Plant Comparison
Andrographis vs Tormentil
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Andrographis and Tormentil: they share 5 indicated uses (arthritis / joint pain, inflammation (general), skin irritation, …); 1 pharmacological action in common.
Evidence face-off — shared uses
| Condition | Andrographis | Tormentil | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 5/10 | 1/10 | Stronger for Andrographis |
| Inflammation (general) | 5/10 | 3/10 | Stronger for Andrographis |
| Skin irritation | 5/10 | 6/10 | Comparable evidence |
| Sore throat | 7/10 | 2/10 | Stronger for Andrographis |
| Wounds | 5/10 | 5/10 | Comparable evidence |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Pharmacological Actions
Andrographolide, the principal diterpene lactone of Andrographis paniculata, suppresses proliferation and induces apoptosis across breast, lung, colon, cervical, hepatic and haematological cancers via NF-kappaB and PI3K/Akt inhibition (preclinical).
Anti-inflammatory gargle / mouthwash for sore throat and inflammation of the mouth and throat
Astringent for mild diarrhoea (ellagitannins tighten the gut lining) - in a paediatric RCT, tormentil root extract shortened rotavirus diarrhoea (3 vs 5 days) and reduced rehydration needs
Traditional & Indicated Uses
inferred from anti-inflammatory action
Andrographolide (from Andrographis paniculata) acts as a chemopreventive and antitumour agent against breast, lung, colorectal, cervical, prostate and hepatocellular cancers and leukaemia, inducing apoptosis and inhibiting NF-kappaB and PI3K/AKT signalling (preclinical).
Symptomatic relief of the common cold and acute upper respiratory tract infection (reduces symptom severity and duration)
Immunostimulant / immune support
Symptomatic relief of the common cold and acute upper respiratory tract infection (reduces symptom severity and duration)
inferred from anti-inflammatory action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
Astringent for mild diarrhoea (ellagitannins tighten the gut lining) - in a paediatric RCT, tormentil root extract shortened rotavirus diarrhoea (3 vs 5 days) and reduced rehydration needs
Supportive in inflammatory bowel disease / ulcerative colitis (limited trial evidence)
Anti-inflammatory gargle / mouthwash for sore throat and inflammation of the mouth and throat
inferred from astringent action
Anti-inflammatory gargle / mouthwash for sore throat and inflammation of the mouth and throat
Safety, Cautions & Contraindications
Avoid in pregnancy and when trying to conceive: high doses have shown reproductive toxicity in animals and the herb has a traditional reputation as an abortifacient.
High doses have caused nephrotoxicity and reproductive toxicity in studies; use standardized products at recommended doses and avoid prolonged high-dose use.
Tannin-rich: high or prolonged intake may cause stomach upset or constipation and can reduce the absorption of iron and some medicines taken at the same time.
Diarrhoea persisting more than 3-4 days, or with fever or blood in the stool, needs medical care. Use in pregnancy and breastfeeding is not recommended in the absence of data.
External Ids
Botanical Description
Erect, branching annual herb with a slender, quadrangular (square-sectioned), dark green stem. The leaves are opposite, lance-shaped and glabrous, with a short stalk. Small, two-lipped, white flowers with purple-pink markings are borne in loose, spreading axillary and terminal racemes. The whole plant, and especially the leaves, is intensely and characteristically bitter.[11]
Low, sprawling to semi-erect perennial herb (Rosaceae) with wiry stems. Leaves are palmate, typically with 4-5 leaflets and large leaf-like stipules that give the impression of more leaflets. Flowers are small, yellow and four-petalled - unusual among Potentilla species, most of which have five petals. The thick, woody rhizome is reddish inside when cut, the origin of the old name 'bloodroot' for this European species.[14]
Habitat
Native to India and Sri Lanka and widely distributed through South and Southeast Asia, growing wild in plains, hillsides, roadsides and cultivated fields; also grown commercially as a medicinal crop.[11]
Native to Europe and western Asia, common in acidic grassland, heath, moorland, open woodland and pastures on poor, well-drained soils.[14]
Harvesting
The aerial parts (leaves and tender stems) are cut just before or at the onset of flowering, when andrographolide content is typically highest, and dried in shade to preserve the bitter diterpenoid lactones.[11]
The rhizome is dug in autumn or early spring, when tannin content is highest, then cleaned and dried.[14]
Traditional Uses
Andrographis, the 'king of bitters', is a cornerstone bitter tonic of Ayurvedic and traditional Chinese medicine (Chuan xin lian), used for fevers, colds, sore throat, infections and liver complaints. This traditional reputation for treating the common cold and upper respiratory infections is now supported by clinical trials of standardised extracts.[10, 12]
Tormentil rhizome has an official European herbal-monograph tradition for mild diarrhoea and inflammation of the mouth and throat, reflecting its long folk use as a powerful astringent for gut and mucous-membrane complaints. Modern trials confirm its ellagitannin-rich rhizome shortens the duration of infectious (rotavirus) diarrhoea.[8, 14, 15]
Preparations
Dried aerial parts infused or lightly decocted in hot water as a very bitter traditional fever and cold remedy.
