Plant Comparison
Andrographis vs Holy Basil
A side-by-side comparison of two medicinal plants — every documented constituent, action, use, safety note and cited source, assembled automatically from the Omnia Sana database.
At a glance
Andrographis and Holy Basil: they share 6 indicated uses (arthritis / joint pain, cancer (anticancer research), cold & flu, …); 3 pharmacological actions in common.
Evidence face-off — shared uses
| Condition | Andrographis | Holy Basil | Verdict |
|---|---|---|---|
| Arthritis / joint pain | 5/10 | 1/10 | Stronger for Andrographis |
| Cancer (anticancer research) | 2/10 | 8/10 | Stronger for Holy Basil |
| Cold & flu | 8/10 | 7/10 | Comparable evidence |
| Immune support | 5/10 | 7/10 | Stronger for Holy Basil |
| Inflammation (general) | 5/10 | 1/10 | Stronger for Andrographis |
| Skin irritation | 5/10 | 1/10 | Stronger for Andrographis |
Evidence scores (1–10) are computed from the tier of each cited source. “Comparable” means the two scores are within one point. Follow a score to its detailed sources.
Key Constituents
Pharmacological Actions
Andrographolide, the principal diterpene lactone of Andrographis paniculata, suppresses proliferation and induces apoptosis across breast, lung, colon, cervical, hepatic and haematological cancers via NF-kappaB and PI3K/Akt inhibition (preclinical).
Adaptogen for stress and anxiety (improves stress scores and well-being in trials)
Cognitive support - a placebo-controlled study in healthy adults found improved reaction time and accuracy and shorter P300 latency
Traditional & Indicated Uses
inferred from anti-inflammatory action
Andrographolide (from Andrographis paniculata) acts as a chemopreventive and antitumour agent against breast, lung, colorectal, cervical, prostate and hepatocellular cancers and leukaemia, inducing apoptosis and inhibiting NF-kappaB and PI3K/AKT signalling (preclinical).
Symptomatic relief of the common cold and acute upper respiratory tract infection (reduces symptom severity and duration)
Immunostimulant / immune support
Symptomatic relief of the common cold and acute upper respiratory tract infection (reduces symptom severity and duration)
inferred from anti-inflammatory action
inferred from anti-inflammatory action
Adaptogen for stress and anxiety (improves stress scores and well-being in trials)
inferred from anti-inflammatory action
Supports blood-sugar control (lowers fasting and post-meal glucose)
inferred from anticancer action
inferred from neuroprotective action
inferred from adaptogen action
inferred from anti-inflammatory action
inferred from anti-inflammatory action
Safety, Cautions & Contraindications
Avoid in pregnancy and when trying to conceive: high doses have shown reproductive toxicity in animals and the herb has a traditional reputation as an abortifacient.
High doses have caused nephrotoxicity and reproductive toxicity in studies; use standardized products at recommended doses and avoid prolonged high-dose use.
Generally well tolerated; mild nausea has been reported. Its blood-sugar-lowering effect means caution alongside antidiabetic medicines.
External Ids
Botanical Description
Erect, branching annual herb with a slender, quadrangular (square-sectioned), dark green stem. The leaves are opposite, lance-shaped and glabrous, with a short stalk. Small, two-lipped, white flowers with purple-pink markings are borne in loose, spreading axillary and terminal racemes. The whole plant, and especially the leaves, is intensely and characteristically bitter.[11]
Aromatic annual or short-lived perennial subshrub (Lamiaceae), 30-75 cm tall, with erect, much-branched, hairy stems often tinged purple. Leaves are opposite, ovate-oblong with a toothed margin, and release a strong, clove-like (eugenol) scent when crushed. Small purplish-pink, two-lipped flowers are borne in elongated terminal racemes. The plant is held sacred in Hindu tradition (Tulsi).[11]
Habitat
Native to India and Sri Lanka and widely distributed through South and Southeast Asia, growing wild in plains, hillsides, roadsides and cultivated fields; also grown commercially as a medicinal crop.[11]
Native to the Indian subcontinent and tropical Asia, now cultivated and naturalised throughout the tropics and subtropics worldwide; commonly grown in home gardens and temple courtyards as well as cultivated as a medicinal and aromatic crop.[12]
Harvesting
The aerial parts (leaves and tender stems) are cut just before or at the onset of flowering, when andrographolide content is typically highest, and dried in shade to preserve the bitter diterpenoid lactones.[11]
Leaves are harvested year-round from actively growing plants, ideally picked once morning dew has dried; whole flowering tops are also gathered.
