, K., Liu, Y., Song, J., Guo, L. and Ye, Q (2021) 'Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches', Phytotherapy Research. doi:10.1002/ptr.7324 Randomized trial
https://doi.org/10.1002/ptr.7324 - Gonde, D.P., Bhole, B.K. and Kakad, K.S (2023) 'Andrographolide, diterpenoid constituent of Andrographis paniculata: Review on botany, phytochemistry, molecular docking analysis, and pharmacology', Annales Pharmaceutiques Francaises. doi:10.1016/j.pharma.2023.10.001 Preclinical
https://doi.org/10.1016/j.pharma.2023.10.001 - Hu, X.Y., Wu, R.H., Logue, M., Blondel, C., Lai, L.Y.W., Stuart, B., Flower, A., Fei, Y.T., Moore, M., Shepherd, J., Liu, J.P. and Lewith, G (2017) 'Andrographis paniculata (Chuan Xin Lian) for symptomatic relief of acute respiratory tract infections in adults and children: A systematic review and meta-analysis', PLoS ONE. doi:10.1371/journal.pone.0181780 Meta-analysis / review
https://doi.org/10.1371/journal.pone.0181780 - World Health Organization (2002) 'Herba Andrographidis'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 - Tundis, R. and Patra, J.K. and Bonesi, M. and Das, S. and Nath, R. and Das Talukdar, A. and Das, G. and Loizzo, M.R (2023) 'Anti-Cancer Agent: The Labdane Diterpenoid-Andrographolide', Plants, 12(10), pp. 1969. doi:10.3390/plants12101969 Preclinical
https://doi.org/10.3390/plants12101969 - Mishra, S.K. and Tripathi, S. and Shukla, A. and Oh, S.H. and Kim, H.M (2015) 'Andrographolide and analogues in cancer prevention', Frontiers in Bioscience (Elite Edition), 7(2), pp. 255-266. doi:10.2741/E732 Preclinical
https://doi.org/10.2741/E732 - Paul, S. and Roy, D. and Pati, S. and Sa, G (2021) 'The Adroitness of Andrographolide as a Natural Weapon Against Colorectal Cancer', Frontiers in Pharmacology, 12, pp. 731492. doi:10.3389/fphar.2021.731492 Preclinical
https://doi.org/10.3389/fphar.2021.731492 - Memorial Sloan Kettering Cancer Center (n.d.) 'Andrographis (About Herbs)'. Available at: https://www.mskcc.org/cancer-care/integrative-medicine/herbs/andrographis Traditional / reference
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/andrographis
- Lee, Y., Pham, T.X., Bae, M., Hu, S. and others (2019) 'Blackcurrant (Ribes nigrum) Prevents Obesity-Induced Nonalcoholic Steatohepatitis in Mice', Obesity (Silver Spring), 27(1), pp. 112-120. doi:10.1002/oby.22353 Preclinical
https://doi.org/10.1002/oby.22353 - da Costa, P., Schetinger, M.R.C., Baldissarelli, J., Stefanello, N. and others (2024) 'Blackcurrant (Ribes nigrum L.) improves cholinergic signaling and protects against chronic scopolamine-induced memory impairment in mice', Journal of Psychopharmacology, 38(12), pp. 1170-1183. doi:10.1177/02698811241273776 Preclinical
https://doi.org/10.1177/02698811241273776 - Nanashima, N., Horie, K., Yamanouchi, K., Tomisawa, T. and others (2020) 'Blackcurrant (Ribes nigrum) Extract Prevents Dyslipidemia and Hepatic Steatosis in Ovariectomized Rats', Nutrients, 12(5), pp. 1541. doi:10.3390/nu12051541 Preclinical
https://doi.org/10.3390/nu12051541 - Lee, Y. and Lee, J.Y (2019) 'Blackcurrant (Ribes nigrum) Extract Exerts an Anti-Inflammatory Action by Modulating Macrophage Phenotypes', Nutrients, 11(5), pp. 975. doi:10.3390/nu11050975 Preclinical
https://doi.org/10.3390/nu11050975 - Lappi, J., Raninen, K., Vakevainen, K., Karlund, A. and others (2020) 'Blackcurrant (Ribes nigrum) lowers sugar-induced postprandial glycaemia independently and in a product with fermented quinoa: a randomised crossover trial', British Journal of Nutrition, 126(5), pp. 708-717. doi:10.1017/S0007114520004468 Randomized trial
https://doi.org/10.1017/S0007114520004468 - Horie, K., Maeda, H., Nanashima, N. and Oey, I (2021) 'Potential Vasculoprotective Effects of Blackcurrant (Ribes nigrum) Extract in Diabetic KK-Ay Mice', Molecules, 26(21), pp. 6459. doi:10.3390/molecules26216459 Preclinical
https://doi.org/10.3390/molecules26216459 - Nanashima, N., Horie, K., Kitajima, M., Takamagi, S. and others (2021) 'Hypocholesterolemic Effect of Blackcurrant (Ribes nigrum) Extract in Healthy Female Subjects: A Pilot Study', Molecules, 26(13), pp. 4085. doi:10.3390/molecules26134085 Clinical study
https://doi.org/10.3390/molecules26134085 - Horie, K., Nanashima, N., Maeda, H., Tomisawa, T. and others (2021) 'Blackcurrant (Ribes nigrum L.) Extract Exerts Potential Vasculoprotective Effects in Ovariectomized Rats, Including Prevention of Elastin Degradation and Pathological Vascular Remodeling', Nutrients, 13(2), pp. 560. doi:10.3390/nu13020560 Preclinical
https://doi.org/10.3390/nu13020560 - Oczkowski, M (2021) 'Health-promoting effects of bioactive compounds in blackcurrant (Ribes nigrum L.) berries', Roczniki Panstwowego Zakladu Higieny, 72(3), pp. 229-238. doi:10.32394/rpzh.2021.0174 Meta-analysis / review
https://doi.org/10.32394/rpzh.2021.0174 - Vagiri, M., Conner, S., Stewart, D., Andersson, S.C. and others (2015) 'Phenolic compounds in blackcurrant (Ribes nigrum L.) leaves relative to leaf position and harvest date', Food Chemistry, 172, pp. 135-142. doi:10.1016/j.foodchem.2014.09.041 Preclinical
https://doi.org/10.1016/j.foodchem.2014.09.041 - Gopalan, A., Reuben, S.C., Ahmed, S., Darvesh, A.S., Hohmann, J. and Bishayee, A (2012) 'The health benefits of blackcurrants', 3(8), pp. 795--809. doi:10.1039/c2fo30058c Randomized trial
https://doi.org/10.1039/c2fo30058c - Royal Botanic Gardens, Kew (n.d.). Available at: https://powo.science.kew.org Traditional / reference
https://powo.science.kew.org - Watson, A.W., Haskell-Ramsay, C.F., Kennedy, D.O., Dodd, F.L., Wightman, E.L. and Reay, J.L (2015) 'Acute supplementation with blackcurrant extracts modulates cognitive functioning and inhibits monoamine oxidase-B in healthy young adults', 54(3), pp. 505--513. Traditional / reference
https://scholar.google.com/scholar?q=Acute%20supplementation%20with%20blackcurrant%20extracts%20modulates%20cognitive%20functioning%20and%20inhibits%20monoamine%20oxidase-B%20in%20healthy%20young%20adults - Duke, J.A (2002) 'Handbook of Medicinal Herbs, Second Edition'. Traditional / reference
https://scholar.google.com/scholar?q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.