Dosage
Clinical trials for upper respiratory infection commonly use extracts standardised to around 60-120 mg andrographolide daily, in divided doses, for up to 5-7 days. Educational reference only, not a prescription.
The WHO monograph on Herba Andrographidis gives, by indication - for the common cold, 1.5-3.0 g of the powdered crude drug three times daily, after meals and at bedtime; for pyrexia, a decoction from 3 g of the crude drug twice daily; for diarrhoea, a decoction from 3-9 g as a single dose as needed, or two 500 mg tablets four times daily. Note that the EMA HMPC assessed this herb and issued a public statement rather than a monograph, so there is no EU posology. Educational reference only, not a prescription.
References
Lookalikes Review
References & Sources
- Okonogi, R. and others (2023) 'Efficacy of Andrographis paniculata spray in acute pharyngitis: A randomized controlled trial', Drug Discoveries & Therapeutics, 17(5), pp. 315-321. doi:10.5582/ddt.2023.01053 Randomized trial
https://doi.org/10.5582/ddt.2023.01053 - Hossain, S., Urbi, Z., Karuniawati, H., Mohiuddin, R.B. and others (2018) 'Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide', Critical Reviews in Food Science and Nutrition, 61(10), pp. 1635-1652. doi:10.1080/10408398.2018.1501657 Meta-analysis / review
https://doi.org/10.1080/10408398.2018.1501657 - Worakunphanich, W. and others (2021) 'Andrographis paniculata Formulations: Impact on Diterpene Lactone Oral Bioavailability', European Journal of Drug Metabolism and Pharmacokinetics, 46(5), pp. 565-581. doi:10.1007/s13318-021-00736-7 Meta-analysis / review
https://doi.org/10.1007/s13318-021-00736-7 - Worakunphanich, W., Thavorncharoensap, M., Youngkong, S., Thakkinstian, A. and Chaikledkaew, U (2021) 'Safety of Andrographis paniculata: A systematic review and meta-analysis', Pharmacoepidemiology and Drug Safety, 30(6), pp. 727-739. doi:10.1002/pds.5190 Meta-analysis / review
https://doi.org/10.1002/pds.5190 - Kumar, S., Singh, B. and Bajpai, V (2021) 'Andrographis paniculata (Burm.f.) Nees and its major constituent andrographolide as potential antiviral agents', Journal of Ethnopharmacology, 274, pp. 113954. doi:10.1016/j.jep.2021.113954 Meta-analysis / review
https://doi.org/10.1016/j.jep.2021.113954 - Barbosa, F.L. and others (2021) 'Andrographis paniculata (Burm. f.) Wall. ex Nees: An Updated Review of Phytochemistry, Antimicrobial Pharmacology, and Clinical Safety and Efficacy', Life, 11(4), pp. 348. doi:10.3390/life11040348 Meta-analysis / review
https://doi.org/10.3390/life11040348 - Singh, P. and others (2022) 'Andrographis paniculata mitigates first-line anti-tubercular drugs-induced nephrotoxicity in Wistar rats', Biomarkers, 27(4), pp. 385-394. doi:10.1080/1354750X.2022.2043444 Preclinical
https://doi.org/10.1080/1354750X.2022.2043444 - Coon, J.T. and Ernst, E (2004) 'Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials', Journal of Clinical Pharmacy and Therapeutics, 29(1), pp. 37-45. doi:10.1046/j.1365-2710.2003.00534.x Meta-analysis / review
https://doi.org/10.1046/j.1365-2710.2003.00534.x - Rondee, N. and others (2023) 'The Effects of Andrographis paniculata (Burm.F.) Wall. Ex Nees and Andrographolide on Neuroinflammation in the Treatment of Neurodegenerative Diseases', Nutrients, 15(15), pp. 3428. doi:10.3390/nu15153428 Meta-analysis / review