Traditional Uses
Andrographis, the 'king of bitters', is a cornerstone bitter tonic of Ayurvedic and traditional Chinese medicine (Chuan xin lian), used for fevers, colds, sore throat, infections and liver complaints. This traditional reputation for treating the common cold and upper respiratory infections is now supported by clinical trials of standardised extracts.[10, 12]
Tulsi is one of the most revered plants in Ayurvedic medicine, traditionally used as an adaptogen for stress, a remedy for respiratory complaints (colds, cough, asthma), and a general immune tonic. Modern clinical trials support adaptogenic/anti-stress, blood-sugar-lowering and immunomodulatory effects consistent with these traditional uses.[3, 12]
Preparations
Dried aerial parts infused or lightly decocted in hot water as a very bitter traditional fever and cold remedy.
Dosage
Clinical trials for upper respiratory infection commonly use extracts standardised to around 60-120 mg andrographolide daily, in divided doses, for up to 5-7 days. Educational reference only, not a prescription.
The WHO monograph on Herba Andrographidis gives, by indication - for the common cold, 1.5-3.0 g of the powdered crude drug three times daily, after meals and at bedtime; for pyrexia, a decoction from 3 g of the crude drug twice daily; for diarrhoea, a decoction from 3-9 g as a single dose as needed, or two 500 mg tablets four times daily. Note that the EMA HMPC assessed this herb and issued a public statement rather than a monograph, so there is no EU posology. Educational reference only, not a prescription.
Clinical trials for stress and mood have used standardised dry-extract capsules taken over several weeks; dosing varies by product concentration, so follow the manufacturer's guidance. Educational reference only, not a prescription.
The WHO monograph on Folium Ocimi Sancti gives a daily dosage of 6-12 g of the crude drug as a decoction. This is a whole-day total for the fresh or dried leaf, notably higher than the 1-2 g per cup often quoted in popular sources. Educational reference only, not a prescription.
References
Lookalikes Review
Drug Class Interactions
Not documented
References & Sources
- Okonogi, R. and others (2023) 'Efficacy of Andrographis paniculata spray in acute pharyngitis: A randomized controlled trial', Drug Discoveries & Therapeutics, 17(5), pp. 315-321. doi:10.5582/ddt.2023.01053 Randomized trial
https://doi.org/10.5582/ddt.2023.01053 - Hossain, S., Urbi, Z., Karuniawati, H., Mohiuddin, R.B. and others (2018) 'Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide', Critical Reviews in Food Science and Nutrition, 61(10), pp. 1635-1652. doi:10.1080/10408398.2018.1501657 Meta-analysis / review
https://doi.org/10.1080/10408398.2018.1501657 - Worakunphanich, W. and others (2021) 'Andrographis paniculata Formulations: Impact on Diterpene Lactone Oral Bioavailability', European Journal of Drug Metabolism and Pharmacokinetics, 46(5), pp. 565-581. doi:10.1007/s13318-021-00736-7 Meta-analysis / review
https://doi.org/10.1007/s13318-021-00736-7 - Worakunphanich, W., Thavorncharoensap, M., Youngkong, S., Thakkinstian, A. and Chaikledkaew, U (2021) 'Safety of Andrographis paniculata: A systematic review and meta-analysis', Pharmacoepidemiology and Drug Safety, 30(6), pp. 727-739. doi:10.1002/pds.5190 Meta-analysis / review
https://doi.org/10.1002/pds.5190 - Kumar, S., Singh, B. and Bajpai, V (2021) 'Andrographis paniculata (Burm.f.) Nees and its major constituent andrographolide as potential antiviral agents', Journal of Ethnopharmacology, 274, pp. 113954. doi:10.1016/j.jep.2021.113954 Meta-analysis / review
https://doi.org/10.1016/j.jep.2021.113954 - Barbosa, F.L. and others (2021) 'Andrographis paniculata (Burm. f.) Wall. ex Nees: An Updated Review of Phytochemistry, Antimicrobial Pharmacology, and Clinical Safety and Efficacy', Life, 11(4), pp. 348. doi:10.3390/life11040348 Meta-analysis / review
https://doi.org/10.3390/life11040348 - Singh, P. and others (2022) 'Andrographis paniculata mitigates first-line anti-tubercular drugs-induced nephrotoxicity in Wistar rats', Biomarkers, 27(4), pp. 385-394. doi:10.1080/1354750X.2022.2043444 Preclinical