https://doi.org/10.3390/nu15153428 - Zeng, B., Wei, A., Zhou, Q., Yuan, M., Lei, K., Liu, Y., Song, J., Guo, L. and Ye, Q (2021) 'Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches', Phytotherapy Research. doi:10.1002/ptr.7324 Randomized trial
https://doi.org/10.1002/ptr.7324 - Gonde, D.P., Bhole, B.K. and Kakad, K.S (2023) 'Andrographolide, diterpenoid constituent of Andrographis paniculata: Review on botany, phytochemistry, molecular docking analysis, and pharmacology', Annales Pharmaceutiques Francaises. doi:10.1016/j.pharma.2023.10.001 Preclinical
https://doi.org/10.1016/j.pharma.2023.10.001 - Hu, X.Y., Wu, R.H., Logue, M., Blondel, C., Lai, L.Y.W., Stuart, B., Flower, A., Fei, Y.T., Moore, M., Shepherd, J., Liu, J.P. and Lewith, G (2017) 'Andrographis paniculata (Chuan Xin Lian) for symptomatic relief of acute respiratory tract infections in adults and children: A systematic review and meta-analysis', PLoS ONE. doi:10.1371/journal.pone.0181780 Meta-analysis / review
https://doi.org/10.1371/journal.pone.0181780 - World Health Organization (2002) 'Herba Andrographidis'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 - Tundis, R. and Patra, J.K. and Bonesi, M. and Das, S. and Nath, R. and Das Talukdar, A. and Das, G. and Loizzo, M.R (2023) 'Anti-Cancer Agent: The Labdane Diterpenoid-Andrographolide', Plants, 12(10), pp. 1969. doi:10.3390/plants12101969 Preclinical
https://doi.org/10.3390/plants12101969 - Mishra, S.K. and Tripathi, S. and Shukla, A. and Oh, S.H. and Kim, H.M (2015) 'Andrographolide and analogues in cancer prevention', Frontiers in Bioscience (Elite Edition), 7(2), pp. 255-266. doi:10.2741/E732 Preclinical
https://doi.org/10.2741/E732 - Paul, S. and Roy, D. and Pati, S. and Sa, G (2021) 'The Adroitness of Andrographolide as a Natural Weapon Against Colorectal Cancer', Frontiers in Pharmacology, 12, pp. 731492. doi:10.3389/fphar.2021.731492 Preclinical
https://doi.org/10.3389/fphar.2021.731492 - Memorial Sloan Kettering Cancer Center (n.d.) 'Andrographis (About Herbs)'. Available at: https://www.mskcc.org/cancer-care/integrative-medicine/herbs/andrographis Traditional / reference
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/andrographis
- Bandick, R., Busmann, L.V., Mousavi, S., Shayya, N.W. and others (2023) 'Therapeutic Effects of Oral Application of Menthol and Extracts from Tormentil (Potentilla erecta), Raspberry Leaves and Loosestrife during Acute Murine Campylobacteriosis', Pharmaceutics, 15(10), pp. 2410. doi:10.3390/pharmaceutics15102410 Preclinical
https://doi.org/10.3390/pharmaceutics15102410 - Fecka, I., Kucharska, A.Z. and Kowalczyk, A (2015) 'Quantification of tannins and related polyphenols in commercial products of tormentil (Potentilla tormentilla)', Phytochemical Analysis, 26(5), pp. 353-366. doi:10.1002/pca.2570 Preclinical
https://doi.org/10.1002/pca.2570 - Marcinczyk, N., Jarmoc, D., Leszczynska, A., Zakrzeska, A. and others (2017) 'Antithrombotic Potential of Tormentil Extract in Animal Models', Frontiers in Pharmacology, 8, pp. 534. doi:10.3389/fphar.2017.00534 Preclinical
https://doi.org/10.3389/fphar.2017.00534 - Melzig, M.F. and Bottger, S (2020) 'Tormentillae rhizoma - Review for an Underestimated European Herbal Drug', Planta Medica, 86(15), pp. 1050-1057. doi:10.1055/a-1129-7214 Traditional / reference
https://doi.org/10.1055/a-1129-7214 - Marcinczyk, N., Golaszewska, A., Gromotowicz-Poplawska, A., Misztal, T. and others (2021) 'Multidirectional Effects of Tormentil Extract on Hemostasis in Experimental Diabetes', Frontiers in Pharmacology, 12, pp. 682987. doi:10.3389/fphar.2021.682987 Preclinical