https://doi.org/10.1080/1354750X.2022.2043444 - Coon, J.T. and Ernst, E (2004) 'Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials', Journal of Clinical Pharmacy and Therapeutics, 29(1), pp. 37-45. doi:10.1046/j.1365-2710.2003.00534.x Meta-analysis / review
https://doi.org/10.1046/j.1365-2710.2003.00534.x - Rondee, N. and others (2023) 'The Effects of Andrographis paniculata (Burm.F.) Wall. Ex Nees and Andrographolide on Neuroinflammation in the Treatment of Neurodegenerative Diseases', Nutrients, 15(15), pp. 3428. doi:10.3390/nu15153428 Meta-analysis / review
https://doi.org/10.3390/nu15153428 - Zeng, B., Wei, A., Zhou, Q., Yuan, M., Lei, K., Liu, Y., Song, J., Guo, L. and Ye, Q (2021) 'Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches', Phytotherapy Research. doi:10.1002/ptr.7324 Randomized trial
https://doi.org/10.1002/ptr.7324 - Gonde, D.P., Bhole, B.K. and Kakad, K.S (2023) 'Andrographolide, diterpenoid constituent of Andrographis paniculata: Review on botany, phytochemistry, molecular docking analysis, and pharmacology', Annales Pharmaceutiques Francaises. doi:10.1016/j.pharma.2023.10.001 Preclinical
https://doi.org/10.1016/j.pharma.2023.10.001 - Hu, X.Y., Wu, R.H., Logue, M., Blondel, C., Lai, L.Y.W., Stuart, B., Flower, A., Fei, Y.T., Moore, M., Shepherd, J., Liu, J.P. and Lewith, G (2017) 'Andrographis paniculata (Chuan Xin Lian) for symptomatic relief of acute respiratory tract infections in adults and children: A systematic review and meta-analysis', PLoS ONE. doi:10.1371/journal.pone.0181780 Meta-analysis / review
https://doi.org/10.1371/journal.pone.0181780 - World Health Organization (2002) 'Herba Andrographidis'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 - Tundis, R. and Patra, J.K. and Bonesi, M. and Das, S. and Nath, R. and Das Talukdar, A. and Das, G. and Loizzo, M.R (2023) 'Anti-Cancer Agent: The Labdane Diterpenoid-Andrographolide', Plants, 12(10), pp. 1969. doi:10.3390/plants12101969 Preclinical
https://doi.org/10.3390/plants12101969 - Mishra, S.K. and Tripathi, S. and Shukla, A. and Oh, S.H. and Kim, H.M (2015) 'Andrographolide and analogues in cancer prevention', Frontiers in Bioscience (Elite Edition), 7(2), pp. 255-266. doi:10.2741/E732 Preclinical
https://doi.org/10.2741/E732 - Paul, S. and Roy, D. and Pati, S. and Sa, G (2021) 'The Adroitness of Andrographolide as a Natural Weapon Against Colorectal Cancer', Frontiers in Pharmacology, 12, pp. 731492. doi:10.3389/fphar.2021.731492 Preclinical
https://doi.org/10.3389/fphar.2021.731492 - Memorial Sloan Kettering Cancer Center (n.d.) 'Andrographis (About Herbs)'. Available at: https://www.mskcc.org/cancer-care/integrative-medicine/herbs/andrographis Traditional / reference
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/andrographis
- Lopresti, A.L., Smith, S.J., Metse, A.P. and Drummond, P.D (2022) 'A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (Holixer) on stress, mood, and sleep in adults experiencing stress', Frontiers in Nutrition, 9, pp. 965130. doi:10.3389/fnut.2022.965130 Randomized trial
https://doi.org/10.3389/fnut.2022.965130 - Baliga, M.S., Jimmy, R., Thilakchand, K.R., Sunitha, V. and others (2013) 'Ocimum sanctum L (Holy Basil or Tulsi) and its phytochemicals in the prevention and treatment of cancer', Nutrition and Cancer, 65(Suppl 1), pp. 26-35. doi:10.1080/01635581.2013.785010 Meta-analysis / review
https://doi.org/10.1080/01635581.2013.785010 - Cohen, M.M (2014) 'Tulsi - Ocimum sanctum: A herb for all reasons', Journal of Ayurveda and Integrative Medicine, 5(4), pp. 251-259. doi:10.4103/0975-9476.146554 Meta-analysis / review
https://doi.org/10.4103/0975-9476.146554 - Arya, R., Faruquee, H.M., Shakya, H., Rahman, S.A. and others (2024) 'Harnessing the Antibacterial, Anti-Diabetic and Anti-Carcinogenic Properties of Ocimum tenuiflorum Linn (Tulsi)', Plants, 13(24), pp. 3516. doi:10.3390/plants13243516 Preclinical
https://doi.org/10.3390/plants13243516 - Prakash, P. and Gupta, N (2005) 'Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review', Indian Journal of Physiology and Pharmacology, 49(2), pp. 125-131. Meta-analysis / review
https://scholar.google.com/scholar?q=Therapeutic%20uses%20of%20Ocimum%20sanctum%20Linn%20%28Tulsi%29%20with%20a%20note%20on%20eugenol%20and%20its%20pharmacological%20actions%3A%20a%20short%20review - Jayapal, V., Vidya Raj, C.K., Muthaiah, M., Chadha, V.K. and others (2021) 'In-vitro anti-Mycobacterium tuberculosis effect of essential oil of Ocimum sanctum L. (Tulsi/Basil) leaves', Indian Journal of Tuberculosis, 68(4), pp. 470-473. doi:10.1016/j.ijtb.2021.02.009 Preclinical
https://doi.org/10.1016/j.ijtb.2021.02.009 - Baliga, M.S., Rao, S., Rai, M.P. and D'souza, P (2016) 'Radio protective effects of the Ayurvedic medicinal plant Ocimum sanctum Linn. (Holy Basil): A memoir', Journal of Cancer Research and Therapeutics, 12(1), pp. 20-27. doi:10.4103/0973-1482.151422 Meta-analysis / review
https://doi.org/10.4103/0973-1482.151422 - Kamel, F.O., Karim, S., Bafail, D.A.O., Aldawsari, H.M. and others (2023) 'Hepatoprotective effects of bioactive compounds from traditional herb Tulsi (Ocimum sanctum Linn) against galactosamine-induced hepatotoxicity in rats', Frontiers in Pharmacology, 14, pp. 1213052. doi:10.3389/fphar.2023.1213052 Preclinical
https://doi.org/10.3389/fphar.2023.1213052 - Yadav, I., Kumar, R., Fatima, Z. and Rema, V (2024) 'Ocimum sanctum (Tulsi) as a Potential Immunomodulator for the Treatment of Ischemic Injury in the Brain', Current Molecular Medicine, 24(1), pp. 60-73. doi:10.2174/1566524023666221212155340 Meta-analysis / review
https://doi.org/10.2174/1566524023666221212155340 - Kumar, P. and Patel, D (2023) 'Ocimum Sanctum: An All-Round Treatment for Cancer?', Alternative Therapies in Health and Medicine, 29(4), pp. 253-257. Meta-analysis / review
https://scholar.google.com/scholar?q=Ocimum%20Sanctum%3A%20An%20All-Round%20Treatment%20for%20Cancer%3F - Bhattacharyya, P. and Bishayee, A (2013) 'Ocimum sanctum Linn. (Tulsi): an ethnomedicinal plant for the prevention and treatment of cancer', Anti-Cancer Drugs. doi:10.1097/CAD.0b013e328361aca1 Traditional / reference
https://doi.org/10.1097/CAD.0b013e328361aca1 - Jamshidi, N. and Cohen, M.M (2017) 'The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature', Evidence-Based Complementary and Alternative Medicine. doi:10.1155/2017/9217567 Meta-analysis / review
https://doi.org/10.1155/2017/9217567 - World Health Organization (2002) 'Folium Ocimi Sancti'. Available at: https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 Traditional / reference
https://iris.who.int/items/6418d8af-5200-4e6b-9bf5-004f3aa62a37 - Sampath, S., Mahapatra, S.C., Padhi, M.M., Sharma, R. and Talwar, A (2015) 'Holy basil (Ocimum sanctum Linn.) leaf extract enhances specific cognitive parameters in healthy adult volunteers: A placebo controlled study', Indian Journal of Physiology and Pharmacology, 59(1), pp. 69--77. Randomized trial
https://scholar.google.com/scholar?q=Holy%20basil%20%28Ocimum%20sanctum%20Linn.%29%20leaf%20extract%20enhances%20specific%20cognitive%20parameters%20in%20healthy%20adult%20volunteers%3A%20A%20placebo%20controlled%20study - Jamshidi, N. and Cohen, M.M (2017) 'The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature', Evidence-Based Complementary and Alternative Medicine, 2017, pp. 9217567. doi:10.1155/2017/9217567 Meta-analysis / review
https://doi.org/10.1155/2017/9217567 - Agrawal, P., Rai, V. and Singh, R.B (1996) 'Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus', International Journal of Clinical Pharmacology and Therapeutics, 34(9), pp. 406-409. Randomized trial
https://scholar.google.com/scholar?q=Randomized%20placebo-controlled%2C%20single%20blind%20trial%20of%20holy%20basil%20leaves%20in%20patients%20with%20noninsulin-dependent%20diabetes%20mellitus
Generated automatically from the Omnia Sana plant database and its cited sources. For educational purposes only — not medical advice. Always consult a qualified practitioner before using medicinal plants.