https://doi.org/10.3389/fphar.2021.682987 - Hoffmann, J., Gendrisch, F., Schempp, C.M. and Wolfle, U (2020) 'New Herbal Biomedicines for the Topical Treatment of Dermatological Disorders', Biomedicines, 8(2), pp. 27. doi:10.3390/biomedicines8020027 Traditional / reference
https://doi.org/10.3390/biomedicines8020027 - Tomczyk, M., Sosnowska, K., Pleszczynska, M., Strawa, J. and others (2017) 'Hydrogel Containing an Extract of Tormentillae rhizoma for the Treatment of Biofilm-Related Oral Diseases', Natural Product Communications, 12(3), pp. 417-421. doi:10.1177/1934578x1701200328 Preclinical
https://doi.org/10.1177/1934578x1701200328 - Subbotina, M.D., Timchenko, V.N., Vorobyov, M.M., Konunova, Y.S., Aleksandrovih, Y.S. and Shushunov, S (2003) 'Effect of oral administration of tormentil root extract (Potentilla tormentilla) on rotavirus diarrhea in children: a randomized, double blind, controlled trial', The Pediatric Infectious Disease Journal, 22(8), pp. 706--711. doi:10.1097/01.inf.0000078355.29647.d0 Randomized trial
https://doi.org/10.1097/01.inf.0000078355.29647.d0 - Wan, P., Chen, H., Guo, Y. and Bai, A.P (2014) 'Advances in treatment of ulcerative colitis with herbs: from bench to bedside', World Journal of Gastroenterology, 20(39), pp. 14099-14104. doi:10.3748/wjg.v20.i39.14099 Traditional / reference
https://doi.org/10.3748/wjg.v20.i39.14099 - Wolfle, U., Hoffmann, J., Haarhaus, B., Rao Mittapalli, V. and Schempp, C.M (2017) 'Anti-inflammatory and vasoconstrictive properties of Potentilla erecta - A traditional medicinal plant from the northern hemisphere', Journal of Ethnopharmacology, 204, pp. 86-94. doi:10.1016/j.jep.2017.03.058 Clinical study
https://doi.org/10.1016/j.jep.2017.03.058 - Moss, A.C. and Cheifetz, A.S (2007) 'Reducing the torment of diarrhea: tormentil for active ulcerative colitis', Journal of Clinical Gastroenterology, 41(9), pp. 797-798. doi:10.1097/MCG.0b013e3180684255 Clinical study
https://doi.org/10.1097/MCG.0b013e3180684255 - Shushunov, S., Balashov, L., Kravtsova, A., Krasnogorsky, I., Latte, K.P. and Vasiliev, A (2009) 'Determination of acute toxicity of the aqueous extract of Potentilla erecta (Tormentil) rhizomes in rats and mice', Journal of Medicinal Food, 12(5), pp. 1173-1176. doi:10.1089/jmf.2008.0281 Preclinical
https://doi.org/10.1089/jmf.2008.0281 - Kirsch, J., Jung, A., Hille, K., Konig, B., Hannig, C., Kolling-Speer, I., Speer, K. and Hannig, M (2020) 'Effect of fragaria vesca, hamamelis and tormentil on the initial bacterial colonization in situ', Archives of Oral Biology, 118, pp. 104853. doi:10.1016/j.archoralbio.2020.104853 Preclinical
https://doi.org/10.1016/j.archoralbio.2020.104853 - European Medicines Agency (HMPC) (n.d.) 'European Union herbal monograph on Potentilla erecta (L.) Raeusch., rhizoma (Tormentillae rhizoma)'. Available at: https://www.ema.europa.eu/en/medicines/herbal/tormentillae-rhizoma Traditional / reference
https://www.ema.europa.eu/en/medicines/herbal/tormentillae-rhizoma - ESCOP (European Scientific Cooperative on Phytotherapy) (n.d.) 'Tormentillae rhizoma (Tormentil) monograph', pp. com. Available at: https://www.escop.com/downloads/tormentil/ Traditional / reference
https://www.escop.com/downloads/tormentil/
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.